Clinical trials: Ischemic Brain
Arterial Calcification, Kidney Diseases
Aortic Calcification and Central Blood Pressure in Patients With Chronic Kidney Disease
Aim and background: This study will seek to identify physiological and biochemical factors explaining and predicting a higher than expected central (aortic) blood pressure (BP) in patients with chronic kidney disease (CKD).
- Conditions
- Arterial Calcification, Kidney Diseases, Coronary Artery Disease, Aortic Calcification
- Trial name
- ACCEPT (NCT04114695)
- Where
- Denmark
- Volunteers
- 185 people
- Sponsor
- Central Jutland Regional Hospital
Stroke, Stroke, Acute
Impact of COVID-19 Vaccines on Cerebrovascular Health
Safe and effective severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines may reduce the transmission of and achieve population immunity against the COVID-19 pandemic, which accounted for more than 3.75million…
- Conditions
- Stroke, Stroke, Acute, Stroke, Ischemic, Dementia
- Trial name
- NCT04992195
- Testing
- Laboratory tests and Montreal Cognitive Assessment
- Where
- Hong Kong
- Volunteers
- 415 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Ischemic Stroke, Migraine
Sensitivity to Acute Cerebral Ischemia in Migrainers
Sensitivity to Acute Middle cerebral or intracranial Carotid artery Occlusion in MIGrainers (SMCO-MIG) is a prospective multi-center study to determine if migraine induces a faster infarct growth as assessed by initial multimodal…
- Conditions
- Ischemic Stroke, Migraine, Migraine With Aura
- Trial name
- SAMCO-MIG (NCT03301441)
- Testing
- questionnaire ef-ID Migraine
- Where
- France
- Volunteers
- 605 people
- Sponsor
- University Hospital, Montpellier
Ischemic Stroke
Effect of EA Combined With NGF on Limb Function in Convalescent Patients With Ischemic Stroke
Most ischemic stroke patients are in recovery phase, often accompanied by motor impairment, but they lack effective treatment. The appearance of nerve growth factor (NGF) promotes the development of neuroprotective therapy, but…
- Trial name
- NCT05652751
- Testing
- nerve growth factor, physiological saline, EA
- Where
- China
- Volunteers
- 120 people
- Sponsor
- The Third Affiliated hospital of Zhejiang Chinese Medical University
Ischemic Stroke
Predictors and Prognostic Factors on the Acute Ischemic Stroke
Through 5 years continuous observation of acute ischemic stroke patients in Neurology Department of Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, clinical data about emergency treatment…
- Trial name
- NCT03122002
- Testing
- Drug Therapy, Routine Blood Test and Image Scan, Intravascular therapy
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- Tongji Hospital
Breast Cancer, Colorectal Cancer
Multicenter Prospective Cohort of Informal Caregivers in Burgundy and Franche-Comté
Medical progress and modification of lifestyles have prolonged life expectancy, despite the development of chronic diseases. The support and care are often provided by a network of informal caregivers composed of family, friends…
- Conditions
- Breast Cancer, Colorectal Cancer, Prostate Cancer, Alzheimer Disease
- Trial name
- ICE (NCT02626377)
- Testing
- Support provided by social worker, Information booklet receipt
- Where
- France
- Volunteers
- 186 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Ultrasonography, Carotid Stenosis
Prognostic Value of Carotid CEUS in Acute Ischemic Stroke Patients
Contrast-enhanced ultrasound(CEUS) of carotid artery plaque is a novel method that enabled direct visualization of neovessels in the vulnerable plaque.
- Conditions
- Ultrasonography, Carotid Stenosis, Ischemic Stroke
- Trial name
- NCT03283306
- Where
- South Korea
- Volunteers
- 667 people
- Sponsor
- Seoul National University Hospital
Cardiovascular Diseases, Coronary Disease
Cardiovascular Health Study (CHS)
To determine the extent to which known risk factors predict coronary heart disease and stroke in the elderly, to assess the precipitants of coronary heart disease and stroke in the elderly, and to identify the predictors of…
- Conditions
- Cardiovascular Diseases, Coronary Disease, Heart Diseases, Cerebrovascular Accident
- Trial name
- CHS (NCT00005133)
- Where
- 6 sites in United States
- Volunteers
- 5,888 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Spinal Cord Injury, Stroke (CVA) or Transient Ischemic Attack
Understanding and Enhancing Human Health and Movement
By doing this study, investigators hope to learn how electrical stimulation can improve human movement, biomechanics, and function and to gather information on the safety and effectiveness of an implanted electrical stimulation…
- Conditions
- Spinal Cord Injury, Stroke (CVA) or Transient Ischemic Attack, Multiple Sclerosis
- Trial name
- NCT07738978
- Testing
- Neural Prosthesis
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Louis Stokes VA Medical Center
Aneurysmal Subarachnoid Hemorrhage
Clazosentan in Preventing the Occurrence of Cerebral Vasospasm Following an Aneurysmal Subarachnoid Hemorrhage (aSAH)
The purpose of the study is to measure how effective and safe three different doses of the drug clazosentan are in preventing vasospasm after subarachnoid hemorrhage.
