Clinical trials: Irisin
Hypertension, Vitamin D Deficiency
The Impact of Vitamin D Supplementation in Hypertensive Vitamin D Deficient Patients.
This study will assess the impact of Vitamin D supplementation on hypertensive patients with Vitamin D deficiency, it will also investigate the relationship between serum Vitamin D, irisin levels, blood pressure, and heart rate…
- Trial name
- NCT06645041
- Testing
- Vitamin D (Cholecalciferol )
- Where
- 3 sites in Iraq
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Sulaimani
Uncoupling Protein-1, Polymorphism, Restriction Fragment Length
Effect of an Exercise on Serum Uncoupling Protein-1 Level and the Role of Uncoupling Protein-1-3826 A/G Polymorphism
This study aims to determine the effect of an acute maximal exercise on serum uncoupling protein-1, irisin, interleukin 6 levels, and on blood lipid and lipoprotein concentrations.
- Conditions
- Uncoupling Protein-1, Polymorphism, Restriction Fragment Length, Irisin
- Trial name
- NCT04156113
- Testing
- Yo-Yo intermittent recovery test (level 1)
- Where
- Turkey (Türkiye)
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Eastern Mediterranean University
Hypoxia, Altitude, Exercise Tolerance
Direct and Cross Effects of Adaptation to Systemic Hyperthermia: Impact on Quality of Life, Neurohormonal and Psychophysiological Human Status
Life expectancy and quality of human life are important indicator of the sustainable development of the society. At the same time, the physical, functional, emotional and psychological components of the of the quality of life…
- Conditions
- Hypoxia, Altitude, Exercise Tolerance, Metabolic Disturbance, Quality of Life
- Trial name
- NCT04089410
- Testing
- Hyperthermic Fitness Treatment (HFT), Physical Examination, Assessment of Cardiorespiratory Fitness
- Where
- Russia
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Breast Cancer
Role of Irisin/FNDC5 (rs3480) Single Nucleotide Polymorphism in Breast Cancer
Breast cancer is the most frequent cancer in women worldwide. Its incidence is increasing but mortality has decreased in a considerable way due to the combined effect of early detection and improvement in treatment .
- Trial name
- NCT05876728
- Testing
- Genotyping
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Multiple Sclerosis
Exercise-Induced Irisin and Brain Changes
This single-blind, randomized controlled trial will employ a two-arm parallel design (exercise group vs. control group) with a 12-week intervention period.
- Trial name
- NCT07101653
- Testing
- Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 21 people
- Sponsor
- Firat University
Rheumatoid Arthritis, Sleep Quality
The Effects of Exercise on Serum BDNF and Irisin Levels in Patients With Rheumatoid Arthritis
The aim of our study is to investigate the effects of aerobic exercise on sleep quality, fatigue, quality of life, depression and serum BDNF and irisin levels, which are important biomarkers of sleep in patients with rheumatoid…
- Conditions
- Rheumatoid Arthritis, Sleep Quality, Aerobic Exercise
- Trial name
- NCT05546294
- Testing
- Aerobic and home exercise, Home exercise, Healthy control group
- Where
- Turkey (Türkiye)
- Volunteers
- 151 people
- Sponsor
- Afyonkarahisar Health Sciences University
Ankylosing Spondylitis (AS), Irisin
The Effect of Exercise on Serum Irisin Levels and Clinical Parameters in Patients With Axial Spondyloarthritis.
This study aimed to investigate the effects of high-intensity intermittent exercise and moderate-intensity continuous exercise on serum irisin levels, disease activity, functional status, and quality of life in patients with…
- Trial name
- NCT07327073
- Testing
- High-Intensity Interval Training, Moderate-Intensity Continuous Exercise, control group
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Kirsehir Ahi Evran Universitesi
Sarcopenia
Human Irisin Concentration in Sarcopenia
Irisin has been identified as a novel myokine that drives brown-fat-like conversion of white adipose tissue. In this cross-sectional study, the researches investigated whether serum irisin levels are decreased in patients with…
- Trial name
- NCT01874912
- Where
- South Korea
- Volunteers
- 406 people, healthy volunteers welcome
- Sponsor
- Korea University
Physical Activity, Endothelial Dysfunction
Recreational Physical Activity and Cardiometabolic Profile
The purpose of present study was to investigate the effect of 10 weeks of recreational physical activity program on the irisin levels, progenitor endothelial cells and cardiometabolic profile in healthy children.
