Clinical trials: Ischemia, Brain
Ischemic Stroke, Hyperglycemia
Procoagulant Effects of Hyperglycemia After Acute Stroke: A Pilot Study
Between twenty and fifty percent of people who have acute stroke have hyperglycemia (high blood sugar) with it. The purpose of this study is to examine the relationships between diabetes mellitus, hyperglycemia,whole blood tissue…
- Trial name
- NCT00373269
- Volunteers
- 21 people
- Sponsor
- Temple University
Acute Ischemic Stroke
Phase III Clinical Trial of rhTNK-tPA in Treating Acute Ischemic Stroke With Extended Time Window.
This is a multicenter, randomized, double-blind, placebo-controlled Phase III clinical study designed to evaluate the efficacy of recombinant human tissue-type plasminogen activator variant (rhTNK-tPA) (0.25 mg/kg, maximum dose…
- Trial name
- TRACE-LATE (NCT07201688)
- Testing
- rhTNK-tPA
- Where
- China
- Volunteers
- 890 people
- Sponsor
- CSPC Mingfule Pharmaceutical (Guangzhou) Co., Ltd.
Ischemic Stroke, Depression
Dose Milnacipran Prevent Depressive Symptoms in Patients With Acute Stroke?
Depression is one of the important psychiatric sequelae after stroke. The prevalence of post stroke depression (PSD) is approximately 20-40%.
- Trial name
- NCT00606203
- Testing
- milnacipran
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Chang Gung Memorial Hospital
Stroke, Acute, Acute Ischemic Stroke
Early Rehab With VR for First-time Acute Stroke
The goal of this clinical trial is to confirm the efficacy and feasibility of early rehabilitation combined with virtual reality training in patients following first-time acute stroke.
- Trial name
- NCT05929742
- Testing
- virtual reality training, early rehabilitation
- Where
- Taiwan
- Volunteers
- 38 people
- Sponsor
- National Defense Medical Center, Taiwan
Ischemic Stroke
European Registry on the ACE Reperfusion Catheters and the Penumbra System in the Treatment of Acute Ischemic Stroke
Prospective, single-arm, multicenter, observational registry of the ACE Reperfusion Catheters and the Penumbra System in Europe.
- Trial name
- PROMISE (NCT02678169)
- Testing
- Penumbra Aspiration System
- Where
- Germany
- Volunteers
- 204 people
- Sponsor
- Penumbra Inc.
Intracranial Arteriosclerosis, Ischemic Preconditioning
Remote Ischemic Conditioning Combined With Endovascular Stenting for Symptomatic Intracranial Atherosclerotic Stenosis
The purpose of this registry is to evaluate the safety and efficacy of RIC for patients with symptomatic intracranial atherosclerotic stenosis (sICAS) undergoing endovascular therapy.
- Conditions
- Intracranial Arteriosclerosis, Ischemic Preconditioning, Endovascular Procedures
- Trial name
- NCT05653505
- Testing
- Remote Ischemic Conditioning
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Tianjin Huanhu Hospital
Ischemic Stroke
A Phase 3 Trial of Lesion Network Mapping-Guided cTBS for Motor Recovery After Acute Ischemic Stroke
This Phase 3 study will evaluate whether lesion network mapping-guided continuous theta burst stimulation (cTBS) can improve recovery after acute ischemic stroke.
- Trial name
- MASTRE-3 (NCT07645586)
- Testing
- LNM-navigated cTBS
- Where
- China
- Volunteers
- 584 people
- Sponsor
- Beijing Tiantan Hospital
Cerebral Infarction
Edaravone-Sodium Ozagrel Comparative Post-Marketing Study on Acute Ischemic Stroke
This study is randomized, Sodium Ozagrel (Thromboxane A2 Synthase Inhibitor) controlled study on acute ischemic stroke. The primary endpoints were the rate of patients with modified Rankin Scale score of 0-1 at 3 months.
- Trial name
- NCT00200356
- Testing
- Edaravone, Sodium Ozagrel
- Volunteers
- 401 people
- Sponsor
- Shionogi
Coronary Heart Disease
Exercise and Brain in Coronary Heart Disease
The Heart-Brain project is a randomized controlled trial designed to examine the effects of two different exercise programs of 12-week duration: 1) aerobic high intensity interval training (HIIT), and 2) aerobic HIIT plus…
- Trial name
- Heart-Brain (NCT06214624)
- Testing
- Two types of exercise interventions
- Where
- Spain
- Volunteers
- 96 people
- Sponsor
- Universidad de Granada
Myocardial Infarction, Cardiovascular Death
Prevention of Cardiovascular Events (eg, Death From Heart or Vascular Disease, Heart Attack, or Stroke) in Patients With Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin
This study is being carried out to see if a new drug called ticagrelor given twice daily in addition to the ASA therapy decreases the frequency of cardiovascular events (e.g., death from heart disease, heart attack, or stroke).
- Conditions
- Myocardial Infarction, Cardiovascular Death, Atherothrombosis, Stroke
- Trial name
- PEGASUS (NCT01225562)
- Testing
- Ticagrelor 90 mg, Ticagrelor 60 mg
- Where
- 826 sites in United States, Argentina and 29 more
- Volunteers
- 21,379 people
- Sponsor
- AstraZeneca
Death, Stroke
Postoperative Atrial Fibrillation and Long-term Survival
The aim of the investigators trial was to evaluate association between new onset postoperative atrial fibrillation (POAF) and late cardiovascular morbidity and mortality.
