Clinical trials: Irreversible Pulpitis, open to volunteers
Carious Primary Molars
Pulpotomy With CEM vs Pulpectomy With Ca(OH)2/Iodoform in Primary Molars
Will Calcium-Enriched Mixture (CEM) cement pulpotomy have less postoperative pain and more clinical and radiographic success compared to Calcium Hydroxide/Iodoform (Metapex) pulpectomy when managing second primary molars with…
- Trial name
- NCT07265063
- Testing
- Pulpotomy using Calcium-Enriched Mixture (CEM) Cement, Pulpectomy using Calcium Hydroxide/Iodoform Paste (Metapex)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cairo University
Pain
Comparative Evaluation of Post Obturation Pain After Root Canal Treatment Using Tricalcium Silicate vs Resin-Based Sealers
This is a randomized controlled trial comparing the mean and standard deviation of postobturation pain using two different sealers: a tricalcium silicate-based sealer (CeraSeal) and a resin-based sealer (Endoplus) in patients…
- Trial name
- NCT07388368
- Testing
- Tricalcium silicate sealar, Resin based sealer
- Where
- Pakistan
- Volunteers
- 118 people
- Sponsor
- Armed Forces Institute of Dentistry, Pakistan
Irriversible Pulpitis, Irrigation
Comparison of Post-operative Pain After Different Root Canal Irrigant Activation Methods
root canal irrigation protocol
- Conditions
- Irriversible Pulpitis, Irrigation, Activation, Patient
- Trial name
- NCT07196215
- Testing
- passive ultrasonic activation, sonic activation
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- RANA AHMAD
Post-endodontic Pain, Ibuprofen
Effect of Pre-medication With Anti-inflammatory Drugs(Ibuprofen and Dexamethasone)on Post-Endodontic Pain
Effect of pre-medication with anti-inflammatory drugs(ibuprofen and dexamethasone)on Post-Endodontic pain with symptomatic irreversible pulpitis
- Conditions
- Post-endodontic Pain, Ibuprofen, Dexamethasone
- Trial name
- NCT06980870
- Testing
- Anti-inflammatory drug (ibuprofen), Anti-inflammatory drug (dexamethsaone)
- Where
- Pakistan
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Armed Forces Institute of Dentistry, Pakistan
Symptomatic Irreversible Pulpitis (SIP)
Hypertonic Saline as a Final Flush and Post-Operative Pain After Single Visit Root Canal Treatment in Mandibular Premolar.
This randomized controlled trial evaluates whether a final flush with 3% hypertonic saline, compared with 0.9% normal saline, reduces post-operative pain and periapical Substance P (SP) levels after single-visit root canal…
- Trial name
- Hypertonic (NCT07701551)
- Testing
- Normal (0.9%) saline, Hypertonic 3% saline
- Volunteers
- 40 people
- Sponsor
- Cairo University
Irreversible Pulpitis With Apical Periodontitis, Symptomatic Apical Periodontitis
Comparison of the Pain Levels of Single-Dose Premedication With Piroxicam and Prednisolone on Post-Endodontic Pain in Single-Visit Root Canal Treatment of Premolars
To compare the post operative mean pain scores by administering single-dose preoperative piroxicam and prednisolone in patients of irreversible pulpitis with symptomatic apical periodontitis.
- Trial name
- NCT07281807
- Testing
- Group B: patients will be given prednisolone 20mg as premedication, piroxicam 20mg
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- RANA AHMAD
Pulpitis
Submucosal Cryotherapy and Anti-inflammatory Drugs for Postoperative Pain Following Root Canal Treatment in Maxillary Molars
Pain after root canal treatment is a common problem, particularly in teeth with symptomatic irreversible pulpitis, a condition involving severe inflammation of the tissue inside the tooth.
- Trial name
- NCT07919938
- Testing
- Articaine Hydrochloride With Epinephrine, Submucosal Cryotherapy, Diclofenac Sodium
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Suez Canal University
Concerned Growth Factor Versus Miniral Trioide Aggregate in Management of Mature Permanent Molar With Irreversible Pulpitis
Concerned Growth Factor VS Miniral Trioide Aggregate in Treatment of Mature Permanent Teeth of Children With Symptomatic Irreversible Pulpitis.
