Clinical trials: Irritable Colon
Irritable Bowel Syndrome (IBS)
Microbe-Gut Interaction in Microscopic Colitis and Post-Infectious Irritable Bowel Syndrome (IBS)
Objective: This study aims elucidate the pathophysiological link between the environment in the colon (mainly the microbiota), the local immune system and activation of the enteric nervous system in patients with post-infectious…
- Trial name
- NCT01787253
- Where
- Sweden
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Örebro University, Sweden
Irritable Bowel Syndrome, Dyspepsia
Treatment of Functional Abdominal Distension by Non-instrumental Biofeedback
Background. Abdominal distention is produced by an abnormal somatic postural tone. The authors developed an original biofeedback technique based on electromyography-guided control of abdominothoracic muscular activity.
- Conditions
- Irritable Bowel Syndrome, Dyspepsia, Functional Bloating
- Trial name
- NCT06150638
- Testing
- Biofeedback
- Where
- Spain
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Abdominal Pain
Objective Integrated Multimodal Electrophysiological Index for the Quantification of Visceral Pain
The objectives of the study are to 1) Conduct telemetric biosignals (EDA, ECG, and EMG) recording in healthy controls and IBS participants experiencing cutaneous and visceral pain; and 2) Validate the OIME index as a biomarker…
- Trial name
- OIME (NCT06381921)
- Testing
- IBS-PPSM intervention
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Connecticut
Crohn Disease, Ulcerative Colitis
OptiCal Study -Optimizing Fecal Calprotectin Monitoring: a Clinical Study Comparing CalproLab Against PhiCal and Evaluating Its Association With the Gut Microbiome
Study Aims: To analyze stool specimens to test and validate the CalproLab assay against the predicate PhiCal in order to determine performance characteristics. And to correlate Calpro levels to the gut microbiome composition.
- Conditions
- Crohn Disease, Ulcerative Colitis, Irritable Bowel Syndrome, Celiac Disease
- Trial name
- OptiCal (NCT03051204)
- Where
- United States
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Lower Abdominal Pain, Diarrhea
Efficacy and Safety of Encapsulated Bifidobacterium Longum BBH016 in Subjects With Lower Gastrointestinal Symptoms
Functional lower gastrointestinal (GI) symptoms such as abdominal pain, diarrhea, loose stools, and bloating are common in adults without identifiable organic disease and are associated with impaired quality of life and increased…
- Conditions
- Lower Abdominal Pain, Diarrhea, Irritable Bowel Syndrome
- Trial name
- NCT07484412
- Testing
- Bifidobacterium longum BBH016
- Where
- South Korea
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Seoul National University Bundang Hospital
Irritable Bowel
Effect of 6 Weeks Daily Consumption of a Cereal-based Juice Beverage on Gastrointestinal Health
The project is a randomized, 2-way, blinded parallel trial in which 56 healthy adults of both genders with frequent occurrence of stomach trouble.This intervention trial with 6 weeks of daily intake β-glucans will be carried out…
- Trial name
- NEWDRINK (NCT03046667)
- Testing
- Barley β-glucan, Control
- Where
- Denmark
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Amyotrophic Lateral Sclerosis (ALS), Angina, Stable
Quest to Analyze One Thousand Humans Meditating
This study will be focused on assessing the molecular, physiological, and emotional correlates of an intensive meditation experience in the context of a retreat setting in a large 2000 plus-person cohort comprised of healthy and…
- Conditions
- Amyotrophic Lateral Sclerosis (ALS), Angina, Stable, Anxiety, Asthma
- Trial name
- QUANTUM (NCT06583395)
- Testing
- Advanced multi-component meditation practice
- Where
- United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Tobias Moeller-Bertram
Irritable Bowel Syndrome
Effect of Hypnotherapy and Educational Intervention in Irritable Bowel Syndrome
Aim: Gut directed hypnotherapy can reduce IBS symptoms but the mechanisms underlying this therapeutic effect remain unknown. We determined the effect of hypnotherapy and educational intervention on brain responses to cued rectal…
- Trial name
- NCT01815164
- Testing
- Hypnotherapy, Educational intervention
- Where
- Sweden
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University Hospital, Linkoeping
Irritable Bowel Syndrome, Dysbiosis
Fecal Microbiota Transplantation and ACHIM for Manipulating Gut Microbiota in IBS Patients
The double-blinded placebo-controlled study compares the effect of fecal microbiota transplantation vs. Anaerobically Cultivated Human Intestinal Microbiota (ACHIM) or placebo (own feces) on manipulating the gut microbiota in…
- Trial name
- NCT05088434
- Testing
- Anaerobically Cultivated Human Intestinal Microbiota (ACHIM), Donor fecal microbiota transplantation
- Where
- Norway
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
