Atherosclerosis Occlusive DiseaseNCT07288164
Comparison of Eversion and Conventional Techniques in Carotid Endarterectomy
An observational study of Atherosclerosis Occlusive Disease and Stroke (CVA) or Transient Ischemic Attack, run by Kastamonu University at 1 site in Turkey (Türkiye).
Trial summary
Atherosclerotic carotid artery disease is responsible for approximately 20% of strokes worldwide, and its treatment options include medical therapy, surgery, and stenting.Surgical management is prioritized over medical and stent based approaches and can be performed using either the conventional methed closed… Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Atherosclerosis Occlusive Disease, Stroke (CVA) or Transient Ischemic Attack, Endarterectomy, Carotid
- What is being tested?
- Carotid endarterectomy, conventional and Carotid endarterectomy, eversion
- Type of treatment
- Surgery or procedure
- How many people
- 129 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 15 May 2025to 30 Sep 2025
- How long will I take part?
- 30 Days
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Carotid endarterectomy was performed in patients with 50-99% stenosis who had experienced stroke or transient ischemic attack (TIA) within the last six months, as well as in asymptomatic patients with 70-99% stenosis. These patients were divided into two groups according to the surgical technique applied conventional or eversion carotid endarterectomy and intraoperative and early postoperative outcomes were compared between the groups.
Who may be able to join
- -Patients undergoing isolated carotid endarterectomy, either emergently or electively
Who cannot join
- Patients younger than 18 years of age
- Patients scheduled for concomitant cardiac surgery
- Reoperations
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital
Istanbul
About this study
Official title: Comparison of Operative and Early Postoperative Outcomes Between Eversion and Conventional Techniques in Carotid Endarterectomy
Atherosclerotic carotid artery disease is responsible for approximately 20% of strokes worldwide, and its treatment options include medical therapy, surgery, and stenting.Surgical management is prioritized over medical and stent based approaches and can be performed using either the conventional methed closed primarily or with a patch or the eversion technique.The aim of this study was to compare the intraoperative and early postoperative outcomes of the eversion technique and the conventional method with primary closure.
- Conditions
- Atherosclerosis Occlusive Disease, Stroke (CVA) or Transient Ischemic Attack, Endarterectomy, Carotid
- Being tested
- Carotid endarterectomy, conventional, Carotid endarterectomy, eversion
- Medical subject headings
- Stroke, Ischemic Attack, Transient
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Carotid endarterectomy, conventionalProcedure or surgery
In this study, patients were divided into two groups according to whether they underwent conventional or eversion endarterectomy. Although the eversion technique is the oldest method, the conventional approach is still widely performed due to its ease of application, despite not being recommended in current guidelines. Therefore, our aim is to contribute to the literature by comparing these two methods. The conventional method is performed with a longitudinal incision extending from the common carotid artery (CCA) to the internal carotid artery (ICA) up to the end of the plaque. The arteriotomy is then closed either primarily or with the use of a patch. In our study, we performed only the primary closure method..
Carotid endarterectomy, eversionProcedure or surgery
In this study, patients were divided into two groups according to whether they underwent conventional or eversion endarterectomy. Although the eversion technique is the oldest method, the conventional approach is still widely performed due to its ease of application, despite not being recommended in current guidelines. Therefore, our aim is to contribute to the literature by comparing these two methods.The eversion method is performed by transecting the internal carotid artery (ICA) from the common carotid artery (CCA). The arteriotomy is then closed in an end to side fashion.
| Study group | Role | What they receive |
|---|---|---|
| Conventional endarterectomy | Who were performed conventional,primarily endarterectomy patients are included this group Receives: Procedure: Carotid endarterectomy, conventional | |
| Eversion | Who were performed eversion endarterectomy patients are included this group Receives: Procedure: Carotid endarterectomy, eversion |
What is being measured
The primary outcome is the main question the study is designed to answer.
Number of participants with stroke and death
All strokes and/or deaths occurring within 30 days after surgery
Measured: 30 days
Number of participants with symptoms of occlusion
Early carotid restenosis or occlusion within 30 days after surgery
Measured: Postoperative 30 days
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted17 Dec 2025
- Study start15 May 2025
- Primary completion30 Aug 2025
- Study completion30 Sep 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (11)Papers the sponsor has linked to this study.
