Clinical trials: Irritability
Allergic Rhinitis, Asthma
Integrating Targeted MedlinePlus Health Prescriptions Into Clinic Practice Workflow
The specific aim of this proposed project is to implement a standard process for integrating MedlinePlus health information prescriptions into the clinic workflow.
- Conditions
- Allergic Rhinitis, Asthma, Back Pain, Benign Prostatic Hypertrophy
- Trial name
- NCT00634608
- Testing
- Health Information Prescription
- Where
- United States
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Irritable Bowel Syndrome
A Phase 1, First Time in Human (FTIH) Study to Evaluate GSK3352589, a REarranged During Transfection (RET) Growth Factor Receptor Tyrosine Kinase Inhibitor, in Healthy Volunteers
This FTIH study is designed to assess the safety, tolerability and pharmacokinetic (PK) of escalating single and repeat oral doses of GSK3352589 in normal healthy volunteers.
- Trial name
- NCT03154086
- Testing
- GSK3352589
- Where
- Australia
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Skin Irritation
Repeat Insult Patch Test of Skin Irritation/Sensitization for Cetaphil Dermacontrol Oil Control Moisturizer SPF 30
Determine if Cetaphil DermaControl Oil Control Moisturizer SPF 30 proves to be a contact sensitizer or irritant in certain individuals
- Trial name
- NCT01887808
- Testing
- Cetaphil DermaControl Oil Control Moisturizer SPF 30
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Galderma R&D
Irritable Bowel Syndrome
Multicenter Withdrawal Clinical Trials of N-acetyl Glucosamine Capsule for IBS-D Treatment
This study is a withdrawal randomized clinical trail to evaluate the clinical efficacy and safety of 1.1 chemical drugs N-acetyl glucosamine on Chinese IBS-D patients coming from four centers in chongqing.
- Trial name
- NCT01893606
- Testing
- N-acetyl-D-glucosamine
- Where
- China
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Third Military Medical University
Hygiene
Dermacyd Breeze Pocket BR (Lactic Acid) - Acceptability
The purpose of this study is to prove the safety of the gynaecological formulation in normal conditions of use.
- Trial name
- NCT00793026
- Testing
- Dermacyd Breeze Pocket BR (Lactic Acid)
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sanofi
Healthy
A Comparative Study to Evaluate Two Air-Activated Adhesive Backed Heat Patches
A disposable, air-activated, adhesive backed heat patch is being evaluated. Study terminated -O subjects.
- Trial name
- NCT02080143
- Testing
- Thermal Adhesion Patch
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Chattem, Inc.
Hygiene
Dermacyd Femina (Lactic Acid) Pocket BR - Photo Evaluation
To demonstrate the absence of photoirritation and photosensitization potential of the product Dermacyd Femina (Lactic Acid) Pocket BR.
- Trial name
- NCT00783640
- Testing
- Lactic Acid
- Where
- Brazil
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Sanofi
Skin Irritation, Healthy Volunteers
Safety of Topical Exosome-Containing Liquid in Healthy Volunteers
This Phase 1 split-site pilot study will evaluate the safety and dermal tolerability of a topical exosome-containing liquid in 10 healthy adult volunteers.
- Trial name
- EV-SAFE-1 (NCT07703969)
- Testing
- Exosome-Containing Liquid, Vehicle Liquid
- Where
- Kazakhstan
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- West Kazakhstan Marat Ospanov Medical University
Stress, Irritable Bowel Syndrome
Evaluating and Treating Potential Research Participants With Digestive Disorders
Background: Some research studies focus on digestive disorders, such as nutritional, gastrointestinal, and liver disorders. Researchers want to examine and treat people with digestive disorders in order to learn more about these…
- Conditions
- Stress, Irritable Bowel Syndrome, Obesity, Abdominal Pain
- Trial name
- NCT01736280
- Testing
- Standard of Care
- Where
- United States
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- National Institute of Nursing Research (NINR)
Irritability
Study Brain Mechanisms of Frustration With Magnetoencephalography in Healthy Volunteers
Background: Irritability can be defined as an unusually strong response to frustration; these responses may include severe temper outbursts and a constant grumpy mood.
- Trial name
- NCT06484088
- Testing
- Frustration task
- Where
- 2 sites in United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Insomnia, Nocturnal Awakening
Use Of The Dietary Supplement 5-ALA And Its Relationship With Sleep And Mood
PURPOSE: The purpose of this investigation is to determine if a relationship exists between the administration of a dietary supplement containing 5-ALA and sleep and mood.