Concerned Growth factor versus Miniral Trioide aggregate in management of Mature permanent Molar of children with irreversible pulpitis
- Trial name
- NCT07138287
- Testing
- Concerned Growth factor in management of Mature permanent Molar with irreversible pulpitis
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Minia University
Postoperative Pain, Irreversible Pulpitis
Impact of Cross-Sectional Design in Single-File Rotary System on Apical Debris Extrusion
Endodontic treatment aims to achieve optimal biological outcomes while minimizing patient's discomfort during and after the procedure.
- Trial name
- NCT07808684
- Testing
- AF One single-file rotary system
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Minia University
Pain
Anesthetic Effectiveness of Mental/Incisive Nerve Block Versus Inferior Nerve Block Using 4% Articaine and 2% Lidocaine in Mandibular First and Second Premolars With Symptomatic Irreversible Pulpitis.
The purpose of this study is to check the anesthetic effectiveness of 4% Articaine and 2% Lidocaine in IANB Vs Mental nerve block in 1st and 2nd premolars with symptomatic Irreversible Pulpitis.
- Trial name
- NCT07905196
- Testing
- Group A : MINB with 2% Lidocaine HCL+ 1:1000,000 Epinephrine - 1.8 ml, Group B : MINB with 4% Articaine HCL + 1:1000,000 Epinephrine - 1.8 ml, Group C : IANB with 2% Lidocaine HCL + 1:1000,000 Epinephrine - 1.8 ml
- Where
- Pakistan
- Volunteers
- 108 people
- Sponsor
- Foundation University Islamabad
Symptomatic Irreversible Pulpitis With Apical Peridontitis
Neurokinin A and Matrix Metalloproteinase 9 Levels in Gingival Crevicular Fluid Samples of Teeth With Symptomatic Irreversible Pulpitis With Symptomatic Apical Periodontitis
The aim of this study is to investigate the levels Neurokinin A and of Matrix Mtalloproteinase (MMP-9) in gingival crevicular fluid samples (GCF) as potential biomarkers for the diagnosis of symptomatic irreversible pulpitis with…
- Trial name
- NCT07289074
- Testing
- Gingival crevicular fluid samples from the symptomatic teeth and the healthy contrlateral teeth
- Where
- Egypt
- Volunteers
- 23 people
- Sponsor
- Hadeer Mostafa El Mohamady El Feky
Postoperative Pain
The Effect of Anti-inflammatory Cryoagent on the Level of Postoperative Pain in Patients With Symptomatic Irreversible Pulpitis and Apical Periodontitis.
The aim of this study is comparative between: 1. Intra-radicular cryotherapy using cold anti-inflammatory {ketorolac tromethamine at 2-5C}. 2.
- Trial name
- NCT06584188
- Testing
- anti-inflammatory ketorolac tromethamine
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Pulpitis - Irreversible
Effect of Menstrual Phase on the Anesthetic Efficacy
The goal of this observational prospective clinical study is to learn whether the menstrual phase influences the anesthetic efficacy of inferior alveolar nerve block (IANB) in female patients aged 20-40 years with symptomatic…
- Trial name
- NCT07306533
- Testing
- Inferior Alveolar Nerve Block
- Where
- India
- Volunteers
- 150 people
- Sponsor
- Jamia Millia Islamia
Irreversible Pulpitis With Apical Periodontitis
Full Pulpotomy in Permanent Teeth With Irreversible Pulpitis and Apical Periodontitis
This study will evaluate whether full pulpotomy can successfully treat mature permanent teeth with irreversible pulp inflammation and a periapical lesion.
- Trial name
- NCT07768852
- Testing
- Full pulpotomy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- King Abdullah University Hospital
Symptomatic Irreversible Pulpitis (SIP), Dental Pain
Intraligamentary vs Inferior Alveolar Nerve Block for Pulpitis: A Randomized Clinical Trial
This multicenter randomized trial compares the clinical effectiveness of intraligamentary injection versus inferior alveolar nerve block (IANB) in patients with symptomatic irreversible pulpitis in mandibular molars.
