Clinical trials: Ischemia, Myocardial
Acute Myocardial Injuries
Mason Heart Study With MCG
Heart disease is the number one cause of death in the United States, with over 650,000 deaths in 2019 alone. Many healthy individuals possess key risk factors for heart disease which include but are not limited to high blood…
- Trial name
- MHS-MCG (NCT04732975)
- Testing
- CardioFlux
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Genetesis Inc.
Coronary Stenosis
IRIS-BioFreedom Cohort in the IRIS-DES Registry
The objective of this study is to evaluate effectiveness and safety of BIOFREEDOM™ FAMILY stent in the "real world" daily practice as compared with other drug-eluting stents.
- Trial name
- IRISBioFreedom (NCT03190057)
- Testing
- BIOFREEDOM™ FAMILY stent
- Where
- 8 sites in South Korea
- Volunteers
- 218 people
- Sponsor
- Seung-Jung Park
Acute Coronary Syndrome
Prognosis of Treated Acute Coronary Syndrome Patients: a Multicenter Study
The MPCS-ACS Study (Multicenter Prospective Cohort Study on Acute Coronary Syndrome) is a comprehensive, forward-looking research project designed to evaluate the prognostic outcomes of patients diagnosed with acute coronary…
- Trial name
- MPCS-ACS (NCT05164601)
- Testing
- No Intervention - Observational Only
- Where
- 2 sites in China
- Volunteers
- 22,500 people
- Sponsor
- Xiang Xie
Acute Coronary Syndrome
Inflammation Reduction by TREhalose AdminisTration
Arterial wall inflammation has been consistently suggested to serve a causal role in promoting atherosclerosis and predisposing to hard cardiovascular outcomes.
- Trial name
- IR-TREAT (NCT03700424)
- Testing
- Trehalose, Normal saline
- Where
- Iran
- Volunteers
- 15 people
- Sponsor
- Mashhad University of Medical Sciences
Myocardial Infarction
Post-conditioning to Reduce Infarct Size
When angioplasty (PTCA) and stenting of the blood vessels of the heart is the treatment for a Heart Attack, there is damage to the heart muscle that is caused by the sudden opening of the blood vessels.
- Trial name
- NCT00755469
- Testing
- Post-conditioning
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Minneapolis Heart Institute Foundation
Coronary Artery Disease, Stable Angina
Validation of the MedHub AutocathFFR Software Device for Non-Invasive Fractional Flow Reserve (FFR)
This observational study evaluated how well the AutocathFFR software measures fractional flow reserve (FFR) from coronary angiogram images.
- Conditions
- Coronary Artery Disease, Stable Angina, Unstable Angina, Non-ST-Elevation Myocardial Infarction
- Trial name
- NCT07763769
- Testing
- MedHub AutocathFFR
- Where
- 4 sites in United States
- Volunteers
- 277 people
- Sponsor
- Medhub Ltd.
Coronary Arteriosclerosis, Myocardial Infarction
Radial Artery Bypass Graft Study of Tromsø
The purpose of this study is to answer, among others, the following questions: 1) What are the outcomes when using the radial artery as a bypass graft in coronary artery bypass surgery (CABG)? 2) Can multidetector computed…
- Trial name
- NCT00113451
- Where
- Norway
- Volunteers
- 119 people
- Sponsor
- University Hospital of North Norway
ST Elevation Myocardial Infarction, Acute Coronary Syndrome
Effects of Acute, Rapid Lowering of LDL Cholesterol With Alirocumab in Patients With STEMI Undergoing Primary PCI
A randomized, double-blind, placebo controlled parallel group clinical trial evaluating the effects of acute treatment with a PCSK9 inhibitor (alirocumab) versus placebo on low-density lipoprotein (LDL) in 100 high-risk patients…
- Conditions
- ST Elevation Myocardial Infarction, Acute Coronary Syndrome, Hypercholesterolemia, Hyperlipidemias
- Trial name
- EPIC STEMI (NCT03718286)
- Testing
- Alirocumab
- Where
- Canada
- Volunteers
- 97 people
- Sponsor
- Population Health Research Institute
Myocardial Infarction, Acute Coronary Syndrome
Impact on Public HEalth of a Network in Acute Myocardial Infarction Care
This is a multicenter retrospective observational study with STEMI (ST Elevation Myocardial Infarction) patients who have been treated in the northern Galician Hospitals.
- Trial name
- iPHENAMIC (NCT02501070)
- Where
- Spain
- Volunteers
- 5,937 people
- Sponsor
- Complexo Hospitalario Universitario de A Coruña
Coronary Artery Disease
Evaluation of Everolimus-Eluting Stents (The K-XIENCE Registry)
The objective of this study is to evaluate effectiveness and safety of everolimus-eluting stents (XIENCE, Abbott) in the "real world" daily practice as compared with first-generation drug-eluting stents (sirolimus-eluting stents).
