Clinical trials: Ischemic Brain Injury
Out-of-Hospital Cardiac Arrest, Hypoxic-Ischemic Brain Injury
Minimal Sedation Versus Standard Continuous Sedation After Out-of-Hospital Cardiac Arrest
Most patients resuscitated from out-of-hospital cardiac arrest (OHCA) remain comatose on hospital admission and are routinely managed with continuous sedation.
- Conditions
- Out-of-Hospital Cardiac Arrest, Hypoxic-Ischemic Brain Injury, Post-Cardiac Arrest Syndrome
- Trial name
- NCT07895771
- Testing
- Minimal sedation, Standard continuous sedation
- Where
- Slovenia
- Volunteers
- 100 people
- Sponsor
- University Medical Centre Ljubljana
Acute Ischemic Stroke, Reperfusion Injury
Wet and Dry Biomarkers to Predict Secondary Injury in Stroke: From Bench to Bedside - The NIMBLE Study
Infarct growth (IG), Hemorrhagic Transformation (HT) and Cerebral Edema (CE) can be considered pivotal phenomena of clinical deterioration following an acute ischemic stroke.
- Conditions
- Acute Ischemic Stroke, Reperfusion Injury, Cerebral Edema, Hemorrhagic Transformation Due to Acute Stroke
- Trial name
- NIMBLE (NCT07422636)
- Where
- Italy
- Volunteers
- 213 people
- Sponsor
- University of Florence
Acute Brain Injury, Mechanical Ventilation
Regional Ventilation Evaluation During Neuro-injury Weaning Study
This study evaluates changes in regional lung ventilation using thoracic electrical impedance tomography (EIT) during the weaning process from mechanical ventilation in ICU patients with acute brain injury.
- Conditions
- Acute Brain Injury, Mechanical Ventilation, Prolonged Weaning, Traumatic Brain Injury
- Trial name
- ReVENtS (NCT07067671)
- Testing
- Internal Thoracic Impedance
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hypoxic-Ischemic Encephalopathy, Hypoglycemia
Quantitative Assessment of Sucking for Early Diagnosis of Brain Injury in Infants at High Risk
The main goal of this study is to quantitatively assess the sucking and feeding activity of infants at high risk of neurological impairment (preterm infants and term infants at risk of abnormal neurodevelopment) during oral…
- Conditions
- Hypoxic-Ischemic Encephalopathy, Hypoglycemia, Neonatal Abstinence Syndrome
- Trial name
- NCT03246243
- Testing
- nfant feeding solution
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Acute Ischemic Stroke, Stroke
MRI-SWI as a Predictor of Functional Outcome in Acute Ischemic Stroke
The purpose of the study is to use diffusion tensor imaging (DTI) derived axial diffusivity and susceptibility weighted imaging (SWI) to evaluate the severity of acute ischemic stroke and to predict its functional outcome.
- Conditions
- Acute Ischemic Stroke, Stroke, Cerebral Stroke, Cerebrovascular Accident
- Trial name
- NCT00696306
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Taipei Medical University WanFang Hospital
Neuro ICU, Sub Arachnoid Hemorrhage
Comparison of Ultrasound Cerebral Perfusion Imaging With Routine Perfusion CT
The primary goal of neurocritical care is to prevent secondary brain injury, which worsens neurological outcomes. Because clinical monitoring is often insufficient due to the patient's condition and medical treatments, multimodal…
- Conditions
- Neuro ICU, Sub Arachnoid Hemorrhage, Neurological Complication, Cerebral Ischemia
- Trial name
- SCULPT (NCT07324421)
- Testing
- Ultrasound contrast agent (Contrast-enhanced ultrasound)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Resolve Stroke
Hypoxic Ischemic Brain Injury, Neonatal Encephalopathy
Perinatal Brain Injury: Potential of Innovative NIRS to Optimize Hypothermia
The purpose of this study is to improve the ability of the investigators to monitor brain health in newborn babies at risk of brain injuries.
- Trial name
- NCT02793999
- Testing
- Near-Infrared Spectroscopy (NIRS)
- Where
- 3 sites in United States
- Volunteers
- 125 people
- Sponsor
- Boston Children's Hospital
Organic Brain Syndrome, Nonpsychotic, Neurocognitive Disorders
Intranasal Inhalations of Bioactive Factors Produced by M2 Macrophages in Patients With Organic Brain Syndrome
The investigators have designed an innovative proof-of-concept trial designed to provide data as to whether the treatment/rehabilitation efficacy and functional outcome of patients with organic brain syndrome are improved with…
- Conditions
- Organic Brain Syndrome, Nonpsychotic, Neurocognitive Disorders, Mental Disorder, Organic, Delirium, Dementia, Amnestic, Cognitive Disorders
- Trial name
- NCT02957123
- Testing
- Intranasal auto-M2-BFs
- Where
- Russia
- Volunteers
- 30 people
- Sponsor
- Russian Academy of Medical Sciences
Hypoxic-Ischemic Encephalopathy, Asphyxia
Hydrocortisone Therapy Optimization During Hypothermia Treatment in Asphyxiated Neonates
This is a prospective, single center, pharmacokinetic study of intravenous hydrocortisone therapy for systemic low blood pressure during hypothermia treatment in asphyxiated newborns.