- Other trials for Atherosclerosis Occlusive DiseaseStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Other
- Time perspective
- Prospective
- Enrolment
- 129 participants (actual)
- Target duration
- 30 Days
Sponsor and investigators
- Lead sponsor
- Kastamonu University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, İsmail DAL, Kastamonu University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07288164
- Sponsor's protocol ID
- KastamanuU
- Status last verified
- Jan 2026
- First submitted
- 4 Dec 2025
- Last updated
- 6 Jan 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Publications
Ferguson GG, Eliasziw M, Barr HW, Clagett GP, Barnes RW, Wallace MC, Taylor DW, Haynes RB, Finan JW, Hachinski VC, Barnett HJ. The North American Symptomatic Carotid Endarterectomy Trial : surgical results in 1415 patients. Stroke. 1999 Sep;30(9):1751-8. doi: 10.1161/01.str.30.9.1751.
PubMed 10471419Wu S, Wang H, Guo J, Zhang F, Pan D, Ning Y, Gu Y, Guo L. Comparative on the effectiveness and safety of different carotid endarterectomy techniques: a single-center Retrospective Study. J Cardiothorac Surg. 2024 Jun 20;19(1):338. doi: 10.1186/s13019-024-02838-0.
PubMed 38902703Schneider JR, Helenowski IB, Jackson CR, Verta MJ, Zamor KC, Patel NH, Kim S, Hoel AW; Society for Vascular Surgery Vascular Quality Initiative and the Mid-America Vascular Study Group. A comparison of results with eversion versus conventional carotid endarterectomy from the Vascular Quality Initiative and the Mid-America Vascular Study Group. J Vasc Surg. 2015 May;61(5):1216-22. doi: 10.1016/j.jvs.2015.01.049.
PubMed 25925539Jonsson M, Lindstrom D, Wanhainen A, Djavani Gidlund K, Gillgren P. Near Infrared Spectroscopy as a Predictor for Shunt Requirement During Carotid Endarterectomy. Eur J Vasc Endovasc Surg. 2017 Jun;53(6):783-791. doi: 10.1016/j.ejvs.2017.02.033. Epub 2017 Apr 19.
PubMed 28431821Ben Ahmed S, Daniel G, Benezit M, Ribal JP, Rosset E. Eversion carotid endarterectomy without shunt: concerning 1385 consecutive cases. J Cardiovasc Surg (Torino). 2017 Aug;58(4):543-550. doi: 10.23736/S0021-9509.16.08495-0. Epub 2015 Feb 12.
PubMed 25673097Deser SB, Demirag MK, Kolbakir F. Does surgical technique influence the postoperative hemodynamic disturbances and neurological outcomes in carotid endarterectomy? Acta Chir Belg. 2019 Apr;119(2):78-82. doi: 10.1080/00015458.2018.1459364. Epub 2018 Apr 27.
PubMed 29701500Yuruk MA, Ozdemir AC. Eversion versus conventional carotid endarterectomy: A retrospective cohort study. Medicine (Baltimore). 2025 Aug 15;104(33):e43908. doi: 10.1097/MD.0000000000043908.
PubMed 40826780Yasa H, Akyuz M, Yakut N, Aslan O, Akyuz D, Ozcem B, Tulukoglu E, Gurbuz A. Comparison of two surgical techniques for carotid endarterectomy: conventional and eversion. Neurochirurgie. 2014 Feb-Apr;60(1-2):33-7. doi: 10.1016/j.neuchi.2013.12.003. Epub 2014 Mar 24.
PubMed 24673880Lee JH, Suh BY. Comparative results of conventional and eversion carotid endarterectomy. Ann Surg Treat Res. 2014 Oct;87(4):192-6. doi: 10.4174/astr.2014.87.4.192. Epub 2014 Sep 25.
PubMed 25317414Kakisis JD, Antonopoulos CN, Moulakakis KG, Schneider F, Geroulakos G, Ricco JB. Protamine Reduces Bleeding Complications without Increasing the Risk of Stroke after Carotid Endarterectomy: A Meta-analysis. Eur J Vasc Endovasc Surg. 2016 Sep;52(3):296-307. doi: 10.1016/j.ejvs.2016.05.033. Epub 2016 Jul 4.