- Trial name
- NCT01350869
- Testing
- Xience
- Where
- South Korea
- Volunteers
- 3,000 people
- Sponsor
- Seung-Jung Park
Essential Hypertension, Chronic Stable Angina
Observational Study to Evaluate the Safety of DILATREND SR Cap. in Korean Patients With Essential Hypertension, Chronic Stable Angina and Congestive Heart Failure
The purpose of this study is to Evaluate the Safety of DILATREND SR Cap. in Korean Patients with Essential hypertension, Chronic stable angina and Congestive heart failure for 52 weeks.
- Conditions
- Essential Hypertension, Chronic Stable Angina, Congestive Heart Failure
- Trial name
- DELIGHT (NCT03063697)
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Chong Kun Dang Pharmaceutical
Coronary Artery Bypass Grafting
Randomized Endo-Vein Graft Prospective
Coronary artery bypass grafting (CABG) is the most common major surgical procedure in the United States with over 300,000 cases performed each year.
- Trial name
- REGROUP (NCT01850082)
- Testing
- Vein Harvesting Procedures
- Where
- 16 sites in United States
- Volunteers
- 1,150 people
- Sponsor
- VA Office of Research and Development
Coronary Artery Disease
FFRangio Accuracy vs. Standard FFR
This is a prospective, observational, multi-center, single-arm, clinical trial designed to assess the efficacy of FFRangio in measuring FFR obtained from angiography compared to Invasive FFR for diagnosing hemodynamically…
- Trial name
- FAST-FFR (NCT03226262)
- Testing
- FFRangio
- Where
- 9 sites in United States, Belgium and 2 more
- Volunteers
- 382 people, healthy volunteers welcome
- Sponsor
- CathWorks Ltd.
Coronary Disease
Improving Medication Adherence Through a Health Literacy-based Intervention for Coronary Heart Disease Patients
This is a multi-center pilot study to examine the effectiveness of a health literacy-based intervention to improve medication adherence and self-efficacy of medication use among individuals with coronary heart disease (CHD).
- Trial name
- NCT04004546
- Testing
- Health literacy-based intervention
- Where
- 2 sites in Hong Kong, Taiwan
- Volunteers
- 60 people
- Sponsor
- Chinese University of Hong Kong
Coronary Artery Disease
Sulfasalazine and Endothelial Function
Experimental studies suggest that systemic inflammation leads to endothelial dysfunction and atherosclerosis. This study will examine the effects of the anti-inflammatory drug sulfasalazine on endothelial function in patients…
- Trial name
- NCT00554203
- Testing
- Sulfasalazine
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Boston University
Myocardial Infarction
Reduced Antithrombotic Strategy for High Bleeding Risk Patients With Myocardial Infarction
Rationale: Heart attacks are a major cause of death and result from coronary blood clots that require acute coronary intervention and antithrombotic drugs to restore blood flow and prevent new heart attacks.
- Trial name
- Dan-DAPT (NCT05262803)
- Testing
- CYP2C19*2/*3, Shorter DAPT duration
- Where
- 6 sites in Denmark
- Volunteers
- 2,808 people
- Sponsor
- Rikke Sorensen
Cardiovascular Diseases, Coronary Arteriosclerosis
Women's Antioxidant and Folic Acid Cardiovascular Study (WAFACS)
To determine if supplements of vitamin C, vitamin E, beta-carotene, and B-vitamins (a combination of folic acid, vitamins B6 and B12) reduce risk of major cardiovascular events in high risk women with a prior history of…
- Conditions
- Cardiovascular Diseases, Coronary Arteriosclerosis, Coronary Disease, Heart Diseases
- Trial name
- WAFACS (NCT00000541)
- Testing
- dietary supplements, vitamin C, vitamin E
- Sponsor
- Brigham and Women's Hospital
Coronary Heart Disease, Cardiovascular Diseases
Comparison Between Propofol and Inhalational Anaesthetic Agents on Cardiovascular Outcomes Following Cardiac Surgery
The objective of this research proposal is to find out whether comparing the two different anaesthetic maintenance techniques (Propofol vs volatile anaesthetics) in adult patients undergoing heart surgery is practical for the…
- Trial name
- COPIA (NCT04039854)
- Testing
- Isoflurane, Sevoflurane or Desflurane, Propofol
- Where
- 2 sites in United Kingdom
- Volunteers
- 50 people
- Sponsor
- King's College Hospital NHS Trust
Coronary Artery Disease, Drug Eluting Stents
Impact of Stepwise Pressure-Increasing NC Balloon Post-Dilation on Stent Expansion
This is a prospective, single-center, single-arm exploratory observational study aiming to evaluate the impact of stepwise pressure-increasing non-compliant (NC) balloon post-dilation on stent expansion rate in patients…
- Trial name
- SPND (NCT07853261)
- Testing
- Coronary stent + non-compliant post-dilation balloon
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Jilin University
Treatment Decision, Coronary Artery Disease
CT Myocardial Perfusion to Guide the Diagnosis and Treatment of Patients With Stable Coronary Artery Disease (POTENTIAL)
The overall goal of this project is to compare the non-revascularization rate of coronary angiography in patients with stable coronary artery disease (CAD) within 90 days after CT myocardial perfusion imaging (CT-MPI) or…
- Trial name
- NCT06119022
- Testing
- Invasive coronary angiography, routine medical treatment
- Where
- 4 sites in China
- Volunteers
- 660 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
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