Clinical trials: Irritation
Effects of Heat, Tolerability
Evaluation of Experimental and Commercial Air-Activated, Adhesive Backed Heat Patches
To assess the safety and tolerability for the extended wear of an experimental air-activated self adhesive patch.
- Conditions
- Effects of Heat, Tolerability, Adhesiveness, Dermal Irritation
- Trial name
- NCT01841801
- Testing
- Thermal Adhesive Patch, Marketed Thermal Adhesive Patch
- Where
- United States
- Volunteers
- 157 people, healthy volunteers welcome
- Sponsor
- Chattem, Inc.
Sensitivity, Contact
Dermatological Assessment of Primary Dermal Irritability Accumulated, Sensitization, Photoallergy and Phototoxicity.
This is a clinical study for health care product safety assessment. The research is going to conducted with 55 subjects, aged 18 to 70 years. The product is applied on the right and/or left participant back.
- Trial name
- NCT04332445
- Testing
- Hyaluronic Acid Gel
- Where
- Brazil
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Herbarium Laboratorio Botanico Ltda
Irritable Bowel Syndrome, Healthy
Remote Study of an Electronic Means to Characterize Bowel Movements in Adult Populations
A remote study to find out if a mobile phone application (HealthMode Stool) can serve as a useful tool to track and characterize daily bowel movements.
- Trial name
- NCT04182048
- Where
- United States
- Volunteers
- 843 people, healthy volunteers welcome
- Sponsor
- HealthMode Inc.
Healthy
Study to Evaluate the Safety, Local and Systemic Tolerability, and Pharmacokinetics of Multiple-Dose Topical Administration of PF-07038124 in Japanese Healthy Participants
The purpose of this study is to evaluate the safety, tolerability, skin irritation potential, and PK of PF-07038124 in Japanese healthy adult participants.
- Trial name
- NCT04863417
- Testing
- PF-07038124 or vehicle
- Where
- Japan
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Pfizer
Hygiene
Dermacyd PH_DETINBACK Tangerine Mix (Lactic Acid)- Compatibility
The purpose of this study is to demonstrate the absence of irritation potential (primary dermic irritability and cumulated dermic irritability) and allergy (sensibilization) of the product Dermacyd PHDETINBACK Tangerine Mix…
- Trial name
- NCT00784160
- Testing
- Lactic Acid (Dermacyd PH_DETINBACK Tangerine Mix)
- Where
- Brazil
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Sanofi
Hygiene
Topic Compatibility Dermacyd Delicata - New Fragrance - Lactoserum - Hygiene
The purpose of this study is to demonstrate the absence of potential irritation (primary dermic irritability and cumulated dermic irritability) and allergy (sensibilization) of the product Dermacyd Delicata (new fragrance of…
- Trial name
- NCT00380991
- Testing
- lactoserum
- Where
- Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Sanofi
Irritable Bowel Syndrome With Constipation
Trial of Linaclotide in Patients With Irritable Bowel Syndrome With Constipation (IBS-C)
The purpose of this study is to determine the safety and efficacy of linaclotide administered to patients with Irritable Bowel Syndrome with Constipation (IBS-C).
- Trial name
- NCT00938717
- Where
- 107 sites in United States
- Volunteers
- 805 people
- Sponsor
- Ironwood Pharmaceuticals, Inc.
Irritable Bowel Syndrome
Effectiveness of On-demand Meteospasmyl® Use in Irritable Bowel Syndrome (IBS)
The purpose of this study is to compare the effectiveness of 2 IBS treatment strategies: Strategy A = MeteoSpasmyl®, on-demand therapy Strategy B = standard of care chosen by the physician
- Trial name
- NCT01404923
- Testing
- anti spasmodic agents, alverine citrate, simeticone
- Volunteers
- 436 people
- Sponsor
- Laboratoires Mayoly Spindler
Irritable Bowel Syndrome With Constipation (IBS-C)
A Phase 3, International, Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group Efficacy and Safety Trial of Linaclotide Administered Orally for 12 Weeks to Patients With Irritable Bowel Syndrome With Constipation (IBS-C)
This clinical trial is an international, multicenter, randomized, double-blind, placebo-controlled, parallel-group trial comparing one dose of linaclotide to placebo.
- Trial name
- D5630C00001 (NCT01880424)
- Testing
- Linaclotide
- Where
- 82 sites in United States, Australia and 3 more
- Volunteers
- 1,722 people
- Sponsor
- AstraZeneca
Irritable Bowel Syndrome
The Efficacy of Sodium Butyrate and Probiotics in Patients With Irritable Bowel Syndrome
According to current IBS management guidelines, probiotic administration reduces IBS-associated symptoms and improves the quality of life.