PubMed 27389942Gahremanpour A, Perin EC, Silva G. Carotid artery stenting versus endarterectomy: a systematic review. Tex Heart Inst J. 2012;39(4):474-87.
PubMed 22949763
Study at a glance
From the registry record, last updated by the sponsor on 6 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparison of Operative and Early Postoperative Outcomes Between Eversion and Conventional Techniques in Carotid Endarterectomy
- ClinicalTrials.gov ID
- NCT07288164
- Acronym / sponsor ID
- KastamanuU
- Conditions
- Atherosclerosis Occlusive Disease, Stroke (CVA) or Transient Ischemic Attack, Endarterectomy, Carotid
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 129 participants (actual)
- Lead sponsor
- Kastamonu UniversityUniversity, hospital or other
- Study start
- 15 May 2025 (actual)
- Primary completion
- 30 Aug 2025 (actual)
- Study completion
- 30 Sep 2025 (actual)
- First posted
- 17 Dec 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Atherosclerotic carotid artery disease is responsible for approximately 20% of strokes worldwide, and its treatment options include medical therapy, surgery, and stenting.Surgical management is prioritized over medical and stent based approaches and can be performed using either the conventional methed closed primarily or with a patch or the eversion technique.The aim of this study was to compare the intraoperative and early postoperative outcomes of the eversion technique and the conventional method with primary closure.
Study design
- Observational model
- Other
- Time perspective
- Prospective
- Target follow-up
- 30 Days
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Conventional endarterectomy | – | Procedure: Carotid endarterectomy, conventionalWho were performed conventional,primarily endarterectomy patients are included this group |
| Eversion | – | Procedure: Carotid endarterectomy, eversionWho were performed eversion endarterectomy patients are included this group |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Carotid endarterectomy was performed in patients with 50-99% stenosis who had experienced stroke or transient ischemic attack (TIA) within the last six months, as well as in asymptomatic patients with 70-99% stenosis. These patients were divided into two groups according to the surgical technique applied conventional or eversion carotid endarterectomy and intraoperative and early postoperative outcomes were compared between the groups.
Key inclusion criteria (1 listed)
- -Patients undergoing isolated carotid endarterectomy, either emergently or electively
Key exclusion criteria (3 listed)
- Patients younger than 18 years of age
- Patients scheduled for concomitant cardiac surgery
- Reoperations
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Carotid endarterectomy, conventionalIn this study, patients were divided into two groups according to whether they underwent conventional or eversion endarterectomy. Although the eversion technique is the oldest method, the conventional approach is still widely performed due to its ease of application, despite not being recommended in current guidelines. Therefore, our aim is to contribute to the literature by comparing these two methods. The conventional method is performed with a longitudinal incision extending from the common carotid artery (CCA) to the internal carotid artery (ICA) up to the end of the plaque. The arteriotomy is then closed either primarily or with the use of a patch. In our study, we performed only the primary closure method.. | Procedure or surgery | Conventional endarterectomy |
| Carotid endarterectomy, eversionIn this study, patients were divided into two groups according to whether they underwent conventional or eversion endarterectomy. Although the eversion technique is the oldest method, the conventional approach is still widely performed due to its ease of application, despite not being recommended in current guidelines. Therefore, our aim is to contribute to the literature by comparing these two methods.The eversion method is performed by transecting the internal carotid artery (ICA) from the common carotid artery (CCA). The arteriotomy is then closed in an end to side fashion. | Procedure or surgery | Eversion |
Primary outcome
Number of participants with stroke and death
Time frame: 30 days
All strokes and/or deaths occurring within 30 days after surgery
Number of participants with symptoms of occlusion
Time frame: Postoperative 30 days
Early carotid restenosis or occlusion within 30 days after surgery
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 6 Jan 2026.
