Clinical trials: Ischemia Preconditioning
Heart Defects, Congenital, Myocardial Reperfusion Injury
Morphine Versus Fentanyl for Myocardial Protection in Acyanotic Children Undergoing Congenital Open-Heart Surgery
This study compared two opioid pain medications - morphine and fentanyl - used during open-heart surgery in young children born with heart defects (congenital heart disease).
- Trial name
- MorphPed (NCT07839273)
- Testing
- Fentanyl (IV), morphine
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Baskent University
Ischemic Preconditioning
Preconditioning With Limb Ischemia for Subarachnoid Hemorrhage
The purpose of this study is to learn about protecting the brain from dangerous low blood flow.
- Trial name
- PreLIMBS (NCT02411266)
- Testing
- ischemic conditioning group
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- University of Miami
Head and Neck Neoplasms
Remote Ischemic Preconditioning in Head and Neck Cancer Reconstruction - A Randomized Controlled Trial
The purpose of the trial is to investigate, if remote ischemic preconditioning reduces the risk of complications in patients undergoing resection of head and neck cancer and immediate reconstruction with autologous free tissue…
- Trial name
- RIPC-HNC (NCT02548377)
- Testing
- Remote ischemic preconditioning
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Aarhus University Hospital Skejby
Bilateral Limb Ischemic Preconditioning, Intracranial Arterial Stenosis
Feasibility, Safety and Efficacy of Remote Ischemic Preconditioning for Symptomatic Intracranial Arterial Stenosis in Octogenarians
Making a limb transiently ischemic induces ischemic tolerance in distant organs such as the heart. This study aims to evaluate the feasibility, safety and initial efficacy of using briefly repetitive bilateral limb ischemic…
- Trial name
- NCT01570231
- Testing
- bilateral limb ischemic preconditioning (Doctormate, IPC-906X)
- Where
- China
- Volunteers
- 58 people
- Sponsor
- Ji Xunming
Acute Lung Injury
Effects of Remote Ischemic Preconditioning and Postconditioning on Lung Injury During Cardiopulmonary Bypass
Remote Ischemic Preconditioning(RIPC) and remote ischemic postconditioning(RIPoC) seems to have a protective effect during ischemic period.
- Trial name
- NCT01144585
- Testing
- remote ischemic preconditioning and postconditioning, Control
- Where
- South Korea
- Volunteers
- 76 people
- Sponsor
- Seoul National University Hospital
Hemodialysis
Intradialytic Exercise and Remote Ischaemic Preconditioning: a Cardioprotective Role ?
The aim of this clinical trial is to evaluate whether intermittent exercise and remote ischaemic preconditioning (rIPC) during haemodialysis (HD) can provide cardioprotection in adult patients (aged 20-79 years) undergoing HD for…
- Trial name
- EXPI-DIAL (NCT06856512)
- Testing
- Remote ischaemic preconditioning, Exercise, standard dialysis
- Where
- 3 sites in France
- Volunteers
- 33 people
- Sponsor
- University of Avignon
Cerebrovascular Disease, Stroke
Remote Ischemic Limb Preconditioning In Healthy Volunteers
The investigators would like to determine if remote ischemic leg preconditioning in healthy volunteers improves cerebral vasomotor reactivity as measured by breath holding and transcranial doppler vasomotor reactivity.
- Trial name
- NCT02553655
- Testing
- 4x 5min Limb Preconditioning, 3x 10min Limb Preconditioning
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Miami
Stroke, TIA
The Effect Of Remote Limb Ischemic Preconditioning For Carotid Artery Stenting
Remote limb ischemic preconditioning is neuro-protective and anti-inflammatory for ischemia- reperfusion injury. As the extent of its effect is unknown, the investigators will use clinical outcome, serum biochemical markers and…
- Conditions
- Stroke, TIA, Coronary Stenosis
- Trial name
- NCT01175876
- Testing
- remote limb ischemic preconditioning, Carotid Artery Stenting
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Capital Medical University
Tissue Donors, Liver Transplantation
The Effect of Remote Ischemic Preconditioning in Living Donor Hepatectomy
Liver transplantation is the gold standard treatment for patients with end-stage liver disease. Despite its outstanding success, liver transplantation still entails certain complications including ischemia-reperfusion injury.
- Conditions
- Tissue Donors, Liver Transplantation, Ischemia Reperfusion Injury
- Trial name
- NCT03386435
- Testing
- remote ischemic preconditioning
- Where
- South Korea
- Volunteers
- 160 people
- Sponsor
- Asan Medical Center
Cerebrovascular Disease
The Neuroprotective Effect of Remote Ischemic Preconditioning on Ischemic Cerebral Vascular Disease
This study is a prospective, randomized, single-center trial, designed to observe the effect of remote limb ischemic preconditioning on ischemic cerebral vascular disease.
