Clinical trials: Iris
Psoriasis
Value Based Healthcare in Psoriasis
Rationale: Currently, the healthcare sector is under tremendous financial pressure, and many acknowledge that a dramatic shift is required as the current system is not sustainable.
- Trial name
- IRIS (NCT05480917)
- Testing
- Patients receiving PsoPlus care
- Where
- 2 sites in Belgium
- Volunteers
- 350 people
- Sponsor
- University Hospital, Ghent
Benign Prostatic Hyperplasia, Silodosin
Pupil Size and Choroidal Thickness Changes With Tamsulosin vs. Silodosin in Benign Prostatic Hyperplasia Patients
Benign prostatic hyperplasia (BPH) is a common disease in men and is treated with alpha-blockers, particularly tamsulosin and silodosin.
- Conditions
- Benign Prostatic Hyperplasia, Silodosin, Tamsulosin, Choroid
- Trial name
- NCT07743060
- Testing
- tamsulosin 0.4mg, Silodosin 8 mg
- Volunteers
- 40 people
- Sponsor
- Mohsen Pourazizi
Coronary Stenosis, Coronary Disease
IRIS-Firehawk® Cohort in the IRIS-DES Registry
The objective of this study is to evaluate effectiveness and safety of Firehawk® stent in the "real world" daily practice as compared with other drug-eluting stents.
- Trial name
- IRIS Firehawk (NCT03380286)
- Testing
- Firehawk
- Where
- South Korea
- Sponsor
- Duk-Woo Park, MD
Presbyopia, Ametropia
Clinical Trial With Artiflex Presbyopic (Artiplus)
The purpose of this clinical trial is to evaluate the effectiveness and safety of the multifocal Artiflex Presbyopic (Artiplus) intraocular lens.
- Conditions
- Presbyopia, Ametropia, Refractive Errors, Myopia
- Trial name
- NCT04632784
- Testing
- Artiflex Presbyopic (Artiplus) implantation
- Where
- 7 sites in South Korea, Spain
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Ophtec BV
Open Angle Glaucoma, Pseudoexfoliation Glaucoma
Trabeculopuncture as Predictive Test for the Success of Ab Interno Trabeculectomy
The purpose of this study is to perform trabeculopuncture a test to determine the distal outflow tract function to predict the success of ab interno trabeculectomy.
- Trial name
- NCT06523751
- Testing
- Trabeculopuncture
- Where
- Germany
- Volunteers
- 55 people
- Sponsor
- Wuerzburg University Hospital
Low Vision
Performance of Rigid Gas Permeable (RGP) Scleral Contact Lenses With a Passive Artificial Iris
Data from 15 healthy subjects will be recorded in two testing sessions spread on two days, using three lens designs (A, B and C).
- Trial name
- RGPIRIS_PA (NCT04040790)
- Testing
- Scleral contact lens without a passive artificial iris, Scleral contact lens with a passive artificial iris with low contrast (<1:5), Scleral contact lens with a passive artificial iris with high contrast (>1:5)
- Where
- Belgium
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Ghent
Pseudo Exfoliation Syndrome
Natural History of IOL in Pseudo Exfoliation Syndrome
The purpose of this study is to determine the natural course of IOL in PXF, To demonstrate use of a clinical grading system for PXF, To strategize a way to prevent IOL dislocation, subluxation post operatively, To demonstrate…
- Trial name
- PXF (NCT01255995)
- Testing
- Capsular Tension Ring
- Where
- 4 sites in India
- Volunteers
- 1,500 people
- Sponsor
- Aurolab
Locally Advanced Pancreatic Cancer, Metastatic Pancreatic Cancer
2nd-line Therapy With Nal-IRI After Gem/Nab-pac in Advanced Pancreatic Cancer - Predictive Role of 1st-line Therapy
Second-line therapy with Nal-IRI after failure gemcitabine/nab-paclitaxel in advanced pancreatic cancer - predictive role of 1st-line therapy
- Trial name
- PREDICT (NCT03468335)
- Testing
- Irinotecan Liposomal Injection [Onivyde]
- Where
- 35 sites in Germany
- Volunteers
- 151 people
- Sponsor
- AIO-Studien-gGmbH
Colorectal Cancer, Resistance
Chronic Inflammation, Plasma Proteins Signature, Survival Outcomes and Clinical Response, in Patients Receiving Bevacizumab Combined With Oxaliplatin-based Chemotherapy (Bev/OX) or Bevacizumab Combined With Irinotecan-based Chemotherapy (Bev/IRI)
Cancer-derived inflammation attenuates the efficacy of adjuvant chemotherapy (CT) in postoperative or metastatic colorectal cancer (mCRC).
- Conditions
- Colorectal Cancer, Resistance, Bevacizimab, Inflamation
- Trial name
- NCT07241403
- Where
- China
- Volunteers
- 698 people
- Sponsor
- Second Affiliated Hospital of Nanchang University
Full Aniridia, Partial Aniridia
Safety and Effectiveness of the CustomFlex Artificial Iris Prosthesis for the Treatment of Iris Defects
The purpose of this study is to study the long term safety and effectiveness of an artificial iris prosthesis for the treatment of iris defects.
- Trial name
- NCT01860612
- Testing
- Artificial Iris (CustomFlex)
- Where
- 13 sites in United States
- Volunteers
- 500 people
- Sponsor
- Clinical Research Consultants, Inc.
Open-Angle Glaucoma, Ocular Hypertension
Study of TRAVATAN in Subjects With Iris Pigmentation Changes
The purpose of this study was to monitor iris pigmentation changes over a 5-year period in patients with open-angle glaucoma or ocular hypertension.
