Clinical trials: Ischemia, Brain
Ischemic Stroke
Improving Early Reperfusion With Adjuvant Dornase Alfa in Large Vessel Ischemic Stroke (EXTEND-IA DNase)
Patients presenting to the emergency department with acute ischemic stroke, who are are eligible for standard intravenous thrombolytic therapy within 4.5 hours of stroke onset will be assessed for major vessel occlusion to…
- Trial name
- NCT05203224
- Testing
- Dornase Alfa
- Where
- 3 sites in Australia
- Volunteers
- 330 people
- Sponsor
- University of Melbourne
Acute Ischemic Stroke, Physical Activity
Physical Activity Immediately After Acute Cerebral Ischemia
Stroke is the leading cause of adult disability in Europe and United States and the second leading cause of death worldwide and affects more than 10,000 Danes each year.
- Conditions
- Acute Ischemic Stroke, Physical Activity, Accelerometer
- Trial name
- NCT01594190
- Testing
- physical activity 15 minutes/day, physical activity, 2 x 30 minutes/day
- Where
- Denmark
- Volunteers
- 250 people
- Sponsor
- Hillerod Hospital, Denmark
Stroke, Acute
Reperfusion With Cooling in Cerebral Acute Ischemia
The purpose of this study is to determine whether reducing a patients body temperature (mild hypothermia of 33 degrees Centigrade) will significantly reduce the risk of brain injury (notably reperfusion injury and hemorrhagic…
- Trial name
- ReCCLAIM (NCT01585597)
- Testing
- Zoll- Coolgaurd 3000
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Emory University
Ischemic Stroke, Cerebral Veinous Thrombosis
Thrombus Composition in Cerebral Infarctions: Study of Its Association With Plasma Biomarkers, Treatment Efficacy, Etiology and Prognosis.
This study focuses on thrombi collected during mechanical thrombectomy procedures, as well as on plasma biomarkers analyzed concomitantly.
- Trial name
- COMPOCLOT (NCT07384520)
- Volunteers
- 500 people
- Sponsor
- François Delvoye
Cerebrovascular Accident
Safety Study of Interferon Beta 1a to for Acute Stroke
This study will examine the safety of the drug interferon beta 1a in patients with acute ischemic stroke to determine the highest dose patients can tolerate without serious side effects and to determine the best way to give the…
- Trial name
- NCT00097318
- Testing
- Interferon beta-1a
- Where
- 3 sites in United States
- Volunteers
- 60 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Ischemic Stroke
Radial Shock Waves for Functional Disability in Stroke
This is a double blind randomized clinical trial to evaluate the effect of radial shock waves on functional recovery of the upper limb of patients with sequelae of ischemic strokes in the territory of the middle cerebral artery.
- Trial name
- NCT02924168
- Testing
- Active Radial Shockwave
- Where
- Brazil
- Volunteers
- 22 people
- Sponsor
- Marta Imamura
Stroke, Ischemic
Comprehensive Cardiac Rehabilitation Feasibility After Stroke
Comprehensive Cardiovascular Rehabilitation Feasibility After Stroke (CCR FAST) will evaluate the feasibility of enrolling Regions Hospital stroke patients in a Comprehensive Cardiovascular Rehabilitation (CCR) program.
- Trial name
- CCRFast (NCT03944668)
- Testing
- Exercise
- Where
- 3 sites in United States
- Volunteers
- 17 people
- Sponsor
- HealthPartners Institute
Cerebral Ischemia
Impact of Interscalene Nerve Block on Cerebral Perfusion During Surgery in the Beachchair Position
Beachchair position is used by many orthopaedic surgeons for shoulder surgery. Most patients undergoing surgery in this position have no complications.
- Trial name
- NCT01983618
- Testing
- Interscalene nerve block and catheter, Interscalene catheter
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Cognitive Decline, Stroke
Identification of Epigenetic Risk Factors for Ischemic Complication During the TAVR Procedure in the Elderly
Over the past ten years, the number of endovascular procedures has increased by 5% per year in Europe with the development of interventional cardiology, such as percutaneous coronary angioplasty, aortic valve replacements (TAVR)…
- Trial name
- METHYSTROKE (NCT02972008)
- Where
- France
- Volunteers
- 542 people
- Sponsor
- University Hospital, Lille
Stroke
Umbilical Cord Derived Mesenchymal Stem Cells Treatment in Ischemic Stroke
The study aims at estimating the safety and efficacy of the intravenous injection of human umbilical cord mesenchymal stem cell(hUC-MSC) for patients suffering from ischemic stroke in recent 3 months.
