Clinical trials: Irritation
Gas Pain Related Intake
Efficacy and Tolerability of α-galactosidase in Treating Gas-related Symptoms in Children
The aim of this study was to evaluate the efficacy and tolerability of α-galactosidase in pediatric patients with predominant gas-related symptoms.
- Trial name
- NCT01595932
- Testing
- α-galactosidase
- Volunteers
- 52 people
- Sponsor
- Azienda Policlinico Umberto I
Gastroduodenal Erosions
Pilot Study of OXP005 to Assess Gastroduodenal Irritation
Oxford Pharmascience Ltd (the Sponsor) is developing a new naproxen tablet formulation (the study drug, OXP005), for the potential treatment of rheumatic and painful conditions.
- Trial name
- NCT02408978
- Testing
- OXP005, Naproxen
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- Oxford Pharmascience Ltd
Pterygium
The Use of Lidocaine Gel Versus Subconjunctival Xylocaine Injection in Pterygium Excision
In pterygium excision procedures, the subconjunctival injection of xylocain is regarded as an uncomfortable and painful step in the procedure.
- Trial name
- LIDPTER (NCT05978687)
- Testing
- OPHTESIC LIDOCAINE HYDROCHLORIDE 20MG/G, Xylocaine with Epinephrine
- Where
- Belgium
- Volunteers
- 41 people
- Sponsor
- Vrije Universiteit Brussel
IBS - Irritable Bowel Syndrome
Psilocybin-Assisted Psychotherapy in Treating Irritable Bowel Syndrome (IBS)
This study will serve as a pilot randomized controlled trial to assess the feasibility of Psilocybin-Assisted Psychotherapy (PAP) in Treating Irritable Bowel Syndrome (IBS).
- Trial name
- NCT06760533
- Testing
- Psilocybin 25 mg, Psychotherapy Treatment Session, Niacin 100 mg
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- NYU Langone Health
Irritable Bowel Syndrome, IBS
Study of Bacteria on Mood and Bowel Symptoms in Patients With Irritable Bowel Syndrome
The purpose of this study is to determine whether probiotic bacterium Bifidobacterium longum (B. longum) can improve mood and bowel symptoms in patients with Irritable bowel syndrome (IBS).
- Trial name
- NCT01276626
- Testing
- Bifidobacterium longum, Maltodextrin
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Société des Produits Nestlé (SPN)
Irritable Bowel Syndrome Characterized by Constipation
A Trial of Linaclotide 290 μg in Patients With Irritable Bowel Syndrome With Constipation (IBS-C)
To evaluate the efficacy on abdominal symptoms (abdominal bloating, abdominal discomfort, and abdominal pain) and safety of linaclotide 290 μg administered orally to patients with IBS-C.
- Trial name
- NCT03573908
- Testing
- Linaclotide
- Where
- 79 sites in United States
- Volunteers
- 614 people
- Sponsor
- Ironwood Pharmaceuticals, Inc.
Irritable Bowel Syndrome
A Study of Chios Mastic Water in Irritable Bowel Syndrome
Chios mastic is a natural product with strong antimicrobial, anti-inflammatory and antioxidant properties, and well-established benefits for dyspeptic disorders.
- Trial name
- MASTIQUA (NCT04893499)
- Testing
- Chios mastic water, Chios mastic fruit juice
- Where
- Greece
- Volunteers
- 55 people
- Sponsor
- Rutgers, The State University of New Jersey
Pelvic Organ Prolapse, Constipation
Cohort Study of Bowel Function Following Robotic-assisted Laparoscopic Sacrocolpopexy
Compare changes in bowel function before, 6 months and one year after Robotic-assisted laparoscopic sacral colpopexy. Compare objective anatomic outcomes before, 6 months and one year after Robotic-assisted laparoscopic sacral…
- Conditions
- Pelvic Organ Prolapse, Constipation, Bowel Dysfunction, Irritable Bowel Syndrome
- Trial name
- NCT01618292
- Testing
- Robotic sacral colpopexy
- Where
- United States
- Volunteers
- 393 people
- Sponsor
- Atlantic Health System
Irritable Bowel Syndrome, IBS - Irritable Bowel Syndrome
Human Milk Oligosaccharides (HMOs) for Irritable Bowel Syndrome (IBS)
To assess the effects of a Human Milk Oligosaccharide mix given once daily for 12 weeks on stool consistency and abdominal pain compared to placebo in individuals with Irritable Bowel Syndrome (IBS).
- Trial name
- HIBS (NCT05205785)
- Testing
- Human Milk Oligosaccharide Mix
- Where
- Ireland
- Volunteers
- 204 people
- Sponsor
- dsm-firmenich Switzerland AG
Irritable Bowel Syndrome
A Four Arm Study to Evaluate the Safety and Efficacy of 3 Different Doses of RVX-100 Versus Placebo in Subjects With Irritable Bowel Syndrome Accompanied by Diarrhea (IBS-D)
The purpose of this study is to determine if RVX-100 is safe and effective in treating acute abdominal pain in patients with irritable bowel syndrome accompanied by diarrhea.
