Clinical trials: Ischemic Brain
Stroke, Ischemic, Stroke, Acute
Efficacy of Intravenous Tissue-type Plasminogen Activator on Acute Ischemic Stroke Patients With Large Vessel Occlusions
This is an observational prospective study about the reperfusion rate of intravenous thrombolysis on ischemic stroke patients with large vessel occlusions and predictor factors of successful recanalization.
- Trial name
- NCT04170647
- Testing
- Plasminogen Activators
- Where
- Vietnam
- Volunteers
- 81 people
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Ischemic Stroke
Swiss Intravenous and Intra-arterial Thrombolysis for Treatment of Acute Ischemic Stroke Registry
The clinical and radiological data of patients with an acute ischemic stroke treated with intravenous thrombolysis (IVT) or intraarterial thrombolysis (IAT) in a Swiss stroke unit are assessed in a Swiss Multicenter Thrombolysis…
- Trial name
- SWISS (NCT00811538)
- Testing
- Intravenous Thrombolysis, Intraarterial Thrombolysis
- Where
- Switzerland
- Volunteers
- 1,476 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Acute Ischaemic Stroke
Magnetic Resonance Post-contrast Vascular Hyperintensities at 3 T: a Sensitive Sign of Vascular Occlusion in Acute Ischaemic Stroke
Magnetic resonance imaging (MRI) is the diagnostic cornerstone for precisely identifying acute ischaemic strokes and locating vascular occlusions.
- Trial name
- NCT03971526
- Testing
- MRI images review
- Volunteers
- 130 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Ischemic Stroke
Bridging Thrombolysis Versus Direct Mechanical Thrombectomy in Acute Ischemic Stroke
Intravenous thrombolysis with recombinant tissue-type plasminogen activator (IV t-PA) has been the only proven therapy for acute ischemic stroke (AIS) for almost 20 years.
- Trial name
- SWIFT DIRECT (NCT03192332)
- Testing
- Stent-retriever thrombectomy with revascularization device of the Solitaire™ type, Intravenous thrombolysis with recombinant tissue-type plasminogen activator (IV t-PA)
- Where
- 48 sites in Austria, Canada and 6 more
- Volunteers
- 410 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Ischemic Stroke, Post-stroke Cognitive Impairment
Safety and Efficacy of ALZT-OP1a as Adjuvant Treatment in Subjects With Post-Ischemic Stroke Cognitive Impairment (PSCI)
This is a Phase II, randomized, double-blinded, placebo-controlled study for subjects with evidence of PSCI.
- Trial name
- NCT03202147
- Testing
- Cromolyn
- Sponsor
- AZTherapies, Inc.
Carotid Artery Stenosis
Balloon Guide Catheter Combined With Filter Protection for Carotid Artery Stenting
This multicenter, randomized, controlled trial evaluates a combined embolic protection strategy during carotid artery stenting (CAS). Carotid artery stenosis is a major cause of stroke.
- Trial name
- ANGEL-BEACON (NCT07247864)
- Testing
- Balloon Guide Catheter, Distal Filter Protection Device
- Where
- China
- Volunteers
- 296 people
- Sponsor
- Beijing Anzhen Hospital
Atherosclerosis, Cardiovascular Diseases
Multi-Ethnic Study of Atherosclerosis (MESA)
The Multi-Ethnic Study of Atherosclerosis (MESA) is a study of the characteristics of subclinical cardiovascular disease and the risk factors that predict progression to clinically overt cardiovascular disease or progression of…
- Conditions
- Atherosclerosis, Cardiovascular Diseases, Heart Diseases, Coronary Artery Disease
- Trial name
- NCT00005487
- Volunteers
- 6,418 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Congenital Heart Disease in Children, Neuroprotection
Cerebrum and Cardiac Protection With Allopurinol in Neonates With Critical Congenital Heart Disease Requiring Cardiac Surgery With Cardiopulmonary Bypass
Neurodevelopmental impairment due to delayed brain development and brain injury is a fundamental problem in children with critical congenital heart disease (CCHD).
- Trial name
- CRUCIAL (NCT04217421)
- Testing
- Allopurinol, Mannitol
- Where
- 4 sites in Netherlands
- Volunteers
- 236 people
- Sponsor
- dr. M.J.N.L. Benders
Stroke, Cerebrovascular Stroke
General Anesthesia for Endovascular Thrombectomy; A Pilot Study.
This study evaluates the outcomes of stroke patients treated for intravascular thrombectomy, using either a local anesthetic with sedation, or a general anesthetic.
- Conditions
- Stroke, Cerebrovascular Stroke, Brain Ischemia, Brain Diseases
- Trial name
- NCT02639806
- Testing
- Sevoflurane, Lidocaine
- Where
- Canada
- Volunteers
- 34 people
- Sponsor
- University of Saskatchewan
Intracranial Aneurysms, Flow Diverter
Surface-Modified Flow Diverter for Intracranial Aneurysms: Assessment of Ischemic and Clinical Outcomes
Flow diverters (FDs) have become a mainstay of endovascular therapy for unruptured intracranial aneurysms (UIAs), yet their implantation carries an inherent risk of ischemic complications.
