Clinical trials: Ischaemia Reperfusion Injury of Liver
Terminal Liver Disease, Ischemia Reperfusion Injury
TOP-Study (Tacrolimus Organ Perfusion): Treatment of Ischemia Reperfusion Injury in Marginal Organs With an ex Vivo Tacrolimus Perfusion
Utilisation of extended criteria donors due to critical organ shortage contributes to increased ischemia reperfusion injury as well as mortality following liver transplantation.
- Conditions
- Terminal Liver Disease, Ischemia Reperfusion Injury, Graft Dysfunction, Graft Failure
- Trial name
- TOP (NCT01564095)
- Testing
- Tacrolimus
- Where
- 7 sites in Germany
- Volunteers
- 25 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Liver Transplant
Trial of Inhaled Nitric Oxide (iNO) on Ischemia / Reperfusion Injury During Orthotopic Liver Transplantation With Marginal Grafts
This study is being done to determine if patients receiving (iNO) will have increased liver function and less damage from IR than patients who do not receive (iNO).
- Trial name
- NCT01172691
- Testing
- Inhaled Nitric Oxide (iNO)
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Baylor Research Institute
Liver Failure, Liver Failure, Acute
Use of N-Acetylcysteine During Liver Procurement
Randomized prospective study on the impact on the post-LT outcome by the infusion of N-acetylcysteine (NAC) during the liver procurement procedure, as an anti-oxidant agent to reduce the ischemia-reperfusion damage of organs for…
- Conditions
- Liver Failure, Liver Failure, Acute, Liver Diseases, Carcinoma, Hepatocellular
- Trial name
- NCT01394497
- Testing
- N-acetylcystein
- Where
- Italy
- Volunteers
- 140 people
- Sponsor
- Azienda Ospedaliera di Padova
Ischemia/Reperfusion Injury of Liver Graft, Ischemia/Reperfusion Injury of Kidney
The Effect of Remote Ischemic Postconditioning on Liver Graft and Renal Function in Patients Undergoing Living-related Liver Transplantation
The investigators are trying to evaluate the clinical effect of remote ischemic postconditioning on liver graft function and postoperative renal function in subjects undergoing living-donor liver transplantation.
- Conditions
- Ischemia/Reperfusion Injury of Liver Graft, Ischemia/Reperfusion Injury of Kidney, Remote Ischemic Postconditioning
- Trial name
- NCT01637038
- Testing
- RIPC
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Samsung Medical Center
Reperfusion Injury
Combined Drug Approach to Prevent Ischemia-reperfusion Injury During Transplantation of Livers (CAPITL)
The purpose of this study is to establish the effectiveness of the combined drug approach (anti-thrombin III, infliximab, apotransferrin, human recombinant erythropoietin beta, C1-inhibitor, glutathione, alfa-tocopherol…
- Trial name
- CAPITL (NCT02251041)
- Testing
- Antithrombin-III, Infliximab, Apotransferrin
- Where
- Belgium
- Volunteers
- 143 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Liver Transplant Disorder, Reperfusion Injury
Cardiac Strain Using Speckle Tracking Echocardiography During Orthotopic Liver Transplantation
Researchers are trying to improve the understanding of systolic function of the heart at the time of liver reperfusion in patients undergoing orthotopic liver transplantation.
- Trial name
- NCT04316468
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
Fatty Liver, Liver Transplant; Complications
Single-Cell and Spatial Transcriptomics Analysis of Steatotic Donor Liver Susceptibility to Post-Transplant Injury
The goal of this observational study is to understand why liver transplants from donors with fatty liver disease (steatotic donor livers) are more vulnerable to post-transplant injury, analyzing historical clinical data and…
- Conditions
- Fatty Liver, Liver Transplant; Complications, Ischaemia Reperfusion Injury of Liver, End Stage Liver Disease
- Trial name
- NCT07362745
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Xijing Hospital
Liver Diseases, Kidney Diseases
Clinical Trial of New Hypothermic Oxygenated Perfusion System Versus Static Cold Storage
With the present study the investigators will evaluate the benefit of end-ischemic HOPE on ECD grafts (livers and kidneys) as compared to SCS.
- Trial name
- NCT03837197
- Testing
- Kidney-Hypothermic oxygenated, Liver-Hypothermic oxygenated
- Where
- Italy
- Volunteers
- 220 people
- Sponsor
- University of Bologna
Organ Transplant, Ischemic Reperfusion Injury
PERTRIAL - Perla® Preservation Solution
Perla® is a Cold Preservation Solution, with purpose to wash out, preserve during transport liver and kidney grafts in optimal conditions from the donor to the recipient.
- Trial name
- NCT05194306
- Testing
- Perla® Cold Preservation solution
- Where
- Spain
- Volunteers
- 11 people
- Sponsor
- Advanced Life Solutions
Remote Organ Ischemic Preconditioning
The Effects Of Remote Organ Ischemic Preconditioning On Systemic Inflammatory And Glycocalyx Integrity Parameters
Ischemia-reperfusion (IR) injury during liver transplantation is one of the major causes of mortality and morbidity associated with transplantation.