- Conditions
- Physical Activity, Endothelial Dysfunction, Metabolic Syndrome x
- Trial name
- NCT02982967
- Testing
- Physical Activity
- Where
- Brazil
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Exercise Physiology, Metabolic Hormones
Effects of Different Exercise Types on Irisin, Leptin, and Ghrelin Levels in Sedentary Women
This interventional study aims to investigate the acute effects of three different exercise modalities-aerobic exercise, anaerobic exercise, and high-intensity interval training (HIIT)-on irisin, leptin, and ghrelin levels in…
- Trial name
- ILEX (NCT07805772)
- Testing
- Aerobic Exercise, Anaerobic Exercise, High-Intensity Interval Training (HIIT)
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Inonu University
Endometrial Hyperplasia
Irisin Hormone Levels in Endometrial Hyperplasia
The purpose of the study is to determine serum irisin hormone levels an its relation between endometrial hyperplasia
- Trial name
- NCT02903797
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Kayseri Education and Research Hospital
Liver Fat, Type 2 Diabetes
EXIT: Prospective Study of the Response to Exercise
Background : Regular exercise is a cornerstone in the prevention and the management of comorbidities. Unfortunately, the metabolic benefit of exercise training is not universal and varies among individuals.
- Trial name
- EXIT (NCT02204670)
- Testing
- Acute release of irisin after a single exercise session.
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Kidney Disease, Chronic, Kidney Failure Chronic
Physical Exercise and Biomolecular Analysis to Reduce Uremic Toxins in Chronic Kidney Disease: An Exploratory Study
The accumulation of uremic toxins is detrimental to physiological systems and induces premature biological aging. Renal function assessment methods, such as predictive formulas, may be influenced by ancestry in Brazilians, given…
- Trial name
- DRC_LExS (NCT06910475)
- Testing
- Resistance training, Endurance training, Concurrent training
- Where
- Brazil
- Volunteers
- 1,600 people
- Sponsor
- Catholic University of Brasília
Cognitive Impairment, Healthy Participants
Exercise-Modulated Cognitive Hormones
Investigating the influence of a 12-week exercise regimen structured thrice weekly on cognitive capacity, and related hormones like Leptin, Irisin, BDNF hormones, antioxidant status, and inflammatory cytokines, whether these…
- Trial name
- NCT07341568
- Where
- Saudi Arabia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- King Saud University
BDNF, Irisin
The Acute Effect of Different Resistance Exercise Loads on Irisin and Brain-derived Neurotrophic Factor in Blood Serum and Plasma
The aim of this study is to investigate different resistance training loads on BNDF and irisin levels in platelets, blood serum and plasma.
- Conditions
- BDNF, Irisin, Resistance Exercise, Stroop Test
- Trial name
- NCT07189130
- Testing
- Exercise: 80% 1 RM with 2 minutes break, Exercise: 80% 1RM with1 minute break, Exercise: accenuated eccentric exercise
- Where
- Slovenia
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Ljubljana
MULTIPL SCLEROSİS
Comparison of Frailty, Physical Fitness Parameters, and Irisin Levels Between Patients With Multiple Sclerosis and Healthy Volunteers
Multiple Sclerosis (MS) is a chronic immune-mediated and neurodegenerative disease of the central nervous system that often affects young adults and is more common in women.
- Trial name
- NCT07521982
- Where
- Turkey (Türkiye)
- Volunteers
- 782 people, healthy volunteers welcome
- Sponsor
- Baskent University
Exercise Training Adaptation, Exercise Physiology
SPORT-SPECIFIC HIIT IN ELITE KICKBOXERS
This study examines how sport-specific high-intensity interval training (HIIT) affects the body in elite kickboxers. Participants are randomly assigned to either a HIIT training group or a control group.
- Conditions
- Exercise Training Adaptation, Exercise Physiology, High-Intensity Interval Training
- Trial name
- HIIT-KICK (NCT07449663)
- Testing
- Sport-Specific High-Intensity Interval Training, Regular Training
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Adiyaman University
Serum Irisin Levels in Obese Children
Serum Irisin Levels in Obese Children
Irisin is a myokine induced by exercise, that converts white fat tissue to brown fat tissue, thereby increases thermogenesis and energy expenditure.
- Trial name
- NCT04524936
- Testing
- blood sample
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Eskisehir Osmangazi University
Systemic Inflammatory Response Syndrome (SIRS)
Myostatin and Irisin Levels in Predicting the Outcome of Patients With Systemic Inflammation: A Prospective Observational Study
Systemic inflammatory response syndrome (SIRS) is associated with severe metabolic stress that can lead to rapid breakdown of skeletal muscle and the development of stress-related malnutrition.
- Trial name
- NCT07476391
- Where
- Czechia
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Peripartum Cardiomyopathy
Irisin Expression and Gene Polymorphism With Peripartum Cardiomyopathy.
this is an observertional study aimed at Study the association between the level of irisin expression and (Fibronectin Type III Domain Containing 5 (FDNC5) gene polymorphism in female patients with peripartum cardiomyopathy.
- Trial name
- NCT04927715
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Sohag University