Clinical trials: Ischaemic Reperfusion Injury
Elective Percutaneous Coronary Intervention, Ischemic Reperfusion Injury
Cardio-protective Effect of Metformin in Patients Undergoing PCI
This is a two-arm randomized parallel study. Patients who will be meeting the above-mentioned criteria and agree to take part in the study, were asked to sign an informed consent prior conducting the study.
- Trial name
- NCT05708053
- Testing
- Metformin
- Where
- 3 sites in Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Future University in Egypt
Reperfusion Injury
Role of Volatile Anesthetics for Hepatic Protection
This study aims to evaluate the attenuation of ischemic-reperfusion injury in the liver after sevoflurane preconditioning. In the presence of sevoflurane, an attenuation of liver injury is hypothesized (diminished increase of…
- Trial name
- NCT00516711
- Testing
- Sevoflurane
- Where
- Switzerland
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Zurich
Hyperglycemia
Ischemia/Reperfusion Injury of Human Endothelium: Role of Glucose and Statins
Anesthetic preconditioning (APC, a brief exposure to an anesthetic gas) has become an area of intense research interest because of its ability to protect tissue and organs from injury resulting from a cessation of blood flow and…
- Trial name
- NCT00995670
- Testing
- 5% dextrose, Vitamin C, Simvastatin
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Ischemia-Reperfusion Injury, Myocardial Infarction
Infusion of a Single Dose of Erythropoietin to Prevent Injury in an Ischemia Reperfusion Forearm Model
Rationale: The investigators hypothesize that EPO protects against apoptosis after acute ischemia in man and that it is detectable using the annexin-A5 model.
- Trial name
- IPIIR (NCT00691613)
- Testing
- Epoetin alpha, NaCl
- Where
- Netherlands
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Priapism, Reperfusion Injury
Investigation of the Protective Effect of Alpha Lipoic Acid on Ischemic Reperfusion Damage in Ischemic Priapism in Rats
The condition known in medical terminology as 'Priapism' refers to the state of erection in the male sexual organ persisting partially or completely for more than 4 hours without sexual stimulation or orgasm.
- Trial name
- NCT07391709
- Testing
- Ischemic priapism + reperfusion, Ischemic priapism + reperfusion + ALA
- Where
- Turkey (Türkiye)
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Trabzon Kanuni Education and Research Hospital
Ischemia Reperfusion Injury
Does Caffeine Reduce Rosuvastatin-Induced Protection Against Ischemia-Reperfusion Injury?
Does caffeine reduce rosuvastatin induced protection against ischemia reperfusion injury?
- Trial name
- NCT00457652
- Testing
- Rosuvastatin
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Central Sympathetic Nervous System Diseases
Role of Sympathetic Activation in Ischemia Reperfusion Injury
This study is designed to assess the effect of forearm ischemia-reperfusion injury on sympathetic nerve activity. To determine whether reduced sympathetic responsiveness is a contributor to the protective effects of remote…
- Trial name
- NCT04479813
- Testing
- Moxonidine 0.2 MG
- Where
- Australia
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Royal Perth Hospital
Ischemia Reperfusion Injury, Cardiovascular Disease
Does Atorvastatin Reduce Ischemia-Reperfusion Injury in Humans in-Vivo?
To study the impact of 3 day exposure to atorvastatin 80mg on Annexin A5 targeting after ischemic exercise in the non-dominant forearm.
- Trial name
- NCT00441597
- Testing
- atorvastatin
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Reperfusion Injury, Vascular Complications
Trial to Investigate the Effect of Dapagliflozin on Ischemia Reperfusion Induced Endothelial Dysfunction
The aim of the study is to investigate the effect of dapagliflozin or placebo on acetylcholine (Ach)- or nitroglycerin (GTN)-induced vasodilation of the forearm resistance vasculature, as determined by FBF measurement before and…
- Trial name
- NCT05217654
- Testing
- Dapagliflozin 10mg
- Where
- Austria
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Metabolic Syndrome, Vascular Injury
Therapeutic Strategies to Reduce Endothelial Ischemia-reperfusion Injury
The objective of this clinical trial is to better understand how lactate, a naturally occurring energy substance, can be used to lessen damage to the vascular system in adults with a high cardiovascular disease risk.