- Background: PubMed 10471419Ferguson GG, Eliasziw M, Barr HW, Clagett GP, Barnes RW, Wallace MC, Taylor DW, Haynes RB, Finan JW, Hachinski VC, Barnett HJ. The North American Symptomatic Carotid Endarterectomy Trial : surgical results in 1415 patients. Stroke. 1999 Sep;30(9):1751-8. doi: 10.1161/01.str.30.9.1751.
- Background: PubMed 38902703Wu S, Wang H, Guo J, Zhang F, Pan D, Ning Y, Gu Y, Guo L. Comparative on the effectiveness and safety of different carotid endarterectomy techniques: a single-center Retrospective Study. J Cardiothorac Surg. 2024 Jun 20;19(1):338. doi: 10.1186/s13019-024-02838-0.
- Background: PubMed 25925539Schneider JR, Helenowski IB, Jackson CR, Verta MJ, Zamor KC, Patel NH, Kim S, Hoel AW; Society for Vascular Surgery Vascular Quality Initiative and the Mid-America Vascular Study Group. A comparison of results with eversion versus conventional carotid endarterectomy from the Vascular Quality Initiative and the Mid-America Vascular Study Group. J Vasc Surg. 2015 May;61(5):1216-22. doi: 10.1016/j.jvs.2015.01.049.
- Background: PubMed 28431821Jonsson M, Lindstrom D, Wanhainen A, Djavani Gidlund K, Gillgren P. Near Infrared Spectroscopy as a Predictor for Shunt Requirement During Carotid Endarterectomy. Eur J Vasc Endovasc Surg. 2017 Jun;53(6):783-791. doi: 10.1016/j.ejvs.2017.02.033. Epub 2017 Apr 19.
- Background: PubMed 25673097Ben Ahmed S, Daniel G, Benezit M, Ribal JP, Rosset E. Eversion carotid endarterectomy without shunt: concerning 1385 consecutive cases. J Cardiovasc Surg (Torino). 2017 Aug;58(4):543-550. doi: 10.23736/S0021-9509.16.08495-0. Epub 2015 Feb 12.
- Background: PubMed 29701500Deser SB, Demirag MK, Kolbakir F. Does surgical technique influence the postoperative hemodynamic disturbances and neurological outcomes in carotid endarterectomy? Acta Chir Belg. 2019 Apr;119(2):78-82. doi: 10.1080/00015458.2018.1459364. Epub 2018 Apr 27.
- Background: PubMed 40826780Yuruk MA, Ozdemir AC. Eversion versus conventional carotid endarterectomy: A retrospective cohort study. Medicine (Baltimore). 2025 Aug 15;104(33):e43908. doi: 10.1097/MD.0000000000043908.
- Background: PubMed 24673880Yasa H, Akyuz M, Yakut N, Aslan O, Akyuz D, Ozcem B, Tulukoglu E, Gurbuz A. Comparison of two surgical techniques for carotid endarterectomy: conventional and eversion. Neurochirurgie. 2014 Feb-Apr;60(1-2):33-7. doi: 10.1016/j.neuchi.2013.12.003. Epub 2014 Mar 24.
- Background: PubMed 25317414Lee JH, Suh BY. Comparative results of conventional and eversion carotid endarterectomy. Ann Surg Treat Res. 2014 Oct;87(4):192-6. doi: 10.4174/astr.2014.87.4.192. Epub 2014 Sep 25.
- Background: PubMed 27389942Kakisis JD, Antonopoulos CN, Moulakakis KG, Schneider F, Geroulakos G, Ricco JB. Protamine Reduces Bleeding Complications without Increasing the Risk of Stroke after Carotid Endarterectomy: A Meta-analysis. Eur J Vasc Endovasc Surg. 2016 Sep;52(3):296-307. doi: 10.1016/j.ejvs.2016.05.033. Epub 2016 Jul 4.
- Background: PubMed 22949763Gahremanpour A, Perin EC, Silva G. Carotid artery stenting versus endarterectomy: a systematic review. Tex Heart Inst J. 2012;39(4):474-87.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Atherosclerosis Occlusive Disease and Stroke (CVA) or Transient Ischemic Attack, run by Kastamonu University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 6 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Number of participants with stroke and death (time frame: 30 days). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07288164, which also lists 11 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 6 Jan 2026; AzTrials last refreshed its copy on 2 Nov 2026.