Clinical trials: Ischemia, Brain
Infarction, Stroke
Polymorphisms in the Vitamin D System and Health
Polymorphisms in the vitamin D system appear to affect the serum 25(OH)D levels. If so one would expect these polymorphisms to be associated with vitamin D related conditions and diseases, which will be tested in the present…
- Conditions
- Infarction, Stroke, Diabetes, Fracture
- Trial name
- NCT01395303
- Where
- Norway
- Volunteers
- 9,700 people, healthy volunteers welcome
- Sponsor
- University of Tromso
Ischemic Stroke
Head dOwn Position Before Endovascular Treatment for Large veSsel Occlusion (HOPES5)
Recent studies suggest that head-down positioning (HDP) intervention may improve outcomes in ischemic stroke. In the era of reperfusion therapy, a key protective strategy is to administer neuroprotective interventions before…
- Trial name
- NCT07172789
- Testing
- head down position
- Where
- China
- Volunteers
- 210 people
- Sponsor
- General Hospital of Shenyang Military Region
Coronary Artery Disease, Aortic Valve Stenosis
Comparative Analysis of the Microcirculation During Cardiac Surgery With Minimal Invasive Versus Conventional Extracorporeal Circulation
The aim of the proposed study is to evaluate microcirculatory alterations in patients undergoing open heart surgery with minimal invasive versus conventional extracorporeal circulation.
- Conditions
- Coronary Artery Disease, Aortic Valve Stenosis, Mitral Disease
- Trial name
- NCT05479188
- Testing
- Sublingual microscopy
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- Aristotle University Of Thessaloniki
Aortic Valve Stenosis, Brain Diseases
Brain Lesions After Transcatheter Aortic Valve Replacement
The Brain lEsions after TrAnscatheter aorTic ValvE Replacement (BETTER) registry is a prospective, observational, multi-center registry aiming to assess the presence of new brain microbleeds assessed on susceptibility-weighted…
- Trial name
- NCT05065697
- Testing
- Brain MRI
- Volunteers
- 150 people
- Sponsor
- West China Hospital
Stroke, Carotid Stenosis
Study of Early Versus Delayed Carotid Endarterectomy (CEA) for Small to Medium-sized Ischemic Stroke Caused by High-grade Carotid Stenosis
Pilot study of early versus delayed carotid endarterectomy (CEA) for small to medium-sized ischemic stroke caused by high-grade carotid stenosis.
- Trial name
- NCT00315562
- Testing
- carotid endarterectomy
- Where
- United States
- Sponsor
- University of California, San Diego
Acute Ischemic Stroke
The Vesalio NeVa Stent Retriever Study for Treatment of Large Vessel Occlusion Strokes: CLEAR Study
A prospective, open label, single-arm 90-day study designed to assess the safety, performance and efficacy of thrombus removal in subjects presenting with acute ischemic stroke with the NeVa stent retrievers.
- Trial name
- NCT04514562
- Testing
- NeVa Stent Retrievers
- Where
- 7 sites in United States
- Volunteers
- 120 people
- Sponsor
- Vesalio
Coronary Artery Disease, Arteriosclerosis
Associations Between Diabetes, Arterial Stiffness and Fibulin-1 in Patients Undergoing Heart- and Vascular Surgery?
Diabetes Mellitus (DM) is frequently appearing in patients with cardiovascular disease and these patients, as a consequence herby, has a lesser prognosis. DM is often related to increased arterial stiffness and hypertension.
- Conditions
- Coronary Artery Disease, Arteriosclerosis, Carotid Stenosis, Thrombosis
- Trial name
- NCT01106573
- Where
- Denmark
- Volunteers
- 1,400 people
- Sponsor
- Odense University Hospital
Acute Stroke, Ischemic Stroke
Impact of Stroke Unit Care on Acute Stroke Outcomes
This observational study is designed to evaluate and compare the recovery outcomes of patients who have experienced their first acute stroke.
- Conditions
- Acute Stroke, Ischemic Stroke, Hemorrhagic Stroke
- Trial name
- NCT07750860
- Volunteers
- 140 people
- Sponsor
- Assiut University
Acute Ischemic Stroke, Atrial Fibrillation
Berlin Atrial Fibrillation Registry
Investigator-initiated prospective multicentre hospital-based registry to uncover the proportion of self-reported anticoagulation in stroke patients with atrial fibrillation and assessing the proportion of stroke, intracranial…
- Trial name
- NCT02306824
- Where
- Germany
- Volunteers
- 1,080 people
- Sponsor
- Charite University, Berlin, Germany
Hemodynamic Stability, Ischemic Strokes
Ciprofol vs Propofol for Hemodynamic Stability in Patients Having General Anesthesia for Endovascular Thrombectomy After Ischemic Stroke
Endovascular therapy (EVT) improves the prognosis of patients with acute ischemic stroke (AIS). EVT has been established as a standard of care for AIS caused with large vessel occlusion based on numerous randomized controlled…
- Trial name
- NCT07696208
- Testing
- Ciprofol, Propofol
- Where
- China
- Volunteers
- 124 people
- Sponsor
- RenJi Hospital
Cerebral Ischemia, Cardiac Arrest
Neuroprotective Goal Directed Hemodynamic Optimization in Post-cardiac Arrest Patients
The primary objective of the Neuroprotect trial is to assess whether or not a new goal directed hemodynamic optimization strategy can reduce cerebral ischemia in post-cardiac arrest (CA) patients.
