Clinical trials: Investigation Time
Left Ventricular Systolic Dysfunction, Heart Failure (Pediatric)
A Study to Learn More About How Safe Finerenone is, When it is Taken for a Longer Time With Standard Treatment, in Children and Young Adults With Heart Failure and Left Ventricular Systolic Dysfunction
Researchers are looking for a better way to treat children and young adults who have heart failure with left ventricular systolic dysfunction (LVSD).
- Trial name
- FIORELLO (NCT07192952)
- Testing
- Finerenone (Kerendia, BAY94-8862)
- Where
- 132 sites in United States, Argentina and 21 more
- Volunteers
- 117 people
- Sponsor
- Bayer
Dry Eye Syndrome
Evaluation of Tear Osmolarity Over Time With Sustained Use of Thera Tears Lubricating Drops
The objective of the study is to demonstrate a change in osmolarity over time when moderate to severe dry eye subjects are treated with TheraTears lubricating drops.
- Trial name
- AKORN (NCT02758327)
- Testing
- TheraTears Lubricating Eye Drops
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Koffler Vision Group
Bronchiectasis
Evaluation of Motor Imagery, Cognitive Function and Reaction Time in Children With Bronchiectasis
The aim of this study was to evaluate motor imagery ability, reaction time and cognitive function parameters in children with CF and non-CF bronchiectasis compared to healthy peers.
- Trial name
- NCT06630403
- Testing
- Demographic Data, Disease History, Pulmonary Function Test
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Atlas University
Dementia
Targeted Interdisciplinary Model for Evaluation and Treatment of Neuropsychiatric Symptoms in Home Care Services
Continuity of care in home care services is necessary to facilitate the assessment and treatment of persons with dementia and cognitive failure.
- Trial name
- NCT04034680
- Testing
- TIME, Education-only intervention
- Where
- Norway
- Volunteers
- 40 people
- Sponsor
- Sykehuset Innlandet HF
Infertility, Poor Ovarian Reserve
Ovarian PRP Injections for Improved Embryo Quality Using Embryo Quality Score
Patients will have ovarian PRP treatments and embryo development will be observed using time-lapse imaging and AI software.
- Conditions
- Infertility, Poor Ovarian Reserve, Embryo Growth Disorder, in Vitro Fertilization
- Trial name
- NCT07020546
- Testing
- Ovarian Platelet-rich plasma (PRP) injections
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Generation Next Fertility
Advanced Cancer
A Study to Test Combination Treatments in People With Advanced Renal Cell Carcinoma
The purpose of this study is to test the effectiveness and safety of various nivolumab combinations compared to nivolumab and ipilimumab in participants with advanced kidney cancer
- Trial name
- FRACTION-RCC (NCT02996110)
- Testing
- Nivolumab, Ipilimumab, Relatlimab
- Where
- 32 sites in United States, Australia and 4 more
- Volunteers
- 182 people
- Sponsor
- Bristol-Myers Squibb
Allergic Conjunctivitis
A Multi-Center, Evaluation of the Onset and Duration of Action of AC-170 0.24% Compared to Vehicle
The purpose of this study is to evaluate the onset and duration of action of AC-170 0.24% compared to vehicle in the prevention of the signs and symptoms of allergic conjunctivitis in the conjunctival allergen challenge (CAC)…
- Trial name
- NCT01881113
- Testing
- AC-170 0.24%, AC-170 0%
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- Aciex Therapeutics, Inc.
Prostate Cancer
Exisulind and Intermittent Androgen Suppression (ADT) in Biochemical Relapsed Prostate Cancer
The purpose of this research study is to determine if an investigational drug called Exisulind will extend the "off-treatment" period of patients receiving Intermittent Androgen Suppression (ADT).
- Trial name
- NCT00283803
- Testing
- Exisulind, luteinizing hormone-releasing hormone (LHRH) agonist, Antiandrogen
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Washington
High Altitude Effects, High Altitude
Assessment of Heart Rate Variability HRV During Descent DE From 2850m to Sea Level and During Re-ascent A From Sea Level to 2850m in Patients With Pulmonary Arterial Hypertension PAH
To study the effect of relocation from high altitude (Quito Ecuador: 2850m) to sea level and re-ascent from sea level to 2850m on heart rate variability and other hemodynamic parameters in patients with pulmonary arterial…
- Conditions
- High Altitude Effects, High Altitude, Pulmonary Vascular Disease, Pulmonary Arterial Hypertension (PAH)
- Trial name
- NCT07801859
- Testing
- Descent and re-ascent (2850m, sea level)
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Silvia Ulrich Somaini
Percutaneous Coronary Intervention, Dual Antiplatelet Therapy
Efficacy and Safety of Short Duration of DAPT After GENOSS® DES Implantation in Patients with Coronary Artery Disease
The objective of study is to evaluate the efficacy and safety of short duration of DAPT after GENOSS® DES Implantation in patients with coronary artery disease.
- Trial name
- DAPTShort (NCT06075420)
- Where
- South Korea
- Volunteers
- 1,000 people
- Sponsor
- Genoss Co., Ltd.