- Trial name
- NCT01321749
- Testing
- Remote ischemic preconditioning (RIPC)
- Where
- China
- Volunteers
- 196 people
- Sponsor
- Capital Medical University
Acute Kidney Injury, Dialysis
Renal Effects of RIPC in Patients After Total Arch Replacement
The purpose of this study is to test the hypothesis that remote ischemic preconditioning prevents acute kidney injury and improves clinical outcomes in patients undergoing total arch replacement.
- Trial name
- RenRIPC-TAR (NCT03141385)
- Testing
- remote ischemic preconditioning, Control
- Where
- China
- Volunteers
- 130 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Lactic Acidosis
Remote Ischemic Preconditioning During Cardiopulmonary Bypass
The objective of study is to detect effect of remote ischemic preconditioning on serum lactate levels during and after cardiac surgery with cardiopulmonary bypass in addition to its effect on cardiac and renal clinical outcomes.
- Trial name
- RIPC (NCT03723993)
- Testing
- Inflated cuff, Non inflated cuff
- Where
- Egypt
- Volunteers
- healthy volunteers welcome
- Sponsor
- Fayoum University
Abdominal Aortic Aneurysm
Limb Remote Ischemic Preconditioning Reduces Heart and Lung Injury After Abdominal Aortic Aneurysm Repair
To investigate whether limb remote ischemic preconditioning (LRIP) has protective effects against intestinal and pulmonary injury in patients undergoing open infrarenal abdominal aortic aneurysm (AAA) repair.
- Trial name
- NCT01344239
- Testing
- Limb remote ischemic preconditioning(LRIP)
- Volunteers
- 62 people
- Sponsor
- Cai Li
Peripheral Arterial Disease, Vascular Surgery
Remote Ischemic Preconditioning Prior to Vascular Surgery
The investigators have previously shown that elective vascular surgery is a high-risk operation with an anticipated risk of either death or heart attack of 15%.
- Trial name
- CRIPES (NCT01558596)
- Testing
- Preconditioning, Control
- Where
- United States
- Volunteers
- 201 people
- Sponsor
- VA Office of Research and Development
Complication of Surgical Procedure, Flap Ischemia
Flap Preconditioning by Intermittent Negative Pressure
A randomized controlled trial to investigate the effect of negative pressure preconditioning of flaps on surgical outcome and microcirculation of the tissue.
- Trial name
- NCT03900065
- Testing
- Preconditioning
- Where
- Germany
- Volunteers
- 32 people
- Sponsor
- Ruhr University of Bochum
Renal Cell Carcinoma (RCC), Renal Function Abnormal
Ischemic Preconditioning Reduces the Severity of Acute Kidney Injury After Partial Nephrectomy
It is demonstrated that remote ischemic preconditioning can alleviate the degree of acute renal injury on the operated side in patients undergoing partial nephrectomy.
- Trial name
- NCT07497958
- Testing
- Ischemic preconditioning, NO ischemic preconditioning
- Where
- China
- Volunteers
- 174 people
- Sponsor
- Sun Yat-sen University
Heart Valve Surgery, Acute Kidney Injury
Effects of Remote Ischemic Preconditioning at Different Time Phases in Patients Undergoing Heart Valve Surgery
Patients undergoing heart valve surgery require cardiopulmonary bypass, a procedure that can lead to a temporary reduction in blood flow to major organs and subsequent ischemia-reperfusion injury, thereby triggering postoperative…
- Trial name
- NCT07888634
- Testing
- remote ischemic preconditioning
- Where
- China
- Volunteers
- 291 people
- Sponsor
- Fujian Medical University Union Hospital
Ischemic Preconditioning, Autonomic Nervous System (ANS) Functioning and Mood State
The Impact of Ischemic Preconditioning on Exercise Performance and Physiological Function
Ischemic Preconditioning has been confirmed to prevent long-term ischemic damage to tissues, among which the improvement of autonomic nerve system function may be one of its mechanisms of action.
- Trial name
- NCT07146399
- Testing
- Ischemic Preconditioning
- Where
- China
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Ziyue Ou
Limb Ischemia, Ischemic Preconditioning
Model System for Transient Forearm Blood Vessel Dysfunction
This study will develop a model system that can be used to test medications for improving the ability of blood vessels to resist damage from diseases such as heart attack and stroke.
- Trial name
- NCT00453531
- Testing
- Limb Ischemia, Acetylcholine
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Subarachnoid Hemorrhage
Preconditioning for Aneurismal Subarachnoid Hemorrhage
In remote preconditioning, ischemia in one organ protects distant organs from ischemic insults. e.g. brief induced limb ischemia protects the brain from an otherwise more severe stroke.
- Trial name
- NCT01110239
- Testing
- remote limb preconditioning
- Volunteers
- 34 people
- Sponsor
- University of Miami