Clinical trials: Irritability
Healthy
Dermatological Evaluation of Topic Compatibility-Dermacyd Tina Gel Tangerina Mix
The purpose of this study is to demonstrate the absence of irritation potential (primary dermic irritability and cumulated dermic irritability) and allergy (sensibilization) of the product Dermacyd Tina Gel Tangerina Mix
- Trial name
- NCT00669058
- Testing
- Lactic acid (Dermacid)
- Where
- Brazil
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Sanofi
Functional Dyspepsia, Irritable Bowel Syndrome
The Efficacy and Safety of "BST104" (Lonicera Flos Extract) in Mild to Moderate Functional Dyspepsia Subjects
This study was conducted to prove the efficacy of BST-104 in patients with mild to moderate FD.
- Trial name
- NCT04008901
- Testing
- BST-104 (Lonicera Flos Extract)
- Where
- South Korea
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Seoul National University Bundang Hospital
Constipation-predominant Irritable Bowel Syndrome
Effect of Saccharomyces Cerevisiae on the Improvement of Gastro-intestinal Disorders Associated to IBS With C Phenotype
The main objective is to assess the effect of an 8-week daily supplementation with IbSium® (probiotic yeast Saccharomyces cerevisiae CNCM I-3856) on the improvement gastro-intestinal disorders associated to the type C IBS…
- Trial name
- IBS-GO (NCT03150212)
- Testing
- Saccharomyces cerevisiae CNCM I-3856
- Where
- 5 sites in France
- Volunteers
- 456 people, healthy volunteers welcome
- Sponsor
- Lesaffre International
Huntington Disease, Irritability
Evaluating the Efficacy of Dextromethorphan/Quinidine in Treating Irritability in Huntington's Disease
The purpose of this study is to assess efficacy and safety of dextromethorphan/quinidine 20mg/10mg (DM/Q 20mg/10mg) in patients with irritability due to Huntington's disease.
- Trial name
- NCT03854019
- Testing
- Dextromethorphan/quinidine 20mg/10mg (DM/Q 20mg/10mg)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Irritation
An Irritation Study With New Calcipotriol Ointment Formulations in Healthy Subjects
The purpose of this trial is to compare the skin irritation potential of eight different formulations of vitamin D analogues after repeated applications on intact skin of healthy subjects.
- Trial name
- NCT01105234
- Testing
- Six different calcipotriol ointment formulations, and two currently marketed topical vitamin D analogues.
- Where
- France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- LEO Pharma
Sunscreening Agents
Evaluation of the Irritation Potential of Products in Human Eyes.
To evaluate the human eye irritation potential of two test sunscreen formulation
- Trial name
- NCT02728856
- Testing
- Sunscreen Spray SPF50 Z15-034(BAY987516), Sunscreen Spray SPF50 Z15-038(BAY987516)
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Bayer
IBS
Fecal Metabolome and the Intestinal Microbiota in Irritable Bowel Syndrome
The purpose of this study is to find out the relationship between the bile acids, fatty acids (fatty acids are part of the diet) and bacteria that are present in the intestines.
- Trial name
- IBS (NCT02981888)
- Testing
- X-Ray
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Indiana University
Irritable Bowel Syndrome
Dieta Mediterranea e Sindrome Dell'Intestino Irritabile in Pazienti Pediatrici
The goal of this observational study is to observe pediatric patients with IBS (irritable bowel syndrome). The main question it aims to answer are: adherence to the Mediterranean diet of children with IBS in patients not adhering…
- Trial name
- NCT05738343
- Testing
- dieta mediterranea
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Healthy
Evaluation of Skin Irritation Potential With PF-06700841 Cream Formulation Using Negative Control in Adult Japanese Healthy Participants
This is a Phase 1, single center, randomized, vehicle and white petrolatum controlled, evaluator blinded study to assess the skin irritation potential with a range of concentrations of PF-06700841 cream including vehicle and…
- Trial name
- NCT03916250
- Testing
- PF-06700841 cream, White petrolatum
- Where
- Japan
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Pfizer
Irritable Bowel Syndrome
Gastrointestinal Symptoms in Healthy Subjects and Patients With Irritable Bowel Syndrome
The aim of this study performed in Irritable Bowel Syndrome (IBS) subjects and healthy patients is to demonstrate the ability of composite score of frequency of gastrointestinal symptoms to discriminate healthy subjects and IBS…
- Trial name
- NCT01457378
- Where
- 2 sites in France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Danone Global Research & Innovation Center
Attention Deficit Hyperactivity Disorder
Micronutrients for Attention-Deficit Hyperactivity Disorder in Youth (MADDY) Study
This proposed research will use randomized control trial (RCT) methodology and compare micronutrients with placebo in 135 children with ADHD.
