Clinical trials: Ischemia, Brain
Hypoxic-Ischemic Encephalopathy, Neonatal Encephalopathy
The Impact of Holding on Stress and Bonding in Mother-Infant Pairs During Therapeutic Hypothermia
This research is being done to try to improve the experience of mothers and babies during therapeutic hypothermia. Currently, mothers are not able to hold their baby during hypothermia treatment.
- Trial name
- NCT03837717
- Testing
- Holding, Saliva collection, No Holding
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- MaineHealth
Cerebral Infarction
"Evaluation by Transcranial Magnetic Stimulation of the Benefit of Fluoxetine on Motor Recovery After Stroke"
The objective of this study is to better characterize the mechanisms of action of fluoxetine in motor recovery and more specifically to identify the neurophysiological substrate underlying fluoxetine-induced motor recovery in…
- Trial name
- EFLUSTIM (NCT02063425)
- Testing
- Fluoxetine
- Where
- France
- Volunteers
- 6 people
- Sponsor
- Centre Hospitalier St Anne
Subacute Stroke, Ischemic Stroke
Segmental Vibrator With NMES on Lower Limb Function in Subacute Stroke
Stroke is one of the world's leading causes of death and disability. It can cause a variety of motor disorders, such as apraxia, sensory deficits, abnormal muscle tone, inadequate weight transfer, lack of fine motor skills…
- Trial name
- NCT06927206
- Testing
- Experimental Group A: Segmental vibrator only on dorsiflexor, Experimental Group B: Segmental vibrator + Electrical stimulation on dorsiflexors
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- Riphah International University
Ischemic Stroke, Dysphagia
Effect of Specific Mode Electroacupuncture Stimulation Combined with NGF on Dysphagia After Ischaemic Stroke: a Pilot Randomized Controlled Trial
Ischemic stroke is a common clinical disease, often accompanied by dysphagia. At present, clinical treatment for patients with dysphagia after ischemic stroke is limited.
- Trial name
- NCT06737549
- Testing
- Nerver growth factor (NGF) injection, EA intervention, Acupuncture intervention
- Where
- China
- Volunteers
- 144 people
- Sponsor
- The Third Affiliated hospital of Zhejiang Chinese Medical University
Ischemic Cerebrovascular Accident
Mechanical Opening Device Implantation Following Intravenous r-tPA for Recanalization in Acute Ischemic Stroke
This study is to test a hypothesis that temporary implantation of JRecanTM blood flow recanalisation device within 6.5 hours of symptom onset of acute ischemic stroke due to a major intracranial artery occlusion following IV…
- Trial name
- NCT02347358
- Testing
- JRecanTM blood FR device, IV r-tPA
- Volunteers
- 100 people
- Sponsor
- The Second Artillery General Hospital
Transient Ischemic Attack, Minor Ischemic Stroke
Dabigatran Following Transient Ischemic Attack and Minor Stroke
Rationale: To date, anticoagulant therapy in acute stroke has also been limited by excess hemorrhagic events. The oral anticoagulant dabigatran is a novel agent, which has been shown to be associated with much lower intracranial…
- Trial name
- DATAS II (NCT02295826)
- Testing
- Dabigatran, Acetylsalicylic acid
- Where
- 6 sites in Canada
- Volunteers
- 300 people
- Sponsor
- University of Alberta
Acute Ischemic Stroke
Safety and Efficacy of SHPL-49 Injection in Participants With Acute Ischemic Stroke
This study is designed to determine the safety and efficacy of SHPL-49 intravenous infusion for 7 consecutive days in the treatment of acute ischemic stroke subjects.
- Trial name
- NCT06202378
- Testing
- 3 ampoules of SHPL-49 Injection, 6 ampoules of SHPL-49 Injection, 0.9% Sodium Chloride Injection
- Where
- 16 sites in China
- Volunteers
- 270 people
- Sponsor
- Shanghai Hutchison Pharmaceuticals Limited
Carotid Stenosis, Hypoperfusion
Physiological Magnetic Resonance Imaging (MRI) to Improve Carotid Endarterectomy Outcomes
The carotid arteries are blood vessels in the neck that supply blood to the brain. Carotid stenosis disease is defined as a narrowing of these arteries due to the build up of plaque.
- Conditions
- Carotid Stenosis, Hypoperfusion, Transient Ischemic Attack
- Trial name
- NCT01272843
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Sunnybrook Health Sciences Centre
Stroke, Ischemic
CASTRO1 - Study on CRP Apheresis After Ischemic Stroke
CASTRO1 is a study to investigate the reduction of C-reactive protein (CRP) by therapeutic apheresis (CRP-apheresis) in patients after primary treatment of ischemic stroke.
- Trial name
- CASTRO1 (NCT04417231)
- Testing
- CRP apheresis
- Where
- Germany
- Volunteers
- 3 people
- Sponsor
- Pentracor GmbH
Stroke Acute, Thrombectomy
Thrombectomy Versus Best Medical Management in Large Vessel Occlusion Stroke Patients Presenting Beyond 24 Hours and With Presence of Collateral Flow on CT Angiography
The goal of this clinical trial is to investigate if endovascular treatment (EVT) can effectively treat patients with large vessel occlusion (LVO) who present beyond the typical 24-hour window after symptom onset.
