Clinical trials: Ischemia, Myocardial
Coronary Arteriosclerosis, Hypoalphalipoproteinemias
High-Density Lipoprotein (HDL) Treatment Study
A low level of plasma high-density lipoprotein (HDL) cholesterol, "the good cholesterol", is the most common lipid abnormality observed in patients with a premature atherosclerotic cardiovascular disease.
- Conditions
- Coronary Arteriosclerosis, Hypoalphalipoproteinemias, Genetic Diseases, Inborn
- Trial name
- NCT00458055
- Testing
- Atorvastatin; Fenofibrate; Niacin
- Where
- Canada
- Volunteers
- 19 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Coronary Artery Disease, Chest Pain
Arterial Stiffness for Improved Prediction of Coronary Artery Disease by Coronary CT Angiography
This study will evaluate the ability of device-estimated pulse wave velocity and machine learning methods to improve the prediction of potential symptomatic coronary artery disease
- Conditions
- Coronary Artery Disease, Chest Pain, Dyspnea, Arterial Stiffness
- Trial name
- NCT06734247
- Testing
- Coronary computer tomography angiography (CCTA), Photoplethysmography (PPG) and single-lead ECG, Brachial single cuff-based arterial stiffness
- Where
- Sweden
- Volunteers
- 156 people
- Sponsor
- Danderyd Hospital
Delirium in Old Age, Delirium in the Intensive Care Unit
Multi-Component Delirium Prevention Bundle in Older Cardiac Intensive Care Unit Patients
The goal of this randomized controlled clinical trial is to learn whether a structured delirium prevention protocol can reduce the occurrence of delirium in older adults admitted to the cardiac intensive care unit (CICU).
- Conditions
- Delirium in Old Age, Delirium in the Intensive Care Unit, Delirium Confusional State, Delirium
- Trial name
- CICUDEL (NCT07776184)
- Testing
- Multicomponent Delirium Prevention Bundle, Control Group
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Tel Aviv Medical Center
Acute Myocardial Infarction (AMI)
Artificial Intelligence Scalable Solution for ST Myocardial Infarction
The ASSIST clinical study is an observational, multicenter study to assess the performance of a cloud-based and AI-powered electrocardiogram (ECG) analysis platform, named Willem™, developed to detect Acute Myocardial Infarction…
- Trial name
- ASSIST (NCT06939738)
- Where
- 5 sites in Portugal, Spain
- Volunteers
- 489 people
- Sponsor
- Idoven 1903 S.L.
Myocardial Infarction, Angina
An Observational Study of Cholesterol in Coronary Arteries
In April 2008, a coronary catheter based imaging system, LipiScan, was cleared by the FDA for use in detecting lipid core containing containing plaques of interest (LCP). These plaques are rich in cholesterol.
- Conditions
- Myocardial Infarction, Angina, Coronary Artery Disease, Myocardial Ischemia
- Trial name
- COLOR (NCT00831116)
- Testing
- Intravascular Near Infrared Spectroscopy
- Where
- 22 sites in United States
- Volunteers
- 2,067 people
- Sponsor
- Infraredx
Coronary Artery Disease
Utilizing Carbon Dioxide for Assessing Coronary Blood Flow in Subjects With Coronary Artery Disease
This is a prospective pilot study to evaluate the safety, tolerability and technical feasibility of utilizing carbon dioxide for assessing coronary blood flow in subjects with coronary artery disease.
- Trial name
- NIMO-CAD (NCT06253884)
- Testing
- RespirAct
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Indiana University
Myocardial Bridge of Coronary Artery, Myocardial Bridge
Myocardialbridge Bypass Graft Surgery Efficacy Verification
Myocardial Bridge Bypass Graft surgery is introduced to relieve the unmedical symptoms of patients with long-segment or deep myocardial bridge, clinical outcomes will be collected to verify the effectiveness of the surgery.
- Conditions
- Myocardial Bridge of Coronary Artery, Myocardial Bridge, Myocardial Bridging, Myocardial Infarction
- Trial name
- NCT06857838
- Testing
- MBBG, MB CABG, MB unroof
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Xi'an International Medical Center Hospital
Coronary Artery Disease
SONICURE（SONICracker for the Treatment of UndeRExpansion）
The first-phase study is a prospective, single-group observational study. It plans to recruit patients with in-stent restenosis caused by poor stent expansion in the coronary artery.
- Trial name
- NCT06924736
- Testing
- Intravascular Shockwave Therapy Device / Disposable Coronary Shockwave Catheter, Non - compliant balloon dilatation catheter
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Shanghai Bluesail Boyuan Medical Technology Co., Ltd.
ST Segment Elevation Myocardial Infarction
Italian Multi-center Registry of Self-apposing Coronary Stent in Patients With STEMI
The aim of this registry is to collect clinical data on nitinol self-expanding STENTYS Xposition S™ in order to evaluate the efficacy and safety in patients presenting with ST segment elevation myocardial infarction
- Trial name
- iPOSITION (NCT02979236)
- Testing
- STENTYS Xposition S
- Where
- 8 sites in Italy
- Volunteers
- 250 people
- Sponsor
- UOSD Emodinamica Diagnostica e Interventistica
Coronary Artery Disease
CArdiac cT in the Treatment of Acute CHest Pain 2 - Myocardial CT Perfusion
The aim of this study is to assess whether the clinical management of patients with recent acute-onset chest pain without acute coronary syndrome may be optimized by a combined coronary CT angiography (CTA) + CT myocardial…
- Trial name
- CATCH2 (NCT02014311)
- Testing
- CTA+CTP guided treatment strategy, CTA guided treatment strategy
- Where
- 7 sites in Denmark
- Volunteers
- 600 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Myocardial Infarction
CARESS in Acute Myocardial Infarction
The aim of this study conducted in patients with high risk ST-segment elevation AMI admitted to hospitals with no PTCA facilities is to compare the effects on clinical outcome and cost-effectiveness of two reperfusion strategies…
- Trial name
- NCT00220571
- Testing
- Coronary Angioplasty (PTCA)
- Where
- 85 sites in France, Italy and 1 more
- Volunteers
- 600 people
- Sponsor
- Società Italiana di Cardiologia Invasiva
Coronary Microvascular Disease, Microvascular Disease
Hyperoxia and Microvascular Dysfunction
Coronary artery disease (CAD) pathophysiology involves endothelium-dependent (e.g. nitric oxide, acetylcholine) and -independent (e.g.
