Clinical trials: Ischemia, Myocardial
Coronary Artery Disease
Impact of Time Restricted Eating on Patients With Coronary Artery Disease (CAD) Undergoing Cardiac Rehabilitation
The purpose of this study is to see if reducing the number of hours during which one eats each day will help reduce levels of LDL cholesterol and improve other markers of metabolic and cardiovascular health (i.e.
- Trial name
- TRE x ICR (NCT05014880)
- Testing
- ICR (Intensive Cardiac Rehabilitation), ICR x TRE (Intensive Cardiac Rehabilitation x Time-Restricted Eating)
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of California, San Diego
Coronary Artery Disease
Japan FFRangio Clinical Outcomes Study
This study aims to collect data on clinical outcomes of real world patients undergoing FFRangio guided treatment for coronary artery disease in Japan and Israel through a retrospective multicentre registry.
- Trial name
- NCT05648396
- Testing
- FFRangio
- Where
- Israel
- Volunteers
- 2,500 people
- Sponsor
- Rabin Medical Center
Cardiovascular Disease, Atherosclerosis
Century Trial, a Randomized Lifestyle Modification Study for Management of Stable Coronary Artery Disease
The Century Trial is a single center Phase III randomized study sponsored by the Albert Weatherhead III Foundation and conducted by Dr. K. Lance Gould.
- Conditions
- Cardiovascular Disease, Atherosclerosis, Coronary Artery Disease, Coronary Stenosis
- Trial name
- Century (NCT00756379)
- Testing
- Comprehensive therapy program for risk factor modification
- Where
- United States
- Volunteers
- 1,085 people
- Sponsor
- The University of Texas Health Science Center, Houston
ST Elevation Myocardial Infarction
Evaluate the Efficacy and Safety of Allogeneic Umbilical Cord Mesenchymal Stem Cells as an Add-On Treatment for Acute ST-elevation Myocardial Infarction (STEMI) Patients
This phase IIa study is to identify the efficacy and safety of IC(intracoronary) and IV(Intravenous) administrations of UMSC01 in patients with STEMI .
- Trial name
- NCT06147986
- Testing
- Allogeneic umbilical cord mesenchymal stem cells, Control group
- Where
- Taiwan
- Volunteers
- 41 people
- Sponsor
- Ever Supreme Bio Technology Co., Ltd.
Coronary Artery Disease, Multi Vessel Coronary Artery Disease
Safety Study of Acellular Tissue Engineered Vessel for Coronary Artery Bypass
To assess safety and feasibility of a coronary bypass created with Vascudyne Acellular Tissue Engineered Vessel (ATEV) with External Support Structure (ESS) in patients requiring multi vessel coronary artery bypass grafting…
- Trial name
- VCAB-2 (NCT07078370)
- Testing
- ATEV with ESS
- Where
- 4 sites in Poland
- Volunteers
- 20 people
- Sponsor
- Vascudyne, Inc.
Hypercholesterolemia, Atherosclerosis
Switching to Rosuvastatin Versus Adding Ezetimibe to Atorvastatin Versus Doubling the Dose of Atorvastatin in Patients With Hypercholesterolemia and Risk Factors (P03708)
This study assesses whether adding ezetimibe 10 mg/d to ongoing treatment with atorvastatin 10 mg/d is more effective than switching the subject to treatment with rosuvastatin 10 mg/d or doubling the dose of atorvastatin to 20…
- Conditions
- Hypercholesterolemia, Atherosclerosis, Coronary Artery Disease
- Trial name
- NCT00651378
- Testing
- Rosuvastatin, Ezetimibe + Atorvastatin, Double Atorvastatin
- Volunteers
- 87 people
- Sponsor
- Organon and Co
Cardiovascular Diseases, Vascular Disease
An Observational Registry Using Drug Eluting Stents (DES) in Patients in a Real-World Setting (DEScover Registry).
The DEScover Registry is designed to observe the results of using Drug Eluting Stents (DES) in patients in a real-world setting.
- Conditions
- Cardiovascular Diseases, Vascular Disease, Arterial Occlusive Disease, Arteriosclerosis
- Trial name
- DESCOVER (NCT00489320)
- Testing
- Cypher Stent
- Where
- United States
- Volunteers
- 7,759 people
- Sponsor
- Cordis US Corp.
Ischemic Heart Disease, Ischemic Coronary Artery Disease
Optical Coherence Tomography in Acute Vessel Evaluation
The purpose is to investigate if a strategy of routine OCT based diagnosis and guidance of PCI improves clinical outcomes compared with a standard strategy of guidance by angiography in patients presenting with ACS
- Conditions
- Ischemic Heart Disease, Ischemic Coronary Artery Disease, ACS (Acute Coronary Syndrome)
- Trial name
- OCTAVE (NCT07422688)
- Testing
- Angiographic Guided PCI, OCT Guided PCI
- Where
- 28 sites in Belgium, Denmark and 10 more
- Volunteers
- 3,000 people
- Sponsor
- Aarhus University Hospital Skejby
Coronary Microvascular Disease, Ticagrelor
Effect of Ticagrelor and Clopidogrel on Coronary Microcirculation in Patients With Acute Myocardial Infarction
Of the patients diagnosed with ST-segment elevation myocardial infarction (STEMI) who underwent reperfusion therapy and have thrombolysis in myocardial infarction (TIMI) 3 flow, about 40% have flow alterations in the coronary…
- Conditions
- Coronary Microvascular Disease, Ticagrelor, Thrombolysis, Microbubble Contrasted Echocardiography
- Trial name
- NCT03104062
- Testing
- Microbubble Contrasted Echocardiography, Platelet Aggregability, Laboratory
- Where
- Brazil
- Volunteers
- 48 people
- Sponsor
- University of Sao Paulo General Hospital
ST Elevation Myocardial Infarction, Cardiogenic Shock
Clinical Characteristics and Outcomes Among STEMI Patients With Cardiogenic Shock at Abu Dhabi City
A retrospective study on the clinical characteristics and treatment outcomes of patients admitted with ST-elevation Myocardial Infarction (STEMI) complicated with cardiogenic shock (CS) during admission or CS development during…
- Trial name
- NCT06535503
- Where
- 2 sites in United Arab Emirates
- Volunteers
- 400 people
- Sponsor
- Abu Dhabi Health Services Company
Diabetes Mellitus
Coronary CT Angiography in Asymptomatic Diabetes Mellitus
The study aims to examine if non-invasive imaging of the coronary arteries by CT angiography using an intra-venous injection of X-ray contrast medium in asymptomatic patients with adult onset diabetes mellitus can predict the…
- Trial name
- NCT00321542
- Testing
- Imaging study, No intervention
- Where
- Israel
- Volunteers
- 793 people
- Sponsor
- Carmel Medical Center
Cardiovascular Disease, Cerebrovascular Accident
A Study to Determine the Degree of Additional Reduction in CV Risk in Lowering LDL Below Minimum Target Levels
The primary objective of this study is to determine the degree of additional reduction in cardiovascular risk that was accrued to patients by lowering their LDL-C beyond the currently accepted minimum target level for patients…
- Conditions
- Cardiovascular Disease, Cerebrovascular Accident, Coronary Heart Disease
- Trial name
- TNT (NCT00327691)
- Testing
- Atorvastatin
- Where
- 314 sites in United States, Australia and 12 more
- Volunteers
- 8,600 people
- Sponsor
- Pfizer
Coronary Artery Bypass Grafting, Postoperative Atrial Fibrillation
Once Versus Twice Bisoprolol Dosage Regimen in Prevention of Atrial Fibrillation Post Coronary Artery Bypass Graft Surgery
The goal of this interventional clinical trial is compare between two different dose regimens of bisoprolol (beta-blocker) in CABG patients in terms of efficacy and safety.