- Trial name
- NCT04216407
- Testing
- Remote ischemic preconditioning
- Where
- Turkey (Türkiye)
- Volunteers
- 22 people
- Sponsor
- Acibadem University
Organ Preservation Solutions
Peri-operative rATG-perfusion of Solid Transplants
The increasing demand for organ transplantation and the shortage of available organs limit the success of organ transplantation programs.
- Trial name
- ATG-perfusion (NCT03377283)
- Testing
- organ perfusion with rabbit anti-thymocyte globulin (rATG), organ perfusion with saline
- Volunteers
- 80 people
- Sponsor
- Medical University Innsbruck
Ischemia Reperfusion Injury
YSPSL for Prevention of Ischemic Reperfusion Injury in Patients Undergoing Cadaveric Orthotopic Liver Transplantation
The study is designed to assess the feasibility of evaluating YSPSL for the amelioration of ischemia reperfusion injury following liver transplantation by administering YSPSL into the liver graft directly ex vivo via the portal…
- Trial name
- YSPSL (NCT00876902)
- Testing
- recombinant P-selectin glycoprotein ligand Ig fusion protein, Viaspan® and saline
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Y's Therapeutics, Inc.
Hepatocellular Carcinoma, Liver Transplant; Complications
Impact of Graft Reconditioning With Hypothermic Machine Perfusion on HCC Recurrence After Liver Transplantation
The use of devices for liver grafts perfusion before transplantation, either hypothermic (HOPE) or normothermic (NMP), is rapidly spreading thanks to the promising results obtained so far in terms of graft survival and…
- Trial name
- NCT06236568
- Testing
- D-HOPE machine perfusion, Liver transplantation
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Azienda Ospedaliero-Universitaria di Modena
Ischemia Re-perfusion Injury
Omega 3 Lipid Emulsions and Liver Transplantation
The study Aims to investigate the possible beneficial impact of peri-operative or post-operative administration of Omega 3 enriched lipid emulsions on recipients for living donor liver transplantation.
- Trial name
- OTLT (NCT01957943)
- Testing
- SMOFLipid, equivalent volume of 10% glucose solution
- Where
- Egypt
- Volunteers
- 114 people
- Sponsor
- Mansoura University
Liver Transplant, Liver Failure
Hypothermic Machine Perfusion for Liver Graft Preservation
The goal of this clinical trial is to evaluate whether hypothermic machine perfusion improves liver graft preservation and post-transplant outcomes compared to conventional static cold storage in adult patients undergoing liver…
- Trial name
- HOPE-Liver (NCT07595627)
- Testing
- Hypothermic Machine Perfusion, Static Cold Storage
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- University of Sao Paulo General Hospital
Hepatic and Hepatobiliary Disorders
Indocyanine Green Clearance Test in Liver Transplantation (LivInG)
The gap between patients awaiting and those undergoing liver transplantation (LT) continues to grow. Marginal organs carry higher risk of failure after LT however they are increasingly used to fill such gap.
- Trial name
- LivInG (NCT05228587)
- Testing
- Indocyanine green
- Where
- Italy
- Volunteers
- 162 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Small-For-Size Liver Syndrome, Ligation
Splenic Artery Ligation and Portocaval Shunt in Small-for-size Syndrome
Our study aimed at assessing the changes of portal vein pressure, portal vein flow and hepatic arterial flow (HAF) in liver remnants ≤ 30% of the standard liver volume by reducing portal vein overflow via ligation of the splenic…
- Conditions
- Small-For-Size Liver Syndrome, Ligation, Liver Regeneration, Splenic Artery
- Trial name
- splen ligation (NCT05459883)
- Testing
- splenic artery ligation
- Where
- Greece
- Volunteers
- 13 people
- Sponsor
- Aretaieion University Hospital
End Stage Liver Failure
N-acetylcysteine in Liver Transplantation
N-acetylcysteine (NAC) is used to treat Tylenol toxicity. NAC is a rich source of the sulfhydryl group (SH) which is important for replenishing the body's glutathione stores.
- Trial name
- NAC (NCT00736541)
- Testing
- N-acetylcysteine
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Ibtesam Hilmi
Liver Transplantation, Ischaemia Reperfusion Injury
Effect of Discarding Initial Reperfusion Blood on Hemodynamics, Liver Function, and 30-Day Outcomes in Liver Transplantation
Hepatic reperfusion during liver transplantation remains a critical phase associated with significant hemodynamic and systemic disturbances, despite advances in surgical and anesthetic management.
- Conditions
- Liver Transplantation, Ischaemia Reperfusion Injury, Perioperative Complications
- Trial name
- NCT07631689
- Testing
- Reperfusion Blood Discard, Standard Liver Transplantation
- Volunteers
- 132 people
- Sponsor
- University of Sao Paulo General Hospital
Reperfusion Injury
Role of Volatile Anesthetics for Hepatic Protection
This study aims to evaluate the attenuation of ischemic-reperfusion injury in the liver after sevoflurane preconditioning. In the presence of sevoflurane, an attenuation of liver injury is hypothesized (diminished increase of…
- Trial name
- NCT00516711
- Testing
- Sevoflurane
- Where
- Switzerland
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Zurich