- Conditions
- Stroke Acute, Thrombectomy, Medical Treatment, Large Vessel Occlusion
- Trial name
- NCT06654375
- Testing
- Endovascular Thrombectomy
- Where
- China
- Volunteers
- 350 people
- Sponsor
- Tianjin Huanhu Hospital
Coronary Disease, Myocardial Infarction
Chronical Illness-related Limitations of the Ability to Cope with Rising Temperatures: an Observational Study, 2nd Wave
The CLIMATE-II Observational Study examines to what extent chronically ill patients experience adverse health effects because of heat and whether the patients' specific health behavior, somatosensory amplification, risk and…
- Conditions
- Coronary Disease, Myocardial Infarction, Heart Failure, Arrhythmias, Cardiac
- Trial name
- CLIMATE-II (NCT06407154)
- Where
- Germany
- Volunteers
- 578 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Transient Ischemic Attack, Minor Stroke
Multiple Interventions to Accelerate the Return to the Pre-event Level of Functioning After a TIA and Minor Stroke
The occurrence of a transient ischemic attack (TIA) or a minor stroke is frequently assumed as a temporary and non-disabling event.
- Trial name
- NCT05369637
- Testing
- Cognitive training, Physical exercise, Behavioral: Nutrition education
- Where
- Portugal
- Volunteers
- 70 people
- Sponsor
- Instituto de Saude Publica da Universidade do Porto
Hypoxic-Ischemic Encephalopathy
MRI of Neonate With HIE Before and During the Moderate Hypothermia
Moderate hypothermia has been demonstrated to be the effective treatment for neonates with hypoxic-ischemic encephalopathy (HIE). However, few studies reveal the actual alterations in physiological parameters (i.e.
- Trial name
- NCT03079492
- Testing
- Magnetic resonance imaging
- Where
- China
- Volunteers
- 30 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Stroke, Ischemic
Optimizing the Radiological Selection and Transfer Model in Stroke Patients Presenting 6-24h After Onset (VESTA Study)
We aim to optimize the radiological selection and the transfer model in patients with a 6-24h stroke for a fairer and broader access to a reperfusion treatment. The specific objectives are: 1.
- Trial name
- VESTA (NCT05299034)
- Testing
- Multiparametric imaging, Non contrast CT+CT angiography
- Where
- Spain
- Volunteers
- 2,173 people
- Sponsor
- Germans Trias i Pujol Hospital
Cerebrovascular Stroke
Sonothrombolysis Potentiated by Microbubbles for Acute Ischemic Stroke
It has proposed the use of ST without microbubble treatment in randomized association with both intravenous and intra-arterial thrombolysis, but combined treatment (rtPA + U.S.) associated with MB diagnostic not yet been…
- Trial name
- NCT01678495
- Testing
- Sulfur hexafluoride + ultrasounds, Recombinant tissue plasminogen activator
- Where
- Spain
- Volunteers
- 24 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Stroke, Ischemic Stroke
Immuno-inflammatory Profile and Response to Ischemic Stroke Reperfusion Therapies (IMMUNOSTROKE)
IMMUNOSTROKE study aims to describe the immuno-inflammatory and thrombo-inflammatory profiles during the course of AIC management by reperfusion treatment and to monitor changes in these different parameters over time.
- Trial name
- IMMUNOSTROKE (NCT04701619)
- Testing
- Immuno-inflammatory profile description in patients with ischemic stroke
- Volunteers
- 300 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Stroke
Evaluation of the ReVive SE Device for Intra-Arterial Thrombectomy in Acute Ischemic Stroke
The main objective of this study is to assess the safety and effectiveness of the ReVive SE (Self- Expanding) Neurothrombectomy Device in subjects requiring mechanical thrombectomy when used according to its Instruction for use…
- Trial name
- Re-ACT (NCT02169492)
- Where
- 8 sites in France
- Volunteers
- 103 people
- Sponsor
- Codman & Shurtleff
Embolic Stroke
Study of the Efficacy, Safety and Tolerability of Low Molecular Weight Heparin vs. Unfractionated Heparin in Stroke
Patients with Atrial fibrillation (AF) make a unique group of ischemic stroke, mostly caused by emboli from the left atrial appendage.
- Trial name
- NCT02159287
- Testing
- Enoxaparin, Heparin
- Where
- 2 sites in Iran
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Shiraz University of Medical Sciences
Cerebrovascular Stroke
BOBBY™ Balloon Guide Catheter for Endovascular Treatment of Acute Ischemic Stroke
Evaluation of the safety and performance of the BOBBY™ Balloon Guide Catheter (BGC) in patients with an acute ischemic stroke treatment, a sudden reduction or termination of the blood circulation of the brain, caused by a clot.
- Trial name
- STRAIT (NCT05361187)
- Testing
- BOBBY™ Balloon Guide Catheter intended for use in neurovascular procedures, performing or as an adjunctive device
- Where
- 9 sites in Germany, Switzerland
- Volunteers
- 171 people
- Sponsor
- Microvention-Terumo, Inc.
Stroke, Cerebral Infarction
SouthErn China REgisTry for Stroke on Traditional Chinese Medicine
Stroke is the first most common cause of death in China and one of the major causes of functional disability in the adult population.The burden of stoke is significantly increased in China in recent years.
- Conditions
- Stroke, Cerebral Infarction, Transient Ischemic Attack, Cerebral Hemorrhage
- Trial name
- SECRETS-TCM (NCT03380481)
- Testing
- observational only-no intervention
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Yefeng Cai
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