- Conditions
- Coronary Artery Bypass Grafting, Postoperative Atrial Fibrillation, Coronary Artery Disease
- Trial name
- NCT05730413
- Testing
- Bisoprolol
- Where
- Egypt
- Volunteers
- 122 people
- Sponsor
- Cairo University
Coronary Artery Disease
Comparison of the Evaluation of CAD by CT AngioScan and Coronary Angiogram
The use of CT Coronary Angioscan (CT-AS) is gaining popularity, but its exact value as evaluation of CAD requires confirmation. We intend to compare the results of CT-AS and convention coronary angiogram results in patients who…
- Trial name
- CTAS-MCAS (NCT01779986)
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Université de Sherbrooke
Syndrome X
Syndrome X and Endothelial Dysfunction
Cardiac syndrome X is characterized by angina, positve stress test, and patent coronary angiography, and its probable mechanism is microvascular dysfunction associated with endothelial dysfunction.
- Trial name
- NCT00190086
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Far Eastern Memorial Hospital
Myocardial Infarction (MI), Heart Disease
Study on Post-acute Myocardial Infarction Ventricular Defect: Outcome Evalutation in Relation to Surgical Timing
The main objective of the study is to identify the optimal surgical timing for the treatment of intraventricular defects after acute myocardial infarction.
- Trial name
- NCT06799780
- Where
- 4 sites in Italy, Spain
- Volunteers
- 100 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Gastrointestinal Bleeding
Early Endoscopy for Acute Upper Gastrointestinal Bleeding in Acute Coronary Syndrome Patients
The primary aim of this study is to compare efficacy of "early endoscopy" and "non-endoscopic treatment" for management of acute upper gastrointestinal (UGI) bleeding in patients with recent acute coronary syndrome (ACS).
- Trial name
- NCT02618980
- Testing
- endoscopic hemostasis
- Where
- Taiwan
- Volunteers
- 43 people
- Sponsor
- Far Eastern Memorial Hospital
Myocardial Infarction, Cardiovascular Disease
Randomized, Open Label Trial of 6 Months Versus 12 Months DAPT After Drug-Eluting Stent in STEMI
OBJECTIVE OF THE STUDY: To test the hypothesis that 6 months DAPT (Dual anti-platelet therapy) after second generation DES (Drug Eluting Stent) implantation in STEMI (ST elevation Myocardial Infarction) is not inferior to 12…
- Trial name
- DAPT-STEMI (NCT01459627)
- Testing
- 6 months DAPT, 12 months DAPT
- Where
- 16 sites in Netherlands, Norway and 2 more
- Volunteers
- 1,100 people
- Sponsor
- Maasstad Hospital
Coronary Artery Disease (CAD), Artificial Intelligence Algorithms
AI Facial Analysis Algorithm to Screening Coronary Artery Disease in High-Risk Community Population
This study aims to evaluate the effectiveness of this facial image-based AI algorithm for screening CAD in high-risk community populations (specifically individuals with diabetes, hypertension, or aged over 65).
- Conditions
- Coronary Artery Disease (CAD), Artificial Intelligence Algorithms, Face, Screening
- Trial name
- NCT07277686
- Testing
- No Intervention
- Where
- 3 sites in China
- Volunteers
- 1,392 people, healthy volunteers welcome
- Sponsor
- China National Center for Cardiovascular Diseases
Coronary Artery Disease, Acute Myocardial Infarction
Beta Blocker De-prescription Following Coronary Artery Bypass Graft Surgery (BEEFBURGER Trial).
Beta-blockers have the greatest cardiovascular impact in patients with reduced heart function/heart failure and in reducing the peri-operative risk of atrial fibrillation.
- Conditions
- Coronary Artery Disease, Acute Myocardial Infarction, Coronary Artery Stenosis, ST Elevation Myocardial Infarction
- Trial name
- BEEFBURGER (NCT04788186)
- Testing
- De-prescribe beta blocker therapy
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- University of Saskatchewan
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