- Trial name
- Recruiting (NCT02580019)
- Testing
- Human umbilical cord mesenchymal stem cells
- Where
- China
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Affiliated Hospital to Academy of Military Medical Sciences
Cerebral Infarction
Yiqi Huoxue Demolition and Recipes on Recovery Stage of Cerebral Infarction
This clinical research is based on the fundamentals of using Chinese medicine, which will improve Qi and promote blood circulation, to treat patients in the recuperating stages of cerebral infarction with deficiency in Qi and…
- Trial name
- NCT02846207
- Testing
- Yiqi huoxue, Yiqi group, Huoxue group
- Where
- 3 sites in China
- Volunteers
- 360 people
- Sponsor
- Dongfang Hospital Beijing University of Chinese Medicine
Acute Ischemic Stroke
Intravenous Tirofiban After Bridging Therapy for Acute Stroke With Atherosclerotic Large Artery Occlusion
The investigators propose to assess the efficacy and safety of intravenous tirofiban after bridging therapy (endovascular therapy [EVT] following intravenous Tenecteplase) for acute ischemic stroke due to intracranial…
- Trial name
- RESCUE-AS (NCT07335107)
- Testing
- Intravenous Tirofiban, Standard Medical Therapy
- Where
- China
- Volunteers
- 564 people
- Sponsor
- Beijing Tiantan Hospital
Venous Thrombosis, Pulmonary Embolism
Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Pratice (UK)
This prospective cohort study will provide information about: characteristics of Rivaroxaban use in patients who are prescribed Rivaroxaban for the first time compared to patients who are prescribed Warfarin for the first time…
- Conditions
- Venous Thrombosis, Pulmonary Embolism, Atrial Fibrillation, Acute Coronary Syndrome
- Trial name
- NCT01947998
- Testing
- Rivaroxaban (Xarelto, Bay59-7939), Warfarin, Antiplatelet drugs
- Where
- United Kingdom
- Volunteers
- 50,299 people
- Sponsor
- Bayer
Stroke, Vascular Severe Brain Injury
Blood Extracellular Vesicles as Predictive Recovery Biomarker After Stroke and Brain Injury
The rehabilitation outcome and recovery, in people after stroke or with vascular severe brain injury(vSBI), are difficult to predict.
- Conditions
- Stroke, Vascular Severe Brain Injury, Rehabilitation
- Trial name
- PRISMA (NCT06871800)
- Testing
- blood withdrawal
- Where
- 3 sites in Italy
- Volunteers
- 60 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Stroke, Stroke, Ischemic
Quantitative EEG Changes Following Repetitive Transcranial Magnetic Stimulation in Patients With Post Stroke (EEG-rTMS)
Quantitative EEG (qEEG) has been used as an effective tool in the diagnosis and prognosis of brain-related diseases. In the literature, a variety of qEEG parameters have been proven informative in the prognosis of stroke.
- Conditions
- Stroke, Stroke, Ischemic, Stroke/Brain Attack
- Trial name
- EEG-rTMS (NCT05657392)
- Testing
- repetitive Transcranial Magnetic Stimulation (rTMS), 32 electrode electroencephalography (EEG)
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Izmir Katip Celebi University
Brain Ischemia, Reduction of Cerebral Air Emboli
Comparative Effectiveness of Unilateral vs. Bilateral Pulmonary Collapse in Cardiac De-airing
To compare the effectiveness of unilateral pulmonary collapse (right lung) to bilateral pulmonary collapse for cardiac de-airing in open left-sided heart surgery.
- Trial name
- NCT02119871
- Testing
- Bilateral Open Pleurae, Right Pleura Open
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Lund University
Hypertension, Diabetes
A Longitudinal Cohort Study to Evaluate Cardiovascular Risk Factors and Disease in Haiti
Investigators will establish a longitudinal cohort of ~3,000 adults >18 years in Port-au-Prince using multistage random sampling, and follow them longitudinally to evaluate the prevalence and incidence of cardiovascular disease…
- Conditions
- Hypertension, Diabetes, Obesity, Kidney Diseases
- Trial name
- NCT03892265
- Testing
- Observational Study
- Where
- Haiti
- Volunteers
- 3,005 people
- Sponsor
- Weill Medical College of Cornell University
Quadriplegia, Amputations
A Study on the Safety and Functionality of the Implantable Wireless Brain-Computer Interfaces for Motor Rehabilitation
The objective of this study is to evaluate the safety and efficacy of minimally invasive, wireless brain-machine interface system (WRS) in patients with paralysis (resulting from spinal cord injuries, brainstem strokes…
- Conditions
- Quadriplegia, Amputations, Spinal Cord Injuries (SCI), Brainstem Stroke
- Trial name
- STAIR (NCT06944834)
- Testing
- Implant
- Where
- China
- Volunteers
- 5 people
- Sponsor
- Shanghai StairMed Technology Co., Ltd.
Stroke, Stroke Rehabilitation
Evaluating Functional Outcomes of 3D-Printed Splints in Post-Stroke Upper Limb Recovery
This study aims to evaluate the upper limb motor recovery using a 3D-printed dynamic orthosis compared to a conventional one as part of a rehabilitation program in individuals with chronic stroke.
- Conditions
- Stroke, Stroke Rehabilitation, Hemiparesis of the Upper Limb Following Stroke
- Trial name
- 3D-splint (NCT07243314)
- Testing
- 3D Printed splint, conventional splint
- Where
- Saudi Arabia
- Volunteers
- 100 people
- Sponsor
- King Saud University
Stroke Ischemic
Paired Associative Stimulation (PAS) for Stroke Rehabilitation
Paired associative stimulation (PAS) delivered with multi-channel deep transcranial magnetic stimulation (dTMS) may enhance motor recovery in patients with first-ever ischemic stroke.
- Trial name
- PAS-Stroke (NCT07691099)
- Testing
- A multi-channel device with deep TMS coil (Brainsway Ltd., Jerusalem, Israel)
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Soroka University Medical Center
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