- Trial name
- NEUROPROTECT (NCT02541591)
- Testing
- Neuroprotective goal directed hemodynamic optimization, MAP > 65mmHg
- Where
- 2 sites in Belgium
- Volunteers
- 112 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Acute Stroke
Neuroprotection With Minocycline Therapy for Acute Stroke Recovery Trial
Background: Stroke is a leading cause of death and chronic serious disability worldwide. Minocycline, a semisynthetic tetracycline, has consistently been shown in recent years to be neuroprotective in animal models of brain…
- Trial name
- NeuMAST (NCT00930020)
- Testing
- Minocycline (Borymycin)
- Where
- Singapore
- Volunteers
- 139 people
- Sponsor
- Singhealth Foundation
Coronary Disease
The Impact of Caffeine on Brachial Endothelial Function in Healthy Subjects and in Patients With Ischemic Heart Disease
Prior work (Chris, M. et al, Clinical Science 2005; 109, 55-60) has demonstrated that drinking a cup of coffee (80-100 mg of caffeine) an hour before endothelium-dependent FMD (flow-mediated dilatation) of the brachial artery…
- Trial name
- NCT00564824
- Testing
- Caffeine
- Where
- Israel
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Acute Ischemic Stroke
Mechanical Thrombectomy in Acute Ischemic Stroke Beyond the Time of Window
Background: intravenous alteplase appears to be much less effective at opening proximal occlusions of the major intracranial arteries, which account for more than one third of cases of acute anterior-circulation stroke and…
- Trial name
- AIS (NCT04087382)
- Testing
- thrombectomy, non intervention group
- Where
- 2 sites in Egypt
- Volunteers
- 57 people
- Sponsor
- Assiut University
Stroke, Acute, Stroke, Ischemic
Low-Frequency REpetitive TRanscranial Magnetic Stimulation in ACute Ischemic StrokE Within 48 Hours
This is a multicenter, open-label, evaluator-blinded, investigator-initiated, randomized clinical trial, to evaluate the clinical efficacy and safety of LF-rTMS in reducing infarct size, reducing disability rate and improving…
- Trial name
- RETRACE-I (NCT06064734)
- Testing
- LF-rTMS
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Beijing Tiantan Hospital
Atherosclerosis Occlusive Disease, Stroke (CVA) or Transient Ischemic Attack
Comparison of Eversion and Conventional Techniques in Carotid Endarterectomy
Atherosclerotic carotid artery disease is responsible for approximately 20% of strokes worldwide, and its treatment options include medical therapy, surgery, and stenting.Surgical management is prioritized over medical and stent…
- Conditions
- Atherosclerosis Occlusive Disease, Stroke (CVA) or Transient Ischemic Attack, Endarterectomy, Carotid
- Trial name
- NCT07288164
- Testing
- Carotid endarterectomy, conventional, Carotid endarterectomy, eversion
- Where
- Turkey (Türkiye)
- Volunteers
- 129 people
- Sponsor
- Kastamonu University
Brain Ischemia, Intracranial Hemorrhages
PreventIon of CArdiovascular Events in iSchemic Stroke Patients With High Risk of Cerebral HemOrrhage
Through this study, the investigators are to prove that Cilostazol effectively prevent cardiovascular events in ischemic stroke patients with high risk of cerebral hemorrhage, along with no significant increase in the risk of…
- Trial name
- PICASSO (NCT01013532)
- Testing
- Cilostazol, Probucol, Aspirin
- Where
- 71 sites in China, Philippines and 1 more
- Volunteers
- 1,600 people
- Sponsor
- Asan Medical Center
Occult Cancer
Intensive Cancer Screening After Cryptogenic Stroke
The INCOGNITO Pilot Trial is a single centre pilot prospective randomized open-label blinded endpoint (PROBE) trial to assess the feasibility of a full-scale randomized trial to determine whether an occult cancer screening…
- Trial name
- INCOGNITO (NCT05733416)
- Testing
- FDG PET/CT, Usual Care
- Where
- 3 sites in Canada
- Volunteers
- 45 people
- Sponsor
- Ottawa Hospital Research Institute
Infarction, Middle Cerebral Artery
Thrombectomy Under Reopro Versus Alteplase to Treat Stoke
Intravenous (IV) Alteplase (rt-PA) is the gold standard for brain infarction within 4 h 30 of symptoms onset. Efficacy of this therapy is limited in the setting of large artery occlusions.
- Trial name
- TURANDOT (NCT02016547)
- Testing
- abciximab IV and thrombectomy, alteplase 0.9mg/kg (10% by IV bolus following by 90% by 1 hour IV drip)
- Where
- France
- Volunteers
- 40 people
- Sponsor
- SOS Attaque Cérébrale
Suspected Arrhythmia, Palpitations
This Exploratory Medical Device Study Evaluated the Arrhythmia Diagnostic Yield of MEMO Patch V2, a Wearable Patch-type Electrocardiographic Monitor, in Adults With Suspected Arrhythmia Who Presented With Symptoms Such as Palpitations or Dizziness, or Who Had Cryptogenic Ischemic Stroke or Transient
This exploratory medical device study evaluated the arrhythmia diagnostic yield of MEMO Patch V2, a wearable patch-type electrocardiographic monitor, in adults with suspected arrhythmia who presented with symptoms such as…
- Conditions
- Suspected Arrhythmia, Palpitations, Dizziness, Cryptogenic Ischemic Stroke
- Trial name
- NCT07722026
- Testing
- MEMO Patch V2, 24-Hour Holter Monitor
- Where
- South Korea
- Volunteers
- 150 people
- Sponsor
- HUINNO Co., Ltd
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