- Conditions
- Symptomatic Irreversible Pulpitis (SIP), Dental Pain, Inferior Alveolar Nerve Block Failure, Local Anesthesia
- Trial name
- NCT07130760
- Testing
- Intraligamentary Injection, Inferior Alveolar Nerve Block
- Where
- 2 sites in Spain
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Aula Dental Avanzada
Postoperative Pain After Endodontic Treatment, Oral Health-Related Quality of Life
Effects of Different Root Canal Filling Materials and Irrigation Agitation Techniques on Postoperative Pain in Teeth With Irreversible Pulpitis: A Randomized Clinical Trial
This clinical study is designed to evaluate the effects of different irrigation agitation techniques and root canal sealers on postoperative pain and oral health-related quality of life in patients with symptomatic irreversible…
- Conditions
- Postoperative Pain After Endodontic Treatment, Oral Health-Related Quality of Life, Symptomatic Irreversible Pulpitis, Endodontic Treatment
- Trial name
- NCT07859384
- Testing
- XP-Endo Finisher, EDDY, Passive Ultrasonic Activation
- Where
- Turkey (Türkiye)
- Volunteers
- 324 people
- Sponsor
- Ankara University
Pulp Therapy, Pulpitis - Irreversible
Evaluation of Pulpotomy Versus Pulpectomy in Primary Molars With Irreversible Pulpitis or Necrotic Pulp
Preserving primary teeth until their normal exfoliation time is crucial for maintaining the child's normal function, esthetics, arch integrity, and correct eruption of permanent successors.
- Conditions
- Pulp Therapy, Pulpitis - Irreversible, Pulp Necrosis
- Trial name
- NCT07230717
- Testing
- Pulpotomy, Pulpectomy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ajman University
Symptomatic Irreversible Pulpitis (SIP), Symptomatic Apical Periodontitis
Comparison of Postoperative Pain After Root Canal Treatment Using Hand-Held vs Rotary ProTaper Files: A Randomized Controlled Trial
This randomized controlled trial aims to compare postoperative pain after root canal treatment using two different types of ProTaper file systems: manual (hand-held) and rotary (engine-driven).
- Conditions
- Symptomatic Irreversible Pulpitis (SIP), Symptomatic Apical Periodontitis, Postoperative Pain After Endodontic Treatment
- Trial name
- NCT07887087
- Testing
- ProTaper Manual Root Canal Instrumentation, ProTaper Rotary Root Canal Instrumentation
- Volunteers
- 200 people
- Sponsor
- College of Physicians and Surgeons Pakistan
Root Canal Treatment, Intra-operative Pain
This Clinical Trial Aims to Compare the Effectiveness of Two Intra-pulpal Cryotherapy Techniques-Endo-ice and Ice Sticks-in Decreasing Intra-operative Pain and Enhancing the Success of Local Anesthesia During Pulpectomy of Mandibular Molars With Symptomatic Irreversible Pulpitis.
The goal of this clinical trail is to compare the analgesic effect of endo-ice and ice-sticks in reducing intra-operative pain during pulpectomy in molars with Symptomatic Irreversible Pulpitis.
- Conditions
- Root Canal Treatment, Intra-operative Pain, Symptomatic Irreversible Pulpitis, Cryotherapy Effect
- Trial name
- NCT07264829
- Testing
- Endo-ice (Refrigerant Spray), Ice-sticks
- Where
- Pakistan
- Volunteers
- 90 people
- Sponsor
- Dow University of Health Sciences
Symptomatic Irreversible Pulpitis
Comparison of Post-Operative Pain Occurrence After Single Visit Root Canal Treatment
The goal of this clinical trial is to compare the post-operative pain occurrence after single visit root canal treatment using Two NiTi Rotary Files.
- Trial name
- NCT06777381
- Testing
- single visit root canal treatment using ProTaper Universal rotary system, single visit root canal treatment using M-Pro rotary system
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- National Research Centre, Egypt