Clinical trials: Irritability
Parkinson Disease, Irritable Bowel Syndrome
Early Signs of Parkinsons Disease in IBS
Bowel symptoms like constipation and abdominal pain are characteristic symptoms of irritable bowel syndrome (IBS). The pathogenesis and pathophysiology are not fully understood but subject to intense research, with emphasis on…
- Trial name
- NCT05573542
- Where
- Sweden
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Örebro University, Sweden
Irritable Bowel Syndrome, Inflammatory Bowel Diseases
The Ecological Role of Yeasts in the Human Gut
Irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD) (categorised into Crohn's disease (CD) and ulcerative colitis (UC)) are chronic gut disorders with debilitating symptoms that profoundly impact quality of life…
- Conditions
- Irritable Bowel Syndrome, Inflammatory Bowel Diseases, Gastrointestinal Disease
- Trial name
- YIG (NCT04138225)
- Where
- United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Grace Ward
Ulcerative Colitis
Melatonin and Ulcerative Colitis: A Pilot Clinical Trial
Ulcerative colitis is an inflammatory bowel disease that afflicts up to one million people in the U.S. Symptoms include rectal urgency, bloody diarrhea, moderate to severe abdominal pain, fever, and fatigue.
- Trial name
- NCT00790478
- Testing
- Melatonin
- Where
- 2 sites in United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Emory University
Acne Vulgaris
Evaluation of Irritation That Could be Caused by Two Facial Gels Applied to Opposite Sides of the Face.
A study to compare the skin irritation potential of two marketed gels for acne treatment, each applied to half of the face of healthy volunteers.
- Trial name
- NCT00714714
- Testing
- Adapalene Gel, Tretinoin Gel
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Bausch Health Americas, Inc.
Irritable Bowel
Effect of Rate Of Delivery on Colonic Fermentation of inuliN (EON)
To test whether slowing the rate of delivery of inulin with either psyllium or divided dosing of inulin, will reduce colonic gas production as compared to inulin combined with placebo.
- Trial name
- EON (NCT05619341)
- Testing
- psyllium, inulin
- Where
- United Kingdom
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Irritable Bowel Syndrome
A Phase 1, Randomized, Placebo-Controlled, Ascending Cohort, Dose Escalation Study in Normal Healthy Volunteers
GSK3179106 is a potent and relatively selective inhibitor of RET kinase which has been designed to be a safe and effective therapy for irritable bowel syndrome (IBS) patients .
- Trial name
- NCT02727283
- Testing
- GSK3179106
- Where
- Australia
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Irritable Bowel Syndrome
Analysis of Differences in Small Intestinal Microbiota Structure and Metabolites Between Patients With Irritable Bowel Syndrome and Healthy Individuals
Irritable Bowel Syndrome (IBS) is a common functional bowel disorder with complex and not yet fully elucidated pathophysiological mechanisms.
- Trial name
- NCT07212569
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Zhongshan Hospital Xiamen University
Unspecified Trauma- and Stressor-Related Disorder
Pulsed ElectroMagnetic Field (PEMF) Therapy in Treating Post-Traumatic Stress Disorder (PTSD) & Trauma
Use of low-voltage, direct current pulsed electromagnetic fields (PEMF) in treating Post Traumatic Stress Disorder (PTSD), complex PTSD (cPTSD) and trauma-related injuries manifesting in physical and/or mental symptoms.
- Trial name
- NCT05033600
- Testing
- S.C.I.O.
- Where
- United Kingdom
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Kasey Phifer
Skin and Connective Tissue Diseases
Skin Irritation Test of LEO 80185 Gel in Healthy Japanese Subjects
The purpose of the study is to investigate skin irritation of LEO 80185 gel, gel vehicle and Liquid Paraffin in healthy Japanese male subjects.
- Trial name
- NCT02379793
- Testing
- LEO 80185 gel, vehicle, liquid paraffin
- Where
- Japan
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- LEO Pharma
Irritable Bowel Syndrome
1H-19F Gastrointestinal MRI in Health and IBS
The aim of this project is to demonstrate and validate the ionizing radiation free and non invasive assessment of small intestinal anatomy, content and function in healthy and disease by a newly developed combined proton (1H) and…
- Trial name
- NCT01347918
- Testing
- 19F capsule, sterculia
- Where
- Switzerland
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Healthy
Comparative Safety Study of New Sinecort Formulation Versus Positive Control
The study is focused to prove a favorable safety profile of the new formulation.
- Trial name
- NCT00885937
- Testing
- Dexpanthenol (Sinecort, BAY81-2996), Positive control, Na-laurylsulfat-solution, Untreated skin under application chamber
- Where
- Germany
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Bayer
Non-erosive Reflux Disease/Diarrheal Irritable Bowel Syndrome
Study on the Rule and Mechanism of Treating Functional Gastrointestinal Diseases From the Perspective of Liver and Spleen
To clarify the changes of intestinal flora - gut - brain axis in FGIDs patients represented by NERD disharmony of liver and stomach and IBS-D disharmony of liver and spleen, and confirm that the imbalance between intestinal flora…
- Trial name
- NCT04454996
- Testing
- tong-jiang granules, Chang 'an II Recipe
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Xiyuan Hospital of China Academy of Chinese Medical Sciences
Campylobacter Infections, Irritable Bowel Syndrome
Epidemiology and Pathophysiology of Post-Infectious Functional GI Disorders
Some people develop chronic abdominal pain with diarrhea or constipation after an episode of acute bacterial gastroenteritis. These symptoms can be consistent with post-infectious irritable bowel syndrome (IBS) and can last long…
- Trial name
- NCT03266068
- Testing
- DNA Analysis of Blood Sample, Flexible sigmoidoscopy with colonic biopsies, Small bowel and colonic gastrointestinal permeability
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic