Clinical trials: Ischemia Limb
Peripheral Arterial Disease, Peripheral Artery Disease
Digital Variance Angiography in Diagnostic Angiographies for Effective Radiation Dose Reduction
Digital Variance Angiography (DVA) is a new tool in medical imaging with proven image quality reserve. The previously observed quality reserve of Digital Variance Angiography (DVA) in lower extremity angiographies, allowed to…
- Conditions
- Peripheral Arterial Disease, Peripheral Artery Disease, Femoral Artery Stenosis, Femoral Artery Occlusion
- Trial name
- NCT04343196
- Testing
- Diagnostic Angiography (DSA or DVA based on randomization result)
- Where
- Hungary
- Volunteers
- 114 people
- Sponsor
- Kinepict Health Ltd.
Critical Limb Ischemia, Ischemia
VEGF Gene Transfer for Critical Limb Ischemia
The purpose of this gene therapy study is to evaluate the safety and efficacy of intramuscular gene transfer using Vascular Endothelial Growth Factor (VEGF) or placebo in patients with moderate to high-risk Critical Limb Ischemia…
- Conditions
- Critical Limb Ischemia, Ischemia, Leg Ulcer
- Trial name
- NCT00304837
- Testing
- pVGI.1 (VEGF-2)
- Where
- 3 sites in United States
- Sponsor
- Losordo, Douglas, M.D.
Aspirin Resistance
Aspirin Resistance and Prognosis of Patients With Critical Limb Ischaemia
Acetylsalicylic acid (Aspirin, ASA) is the most widely prescribed drug used in primary and secondary prevention of cardiovascular disease.
- Trial name
- Aspirine (NCT01104441)
- Where
- 2 sites in France
- Volunteers
- 68 people
- Sponsor
- University Hospital, Limoges
Major Adverse Cardiac Events, Adverse Effect of Unspecified General Anesthetic
Adverse Events in Acute Limb Ischemic Patient Undergoing Revascularization
Acute limb ischemia is one of the devastating vascular emergencies that lead to life and limb loss if the appropriate treatment is not reached.The revascularization is a cornerstone in treating acute limb ischemia.
- Trial name
- NCT05362266
- Where
- 2 sites in Thailand
- Volunteers
- 240 people
- Sponsor
- Mahidol University
Limb Ischemia
Combined Management in ALI ( Image Guided Thrombectomy With Open Transfemoral Access )
Acute limb ischemia (ALI) is a sudden decrease in limb perfusion due to either an embolic or a thrombotic vascular occlusion, defined as the presence of symptoms within two weeks of onset.
- Trial name
- NCT04622878
- Testing
- thrombectomy and PTA
- Volunteers
- 100 people
- Sponsor
- Assiut University
Ischemic Wound of the Lower Limb, Necrotic Arterial Wounds
Randomized Controlled Trial on the Use of Flammacerium in Necrotic Arterial Wounds of the Lower Limb Versus Standard Treatment
Ischemia of an area may lead to a necrotic wound. In lower limb, it especially happens in diabetic or artheriopatic patients. It can lead to an amputation need. Revascularization procedure cannot be provide in all cases.
- Trial name
- Flammacérium (NCT02385903)
- Testing
- Flammacerium, Standard dressing procedure
- Where
- France
- Volunteers
- 55 people
- Sponsor
- University Hospital, Montpellier
Peripheral Arterial Disease, Critical Limb Ischemia
Serranator Recoil Study
The study objective is to assess the ability to define and measure post treatment recoil in infrapopliteal arteries. Preliminary evidence as to the differences between serration angioplasty and standard balloon angioplasty as…
- Trial name
- NCT05161039
- Testing
- Serranator, POBA
- Where
- 2 sites in United States, Germany
- Volunteers
- 20 people
- Sponsor
- Cagent Vascular LLC
Chronic Limb Threatening Ischemia
Laser Atherectomy and Sirolimus-eluting Balloon Angioplasty for CLTI
Peripheral arterial disease (PAD) is a widespread pathology affecting over 200 million adults globally and is primarily caused by atherosclerosis.
- Trial name
- LASER-S (NCT07858539)
- Testing
- Laser atherectomy followed by Sirolimus-eluting balloon angioplasty of femoropopliteal or infrapopliteal or both arterial stenosis or occlusions
- Where
- Greece
- Volunteers
- 55 people
- Sponsor
- Attikon Hospital
Critical Limb Ischemia
Retrograde Recanalization of Infrainguinal Arterial Occlusive Disease.
The spectrum of lower extremity peripheral arterial disease (PAD) ranges from exhibiting no symptoms to limb threatening gangrene.
- Trial name
- NCT04974905
- Testing
- retrograde access for re-canalization of infra-inguinal arterial occlusive disease
- Volunteers
- 40 people
- Sponsor
- Sohag University
Critical Limb Ischemia
Proteomics and Stem Cell Therapy as a New Vascularization Strategy
Neovascularization (NV) is the innate capability to enlarge collateral arteries ("arteriogenesis"), and to stimulate growth of new capillaries, arterioles and venules at the tissue level ("angiogenesis").