- Trial name
- MADDY (NCT03252522)
- Testing
- Broad Spectrum Micronutrients; a 36-ingredient blend of vitamins, minerals, amino acids, and antioxidants
- Where
- 3 sites in United States, Canada
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Behavioral Problem, Irritable Mood
Stop, Focus, Plan, and Change: Predicting Parent and Child Responses to a Brief, Telehealth Parent Training
This study will look at who does not improve after doing a behavioral parent training program briefly through telehealth. It will also study ways to make the intervention better for those that do not improve.
- Conditions
- Behavioral Problem, Irritable Mood, Parenting, Stress
- Trial name
- NCT06505980
- Testing
- Brief Behavioral Parenting Program
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Central Nervous System Sensitization
Correlation Between Central Sensitization Inventory and Posturographic Data
To investigate the use of balance as a screening tool for Central Sensitization, a condition of the nervous system that is associated with the development and maintenance of chronic pain.
- Trial name
- NCT03058003
- Testing
- Posturography Evaluation, Central Sensitization Inventory
- Where
- 2 sites in United States, Australia
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Caps Research Network
IBS (Irritable Bowel Syndrome)
Mechanism of PERK - eIF2a Pathways in Intestinal Mucosal Barrier of IBS-D and the Role "Metabolism Ingredients" of Tongxieyaofang
Diarrhea irritable bowel syndrome(IBS-D）has seriously affected health and quality of life of patients.It may be important pathogenesis in development and recurrence of the process of IBS-D,excessive endoplasmic reticulum stress…
- Trial name
- NCT04122586
- Testing
- Tongxieyaofang(granule)
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Xiyuan Hospital of China Academy of Chinese Medical Sciences
Irritable Bowel Syndrome (IBS)
A Study To Investigate The Effect Of Solabegron (GW427353) On Gastrointestinal Transit In Healthy Volunteers
This study will test the hypothesis that GW427353, a beta-3 adrenergic agonist, retards the emptying of the colon and increases total colonic transit time.
- Trial name
- NCT00401479
- Testing
- Solabegron (GW427353)
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Irritable Bowel Syndrome
The Effect of Gluten in Patients With Irritable Bowel Syndrome and Healthy Volunteers
Patients with Irritable Bowel Syndrome (IBS) often link their symptoms to foods. Interest in dietary management recently increased, including the use of a gluten-free diet.
- Trial name
- PROT-IBS (NCT03869359)
- Testing
- Gluten-free diet with gluten powder
- Where
- Sweden
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Sahlgrenska University Hospital
Irritable Bowel Syndrome
Characterization of Pain Processing Mechanisms in Irritable Bowel Syndrome
The purpose of this study is to provide new information and to determine which kinds of brief, tolerable, experimental pain are affected by the drugs being studied in patients with irritable bowel syndrome, a disease that causes…
- Trial name
- NCT00100425
- Testing
- Viceral Perception Testing
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Menopause, Healthy Female Participants
A Study to Assess the Skin Irritation and Sensitization of Estradiol/Levonorgestrel TDS in Healthy Postmenopausal Subjects
The two products used in this study are transdermal patches that contain selegiline. The test drug is the Estradiol/Levonorgestrel Transdermal Delivery System (TDS). The comparator drug is the Climara Pro® TDS.
- Trial name
- NCT07794150
- Testing
- Estradiol/Levonorgestrel Transdermal System
- Where
- 2 sites in United States, India
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Corium Innovations, Inc.
Irritable Bowel Syndrome
A Phase I, Randomized, Placebo-controlled, Double Blind, Repeat Dose Escalation Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Gastrointestinal Transit Time and Pharmacodynamic Biomarkers of GSK3179106 in Normal Subjects
The current study is designed to assess the safety, tolerability, pharmacokinetics (PK), gastrointestinal (GI) transit time and pharmacodynamic (PD) biomarkers of repeat oral doses of GSK3179106 administered for 14 days in normal…
- Trial name
- NCT02798991
- Testing
- GSK3179106
- Where
- Australia
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Skin Irritation, Sensitization
A Skin Irritation Assessment of Once-Weekly Corplex™ Donepezil Transdermal Delivery System
A study to assess the skin irritation and sensitization potential of Corplex™ Donepezil Transdermal Delivery System (TDS)
- Trial name
- NCT03397862
- Testing
- Donepezil TDS, Vehicle TDS
- Where
- 2 sites in United States
- Volunteers
- 256 people, healthy volunteers welcome
- Sponsor
- Corium, Inc.