Clinical trials: Ischemia, Brain
Myocardial Infarction, Venous Thromboembolism
Comparision Between Activated Partial Thromboplastin Time Versus Anti-Xa Activity in Heparin Monitoring
Background: Unfractionated heparin (UFH) is a sulfated polysaccharide extracted from porcine intestinal mucosa that enhances the inhibitory activity of the natural anticoagulant antithrombin towards most activated clotting…
- Conditions
- Myocardial Infarction, Venous Thromboembolism, Stroke, Bleeding
- Trial name
- CATCH (NCT03426982)
- Testing
- Unfractionated heparin
- Where
- China
- Volunteers
- 700 people
- Sponsor
- Wuhan Asia Heart Hospital
Stroke, Stroke, Acute
Earlier Mobilization Post Acute Thrombolysis
This is a phase III trial trying to determine whether 12-hour bed rest following IV thrombolysis therapy (i.e. tPA) for ischemic stroke is non-inferior to 24-hour bed rest by measure of outcomes on the modified Rankin Scale (mRS)…
- Conditions
- Stroke, Stroke, Acute, Stroke, Ischemic
- Trial name
- EMPATHY-I (NCT04153942)
- Testing
- Mobilization
- Sponsor
- Brian Silver
Ischemic Stroke
A Cohort Study on Thrombectomy for Stroke
The cerebral collateral circulation refers to the subsidiary network of vascular channels that stabilize cerebral blood flow when principal conduits fail. Collateral status differs among patients with acute ischemic stroke.
- Trial name
- NCT04637074
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Ning Wang, MD., PhD.
Coronary Artery Disease, Postoperative Cognitive Dysfunction
Cerebral Oximetry and Neurocognitive Functions in Cardiosurgical Patients
It is previously reported that the cerebral oxygen desaturation during cardiac surgery is associated with an increased incidence of cognitive impairment.
- Conditions
- Coronary Artery Disease, Postoperative Cognitive Dysfunction, Neurological Impairment
- Trial name
- NCT00917124
- Testing
- INVOS
- Where
- Croatia
- Volunteers
- 200 people
- Sponsor
- University of Zagreb
Ischemic Stroke
Combination of Conditioned Medium and Umbilical Cord-Mesenchymal Stem Cells Therapy for Acute Stroke Infarct
The purpose of this study was to determine the effectiveness of a combination of intranasal conditioned medium (CM) with intraparenchymal umbilical cord mesenchymal stem cells (UC-MSCs) transplantation in acute stroke patients to…
- Trial name
- NCT05008588
- Testing
- Conditioned Medium, Umbilical Cord Mesenchymal Stem Cells, Neurologic and Neutrophic Drugs
- Where
- 2 sites in Indonesia
- Volunteers
- 15 people
- Sponsor
- PT. Prodia Stem Cell Indonesia
Motor Neuropathy
Stroke Recovery Research Based on EEG-fMRI
This study is aimed to investigate the post-stroke motor recovery of patients with ischemic stroke based on their neural features extracted from EEG-fMRI data.
- Trial name
- EEG-fMRI (NCT05427422)
- Testing
- MRI recording, EEG recording
- Where
- China
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- Xi'an Jiaotong University
Hypoxic Ischemic Encephalopathy (HIE)
Neonates With Hypoxic Ischemic Encephalopathy (HIE)
Assessment of the potential neuroprotective effect of magnesium sulphate and caffeine in treating asphyxiated newborns and improvement of the neurological outcome of Hypoxic Ischemic Encephalopathy in Assiut university hospital…
- Trial name
- NCT06694545
- Volunteers
- 72 people
- Sponsor
- Assiut University
Neuro ICU, Sub Arachnoid Hemorrhage
Comparison of Ultrasound Cerebral Perfusion Imaging With Routine Perfusion CT
The primary goal of neurocritical care is to prevent secondary brain injury, which worsens neurological outcomes. Because clinical monitoring is often insufficient due to the patient's condition and medical treatments, multimodal…
- Conditions
- Neuro ICU, Sub Arachnoid Hemorrhage, Neurological Complication, Cerebral Ischemia
- Trial name
- SCULPT (NCT07324421)
- Testing
- Ultrasound contrast agent (Contrast-enhanced ultrasound)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Resolve Stroke
Ischemic Stroke
Efficacy and Safety Study of Ultra-early Mobile Stroke Unit Neuroprotection Combined With Revascularization for Acute Ischemic Stroke (EXCELLENT)
EXCELLENT was a prospective, multicenter, randomized, double-blind, placebo-controlled clinical study in which participants were randomized participants were randomized (1:1) to receive either IV thrombolysis + edaravone or IV…
- Trial name
- EXCELLENT (NCT07119021)
- Testing
- Intravenous thrombolysis + edaravone
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Ruijun Ji
Cadasil
CADASIL Registry Study
The aim of this study is to determine the clinical spectrum and natural progression of Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) and related disorders in a prospective…
- Trial name
- NCT04310098
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Bin Cai
Acute Ischemic Stroke
Radiohistological Correlation of Thrombohemorrhagic Remodeling in the Acute Phase of Ischemic Stroke Managed by Decompressive Hemicraniectomy
Recent years have witnessed a change in the therapeutic paradigm of stroke with the advent of mechanical thrombectomy as the reference treatment.
