Clinical trials: Ischemia Preconditioning
Ischemic Preconditioning
The Biology of Chronic Preconditioning: Genomic and Physiologic Mechanisms of Response
The purpose of this study is to assess the effects of repeated RIPC and exercise, on exercise performance, skeletal muscle responses and circulating cellular and humoral biology in humans
- Trial name
- NCT01164618
- Testing
- Remote ischemic preconditioning (RIPC), Exercise
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Ischemic Preconditioning
Cutaneous Remote Ischemic Preconditioning in Plastic Surgery
Background: In plastic and reconstructive surgery, free flaps are routinely used for treatment of soft tissue defects. Treatment strategies aim at reducing or preventing flap necrosis by conditioning tissue tolerance against…
- Trial name
- RIPC (NCT01235286)
- Testing
- remote ischemic preconditioning
- Where
- Germany
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Hannover Medical School
Hyperglycemia
Ischemia/Reperfusion Injury of Human Endothelium: Role of Glucose and Statins
Anesthetic preconditioning (APC, a brief exposure to an anesthetic gas) has become an area of intense research interest because of its ability to protect tissue and organs from injury resulting from a cessation of blood flow and…
- Trial name
- NCT00995670
- Testing
- 5% dextrose, Vitamin C, Simvastatin
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Hemodialysis, Ischemia Preconditioning
Assessment of the Impact of Repeated Ischemic Preconditioning Episodes on Hemodynamic and Metabolic Parameters in Patients at Various Stages of Chronic Kidney Disease
The aim of our study is to evaluate the impact of repeated episodes of ischemic quenching on changes in blood pressure, heart rate and laboratory parameters of inflammation in patients with kidney diseases.
- Conditions
- Hemodialysis, Ischemia Preconditioning, Chronic Kidney Disease, Blood Pressure Disorders
- Trial name
- NCT07746102
- Testing
- Preconditioning with control ischemic episodes
- Where
- 2 sites in Poland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Medical University of Lodz
Tourniquets
Ischemic Preconditioning and Thiol-disulfide Balance
Various strategies have been proposed to prevent or mitigate the effects of ischemia-reperfusion injury following the use of tourniquets in orthopedic surgery cases.
- Trial name
- NCT05082207
- Testing
- Remote Ischemic Preconditioning
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Konya Meram State Hospital
Reperfusion Injury
Remote Ischaemic PreConditioning (RIPC) in Partial Nephrectomy for the Prevention of Ischemia/Reperfusion Injury
"Remote Ischaemic PreConditioning" (RIPC) is performed prior to partial nephrectomy. Postoperative calprotectin dynamics and Blood Oxygen-Level-Dependent (BOLD) MRI are used to to demonstrate the potential renoprotective effect…
- Trial name
- NCT03068689
- Testing
- RIPC
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Ischemic Preconditioning, Coenzyme Q Deficiency
Effect of CoQ10 on the Endocrine Function of Skeletal Muscle
Recent studies have also shown that repeated episodes of ischemia, followed by reperfusion (IPC), can contribute to the development of adaptive changes not only in the area of the heart muscle, but also in the structure of the…
- Conditions
- Ischemic Preconditioning, Coenzyme Q Deficiency, Exercise Training
- Trial name
- NCT05412888
- Testing
- CoQ10 supplementation, Ischemic preconditioning training, IPC training combined with CoQ10 supplementation
- Where
- Poland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Medical University of Gdansk
Peripheral Vascular Disease
RCT to Evaluate the Renal Protective Effects of Remote Ischaemic Preconditioning in Peripheral Angioplasty
This study aims to demonstrate if remote ischaemic preconditioning (RIPC) may confer renal protection in patients undergoing peripheral angioplasty.
