Clinical trials: Ischemia, Brain
Myocardial Depression, Takotsubo Syndrome
Predicting the Development of Myocardial Depression in Acute Neurological Patients
The purpose of this study is to assess the levels of serum catecholamines associated with myocardial depression (MD) in patients with acute neurological injury.
- Conditions
- Myocardial Depression, Takotsubo Syndrome, Subarachnoid Hemorrhage, Acute Ischemic Stroke
- Trial name
- NCT03801694
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Ohio State University
Acute Ischemic Stroke
Arterial Spin Label Depicted Ischemic Stroke Cohort (ASLIS)
Establish a clinical cohort of acute ischemic stroke patients and find the determinant of the prognosis.
- Trial name
- ASLIS (NCT05920902)
- Testing
- routine therapy of acute ischemia stroke
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Death, Carotid Artery Disease
NOR-SYS: The Norwegian Stroke in the Young Study
NOR-SYS is a clinical research program about young ischemic stroke patients from 15 to 60 years. Patients, partners and the couple´s adult children who are at least 18 years old, are all invited to ultrasound examinations due to…
- Conditions
- Death, Carotid Artery Disease, Cardiovascular Disease, Peripheral Artery Disease
- Trial name
- NOR-SYS (NCT01597453)
- Testing
- Lifestyle counseling
- Where
- Norway
- Volunteers
- 1,062 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
Coronary Heart Disease, Stroke
The Copenhagen City Heart Study
The Copenhagen City Heart Study is an ongoing cardiovascular population study initiated in 1976 which has examined approximately 25,000 individuals from the general population.
- Conditions
- Coronary Heart Disease, Stroke, Heart Failure, Cancer
- Trial name
- CCHS (NCT02993172)
- Volunteers
- 23,891 people
- Sponsor
- Bispebjerg Hospital
Carotid Stenosis, Ischemic Stroke
Symptomatic Carotid Outcomes Registry
The purpose of this study is to build upon trials done over 30 years ago, which did not include statins, new antiplatelet agents, and newer antihypertensive medications.
- Conditions
- Carotid Stenosis, Ischemic Stroke, Transient Ischemic Attack
- Trial name
- SCORE (NCT05300737)
- Testing
- intensive medical therapy
- Where
- 18 sites in United States, Canada
- Volunteers
- 114 people
- Sponsor
- University of Maryland, Baltimore
Carotid Artery Diseases, Carotid Artery Stenosis
Timing Carotid Stent Clinical Study for the Treatment of Carotid Artery Stenosis（Timing Trial）
Evaluate the safety and efficacy of the Timing Carotid Stent for the treatment of carotid artery stenosis in patients.
- Conditions
- Carotid Artery Diseases, Carotid Artery Stenosis, Stroke, Ischemic Stroke
- Trial name
- NCT05574972
- Testing
- Timing Carotid Stent, Carotid Wallstent
- Where
- China
- Volunteers
- 178 people
- Sponsor
- Suzhou Zenith Vascular SciTech Limited
Stroke, Acute Ischemic
Macrowire for IntracraNial Thrombectomy
The aim of this study is to develop a multicenter database of patient data and outcomes for patients undergoing intracranial thrombectomy for acute ischemic stroke secondary to emergent large vessel occlusion with delivery of…
- Trial name
- MINT (NCT06148675)
- Testing
- No Intervention
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- Indiana University
Atrial Fibrillation, Ischemic Stroke
Direct Oral Anticoagulants in Patients With Atrial Fibrillation (DOACs vs Warfarin)
The purpose of this study is to assess safety and effectiveness of direct oral anticoagulants (DOACs) and warfarin for stroke prevention in patients with non-valvular atrial fibrillation (AF).
- Conditions
- Atrial Fibrillation, Ischemic Stroke, Systemic Embolization, Major Bleed
- Trial name
- NCT03596502
- Testing
- Direct oral anticoagulants (DOACs), Warfarin
- Where
- Canada
- Volunteers
- 402,764 people
- Sponsor
- Canadian Network for Observational Drug Effect Studies, CNODES
Acute Ischemic Stroke
Rescue Distal Thrombectomy in Treatment for Persistent Distal Occlusions
The goal of this clinical trial is to determine whether rescue distal mechanical thrombectomy can improve outcomes in patients with persistent distal occlusions after successful proximal mechanical thrombectomy for acute ischemic…
- Trial name
- 2BE3-PhaseII (NCT07533253)
- Testing
- Proximal mechanical thrombectomy, Rescue distal mechanical thrombectomy, Conservative management
- Where
- Canada
- Volunteers
- 72 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Blood Pressure
Tailored Interventions to Improve Hypertension Management After Stroke or Transient Ischemic Attack (TIA)
The purpose of this study is to determine the effectiveness of interventions to improve adherence to medication and healthier lifestyle choices on blood pressure over a 6 month period in a group of people at high risk for…
- Trial name
- TIMSII (NCT01038375)
- Testing
- lifestyle counseling, home blood pressure monitoring
- Where
- 3 sites in Canada
- Volunteers
- 56 people
- Sponsor
- Hamilton Health Sciences Corporation
Acute Ischemic Stroke
Efficacy and Safety Evaluation of the Thromboaspiration Catheter System iNstroke in Patients With Acute Ischemic Stroke
First prospective, single-arm, single-centre study to evaluate the efficacy and safety of the iNstroke thromboaspiration catheter system (iNstroke) for stroke in patients with acute ischemic stroke.