- Conditions
- Hypoxic-Ischemic Encephalopathy, Asphyxia, Hypotension, Circulatory Failure Neonatal
- Trial name
- UniCort (NCT05836610)
- Testing
- Hydrocortisone
- Where
- Hungary
- Volunteers
- 50 people
- Sponsor
- Semmelweis University
Apoplexy, Femoral Neck Fracture
Epidemiology of Aeromedical Evacuation
Increasing air travel has resulted in a significant increase in aeromedical evacuation over the past decade. However there is only a small amount of epidemiological data available on the diagnosis, costs and transport…
- Conditions
- Apoplexy, Femoral Neck Fracture, Myocardial Infarction, Subarachnoid Hemorrhage
- Trial name
- NCT01071382
- Volunteers
- 504 people
- Sponsor
- Ruhr University of Bochum
Brain Injury, Acute
Non-Invasive Monitoring Methods in Patients With Acute Brain Injury
Life-threatening mass effect (LTME) arises when brain swelling displaces or compresses crucial midline structures subsequent to acute brain injuries (ABIs) like traumatic brain injury (TBI), ischemic stroke (IS), and…
- Trial name
- NIMABI (NCT06504238)
- Where
- United States
- Volunteers
- 720 people
- Sponsor
- Boston Medical Center
Ischemic Stroke
Reperfusion Injury After Endovascular Stroke Treatment
Endovascular stroke treatment with mechanical thrombectomy (MT) has become the standard therapy for intracranial large vessel occlusion (LVO).
- Trial name
- DYNASTROKE (NCT05273216)
- Testing
- Transcranial Duplex Sonography, Brain MRI, Blood biomarkers
- Where
- 3 sites in Austria
- Volunteers
- 600 people
- Sponsor
- Medical University of Graz
Embolic Stroke of Undetermined Source
Embolic Stroke of Undetermined Source, Continuous Electrocardiography and Transthoracic ECHOcardiography in Hospitalized Patients With Ischemic Stroke
Transthoracic echocardiography (TTE) is recommended in patients with ischemic stroke when cardiac etiology is suspected to help plan secondary stroke management.
- Trial name
- ESECHO (NCT04808258)
- Testing
- C3+ Holter Monitor
- Where
- 2 sites in Denmark
- Volunteers
- 500 people
- Sponsor
- Herlev and Gentofte Hospital
Severe Traumatic Brain Injury
Brain Tissue Oxygen Monitoring in Traumatic Brain Injury (TBI)
Traumatic brain injury (TBI) is a major cause of death and disability, with an estimated cost of 45 billion dollars a year in the United States alone.
- Trial name
- BOOST 2 (NCT00974259)
- Testing
- Management protocol based on pBrO2 and ICP values., Management protocol based on ICP values only.
- Where
- 10 sites in United States
- Volunteers
- 122 people
- Sponsor
- University of Pennsylvania
Severe Traumatic Brain Injury, Subarachnoid Hemorrhage
Cortical Excitability in Patients With Severe Brain Injury
The aim of the study is to evaluate the cortical excitability in the severe brain injured patients. We hypothesize that: 1. There is a continuous decrease in intracortical inhibition from healthy subjects to awake patients with…
- Conditions
- Severe Traumatic Brain Injury, Subarachnoid Hemorrhage, Anoxic Brain Injury
- Trial name
- NCT00788723
- Testing
- Transcranial Magnetic Stimulation
- Where
- Denmark
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Acute Brain Injuries, Consciousness Disorders
CONNECT-ME: Consciousness in Neurocritical Care Cohort Study Using fMRI and EEG
Detecting preserved consciousness in brain-injured patients by traditional clinical means requires presence of motor function. Otherwise, patients may be erroneously classified as being in a vegetative state.
- Trial name
- CONNECT-ME (NCT02644265)
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Tetraplegia/Tetraparesis, Quadriplegia
UAE-PRIME: A Feasibility Study of a Precise Robotically Implanted Brain-Computer Interface for the Control of External Devices
The UAE-PRIME Study is a feasibility study designed to assess the initial clinical safety and functionality of the Neuralink N1 Implant and R1 Robot.
- Conditions
- Tetraplegia/Tetraparesis, Quadriplegia, Quadriplegia/Tetraplegia, Cervical Spinal Cord Injury
- Trial name
- UAE-PRIME (NCT06992596)
- Testing
- N1 Implant, R1 Robot
- Where
- United Arab Emirates
- Volunteers
- 10 people
- Sponsor
- Neuralink Corp
Chronic Ischemic Stroke
A Study of ASP2246 for People Who Have Movement Problems Caused by Brain Injury After a Stroke
This study is for adults who have difficulty moving a few months after a stroke. In this study, ASP2246 will be given to people for the first time. This is known as a "first in human" study.
- Trial name
- NCT07318714
- Testing
- ASP2246, Brain surgery, Rehabilitation therapy
- Where
- 5 sites in Japan
- Volunteers
- 84 people
- Sponsor
- Astellas Pharma Inc
Traumatic Brain Injury, Acquired Brain Injury
Venous and Cerebral Glucose Microdialysis in Neurocritical Care: Validation & Correlation
This study evaluates the validity of an intravascular continuous glucose monitoring microdialysis probe, and compares the values to routinely inserted cerebral glucose microdialysis to evaluate the hypothesised relationship…
- Conditions
- Traumatic Brain Injury, Acquired Brain Injury, Intracerebral Hemorrhage, Subarachnoid Hemorrhage
- Trial name
- NCT03246607
- Testing
- MicroEye & ContinuMon
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Dr Andrew Stevens
Cardiovascular Diseases, Non-communicable Disease
Effects of Primary Prevention in Elderly People-The Healthy Aging Initiative
The number of elderly will increase rapidly in Europe in the next 30 years, which affects the country's economic and social development, welfare, health care, and also the individuals.
- Trial name
- HAI (NCT03312439)
- Testing
- Given advice
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Region Västerbotten