- Trial name
- PRISMATIC (NCT07674004)
- Testing
- LFD, PED Shield
- Where
- China
- Volunteers
- 196 people
- Sponsor
- Henan Provincial People's Hospital
Ischemic Preconditioning
Remote Ischemic Preconditioning of Dynamic Cerebral Autoregulation in Healthy Adults
The purpose of this study is to determine the impact of remote ischemic preconditioning on dynamic cerebral autoregulation and related hematology indexes in healthy adults.
- Trial name
- RIPCA (NCT02965547)
- Testing
- Remote ischemic conditioning equipment, Intravenous blood collection, dCA measurement
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Yi Yang
Stroke, Endovascular Therapy
Investigation and Study on the Status of Endovascular Therapy in Acute Ischemic Stroke Ischemic Stroke
This study aims to build a database for patients with acute ischemic stroke who receive endovascular therapy and analyze the current situation, effectiveness, safety and cost-effectiveness of endovascular therapy for acute…
- Trial name
- IS-EVT (NCT03909438)
- Testing
- Endovascular Thrombectomy
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Psoriasis, Cardiovascular Diseases
Prevalence and Risk Factors asSOciated With CArdiac comorbiDIty in psoriAsis
In a prospective cohort study (n = 1.000), the investigators aim to investigate the correlation between cardiac biomarkers and advanced echocardiography and determine whether these are prognostic markers of heart disease in…
- Conditions
- Psoriasis, Cardiovascular Diseases, Cardiovascular Risk Factor, Cardiovascular Pathology
- Trial name
- PSOCADIA (NCT04950218)
- Where
- Denmark
- Volunteers
- 1,000 people
- Sponsor
- Herlev and Gentofte Hospital
Stroke, Ischemic Stroke
Myosuit Chronic Stroke Protocol
A stroke is a vascular condition that can suddenly cause the loss of neurological functions. The disability derived from a stroke can imply reduced communication and limited activities of daily living in the long term.
- Conditions
- Stroke, Ischemic Stroke, Haemorrhagic Stroke
- Trial name
- MyoSCSP (NCT05579197)
- Testing
- Lower-limb robotic intervention
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Intracranial Arterial Stenosis, Intracranial Atherosclerosis
Surgical Indirect Revascularization For Symptomatic Intracranial Arterial Stenosis
Stroke due to intracranial arterial atherosclerosis is a significant medical problem, carrying one of the highest rates of recurrent stroke despite best medical therapy, with annual recurrence rates as elevated as 25% in high…
- Conditions
- Intracranial Arterial Stenosis, Intracranial Atherosclerosis, Ischemic Stroke, Cerebral Angiogenesis
- Trial name
- ERSIAS (NCT01819597)
- Testing
- Encephaloduroarteriosynangiosis (EDAS)
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Cedars-Sinai Medical Center
TIA (Transient Ischemic Attack)
Transient Ischemic Attack (TIA) and Spoken Language
Transient Ischaemic Attack (also known as TIA or 'mini-stroke') affects about 46,000 people in the UK each year. It is assumed that people recover fully within 24 hours.
- Trial name
- NCT07206433
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Newcastle University
Traumatic Brain Injury (TBI) Patients, Stroke Hemorrhagic
Non-invasive Intracranial Pressure Monitoring to Improve Emergency Care in Brazil's Public Health System
The goal of this observational study is to evaluate the diagnostic accuracy of non-invasive intracranial pressure (ICP) and intracranial compliance (ICC) pulse morphology and associated parameters (such as the P2/P1 ratio and…
- Conditions
- Traumatic Brain Injury (TBI) Patients, Stroke Hemorrhagic, Stroke Ischemic
- Trial name
- NCT07210333
- Testing
- non-invasive intracranial pressure monitoring
- Where
- 3 sites in Brazil
- Volunteers
- 300 people
- Sponsor
- Braincare USA Corp
Stroke, Acute, Thromboses, Intracranial
Alteplase Compared to Tenecteplase in Patients With Acute Ischemic Stroke
The proposed trial is a pragmatic, registry linked, prospective, randomized (1:1) controlled, open-label parallel group clinical trial with blinded endpoint assessment of 1600 patients to test if intravenous tenecteplase (0.25…
- Trial name
- AcT (NCT03889249)
- Testing
- Tenecteplase, Alteplase
- Where
- 22 sites in Canada
- Volunteers
- 1,600 people
- Sponsor
- University of Calgary
Acute Ischemic Stroke
Safety, Performance of CEREGLIDE 92 Intermediate Catheter in Treatment of Acute Ischemic Stroke
The device is indicated for use in the revascularization of patients with acute ischemic stroke secondary to intracranial large vessel occlusive disease
- Trial name
- SPLENDID (NCT06386289)
- Testing
- Cereglide 92
- Sponsor
- Cerenovus, Part of DePuy Synthes Products, Inc.
Acute Ischemic Stroke From Large Vessel Occlusion
The Preliminary Efficacy and Safety of Intra-Arterial Albumin as Adjunct to Mechanical Thrombectomy in Acute Ischemic Stroke
Albumin-assisted therapy has demonstrated good safety and potential neuroprotective effects following mechanical thrombectomy. To further systematically evaluate its efficacy and safety, we are conducting a Phase IIa clinical…
- Trial name
- NCT07294391
- Testing
- Human serum albumin infusion 20%
- Volunteers
- 60 people
- Sponsor
- Tianjin Huanhu Hospital
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