- Trial name
- NCT00047554
- Testing
- Travoprost, 0.004% ophthalmic solution
- Volunteers
- 336 people
- Sponsor
- Alcon Research
Intraocular Melanoma, Melanoma (Skin)
Temozolomide and Interferon Alfa in Treating Patients With Stage III or Stage IV Melanoma
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Interferon alfa may interfere with the growth of cancer cells.
- Trial name
- NCT00027742
- Testing
- pegylated interferon alfa, temozolomide
- Where
- United States
- Sponsor
- Memorial Sloan Kettering Cancer Center
Ocular Hypertension, Open-Angle Glaucoma
Assessing Cosopt Switch Patients
To assess the safety and efficacy of a cohort of patients switched to the dorzolamide/timolol maleate fixed combination because they are insufficiently controlled on latanoprost monotherapy.
- Conditions
- Ocular Hypertension, Open-Angle Glaucoma, Exfoliation Syndrome, Glaucoma, Pigmentary
- Trial name
- NCT00273442
- Testing
- timolol maleate, dorzolamide/timolol maleate fixed combination
- Where
- 5 sites in United States
- Volunteers
- 60 people
- Sponsor
- Pharmaceutical Research Network
Fuchs' Endothelial Corneal Dystrophy, Bullous Keratopathy
Study of Endothelial Keratoplasty Outcomes
Endothelial keratoplasty is a cornea-sparing transplant technique that replaces only the diseased endothelial cell layer of the patient's cornea.
- Conditions
- Fuchs' Endothelial Corneal Dystrophy, Bullous Keratopathy, Iridocorneal Endothelial Syndrome, Posterior Polymorphous Dystrophy
- Trial name
- NCT00800111
- Testing
- endothelial keratoplasty
- Where
- United States
- Volunteers
- 2,593 people
- Sponsor
- Cornea Research Foundation of America
Graft Failure, Ischemia-reperfusion Injury
Induction of HO-1; a Therapeutic Approach to Reduce Ischaemia Reperfusion Injury (IRI) Following Deceased Donor Renal Transplantation
This is a blinded, placebo-controlled, randomised controlled trial looking at the effects of Heme arginate (HA) on cadaveric renal transplantation.
- Trial name
- HOT (NCT01430156)
- Testing
- Heme arginate (Normosang), 0.9% sodium chloride
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Edinburgh
Cataract, Pseudoexfoliation Syndrome
Bromfenac to Reduce Inflammation in Patients With Pseudoexfoliation Syndrome After Cataract Surgery
OBJECTIVE To evaluate the efficacy of bromfenac ophthalmic solution 0.09% for reducing postoperative inflammation in eyes with pseudoexfoliation syndrome (PEX) undergoing cataract surgery and receiving standard postoperative eye…
- Trial name
- REPEX (NCT02137161)
- Testing
- Dexamethasone+Tobramycin eye drop, Bromfenac eye drop
- Where
- Italy
- Volunteers
- 62 people
- Sponsor
- Azienda USL Reggio Emilia - IRCCS
Rectal Cancer Patients
Short-Course Radiotherapy, Nal-IRI, Capecitabine, and Camrelizumab for Locally Advanced MSS Rectal Cancer
This study is for adults with locally advanced rectal cancer that has not spread to distant organs, and is classified as pMMR or MSS (which means it typically does not respond well to immunotherapy alone).
- Trial name
- NCT07521605
- Testing
- Short-Course Radiotherapy, Liposomal Irinotecan (nal-IRI), Capecitabine
- Where
- China
- Volunteers
- 44 people
- Sponsor
- Guangdong Provincial People's Hospital
Hypercholesterolemia, Dyslipidaemia
Treatment of Hypercholesterolaemia in South Asian Subjects (IRIS)
The purpose of this study is to compare the effect of 6 weeks of treatment with Rosuvastatin with 6 weeks of treatment with Atorvastatin in South Asian subjects with hypercholesterolemia.
- Trial name
- IRIS (NCT00654225)
- Testing
- Rosuvastatin, Atorvastatin
- Volunteers
- 2,340 people
- Sponsor
- AstraZeneca
Glaucoma Capsulare, Genetic Predisposition to Disease
Genetic and Risk Factors in Exfoliation Glaucoma Patients
Prospective non-randomised cohort study enrolling patients with exfoliation glaucoma. All patients were ophthalmological examined at inclusion. Blood samples were taken for genetic analysis.
- Conditions
- Glaucoma Capsulare, Genetic Predisposition to Disease, Risk Reduction
- Trial name
- NCT06237764
- Testing
- No intervention
- Where
- Sweden
- Volunteers
- 130 people
- Sponsor
- Göteborg University
Adenocarcinoma Metastatic, Biliary Tract Cancer
Nal-IRI With 5-fluorouracil (5-FU) and Leucovorin or Gemcitabine Plus Cisplatin in Advanced Biliary-tract Cancer
AIO-YMO/HEP-0315 (NIFE) is an open label, non-comparative, randomized, multicenter phase II trial
- Conditions
- Adenocarcinoma Metastatic, Biliary Tract Cancer, Adenocarcinoma of the Biliary Tract, Adenocarinoma Locally Advanced
- Trial name
- NIFE (NCT03044587)
- Testing
- Arm NaI-IRI + 5-FU + Leucovorin (Arm A), Arm Cisplatin + Gemcitabine (Arm B)
- Where
- Germany
- Volunteers
- 93 people
- Sponsor
- AIO-Studien-gGmbH