- Conditions
- Insomnia, Nocturnal Awakening, Irritability, Coping Behavior
- Trial name
- NCT01508741
- Testing
- 5-Aminolevulinic Acid (5-ALA)
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- University of Hawaii
Irritable Bowel Syndrome
Phase I Clinical Trial of DA-6886 in Healthy Male Subjects
DA-6886_IBS_I is a phase I, dose block-randomized, double-blind, placebo-controlled, single/multiple dosing, dose escalation clinical trial with open-labelled food effect study of single dose to investigate the safety…
- Trial name
- NCT01633723
- Testing
- DA-6886
- Where
- South Korea
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Dong-A ST Co., Ltd.
Inflammatory Bowel Diseases, Irritable Bowel Syndrome
Precision Diagnostics of Functional and Organic Intestinal Pathology Based on Cellular and Molecular Profiling
Differential diagnosis of functional and organic intestinal pathology is carried out in line with approved clinical guidelines and includes a significant list of interventions.
- Conditions
- Inflammatory Bowel Diseases, Irritable Bowel Syndrome, Healthy Volunteers
- Trial name
- NCT05277662
- Testing
- cell and molecular diagnostics in accordance with functional test results
- Where
- 2 sites in Russia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Moscow State University of Medicine and Dentistry
Irritable Bowel Syndrome
Effect of Modified Cellulose on Colonic Fermentation of Inulin
A 3-way randomised cross-over study to test the hypothesis that combining either psyllium or methylcellulose to form a gel incorporating inulin will reduce gas production as compared to inulin given with a placebo, maltodextrin.
- Trial name
- COCOA2 (NCT05911347)
- Testing
- Psyllium, Methylcellulose, Maltodextrin
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Female Dry Genital Mucosa
Dermal and Gynecological Acceptability (Irritability and Sensitization in the Genital Mucosa) of an Investigational Product and Evaluation of Moisture Efficacy by TEWL and Perceived Efficacy.
To evaluate the safety of an investigational product through the verification of signs of irritability and sensitization of the genital mucosa, as well as the instrumental moisturizing efficacy by TEWL and barrier integrity…
- Trial name
- DERM GYN ACCEP (NCT03007615)
- Testing
- Intimate Lubricant Gel
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Kley Hertz S/A
Normal Skin
To Assess Skin Safety of Test Product(s) by Patch Test on Adult Healthy Human Subjects.
To Check Dermatological Safety of Test Products by 24 Hours Patch Testing
- Trial name
- NCT07065149
- Testing
- 1)0.1% Pinorox® Cream 2)1% Pinorox® Cream 3)Base cream 4)Positive control 5)Negative control
- Where
- India
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- NovoBliss Research Pvt Ltd
Intestinal Diseases, Irritable Bowel Syndrome
Biomarkers for Intestinal Permeability in Patients With Constipation
Our overall objective with this study is firstly to provide a comprehensive assessment of intestinal permeability, mucosal barrier function using existing biomarkers and secondly to explore novel biomarkers for measuring…
- Conditions
- Intestinal Diseases, Irritable Bowel Syndrome, Constipation
- Trial name
- NCT02246647
- Testing
- Permeability measurement, Esophagogastroduodenoscopy, Flexible sigmoidoscopy
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Irritable Bowel Syndrome, Gallstone Disease
Pharmacokinetics, Bioequivalence, and Safety Study of Trimedat® 76,95 mg Orally Disintegrating Tablets and Trimedat® 100 mg Tablets in Healthy Volunteers.
This study aims to evaluate pharmacokinetic profile, safety and establish bioequivalence of the investigational drug Trimedat® 76,95 mg orally disintegrating tablets compared to the reference drug Trimedat® 100 mg tablets in…
- Conditions
- Irritable Bowel Syndrome, Gallstone Disease, GERD, Biliary Dyskinesia
- Trial name
- NCT07421011
- Testing
- Trimedat®
- Where
- Russia
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Valenta Pharm JSC
Hygiene
Dermacyd Femina (Lactic Acid) - Photo Dermatological Evaluation of the Irritation and Sensitivity Potential.
To prove the absence of photo irritation and photo sensitivity potential of the product Dermacyd Femina.
- Trial name
- NCT00705744
- Testing
- Lactic acid (Dermacyd Femina)
- Where
- Brazil
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Sanofi
Inflammation, Microbiota
The Role of Dietary Titanium Dioxide on the Human Gut Microbiome and Health
This proposal will quantify dietary exposure of a nano- food additive in the U.S. food supply, and determine its impact on the human gut microbiome, gut inflammation, permeability and oxidative stress.
- Conditions
- Inflammation, Microbiota, Gastrointestinal Irritation
- Trial name
- NCT05864352
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Lowell