Clinical trials: Ischemia Reperfusion Injury
Primary Graft Dysfunction
Prospective Reduction Of Transplant Complications Through Enhanced Preservation Therapy to Prevent Primary Graft Dysfunction
The goal of this clinical trial is to test the feasibility of the study protocol comparing a novel temperature control system - Xo Port Organ Preservation System - to static ice for heat preservation for Heart Transplant.
- Trial name
- PROTECT-PGD (NCT07230886)
- Testing
- Xo Port Organ Preservation System, Standard of Care - Ice packs
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University Health Network, Toronto
Acute Kidney Injury, Abdominal Aortic Aneurysm
Curcumin to Prevent Complications After Elective Abdominal Aortic Aneurysm (AAA) Repair
The purpose of this program of research is to determine whether curcumin, a natural health product, can prevent acute kidney injury and other complications after elective AAA repair.
- Trial name
- NCT01225094
- Testing
- curcumin
- Where
- 10 sites in Canada
- Volunteers
- 606 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Post-Cardiac Arrest Syndrome
The Holistic Health Care of Post-Cardiac Arrest Survivors: From Patient's Health to Family Resilience
Post-cardiac arrest mortality remains high and proper care after cardiopulmonary resuscitation is an important clinical challenge.
- Trial name
- NCT04859270
- Where
- Taiwan
- Volunteers
- 600 people
- Sponsor
- National Taiwan University Hospital
Intermittent Hypoxia
Effect of Intermittent Hypoxia on Ischemia-reperfusion Injury in Healthy Individuals
The objective of the present study is to determine whether intermittent hypoxia protects against ischemia-reperfusion injury in young and older healthy individuals.
- Trial name
- NCT05423470
- Testing
- Intermittent hypoxia, Intermittent normoxia
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Compartment Syndrome
Management of Compartment Syndrome With Ultrafiltration
This study will test the safety of a new treatment method called tissue ultrafiltration. We will test this method in the treatment of compartment syndrome, a condition that occurs when pressure within the muscles builds to…
- Trial name
- NCT00022815
- Testing
- Tissue ultrafiltration
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Lung Transplant Failure and Rejection, Primary Graft Dysfunction
CLAD: Finding Biomarkers to Predict Rejection and/ or Outcome After Lung Transplantation
Lung transplantation is the ultimate treatment for end stage lung diseases. Survival after lung transplantation is limited mainly due to the development of chronic allograft dysfunction (CLAD).
- Trial name
- NCT04558333
- Testing
- blood and exhaled breath specimens
- Where
- Belgium
- Volunteers
- 24 people
- Sponsor
- University Hospital, Antwerp
Ischemia Reperfusion Injury, Endothelial Dysfunction
Short Term Statin Treatment and Endothelial Dysfunction Due to Ischemia and Reperfusion Injury
Rationale: Apart from their cholesterol lowering effects, statins have cholesterol-independent pleiotropic actions, such as upregulation of 5'-ectonucleotidase and up-regulation of NO-synthase that may increase tolerance against…
- Trial name
- NCT00987974
- Testing
- rosuvastatin, atorvastatin 3 days, rosuvastatin 7 days
- Where
- Netherlands
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
STEMI
Platelet Inhibition to Target Reperfusion Injury
There remains a clinical need to improve health outcomes in patients with ischemic heart disease (IHD) the leading cause of death and disability in Singapore and worldwide.
- Trial name
- PITRI (NCT03102723)
- Testing
- Cangrelor
- Where
- 5 sites in Singapore
- Volunteers
- 228 people
- Sponsor
- National Heart Centre Singapore
Acute Coronary Syndromes, Acute Myocardial Infarction
Effect of Adjunctive Intracoronary Streptokinase on Late Term Left Ventricular Infarct Size and Volumes in Patients With Acute Myocardial Infarction
The investigators hypothesized that complementary intracoronary streptokinase administration to primary percutaneous intervention in patients with acute myocardial infarction may provide limitation infarct size and improvement in…
- Conditions
- Acute Coronary Syndromes, Acute Myocardial Infarction, Reperfusion Injury
- Trial name
- NCT00627809
- Testing
- Streptokinase, primary percutaneous coronary intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 53 people
- Sponsor
- Istanbul University
Acute Ischemic Stroke
Rapid Local Ischemic Postconditioning on Stroke After Thrombectomy
The main goal of this study is to find out if a new, quick "brain rescue" procedure can help people recover better from a severe stroke caused by a large vessel occlusion.