- Trial name
- ASPiC (NCT05720975)
- Testing
- iNstroke
- Where
- Spain
- Volunteers
- 113 people
- Sponsor
- iVascular S.L.U.
Cardiac Ischemia, Thoracic Cancer
Perioperative Troponin I and NT Pro-BNP in Lung Resection
After lung resection, troponin elevation may be regulated by mechanisms other than myocardial ischemia. Perioperative natriuretic peptides measurement may help identify changes in ventricular function during thoracic surgery.
- Conditions
- Cardiac Ischemia, Thoracic Cancer, Complication,Postoperative
- Trial name
- NCT04749212
- Testing
- serum high-sensitivity Troponin I (TnI) and NT-Pro-Brain Natriuretic Peptide (NT-proBNP)
- Where
- Spain
- Volunteers
- 475 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Cerebral Infarction, Thrombolysis
Early Low-dose ASpirin Use After Intravenous Thrombolysis for Acute Ischemic Cerebral Infarction（ELASTIC）
This study evaluates whether early administration of low-dose aspirin (100mg) at 2 hours post-intravenous thrombolysis, compared to the standard timing of 24 hours, improves functional outcomes in patients with acute ischemic…
- Trial name
- ELASTIC (NCT07563673)
- Testing
- Aspirin (Early, 2h), Aspirin (Standard, 24h)
- Where
- China
- Volunteers
- 210 people
- Sponsor
- Beijing Chao Yang Hospital
Ischemic Stroke, Acute, Blood Pressure Variability
Continuous Blood Pressure Variability and Small Vessel Disease in Acute Ischemic Stroke
This prospective observational cohort study examines whether blood pressure variability and nighttime blood pressure patterns, measured non-invasively over 72 hours with a cuffless ring-type wearable device, help predict recovery…
- Conditions
- Ischemic Stroke, Acute, Blood Pressure Variability, Cerebral Small Vessel Disease, White Matter Hyperintensity
- Trial name
- COMPASS (NCT07903922)
- Testing
- Cuffless ring-type continuous blood pressure monitor
- Where
- South Korea
- Volunteers
- 450 people
- Sponsor
- Minyoul Baik
Acute Ischemic Stroke
Safety and Efficacy of Human Adipose-Derived Stem Cell Exosomes in Acute Ischemic Stroke
This is a Phase I/II, randomized, double-blind, placebo-controlled, single/multiple ascending dose clinical study (Investigator-Initiated Trial, IIT) evaluating the safety and efficacy of Human Adipose-Derived Stem Cell Exosomes…
- Trial name
- NCT07398612
- Testing
- Human Adipose-Derived Stem Cell Exosomes
- Volunteers
- 60 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Ischemic Stroke
Differentiating Between Brain Hemorrhage and Contrast
The goal of this observational study is to use artificial intelligence to differentiate cerebral hemorrhage from contrast agent extravasation after mechanical revascularization in ischemic stroke.
- Trial name
- NCT06032819
- Volunteers
- 500 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Ischemic Stroke
Recovery by Endovascular Salvage for Cerebral Ultra-acute Embolism (RESCUE)-Japan Registry 2
The aim of this study is to clarify treatment status and clinical results of acute cerebral ischemia after approval of clot retriever in Japan, and also to obtain a basis for comparative studies.
- Trial name
- NCT02419794
- Testing
- endovascular treatment
- Where
- Japan
- Volunteers
- 2,420 people
- Sponsor
- Hyogo Medical University
Stroke, Ischemic Stroke
Hyperbaric Oxygen Post Established Stroke
The purpose of this study is to examine the role of Hyperbaric Oxygen Therapy (HBOT) in improving neurological function in patients who are 6 to 36 months post ischemic stroke.
- Conditions
- Stroke, Ischemic Stroke, Established Stroke
- Trial name
- HOPES (NCT02582502)
- Testing
- Hyperbaric Oxygen
- Where
- Canada
- Volunteers
- 140 people
- Sponsor
- University of British Columbia
Stroke, Acute Cerebrovascular Accident
Radiofrequency and Cryoablation of the Posterior Wall of the Left Atrium
Atrial fibrillation (AF) is the cause of 20% of strokes, and the risk of stroke in a person suffering from this arrhythmia increases by 5 times.
- Conditions
- Stroke, Acute Cerebrovascular Accident, Transient Ischemic Attack, Death
- Trial name
- NCT06253000
- Testing
- Cryoablation, Radiofrequency ablation
- Where
- Russia
- Volunteers
- 158 people
- Sponsor
- Bakulev Scientific Center of Cardiovascular Surgery
Transient Ischemic Attack, Vascular Cognitive Impairment
Reshaping the Path of Vascular Cognitive Impairment (VCI)
The investigators will conduct a proof-of-concept randomized controlled trial study to provide preliminary evidence of efficacy of a resistance exercise training program for maintaining white matter health and improving cognitive…
- Conditions
- Transient Ischemic Attack, Vascular Cognitive Impairment, Subcortical Vascular Dementia
- Trial name
- NCT02669394
- Testing
- Resistance exercise training, Control: stretching and relaxation program
- Where
- Canada
- Volunteers
- 91 people
- Sponsor
- University of British Columbia
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