- Trial name
- NCT01076699
- Testing
- 0.075 mg RVX-100, 0.125 mg RVX-100, 0.250 mg RVX-100
- Where
- United States
- Volunteers
- 192 people
- Sponsor
- Revogenex, Inc.
IBS
Effects of Mexiletine on Colonic Transit in a Patient With Irritable Bowel Syndrome - Constipation (IBS-C)
To understand if Mexiletine will restores normal colonic motility in a patient with irritable bowel syndrome - constipation (IBS-C) and a genetic mutation in SCN5A.
- Trial name
- NCT01717404
- Testing
- Mexiletine
- Volunteers
- 1 people
- Sponsor
- Mayo Clinic
Irritable Bowel Syndrome
Serum Levels of Apelin, Chemerin and Adiponectin Adipokines in Irritable Bowel Syndrome and Healthy Subjects
In this observational case-control study investigators aimed to assess the serum levels of adipokines such as Apelin, Chemerin and adiponectin in patients with irritable bowel syndrome (IBS), and compare it with healthy controls.
- Trial name
- NCT03366389
- Where
- Iran
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Amir Abbasnezhad
Irritable Bowel Syndrome
Clinical Effectiveness of Exposure Based Cognitive Behavioral Group Therapy for IBS
The aim of the study is to evaluate the effects of a specific Cognitive Behavioral treatment protocol for patients with IBS used in routine care at a gastroenterology unit in Stockholm.
- Trial name
- NCT04756414
- Testing
- Exposure based face-to-face Cognitive Behavior Group Therapy
- Volunteers
- 143 people
- Sponsor
- Karolinska Institutet
Irritable Bowel Syndrome With Diarrhea
Evaluating the Safety and Efficacy of the Probiotic Bifidobacterium Longum ES1 and the Post Biotic Heat-treated Bifidobacterium Longum ES1 (HT-ES1) on IBS Symptom Severity in Patients With Diarrhoea Predominant Irritable Bowel Syndrome
Randomized controlled clinical study has been proposed to evaluate the safety and efficacy of ES1 probiotic strain and heat-treated ES1 postbiotic strain in individuals suffering from IBS-D.
- Trial name
- NCT05339243
- Testing
- ES 1, HT ES1
- Where
- 8 sites in India
- Volunteers
- 200 people
- Sponsor
- Vedic Lifesciences Pvt. Ltd.
Inflammatory Bowel Disease, Irritable Bowel Syndrome
BÜHLMANN fCAL™ ELISA - Aid in Differentiation of IBD From IBS
The purpose of this study is to confirm the sensitivity and specificity of the BÜHLMANN fCAL™ ELISA as an aid in diagnosis to differentiate between Inflammatory Bowel Disease (IBD; Crohn's Disease (CD), Ulcerative Colitis (UC)…
- Trial name
- NCT02351635
- Testing
- fecal calprotectin level
- Where
- 7 sites in United States
- Volunteers
- 478 people, healthy volunteers welcome
- Sponsor
- Bühlmann Laboratories AG
Fibromyalgia, Irritable Bowel Syndrome
Fecal Calprotectin Levels in Patients With Fibromyalgia
This study was designed to evaluate fecal calprotectin levels in patients with fibromyalgia syndrome. Fecal calprotectin levels from fibromyalgia patients with and without gastrointestinal symptoms as well as healthy controls…
- Conditions
- Fibromyalgia, Irritable Bowel Syndrome, Abdominal Pain
- Trial name
- NCT05404893
- Testing
- Fecal calprotectin measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ege University
Irritable Bowel Syndrome
Caecal pH as a Biomarker for Irritable Bowel Syndrome
Irritable bowel syndrome is common. Currently, it is a diagnosis of exclusion. There is increasing evidence of the importance of the microbiota in the pathophysiology of this disorder.
- Trial name
- NCT02360384
- Testing
- Linaclotide, FODMAP diet
- Where
- United Kingdom
- Volunteers
- 48 people
- Sponsor
- Wingate Institute of Neurogastroenterology
Skin Barrier to Water Loss, Skin Health
Apple Peptide Complex for Post-Surgical and Aesthetic Skin Recovery
This clinical study evaluates a topical botanical formulation for supporting skin recovery following invasive and non-invasive aesthetic procedures.
- Conditions
- Skin Barrier to Water Loss, Skin Health, Skin Discoloration, Skin Irritation
- Trial name
- APC-SKIN (NCT07807085)
- Testing
- Apple Peptide Complex Post-Aesthetic Care Protocol
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Grow Out Oils Clinical Aromatherapy Company
Irritable Bowel Syndrome
Defining Objective Markers of Compliance for Dietary Therapies in IBS
This research will investigate if a specific marker in your stool or urine can be used to track changes in your carbohydrate intake including fructo-oligosaccharide and mannitol intake
- Trial name
- NCT07494968
- Testing
- Diet A - elimination diet, Diet B - healthy eating diet
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- University of Michigan
Irritable Bowel Syndrome
Harnessing Placebo Effects: Non-Deceptive Use of Placebo in Irritable Bowel Syndrome (IBS)
Irritable bowel syndrome patients will be given either placebo pill or no treatment for a period of 3 weeks.
- Trial name
- NCT01010191
- Testing
- Sugar pill
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Harvard University Faculty of Medicine
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