- Conditions
- Coronary Microvascular Disease, Microvascular Disease, Ischemic Heart Disease
- Trial name
- NCT04321434
- Testing
- Hyperoxia, Normoxia, laser Doppler
- Where
- Belgium
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Université Libre de Bruxelles
ST Elevation Myocardial Infarction, Colchicine
Effect of Colchicine on MMP-9, NOX2, and TGF-β1 in Myocardial Infarct
Reducing NOX-2, MMP-9, and TGF-β1 Expression in Preventing Ventricular Remodelling Post Acute ST-Segment Elevation Myocardial Infarction using Colchicine (Post Late Reperfusion Percutaneous Coronary Intervention and…
- Conditions
- ST Elevation Myocardial Infarction, Colchicine, Cardiac Remodeling, Ventricular
- Trial name
- NCT05709509
- Testing
- Colchicine, Percutaneous Coronary Intervention, Optimal medical treatment including statin, aspirin, P2Y12 inhibitor, and nitrate.
- Where
- Indonesia
- Volunteers
- 148 people
- Sponsor
- RSD dr. Soebandi
Coronary Arteriosclerosis, Myocardial Infarction
Radial Artery Bypass Graft Study of Tromsø
The purpose of this study is to answer, among others, the following questions: 1) What are the outcomes when using the radial artery as a bypass graft in coronary artery bypass surgery (CABG)? 2) Can multidetector computed…
- Trial name
- NCT00113451
- Where
- Norway
- Volunteers
- 119 people
- Sponsor
- University Hospital of North Norway
Acute ST Segment Elevation Myocardial Infarction
Study to Evaluate the Effect on Parameters of Systemic Inflammation and Disease Outcomes and Safety of RPH-104 in Subjects With Acute ST-elevation Myocardial Infarction
The goal of the study was to evaluate the effect of single administration of RPH-104 at 80 mg and 160 mg on parameters of systemic inflammation and outcomes of the disease in subjects with ST-segment elevation myocardial…
- Trial name
- NCT04463251
- Testing
- RPH-104 80 mg
- Where
- 11 sites in United States, Russia
- Volunteers
- 102 people
- Sponsor
- R-Pharm Overseas, Inc.
Acute Coronary Syndrome, Cardiovascular Diseases
Aggressive Smoking Cessation Trial (ASAP)
The ASAP Trial is a 5-year, multi-centre, randomized controlled trial that will assess the efficacy, safety, and tolerability of aggressive smoking cessation therapy among people at elevated cardiovascular risk.
- Trial name
- ASAP (NCT05257629)
- Testing
- Combination Therapy Arm (Varenicline and Nicotine E-Cigarettes Plus Counseling), Varenicline Plus Counseling
- Where
- 13 sites in Canada
- Volunteers
- 798 people
- Sponsor
- Sir Mortimer B. Davis - Jewish General Hospital
Coronary Artery Disease
Coronary MDCTA With Iopamidol Injection 370
Determine the validity and compare the visualization of arterial segments obtained with 3 doses of iopamidol to determine dose for further investigation in future trials.
- Trial name
- NCT00558792
- Testing
- Isovue 370, 70 mL, Isovue 370, 80 mL, Isovue 370, 90 mL
- Where
- United States
- Volunteers
- 210 people
- Sponsor
- Bracco Diagnostics, Inc
Angina (Stable), INOCA (Ischemia With Non Obstructive Coronary Artery Disease)
Diagnostic and Clinical Management of Non-Obstructive Myocardial Ischemia in Patients With Long Covid-19 Syndrome and New Onset Chest Pain
Long Covid-19 INOCA is an investigator-initiated, prospective, randomized, sham-controlled, single center study. Its objective is to investigate the benefits of tailored medical therapy according to the results of the coronary…
- Conditions
- Angina (Stable), INOCA (Ischemia With Non Obstructive Coronary Artery Disease), Long COVID-19 Syndrome
- Trial name
- NCT07559994
- Testing
- Coronary functional test
- Where
- Spain
- Volunteers
- 108 people
- Sponsor
- Fundacion Investigacion Interhospitalaria Cardiovascular
NSTEMI
Incidence of Occluded Culprit Arteries and Impact of Coronary Collaterals on Outcome in Patients With NSTEMI
It is assumed that patients with non-ST-elevation myocardial infarctions (NSTEMI) showing an infero- or posterolateral occluded culprit artery (OCA) during diagnostic angiography frequently elude standard 12-lead…
- Trial name
- NCT01159366
- Testing
- percutaneous coronary intervention
- Where
- Germany
- Volunteers
- 602 people
- Sponsor
- University of Jena
NSTEMI - Non-ST Segment Elevation MI, Unstable Angina
A Multicenter Study on Early Diagnosis of NSTE-ACS Patients Based on Machine Learning Model
Early diagnosis of NSTEMI and UA patients is mainly through the construction of machine learning model.
- Trial name
- NCT04682756
- Testing
- The model of machine learning
- Where
- China
- Volunteers
- 2,500 people
- Sponsor
- First Affiliated Hospital of Xinjiang Medical University
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