- Trial name
- NCT02802852
- Testing
- Pneumatic calf compression, Filgrastim
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Illinois Chicago
Stroke
Augmenting Cerebral Blood Flow in Acute Ischemic Stroke
The most common type of stroke is ischemic (lack of blood flow to the brain due to a clot blocking a blood vessel). Time is brain and an average of 1.9 million brain nerve cells per minute are destroyed in patients experiencing a…
- Trial name
- NCT06911385
- Testing
- Arm Remote Ischemic Conditioning plus Pneumatic Compression lower limb
- Volunteers
- 150 people
- Sponsor
- University of Alberta
Critical Limb Ischemia
Allogeneic Mesenchymal Stem Cells for the Critical Limb Ischemia Therapy
The clinical trial aims to study the safety and efficacy of adult allogeneic mesenchymal stem cells for the treatment of critical limb ischemia.
- Trial name
- NCT03239535
- Testing
- Mesenchymal stem cells, Normal saline
- Where
- Russia
- Volunteers
- 40 people
- Sponsor
- Federal Research Clinical Center of Federal Medical & Biological Agency, Russia
Peripheral Vascular Disease, Intermittent Claudication
DURABILITY-200: EverFlex 200mm Long Nitinol Stents in TASC C&D Femoropopliteal Lesions
The objective of this clinical investigation is to evaluate the long-term (up to 12 months) outcome of the 200 mm long self-expanding nitinol EverFlex (ev3) stent in long femoropopliteal lesions (TASC C \& D) Is is the first time…
- Conditions
- Peripheral Vascular Disease, Intermittent Claudication, Critical Limb Ischemia
- Trial name
- NCT00637741
- Testing
- Everflex 200
- Where
- 2 sites in Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Flanders Medical Research Program
Acute Ischemic Stroke, Upper Extremity Hemiplegia
Kinesio Taping for Upper Extremity Motor Function in Acute Stroke Patients
This randomized, controlled clinical trial was conducted to evaluate the effects of kinesio taping on upper extremity motor recovery in patients with acute ischemic stroke who presented with flaccid muscle tone.
- Conditions
- Acute Ischemic Stroke, Upper Extremity Hemiplegia, Kinesio Taping
- Trial name
- KT-AcuteStroke (NCT07300605)
- Testing
- Kinesio Taping
- Where
- Turkey (Türkiye)
- Volunteers
- 26 people
- Sponsor
- Koç University
Peripheral Artery Disease, Critical Limb Ischemia
Platelet Reactivity in PAD Undergoing Percutaneous Angioplasty
Dual antiplatelet therapy has a key role in a prevention of thrombosis of treated artery in patients undergoing percutaneous transluminal angioplasty (PTA).
- Conditions
- Peripheral Artery Disease, Critical Limb Ischemia, Claudication, Intermittent
- Trial name
- PAD (NCT04165629)
- Testing
- Aspirin 300mg and Clopidogrel 300mg
- Where
- Serbia
- Volunteers
- 450 people
- Sponsor
- Clinical Centre of Serbia
Ischemic Stroke, Upper Extremity Hemiparesis
Patient-tailored Transcranial Direct Current Stimulation to Improve Stroke Rehabilitation
In a double-blinded sham-controlled study the effect of patient-tailored transcranial direct current stimulation during rehabilitation training will be examined.
- Trial name
- PRACTISE (NCT05355831)
- Testing
- Active Transcranial Direct Current Stimulation
- Where
- 3 sites in Denmark
- Volunteers
- 22 people
- Sponsor
- Christina Kruuse
Peripheral Vascular Disease, Intermittent Claudication
Intermittent Negative Pressure; Impact on Peripheral Artery Disease and Intermittent Claudication
The objective is to ensure the pro-active collection of information on quality, safety and performance of FlowOx™ after it is placed on the market.
- Conditions
- Peripheral Vascular Disease, Intermittent Claudication, Walking, Difficulty, Critical Limb Ischemia
- Trial name
- FlowOx (NCT04100681)
- Testing
- Active FlowOx™
- Where
- 5 sites in Germany
- Volunteers
- 16 people
- Sponsor
- Otivio AS
Tetraplegia, Spinal Cord Injury
Cortical Recording and Stimulating Array Brain-Machine Interface
The purpose of this research study is to demonstrate the safety and efficacy of using two CRS Arrays (microelectrodes) for long-term recording of brain motor cortex activity and microstimulation of brain sensory cortex.
- Conditions
- Tetraplegia, Spinal Cord Injury, Brainstem Stroke, Brachial Plexus Injury
- Trial name
- CRS-BMI (NCT01894802)
- Testing
- Implantation of CRS Arrays
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Michael Boninger
Peripheral Arterial Disease, Diabetic Angiopathies
Evaluating Bu Yang Huanwu Decoction For Early Diabetic Vascular Disease
The goal of this clinical trial is to learn if adding a Traditional Chinese Medicine formula, Bu Yang Huanwu Decoction (specifically the capsule form called Hua Yu Wan Capsule), to standard treatment can help prevent leg pain at…
- Conditions
- Peripheral Arterial Disease, Diabetic Angiopathies, Arterial Occlusive Diseases
- Trial name
- NCT07658807
- Testing
- Hua Yu Wan Capsule, Aspirin
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Xuanwu Hospital, Beijing
Peripheral Artery Disease, Quality of Life
VADOplex Critical Limb Ischemia Study
In patients with critical limb ischemia (CLI) and foot ulcers wound healing is an important goal which can normally only be achieved after sufficient treatment of the underlying ischemia (revascularization either by an operation…
- Conditions
- Peripheral Artery Disease, Quality of Life, Wound Healing
- Trial name
- NCT02034539
- Testing
- VADOplex system
- Where
- Germany
- Volunteers
- 38 people
- Sponsor
- Asklepios Kliniken Hamburg GmbH