- Trial name
- RAPIDIMPROVE (NCT07598799)
- Testing
- High-dose RL-IPostC, Low-dose RL-IPostC
- Where
- China
- Volunteers
- 448 people
- Sponsor
- Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Myocardial Reperfusion Injury
Remote Ischemic Postconditioning in Humans
The aim of this study is to evaluate the phenomenon of remote ischemic post-conditioning in humans. The minor myocardial damage associated with percutaneous revascularization procedures may be attenuated by producing controlled…
- Trial name
- NCT01113008
- Testing
- Remote ischemic postconditioning, Control group
- Where
- Spain
- Volunteers
- 266 people
- Sponsor
- Hospital Universitario Virgen de la Victoria
Lung Transplant Failure
Lung PGD Biomarkers in Organ Donors
PGD is a syndrome characterized by alveolocapillary barrier structural and functional alterations with surfactant inactivation and vascular permeability increase, which cause lung edema, parenchymal infiltrate and progressive…
- Trial name
- NCT03089489
- Testing
- lung biomarkers in organ donor for PGD in lung recipient
- Volunteers
- 50 people
- Sponsor
- University Hospital of Mont-Godinne
Ischemia Reperfusion Injury, Ischaemia Reperfusion Injury
Immune Modulation by Ischemic Pre-conditioning in Healthy Individuals: Intracellular Signalling in Regulatory Cells
The aim of the study is to investigate how phosphorylation of STAT3, p38 mitogen-activated protein kinase (MAPK), extracellular signal-regulated kinase (ERK) and protein kinase B (AKT) reacts to remote ischemic conditioning (rIC)…
- Trial name
- KONDI-immun (NCT03541239)
- Testing
- Single Cuff Tourniquet 8000
- Where
- Denmark
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Ischemia
Rosuvastatin and Ischemia Reperfusion
Statins, including rosuvastatin, are drugs that lower plasma cholesterol and prevent atherosclerotic disease. Recent preclinical evidence suggests that statins also increase tissue tolerance to ischemia-reperfusion injury.
- Trial name
- NCT00315510
- Testing
- Rosuvastatin
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Cervical Compression Myelopathy, Ischemia
Clinical Trial of Remote Preconditioning in Patients Undergoing Cervical Decompression Surgery
The purpose of this study is to assess whether a large clinical trial testing the effect of RIPC on neurologic outcome in patients undergoing elective cervical decompression surge is warranted.
- Conditions
- Cervical Compression Myelopathy, Ischemia, Reperfusion Injury, Spinal Cord Injury
- Trial name
- NCT00778323
- Testing
- limb remote ischemic preconditioning (LRIPC)
- Where
- China
- Volunteers
- 51 people
- Sponsor
- Xijing Hospital
Placenta Accreta
The Role of Transdermal CO2 in MDA Level in Patient Underwent Abdominal Aortic Temporary Cross Clamp
The Role of Transdermal Carbon Dioxide in Malondialdehyde Level as Predictor of Ischemia Reperfusion Injury in Patients Underwent Abdominal Aortic Temporary Cross Clamp
- Trial name
- NCT05205304
- Testing
- D'Oxyva
- Where
- Indonesia
- Volunteers
- 30 people
- Sponsor
- Universitas Airlangga
Ischemia/Reperfusion Injury of Liver Graft, Ischemia/Reperfusion Injury of Kidney
The Effect of Remote Ischemic Postconditioning on Liver Graft and Renal Function in Patients Undergoing Living-related Liver Transplantation
The investigators are trying to evaluate the clinical effect of remote ischemic postconditioning on liver graft function and postoperative renal function in subjects undergoing living-donor liver transplantation.
- Conditions
- Ischemia/Reperfusion Injury of Liver Graft, Ischemia/Reperfusion Injury of Kidney, Remote Ischemic Postconditioning
- Trial name
- NCT01637038
- Testing
- RIPC
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Samsung Medical Center
Non-environmental Hypothermia, Cardiac Arrest
Trial of Different Hypothermia Temperatures in Patients Recovered From Out-of-hospital Cardiac Arrest
Mild therapeutic hypothermia in the temperature range of 32º - 34ºC. improves survival in patients recovered from a ventricular fibrillation cardiac arrest.
- Trial name
- NCT01155622
- Testing
- Endovascular Cooling
- Where
- Spain
- Volunteers
- 36 people
- Sponsor
- Hospital Universitario La Paz
Myocardial Reperfusion Injury, Atrial Fibrillation
Inhaled Sevoflurane Compared to Intravenous Sedation Post Coronary Artery Bypass Grafting
Inhaled sevoflurane during coronary artery bypass grafting (CABG) reduces postoperative Troponin levels and may be associated with improved outcome.
- Trial name
- NCT00484575
- Testing
- Sevoflurane, propofol
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Karolinska Institutet
Cardiac Arrest, Extracorporeal Circulation
Cytokine Adsorption in Post-cardiac Arrest Syndrome in Patients Requiring Extracorporeal Cardiopulmonary Resuscitation
Almost all patients with refractory cardiac arrest, who are primarily stabilized under ongoing cardiopulmonary resuscitation by transcutaneous implantation of a venoarterial extracorporeal membrane oxygenation system (va-ECMO for…
- Conditions
- Cardiac Arrest, Extracorporeal Circulation, Extracorporeal Membrane Oxygenation, Cytokine Storm
- Trial name
- CYTER (NCT03685383)
- Testing
- Cytosorb removal column in eCPR, standard eCPR (va-ECMO)
- Where
- Germany
- Volunteers
- 41 people
- Sponsor
- University Hospital Freiburg