- Conditions
- Metabolic Syndrome, Vascular Injury, Ischemic Preconditioning, Endothelial Function (reactive Hyperemia)
- Trial name
- NCT06825143
- Testing
- Ischemic preconditioning, Intravenous lactate infusion, No ischemic preconditioning (control)
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Gary Van Guilder
Caffeine, Ischemic Preconditioning
The Effect of Caffeine on Ischemic Preconditioning
Ischaemic preconditioning (IP) describes the phenomenon that brief periods of ischaemia render the (myocardial) muscle more resistant to a subsequent more prolonged period of ischaemia and reperfusion.
- Conditions
- Caffeine, Ischemic Preconditioning, Ischemia-Reperfusion Injury
- Trial name
- NCT00184912
- Testing
- caffeine, Technetium-TC99m-labeled Annexin A5, ten minutes forearm ischemia
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Peripheral Arterial Occlusive Disease Fontaine Stage IIa
Acute Local Metabolomic Alterations in Blood and Muscle Tissue in Intermittent Claudication
The most common clinical presentation of lower extremity arterial disease is intermittent claudication. Current understanding of the pathophysiology of intermittent claudication, as well as its treatment options are limited.
- Trial name
- NCT05111379
- Where
- Estonia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Tartu
Cardiovascular Disease, Ischemia-Reperfusion Injury
Does Caffeine Reduce Dipyridamole-Induced Protection Against Ischemia-Reperfusion Injury?
The purpose of this project is to explore the interaction between caffeine and dipyridamole on ischemia-reperfusion injury in the forearm.
- Trial name
- NCT00430170
- Testing
- Dipyridamole, caffeine
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Ischemia Reperfusion Injury, Peripheral Artery Disease
Vitamin B6 on Exercise Pressor Reflex on Leg Ischemia-reperfusion
In this study, we are trying to see if vitamin B6 can minimize the amplified blood pressure response to exercise following ischemia-reperfusion injury.
- Trial name
- NCT06369350
- Testing
- Vitamin B6 25 MG, Vitamin B6 50 MG, Vitamin B6 100 MG
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Ischemia Reperfusion Injury
The Effects of Post-Conditioning and Administration of Vitamin C on Intramuscular High Energy Phosphate Levels
Ischemic injury to muscular tissue is common in cardiovascular medicine. The most effective treatment to avoid ischemic damage is the rapid re-establishment of reperfusion.
- Trial name
- IRI in MRI (NCT00534924)
- Testing
- Vit C, Postconditioning, no intervention
- Where
- Austria
- Volunteers
- healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Ischemic Reperfusion Injury
Ischemia Reperfusion: Prostaglandins and Antioxidants
The purposes of this study are two-fold. The first purpose is to determine the effect of taking vitamins on the recovery of an artery (blood vessel) following an induced temporary injury.
- Trial name
- NCT01666587
- Testing
- Antioxidant, Prostaglandin inhibitor (Ibuprophen)
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Essex
Healthy
Sitagliptin and Endothelial Dysfunction
Over the years, numbers of cardioprotective drugs have been evaluated to attenuate lethal ischemia-reperfusion (IR) injuries. There is little study whether sitagliptin protects against endothelial dysfunction induced by IR injury…
- Trial name
- NCT02406950
- Testing
- Sitagliptin
- Where
- South Korea
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Kyunghee University Medical Center
Reperfusion Injury
Remote Ischaemic PreConditioning (RIPC) in Partial Nephrectomy for the Prevention of Ischemia/Reperfusion Injury
"Remote Ischaemic PreConditioning" (RIPC) is performed prior to partial nephrectomy. Postoperative calprotectin dynamics and Blood Oxygen-Level-Dependent (BOLD) MRI are used to to demonstrate the potential renoprotective effect…
- Trial name
- NCT03068689
- Testing
- RIPC
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Ischemia-reperfusion Injury
Heme Arginate in Functional Magnetic Resonance Imaging (fMRI)
Ischemia reperfusion injury may be attenuated by HO-1 induction. Heme arginate showed protective effects during prolonged ischemia in animal studies.
- Trial name
- NCT01461512
- Testing
- heme arginate administration
- Where
- Austria
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- MWolzt
Ischemia-Reperfusion Injury
Adenosine Receptors Influence Ischemia-Reperfusion Injury
Ischemic preconditioning is defined as the development of tolerance to ischemia-reperfusion injury by a previous short bout of ischemia resulting in a marked reduction in infarct size.
- Trial name
- NCT00184847
- Testing
- acetylcholine, twenty minutes of forearm ischemia, three 5-minute periods of forearm ischemia
- Where
- Netherlands
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center