- Conditions
- Death, Stroke, Myocardial Infarction
- Trial name
- POAF (NCT02349269)
- Volunteers
- 519 people, healthy volunteers welcome
- Sponsor
- Kuopio University Hospital
Anoxic-Ischemic Encephalopathy
Study for the Improvement of Long-Term Outcome Prediction in Patients in Coma After Cardiac Arrest
The primary objective of HOPE is to improve the accuracy of outcome prediction in anoxic-ischemic encephalopathy following cardiac arrest by bringing under close scrutiny some of the existing methods used for this purpose (e.g.
- Trial name
- HOPE (NCT02231060)
- Where
- 16 sites in Germany
- Volunteers
- 150 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Intracranial Aneurysm, Brain Arterial Disease
Safety, Performance and Usability of BALT Medical Devices: The EVIDENCE Post Marketing Clinical Follow-up Platform
BALT has designed an electronic platform to continue collecting clinical data as part of the post-marketing clinical follow-up of its devices.
- Conditions
- Intracranial Aneurysm, Brain Arterial Disease, Acute Ischemic Stroke, Peripheral Vascular Diseases
- Trial name
- EVIDENCE (NCT04927156)
- Testing
- BALT medical devices
- Where
- 12 sites in France, Germany and 1 more
- Volunteers
- 10,000 people
- Sponsor
- Balt Extrusion
Music Therapy, Pain
Music Therapy During Hypothermia in the NICU
Background: Hypoxic-ischemic encephalopathy (HIE) is a neurological condition caused by poor oxygenation during the peripartum period.
- Conditions
- Music Therapy, Pain, Allodynia, Neonates
- Trial name
- NCT06951269
- Testing
- Live entrained music therapy
- Where
- Colombia
- Volunteers
- 22 people
- Sponsor
- Fundación Santa Fe de Bogota
Acute Ischemic Stroke
LEG-UP Feasibility Study: Elevated Leg Positioning For Acute Moderate Ischemic Stroke
Augmentation of penumbral perfusion through nonpharmacological hemodynamic interventions such as patient positioning may offer a pragmatic approach to improve outcomes in acute ischemic stroke (AIS).
- Trial name
- LEG-UP (NCT07483580)
- Testing
- Elevated Leg Positioning
- Where
- Philippines
- Volunteers
- 50 people
- Sponsor
- Bonifacio C. Pedreogsa II
Cardiovascular Diseases, Stroke
Prediction of Primary Cardiovascular Events Using the Multimarker Approach
The study of biochemical risk factors for cardiovascular diseases is important not only for analysis, but also for preventive measures, given that changes in the level of biomarkers can be detected before the first clinical…
- Conditions
- Cardiovascular Diseases, Stroke, Myocardial Infarction, Death
- Trial name
- NCT05704569
- Testing
- measurement of multiple biomarkers
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Karaganda Medical University
Stroke, Intracranial Atherosclerosis
High-resolution Magnetic Resonance Imaging of Intracranial Atherosclerotic Plaques in Ischemic Stroke
Intracranial atherosclerotic disease is the most common cause of ischemic stroke in Asia, also in China. Currently, despite vascular recanalization therapy, statins are one of the main drug choices for treating atherosclerotic…
- Conditions
- Stroke, Intracranial Atherosclerosis, High Resolution Magnetic Resonance Imaging
- Trial name
- NCT05897645
- Testing
- Registration
- Where
- China
- Volunteers
- 2,110 people
- Sponsor
- General Hospital of Shenyang Military Region
Ischemic Stroke, Transient Ischemic Attack
StAtins in Frail OldEr Patients with Ischemic Stroke or Transient Ischemic Attack - the Randomized Controlled Trial
Two Dutch guidelines (Stroke and Cardiovascular Risk Management) provide conflicting advice on optimal statin treatment in older patients.
- Trial name
- SAFEST - RCT (NCT06785727)
- Testing
- Statin (atorvastatin, fluvastatin, pravastatin, rosuvastatin or simvastatin)
- Volunteers
- 612 people
- Sponsor
- Prof. dr. Nathalie van der Velde
Ischaemic Stroke
Diagnosis and Treatment of Minor Ischaemic Stroke According to the Etiology and Pathogenesis
Negligence or contempt of the etiology and pathogenesis of minor ischaemic stroke in the early diagnosis and effective treatment leads to more than 40-50% of patient with recurrent episodes, and 10% patient died.
- Trial name
- NCT01665729
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Li Haiyan
Brain Ischemia, Transient Ischemic Attack
ESPRIT: European/Australasian Stroke Prevention in Reversible Ischaemia Trial
The objective of ESPRIT was to compare the efficacy and safety of mild anticoagulation or a combination treatment of aspirin and dipyridamole with the efficacy and safety of treatment with aspirin alone after cerebral ischemia of…
- Conditions
- Brain Ischemia, Transient Ischemic Attack, Arteriosclerosis
- Trial name
- NCT00161070
- Testing
- anticoagulation, aspirin and dipyridamole, aspirin alone
- Where
- Netherlands
- Volunteers
- 4,500 people
- Sponsor
- UMC Utrecht
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