- Trial name
- IBS-Plus (NCT05013060)
- Testing
- Probiotics and microcapsulated sodium butyrate, Maltodextrin
- Where
- Poland
- Volunteers
- 120 people
- Sponsor
- Nordic Biotic Sp. z o.o.
Healthy
Dermacyd Delicata Breeze - Photo Evaluation
The purpose of this study is to prove the absence of photo irritation and photo sensitivity potential of the product Dermacyd Breeze.
- Trial name
- NCT00668486
- Testing
- Lactic acid (Dermacid)
- Where
- Brazil
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Sanofi
Irritable Bowel Syndrome With Constipation (IBS-C)
A Single-Dose, Open-Label, Study to Evaluate the Sustainability of the Effects of SYN-010 in Patients With IBS-C
A Single-Dose, Open-Label, Extension Study to Evaluate the Sustainability of the Effects of SYN-010 in Patients with Irritable Bowel Syndrome with Constipation
- Trial name
- NCT02493036
- Testing
- SYN-010
- Where
- 11 sites in United States
- Volunteers
- 54 people
- Sponsor
- Theriva Biologics, Inc.
Irritability Associated With Autism Spectrum Disorder, Autism Spectrum Disorder
A Study of JZP541 in Adults With Irritability Associated With Autism Spectrum Disorder
Behavior dysregulation is commonly associated with people with autism spectrum disorder (ASD). Irritability is a major safety concern in adults with ASD.
- Conditions
- Irritability Associated With Autism Spectrum Disorder, Autism Spectrum Disorder, ASD
- Trial name
- NCT05733390
- Testing
- JZP541
- Where
- United States
- Sponsor
- Jazz Pharmaceuticals
Irritable Bowel Syndrome (IBS)
A Phase 2, Multi-center Study to Evaluate the Efficacy and Safety of ONO-2952 in Female Subjects With Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D)
The objective of this study is to explore efficacy, safety and tolerability of ONO-2952 in female subjects with Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D).
- Trial name
- RESTORE (NCT01844180)
- Testing
- ONO-2952
- Where
- 48 sites in United States
- Volunteers
- 200 people
- Sponsor
- Ono Pharma USA Inc
Irritable Bowel Syndrome
Vetal Laban Intervention Trial Assessing Bowel Symptoms
A two month intervention trial assessing the effect of Vetal Laban containing L. acidophilus on enhancing functional bowel wellbeing among subjects with irritable bowel syndrome (IBS).
- Trial name
- KF_2013 (NCT01887483)
- Testing
- Vetal Laban active
- Where
- 2 sites in Saudi Arabia
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Danisco
Irritable Bowel Syndrome
A Study to Investigate Abdominal Symptoms With Camlipixant Compared With Placebo in Adults With Irritable Bowel Syndrome - Diarrhea (IBS-D) and Irritable Bowel Syndrome - Mixed (IBS-M)
This study is designed to evaluate the efficacy and safety of camlipixant in adults with IBS-D and IBS-M. The study has two parts.
- Trial name
- BALANCE (NCT07519395)
- Testing
- Camlipixant
- Where
- 114 sites in United States
- Volunteers
- 420 people
- Sponsor
- GlaxoSmithKline
Skin Irritation
Repeat Insult Patch Test of Skin Irritation/Sensitization for Cetaphil Daily Facial Cleanser
Determine if Cetaphil Daily Facial Cleanser is a contact sensitizer or irritant to the skin
- Trial name
- NCT01888887
- Testing
- Cetaphil Daily Facial Cleanser
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Galderma R&D
Irritable Bowel Syndrome
Ibodutant for Relief of Irritable Bowel Syndrome (IRIS)
The purpose of the study is to evaluate the benefit of treatment with oral dose of Ibodutant (code: MEN 15596) on IBS symptoms and the safety and tolerability of this therapy.
- Trial name
- IRIS (NCT00761007)
- Testing
- Ibodutant
- Where
- 6 sites in Denmark, Germany and 4 more
- Volunteers
- 554 people
- Sponsor
- Menarini Group
Coughing, Throat Irritation
A Clinical Trial to Evaluate the Effects of Super Lungs Liquid Drops on Respiratory Comfort, Airway Soothing, and Overall Well-Being
This is a single-group, open-label, fully decentralized (virtual) clinical trial evaluating the effects of Super Lungs Liquid Drops on respiratory comfort, airway soothing, and overall well-being in generally healthy adults aged…
- Trial name
- NCT07694284
- Testing
- Super Lungs Liquid Drops
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- SuperBonsai Inc.
Skin Health
Effect of Baby Wipe Solutions on Fecal Enzyme-induced Irritation
This is a single-center, prospective, single-blind pilot study to determine baby wipe formulations on an adult dermatitis model.
- Trial name
- NCT03346447
- Testing
- Artificial Fecal Enzyme
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Kimberly-Clark Corporation