Mucosa Associated Bacteria in Small Intestine
Changes of Microbiota in Irritable Bowel Syndrome Patients
To investigate the changes of gastrointestinal microbiota in irritable bowel syndrome patients by hydrogen breath test and molecular-based analysis of microbiota in gastrointestinal tract
- Trial name
- NCT01679730
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Far Eastern Memorial Hospital
Irritable Bowel Syndrome
The Effect of Saccharomyces Boulardii in Clinical Presentation and Quality of Life Patient With IBS
This study aims to compare the effectiveness of Saccharomyces Boulardii vs Placebo in patient with Irritable Bowel Syndrome
- Trial name
- NCT05451433
- Testing
- Saccharomyces Boulardii 250 MG
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Fakultas Kedokteran Universitas Indonesia
Gulf War Illness, Persian Gulf War Syndrome
Study of Gulf War Illness (GWI) by Comparing GWI and Healthy Veterans
Determine if: genetic differences of CNDP1 gene the previously defined GWI/Chronic Fatigue Syndrome (GWI/CFS) cerebrospinal fluid proteome contents psychometric other variables can differentiate between veterans of the 1990-1991…
- Trial name
- NCT00810225
- Where
- United States
- Volunteers
- 516 people, healthy volunteers welcome
- Sponsor
- Georgetown University
eHealth, Dietary Modification
One Year Home Monitoring and Treatment of IBS Patients
The purpose of this study Is to evaluate if a 4 weeks probiotic VSL#3 treatment and a strict LFD for 4 weeks are equally good in treating IBS symptoms in IBS patients with diarrhoea or mixed predominance and further evaluate the…
- Conditions
- eHealth, Dietary Modification, Probiotics, Microbiome
- Trial name
- NCT03586622
- Testing
- Low FODMAP diet (LFD), VSL#3®
- Where
- Denmark
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Nordsjaellands Hospital
Inflammatory Bowel Diseases, Irritable Bowel Syndrome
Application of Chemical Sensors for Diagnosis of Inflammatory Bowel Diseases and Irritable Bowel Syndrome by Respiratory Samples
Discriminating irritable bowel syndrome (IBS) from inflammatory bowel disease (IBD), especially with mild disease activity, is common clinical challenge.
- Trial name
- NCT01242163
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Irritable Bowel Syndrome
Brain and Gut Responses to Intragastric Administration of FODMAPs in Healthy Subjects and Patients With Irritable Bowel Syndrome
Low fermentable oligo-, di- and monosaccharides and polyols (FODMAPs) diet is taken as a possible strategy to improve symptoms in IBS patients.
- Trial name
- FODMAPs (NCT04283487)
- Testing
- Fructans, Glucose, Saline
- Where
- Belgium
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Colon, Irritable
Serine Proteases in Gastrointestinal Function and Irritable Bowel Syndrome (IBS)
The proposed pilot project for this seed grant focuses on the role of intestinal serine-proteases in the pathogenesis of diarrhea-predominant IBS (D-IBS).
- Trial name
- NCT01072916
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Non-Coeliac Wheat Sensitivity (NCWS), Irritable Bowel Syndrome
In Vivo Effects of Amylase Trypsin Inhibitors
Wheat is the most important staple food consumed in the Western world and provides beneficial health effects and functional properties.
- Trial name
- ATI (NCT05157867)
- Testing
- Amylase trypsin inhibitors
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Maastricht University
Diarrhea Predominant Irritable Bowel Syndrome
The Effects of Multi-strain Probiotics in Adults With Diarrhea Predominant Irritable Bowel Syndrome
The investigators will evaluate the efficacy of multi-strain probiotics in adults with diarrhea predominant irritable bowel syndrome.
- Trial name
- NCT01637714
- Testing
- Multi-strain probiotics
- Where
- South Korea
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Irritable Bowel Syndrome
Intracolonic FODMAP Infusion in Healthy Volunteers
Irritable bowel syndrome (IBS) is one of the most common chronic diseases of the gut-brain axis. The underlying pathophysiology is multifactorial, poorly understood and differs between the subtypes: constipation-dominant IBS…
- Trial name
- ICOF (NCT06488534)
- Testing
- Fermentable Oligo-, Di- Monosaccharides And Polyols (FODMAPs)
- Where
- Belgium
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
IBD - Inflammatory Bowel Disease, IBS - Irritable Bowel Syndrome
Low FODMAP Diet on Nutritional Status, Disease Activity and Gut Microbiota in IBS and UC With Normal or Overweight BMI
Gastrointestinal disorders represents 20-50% of referrals to the gastroenterologist; being the most affected womens, youths and older adults.
- Conditions
- IBD - Inflammatory Bowel Disease, IBS - Irritable Bowel Syndrome, UC - Ulcerative Colitis
- Trial name
- NCT04143633
- Testing
- Low FODMAP diet, Standard diet
- Where
- Mexico
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Hospital General de Mexico