Heart Failure, Cardiomyopathy
Clinical Evaluation on Advanced Resynchronization
The aim of the study is to compare clinical benefits of the cardiac resynchronisation (CRT) achieved by the PEA optimised pacing configuration and a CRT optimised by standard clinical procedure.
- Trial name
- NCT00658203
- Testing
- New Living CHF
- Where
- 36 sites in France, Germany and 4 more
- Volunteers
- 310 people
- Sponsor
- LivaNova
Attention Deficit Disorder With Hyperactivity, HIV Infections
Assessment of Attentional Functioning in Children With HIV-1 Infection
Children with symptomatic HIV-1 (Human Immunodeficiency Virus) infection are at increased risk for developing severely disabling neurological and neuropsychological deficits.
- Conditions
- Attention Deficit Disorder With Hyperactivity, HIV Infections, Paralysis
- Trial name
- NCT00001497
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- National Cancer Institute (NCI)
Actinic Keratosis (AK)
Indoor Daylight Photodynamic Therapy is an Effective, First-line Treatment for AK, But Its Feasibility is Limited by the Time Required for the Illumination (2 Hours). Our Objective Was to Evaluate the Efficacy of Idl-PDT With an Illumination Time of 1 Hour Versus 2 Hours in the Treatment of Scalp AK
Several treatments are available for actinic keratosis (AK), many of which are hampered by local inflammation, pain, long duration, and slow healing.
- Trial name
- NCT07290959
- Testing
- We conducted an intra-patient, comparative study of idl-PDT with two illumination durations, 1 hour vs. 2 hours, using methyl aminolevulinate and a white LED light for the treatment of scalp AK.
- Where
- Italy
- Volunteers
- 55 people
- Sponsor
- San Salvatore Hospital of L'Aquila
Stress, Drug Abuse
Developing Field Tools for Real-Time Assessment of Exposure to Psychosocial Stress and Drug Use in an Outpatient Treatment Population
Background: Researchers are interested in developing more accurate methods to assess environmental influences on psychological stress and drug use.
- Trial name
- NCT00787423
- Where
- United States
- Volunteers
- 373 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cervical Dystonia, Primary
The Effects of Waning of Botulinum Toxin in the Treatment of Cervical Dystonia
The main treatment for cervical dystonia is botulinum toxin injections. However, some patients receiving this treatment after many years tend to experience short duration of benefit.
- Trial name
- NCT06886750
- Testing
- Botulinum toxin type A injection
- Volunteers
- 45 people
- Sponsor
- Western University, Canada
Type 1 Diabetes
Insulin Pump-RT Advisor (IPRA©): a Decision Support Software for Diabetic Patients Treated by Insulin Pump and Using Continuous Glucose Monitoring. Experimental Study. Evaluation by an Expert Patient Panel.
The purpose of the study is to assess the relevance of the advices provided by the IPRA© smartphone application for guiding the responses of insulin pump treated type 1 diabetes patients using real-time continuous glucose…
- Trial name
- IPRA (NCT01883024)
- Testing
- A decision support software, Insulin Pump, Continuous glucose monitoring
- Where
- France
- Volunteers
- 6 people
- Sponsor
- Rennes University Hospital
Obesity, Weight Maintenance
Real-Time Assessment of Food Craving, Use, and Triggers During Outpatient Treatment of Obesity: A Development and Feasibility Study
The objective of this study will assess the feasibility of utilizing real-time data monitoring in future clinical trials of weight control medications and other treatment modalities, along with the feasibility of distinguishing…
- Trial name
- NCT00198783
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Crowding of Anterior Maxillary Teeth
Efficacy and Periodontal Parameters in Self-ligating Brackets Alone or With Corticotomy vs Conventional Brackets
Patients who have severe crowding on the upper jaw that requires two first premolars extraction will be enrolled in this trial. The different types of brackets, such as self-ligating brackets and conventional brackets, and the…
- Trial name
- NCT04950829
- Testing
- Conventional brackets, Self-ligating brackets, Self-Ligating Brackets with flapless corticotomy
- Where
- Syria
- Volunteers
- 57 people
- Sponsor
- Damascus University
Cardiovascular Disease
Phase II Study To Evaluate The Safety and Efficacy of Hemoglobin Raffimer in Patients Undergoing First Time CABG Surgery
To evaluate the efficacy of Hemolink™ in combination with Intraoperative Autologous Donation (IAD) versus control (IAD alone) in facilitating avoidance of allogeneic RBC transfusion during and following primary CABG surgery
- Trial name
- NCT00038454
- Testing
- Hemolink (hemoglobin raffimer IV solution)
- Where
- 28 sites in United States, Canada and 1 more
- Volunteers
- 180 people
- Sponsor
- Hemosol
COVID-19, Long COVID
Using Data From a Multisensor Rapid Health Assessment Device to Predict Decompensation in Long COVID (AIDI)
We are conducting a research study at the VA hospital in Bedford, MA to learn more about how a multisensor rapid health assessment device, MouthLab, can help predict or anticipate future health complications in patients with…
- Trial name
- AIDI (NCT05713266)
- Testing
- MouthLabTM
- Where
- United States
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- Edith Nourse Rogers Memorial Veterans Hospital
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