Clinical trials: Irritation
Skin Irritation
Repeat Insult Patch Test of Skin Irritation/Sensitization for Cetaphil Daily Facial Cleanser
Determine if Cetaphil Daily Facial Cleanser is a contact sensitizer or irritant to the skin
- Trial name
- NCT01888887
- Testing
- Cetaphil Daily Facial Cleanser
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Galderma R&D
Proof of Concept, Irritable Bowel Syndrome
Validation of the Small Intestine Microbiome Aspiration (SIMBA) Capsule
Prospective, open label trial to establish the ability of the SIMBA Capsule to accurately obtain a sample from the small bowel of participants with IBS (10 constipation-predominant (IBS-C) and 10 diarrhea-predominant (IBS-D)) and…
- Trial name
- NCT04094558
- Testing
- Ingestible capsule, Sedated EGD, Lactulose Breath Test
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Irritable Bowel Syndrome, Irritable Bowel Syndrome - Constipation
Efficacy of Chatbot for Irritable Bowel Syndrome (IBS) Patients
The goal of this clinical trial is to evaluate the efficacy of an automated chatbot system in improving quality of life, reducing depression and anxiety, and decreasing visceral sensitivity in patients with Irritable Bowel…
- Conditions
- Irritable Bowel Syndrome, Irritable Bowel Syndrome - Constipation, Irritable Bowel Syndrome - Diarrhoea, Irritable Bowel Syndrome - Mixed
- Trial name
- IrBiS (NCT06837064)
- Testing
- Chatbot supporting system
- Where
- Russia
- Volunteers
- 54 people
- Sponsor
- Research and Practical Clinical Center for Diagnostics and Telemedicine Technologies of the Moscow Health Care Department
IBS - Irritable Bowel Syndrome
Effect of Postbiotic Product on Colonic Barriers in IBS
Impaired intestinal permeability and microbial dysbiosis are important pathophysiological mechanisms underlying irritable bowel syndrome (IBS).
- Trial name
- NCT05475314
- Testing
- ReFerm(R)
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Nordisk Rebalance A/S
Irritable Bowel Syndrome, FODMAP
The Effect of a Low FODMAP Diet in Irritable Bowel Syndrome Patients
Tertiary care IBS patients will be recruited for a prospective low FODMAP intervention study, hereby focusing on the reintroduction phase of the diet, where patients are blindly challenged with different FODMAP groups…
- Trial name
- FIBS (NCT04373304)
- Testing
- low FODMAP diet
- Where
- Belgium
- Volunteers
- 45 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Irritable Bowel Syndrome
Assessing Associations Between IBS Symptoms, Nutrition and QoL in IBS Patients Using a Questionnaire
This study is a cross-sectional observational study design that aimed to include 2000 IBS patients. We used several validated questionnaires, to assess IBS characteristics (such as subtype, severity), psychological features (QoL…
- Trial name
- IBSQUtrition (NCT03824821)
- Testing
- No intervention
- Where
- Netherlands
- Volunteers
- 2,076 people
- Sponsor
- Wageningen University
Rhinitis, Allergic, Nonseasonal
Nasal Irritation Study: Individual Factors in Nasal Irritant Sensitivity
This study seeks to document differences in nasal irritant sensitivity within the population. The investigators are interested in knowing whether age, gender, and allergy status (nasal allergies) predict nasal irritant…
- Trial name
- NCT00041821
- Testing
- Nasal irritation thresholds and irritant provocation
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
IBS, Constipation Predominant
The Beneficial Effects on the Intestinal Function of a Food Supplement Based on an Extract of Green Tea and a Pool of Probiotics in Subjects With Irritable Bowel Syndrome With Predominance of Constipation
The study will aim to evaluate the effectiveness of the use of a food supplement, based on a green tea extract (Camellia sinensis (L.) Kuntze - folium) and a pool of probiotics (L. plantarum, L. rhamnosus and B. animalis subsp.
- Trial name
- NCT07094035
- Testing
- food supplement based on a mixture of green tea extract and a pool of probiotics.
- Where
- Italy
- Volunteers
- 64 people
- Sponsor
- Adamas Biotech S.r.l.
Irritable Bowel Syndrome With Constipation
A Safety and Efficacy Study of a Range of Linaclotide Doses Administered Orally to Children Ages 7-17 Years, With Irritable Bowel Syndrome With Constipation
The purpose of this study is to evaluate the safety and efficacy of linaclotide for the treatment of Irritable Bowel syndrome with Constipation (IBS-C), in children age 7-17 years.