- Trial name
- CONSCIOUS-1 (NCT00111085)
- Testing
- Clazosentan 1 mg/h, Clazosentan 5 mg/h, Clazosentan 15 mg/h
- Where
- 16 sites in United States, Canada
- Volunteers
- 413 people
- Sponsor
- Idorsia Pharmaceuticals Ltd.
Ischemic Stroke, Atrial Fibrillation
Timing of Anticoagulation After Emergency Endovascular Therapy for Acute Ischemic Stroke With Atrial Fibrillation 2
This study evaluates the safety and efficacy of early versus delayed initiation of direct oral anticoagulants (DOACs) in patients with acute ischemic stroke related to atrial fibrillation who develop hemorrhagic transformation…
- Trial name
- TIMERS-2 (NCT07139314)
- Testing
- Early anticoagulation, Delayed anticoagulation
- Where
- 37 sites in China
- Volunteers
- 240 people
- Sponsor
- Capital Medical University
Dementia, Cognition Disorders
Impact of Anticoagulation Therapy on the Cognitive Decline and Dementia in Patients With Non-Valvular Atrial Fibrillation
Patients will be screened at Intermountain Medical Center and at Intermountain-affiliated anticoagulation clinics in the Salt Lake City region. Patients with non-valvular atrial fibrillation will be considered for study.
- Conditions
- Dementia, Cognition Disorders, Cerebral Ischemic Events
- Trial name
- CAF (NCT03061006)
- Testing
- Dabigatran Etexilate, Warfarin
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- Intermountain Health Care, Inc.
TIA (Transient Ischemic Attack)
Transient Ischemic Attack (TIA) and Spoken Language
Transient Ischaemic Attack (also known as TIA or 'mini-stroke') affects about 46,000 people in the UK each year. It is assumed that people recover fully within 24 hours.
- Trial name
- NCT07206433
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Newcastle University
Intracranial Atherosclerosis, Intracranial Arterial Stenosis
EDAS Revascularization for Symptomatic Intracranial Atherosclerotic Steno-occlusive Disease
ERSIAS IIb is a multicenter randomized controlled trial, with a Phase IIb design, to find out whether encephaloduroarteriosynangiosis (EDAS), a type of indirect surgical revascularization of the brain, added to intensive medical…
- Conditions
- Intracranial Atherosclerosis, Intracranial Arterial Stenosis, Ischemic Stroke
- Trial name
- ERSIAS IIb (NCT07864649)
- Testing
- Encephaloduroarteriosynangiosis (EDAS), Intensive medical management
- Volunteers
- 170 people
- Sponsor
- Cedars-Sinai Medical Center
Stroke, Ischemic, Stroke Hemorrhagic
Promoting Recovery After STroke With Amantadine
The investigators aim to examine whether amantadine can help patients recover from stroke. This will be a blinded randomized clinical trial (RCT).
- Trial name
- PRESTA (NCT05140148)
- Testing
- Amantadine
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Pennsylvania
Myocardial Infarction, Hypertension
Reducing Blood Pressure in Patients With High Cardiovascular Risk
BP-REACH is a study of a team-based (pharmacist and health coach) program for lowering blood pressure for people with a prior stroke or heart attack in the Los Angeles Department of Health Services healthcare system.
- Conditions
- Myocardial Infarction, Hypertension, Stroke
- Trial name
- BP-REACH (NCT05937685)
- Testing
- BP REACH Intervention
- Where
- 4 sites in United States
- Volunteers
- 546 people
- Sponsor
- University of Southern California
Cardiovascular Death, Myocardial Infarction
Construction of a Cohort for Pan-Vascular Disease Among Employees of Taizhou People's Hospital
1. Participant Recruitment During the annual health check-ups for hospital staff, potential participants are recruited. Those who express interest are provided with a detailed explanation of the study's objectives, content, and…
- Conditions
- Cardiovascular Death, Myocardial Infarction, Stroke
- Trial name
- NCT06545799
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Jiangsu Taizhou People's Hospital
Stroke, Acute
Establishment and Validation of a Predictive Model for Hemorrhage
Background: Patients with acute ischemic stroke (AIS) are at risk of hemorrhagic transformation (HT) after intravenous thrombolysis.
- Trial name
- NCT04745052
- Testing
- Clinical observation index
- Where
- 2 sites in China
- Volunteers
- 240 people
- Sponsor
- Shenzhen Second People's Hospital
Ischemic Stroke
Modulation of Cerebral Ischemia by Albumin
A single-center, open-label, randomized, placebo-controlled, prospective phase II clinical trial to investigate the efficacy of low-dose albumin in patients with ischemic stroke with an indication for vasographic intervention.
- Trial name
- MOZEG (NCT07415655)
- Testing
- Albumin infusion
- Where
- Czechia
- Volunteers
- 100 people
- Sponsor
- University Hospital Hradec Kralove
Ischemic Stroke
Asia Africa Streptokinase Trial
Currently, thrombolysis is offered to less than 1% of patients in low to middle income countries (LMICs) where access to health care is often based on the financial capabilities of the patient.
- Trial name
- AASIST (NCT02150785)
- Testing
- Streptokinase
- Sponsor
- University of Alberta