- Trial name
- NCT02054871
- Testing
- RIPC
- Where
- Ireland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mid Western Regional Hospital, Ireland
Physical Performance, Rhabdomyolysis
The Effect of Remote Ischemic Preconditioning on Physical Performance and Exertional Rhabdomyolysis
In order to examine the effect of RIPC on skeleton muscle exertional damage and on aerobic and anaerobic physical performances, 30 healthy volunteers will undergo a series of different physical tests twice; once without…
- Trial name
- NCT02518724
- Testing
- RIPC intervention exposure
- Where
- Israel
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Liver Diseases
Ischemic Preconditioning at a Distance in Liver Surgery
During hepatic transection, it exists a high risk of perioperative blood loss. The haemorrhage and its consequences (hypovolemia and blood transfusion) might impact the short and long term morbidity The vascular control by…
- Trial name
- HEPATOPROTECT (NCT04181502)
- Testing
- pneumatic tourniquet, No inflation
- Where
- France
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Ischemic Preconditioning
Conditioning Based Intervention Strategies
The overall objective of this study is to uncover and utilize the mechanisms behind the activation of endogenous organ protection by remote ischemic conditioning (RIC), high intensity traditional resistance training (TRT) and low…
- Trial name
- ConBIS (NCT03380663)
- Testing
- Remote Ischemic Conditioning (RIC)
- Where
- Denmark
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Blood Loss, Surgical, Blood Transfusion
Bleeding in Knee Arthroplasty After Preconditioning With Sevoflurane
Knee arthroplasty is performed with restriction of blood flow by use of the pressure tourniquet. Ischemia of skeletal musculature is accompanied by the formation of reactive oxygen species and release of vasoactive factors.
- Trial name
- NCT03379103
- Testing
- Sevoflurane, Propofol
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Ischemic Preconditioning, Dietary Exposure
Factors That Influence Blood Vessel Regulation During Exercise in Humans
This study will examine two separate interventions: 1) the effects of ischemic preconditioning or 2) a high fat meal on the capacity of the brachial artery to overcome sympathetic activation and dilate during exercise (also known…
- Trial name
- NCT04887610
- Testing
- Ischemic preconditioning, Ischemic preconditioning control, Low fat meal
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Guelph
Microcirculation, Orthostatic Intolerance
Influence of RIC on the Orthostatic Competence of the Microcirculation
The goal of this clinical trial (pilot study) is to learn about the microcirculatory regulation of the lower extremity under orthostatic stress with and without RIC - Remote Ischemic Preconditioning in healthy participants.
- Conditions
- Microcirculation, Orthostatic Intolerance, Remote Ischemic Preconditioning, Hemodynamics
- Trial name
- NCT05990907
- Testing
- Remote ischemic preconditioning
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- ISAR Klinikum
Cardiovascular Disease
Exercise Test and Cardiac Injury
Strenuous exercise in apparent healthy individuals increases plasma (high sensitive) troponin levels. The underlying mechanism is not yet elucidated, but could be explained by changes due to a mismatch in oxygen demand and supply…
- Trial name
- NCT01660828
- Testing
- remote ischemic preconditioning (RIPC)
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Ischemia-Reperfusion Injury
Adenosine Receptors Influence Ischemia-Reperfusion Injury
Ischemic preconditioning is defined as the development of tolerance to ischemia-reperfusion injury by a previous short bout of ischemia resulting in a marked reduction in infarct size.
- Trial name
- NCT00184847
- Testing
- acetylcholine, twenty minutes of forearm ischemia, three 5-minute periods of forearm ischemia
- Where
- Netherlands
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Renal Disease
Remote Ischemic Preconditioning Living Donor Renal Transplant Protocol
In this study, patients undergoing live donor kidney transplantation will be allocated to the control group or remote ischemic preconditioning group (RIPC).
- Trial name
- NCT03084666
- Testing
- Zimmer ATS tourniquet system
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Physical Performance, Neuromuscular Function
Tissue Flossing and Lower Limb Neuromuscular Function
There is no study investigating different volumes, that is various sets of the configuration of tissue flossing on neuromuscular function.
- Conditions
- Physical Performance, Neuromuscular Function, Tissue Flossing, Ischemic Preconditioning
- Trial name
- MF2-TMG-CMJ (NCT05219344)
- Testing
- Tissue flossing
- Where
- Slovenia
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Ljubljana
Aortic Aneurysm
Preventing Myocardial Ischemia by Preconditioning in Elective Operation for Abdominal Aortic Aneurysm
Primary To investigate whether peripheral predonditioning induced by brief, intermittent constriction of blood supply to an arm can reduce the incidence of perioperative myocardial ischemia in patients operated electively for…
- Trial name
- NCT01523262
- Testing
- preconditioning
- Where
- 2 sites in Denmark
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Blood Pressure, Hemodynamic Response
Ischemic Preconditioning in Resistance Exercise in Older Women
This study investigates whether ischemic preconditioning (IPC) can reduce cardiac demand after resistance exercise in older women.
- Conditions
- Blood Pressure, Hemodynamic Response, Rating of Perceived Exertion, Heart Rate
- Trial name
- NCT07497659
- Testing
- Ischemic Preconditioning
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Triangulo Mineiro