- Trial name
- LIN-MD-63 (NCT02559817)
- Testing
- Linaclotide Dose A, Linaclotide Dose B, Linaclotide Dose C
- Where
- 48 sites in United States, Canada
- Volunteers
- 101 people
- Sponsor
- Forest Laboratories
Major Depressive Disorder and Irritability
Brexpiprazole (OPC 34712) Trial in the Treatment of Adults With Major Depressive Disorder and Irritability
The purpose of this study is to explore the effects of fixed-dosed brexpiprazole adjunctive treatment in subjects with Major Depressive Disorder with irritability
- Trial name
- NCT02212613
- Testing
- Brexpiprazole
- Where
- United States
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Irritable Bowel Syndrome
Evaluation Study of the Intestinal Microbiota and Quality of Life in Patients Suffering From IBS Treated With Bifidice
Irritable bowel syndrome is the most common functional gastrointestinal disease and is characterized by high prevalence and chronic course.The pathology has a strong impact on the quality of life of affected patients and on…
- Trial name
- Bifidice01 (NCT05663060)
- Testing
- Probiotic Formula
- Where
- Italy
- Volunteers
- 8 people
- Sponsor
- Istituto Clinico Humanitas
Irritable Bowel Syndrome
Phase I Clinical Trial of DA-6886 in Healthy Male Subjects
DA-6886_IBS_I is a phase I, dose block-randomized, double-blind, placebo-controlled, single/multiple dosing, dose escalation clinical trial with open-labelled food effect study of single dose to investigate the safety…
- Trial name
- NCT01633723
- Testing
- DA-6886
- Where
- South Korea
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Dong-A ST Co., Ltd.
Irritable Bowel Syndrome, Inflammatory Bowel Diseases
The Ecological Role of Yeasts in the Human Gut
Irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD) (categorised into Crohn's disease (CD) and ulcerative colitis (UC)) are chronic gut disorders with debilitating symptoms that profoundly impact quality of life…
- Conditions
- Irritable Bowel Syndrome, Inflammatory Bowel Diseases, Gastrointestinal Disease
- Trial name
- YIG (NCT04138225)
- Where
- United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Grace Ward
Irritable Bowel Syndrome, Inflammatory Bowel Diseases
Mucosal Innate Immune Activation in Chronic Intestinal Disorders
Crohn's disease and ulcerative colitis are types of chronic intestinal disorder called inflammatory bowel diseases (IBD) that can affect the small and large bowel causing symptoms of abdominal pain, diarrhea, blood in the stool…
- Trial name
- NCT03529318
- Testing
- Biopsies from endoscopy
- Where
- United States
- Sponsor
- University of Arkansas
Upper Airway, Irritation Inflammation, Discomfort
SENOC-I Det Sunda Huset II - Sensitization of Occupants of Water Damaged Buildings.
The study is focussed on two main questions: 1. The importance of dampness of the building and home dust as a factor of the subjects= responses. 2.
- Trial name
- NCT00143650
- Testing
- House dust
- Where
- Denmark
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Functional Gastrointestinal Disorders, Irritable Bowel Syndrome
Fructose Breath-testing in Irritable Bowel Syndrome (IBS)
Background: Breath testing for food intolerances is becoming routine in patients with functional gastrointestinal disorders (FGID).
- Trial name
- NCT02614313
- Testing
- Open breath test with fructose, Blinded breath test with fructose
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Brain-Gut Research Group
Irritable Bowel Syndrome
Mindfulness for Irritable Bowel Syndrome
This study investigates the effectiveness of a 6 week mindfulness intervention in reducing symptoms of Irritable Bowel Syndrome (IBS). All Participants will receive treatment.
- Trial name
- MIBS (NCT02794376)
- Testing
- Mindfulness Based Cognitive Therapy (MBCT), Waiting Period
- Volunteers
- 67 people
- Sponsor
- University of Oxford
Healthy
Cumulative Irritation Test of PAC-14028 in Healthy Volunteers
The purpose of this study is to determine the cumulative irritation potential of the products listed by the Sponsor.
- Trial name
- NCT01638117
- Testing
- PAC14028-Vehicle, PAC14028-0.1, PAC14028-0.3
- Where
- South Korea
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Amorepacific Corporation
Post-infectious Irritable Bowel Syndrome, Irritable Bowel Syndrome
Characterizing Protein Biomarkers of Post-infection Irritable Bowel Syndrome
The investigators will characterize and compare protein signatures between groups with and without post-infection irritable bowel syndrome (PI-IBS).
- Trial name
- NCT06032117
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- University of Nevada, Reno
Breastfeeding Duration, Infant Feeding Practices
Effect of Teté Dance on Breastfeeding Duration in Irritable Infants
This study aims to evaluate the impact of a culturally adapted intervention, the Teté Dance, on the breastfeeding duration of irritable infants. Participants will be mothers of infants experiencing irritability during feeding.
- Trial name
- NCT06751186
- Testing
- Teté Dance Guided Support
- Where
- Peru
- Volunteers
- 150 people
- Sponsor
- Crianzamor
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