- Trial name
- SWI-SURGERY (NCT05847699)
- Testing
- MRI sequences and biopsies
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Cerebral Angiography, Heparinization
Safety and Efficacy of Low-dose hEparinization in Cerebral Angiography sTudy
Purpose: Systemic heparinization is a widely used technique on digital subtraction angiography (DSA). Heparin, however, is associated with a variety of complications, including hemorrhage, thrombocytopenia, and hematomas.
- Trial name
- SELECT (NCT06365398)
- Testing
- Heparin, Heparin Sodium Injection, No heparinization
- Where
- 2 sites in China
- Volunteers
- 180 people
- Sponsor
- Xuanwu Hospital, Beijing
Acute Brain Injuries, Consciousness Disorders
CONNECT-ME: Consciousness in Neurocritical Care Cohort Study Using fMRI and EEG
Detecting preserved consciousness in brain-injured patients by traditional clinical means requires presence of motor function. Otherwise, patients may be erroneously classified as being in a vegetative state.
- Trial name
- CONNECT-ME (NCT02644265)
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Severe Hypoxic-ischemic Encephalopathy
Autologous Cord Blood and Human Placental Derived Stem Cells in Neonates With Severe Hypoxic-Ischemic Encephalopathy
The purpose of this study is to investigate the safety and effectiveness of autologous human placental-derived stem cells (HPDSC) in combination with autologous cord blood in neonates with severe hypoxic-ischemic encephalopathy.
- Trial name
- HPDSC+HIE (NCT02434965)
- Testing
- HPDSC, Cord blood
- Where
- United States
- Sponsor
- New York Medical College
Traumatic Brain Injury
Ischemia Modified Albumin in Traumatic Brain Injury
In the current study the investigators intend to evaluate the role of Ischemia modified albumin (IMA) in the prediction of poor outcome in patients with traumatic brain injury (TBI).
- Trial name
- NCT03637101
- Testing
- Ischemia modified albumin (IMA)
- Where
- Egypt
- Volunteers
- 54 people
- Sponsor
- Kasr El Aini Hospital
Ischemic Stroke, Acute
Emergency Stroke Unit for Acute Cerebrovascular Events ( ESU-ACE-A )
To compare the door-to-needle time of patients with hyperacute ischemic stroke (within 4.5 hours after the onset of symptoms) managed in a standard stroke unit adherent to guidelines versus managed in Emergency Stroke Unit (a new…
- Trial name
- NCT06492239
- Testing
- Emergency Stroke Unit based on 0.23-T MRI, Standard stroke unit adherent to guidelines
- Where
- China
- Volunteers
- 218 people
- Sponsor
- Beijing Tiantan Hospital
Acute Ischemic Stroke
Millipede AspiRation for Revascularization in Stroke (MARRS) Study
The objectives of the study are to examine the performance and safety characteristics of the Millipede System when used for revascularization of patients with acute ischemic stroke due to Large Vessel Occlusions (LVOs) and to…
- Trial name
- MARRS (NCT05714501)
- Testing
- Millipede System
- Where
- 23 sites in United States, France and 1 more
- Volunteers
- 235 people
- Sponsor
- Perfuze
Ischemic Stroke, Thrombi
Acute Anterior or Posterior Cerebral Artery Occlusion Recanalization Therapy and Relationships With Clinical Outcome (ACAPULCO)
Nearly 3% of patients with ischaemic stroke (IS) have an isolated occlusion of the anterior or posterior cerebral artery in the acute phase of the disease.
- Trial name
- ACAPULCO (NCT04823481)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Ischemic Stroke
Prediction of Stroke-associated Pneumonia
Stroke-associated pneumonia (SAP) constitutes a clinically relevant complication of stroke, because it increases the mortality and has a negative impact on the neurological prognosis of the patient.
- Trial name
- PREDICT (NCT01079728)
- Where
- 8 sites in Germany, Spain
- Volunteers
- 486 people
- Sponsor
- Charite University, Berlin, Germany
Stroke
Gastric Feeding for the Prevention of Stroke-Associated Pneumonia
This randomized controlled trial aims to compare the effectiveness of early post-pyloric feeding versus gastric feeding in preventing SAP in patients with severe ischemic stroke.
- Trial name
- FEED-SAP (NCT07630090)
- Testing
- Post-Pyloric Feeding, Gastric Feeding
- Where
- China
- Volunteers
- 174 people
- Sponsor
- Jinling Hospital, China
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