Clinical trials: Ischemic Conditioning
Ischemic Stroke
Combination of Conditioned Medium and Umbilical Cord-Mesenchymal Stem Cells Therapy for Acute Stroke Infarct
The purpose of this study was to determine the effectiveness of a combination of intranasal conditioned medium (CM) with intraparenchymal umbilical cord mesenchymal stem cells (UC-MSCs) transplantation in acute stroke patients to…
- Trial name
- NCT05008588
- Testing
- Conditioned Medium, Umbilical Cord Mesenchymal Stem Cells, Neurologic and Neutrophic Drugs
- Where
- 2 sites in Indonesia
- Volunteers
- 15 people
- Sponsor
- PT. Prodia Stem Cell Indonesia
Acute Ischemic Stroke
Remote Ischemic Conditioning for Acute Moderate Ischemic Stroke Due to Large Artery Atherosclerosis
Large Artery Atherosclerosis is one of the most prevalent causes of stroke worldwide and is associated with a high risk of disability and recurrent strokes.
- Trial name
- RIC-LAA (NCT06775782)
- Testing
- Remote Ischemic Conditioning (RIC) treatment, Medical Management
- Where
- China
- Volunteers
- 1,150 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Aging, Fragility
Ischemic Conditioning to Promote Microvascular Resiliency in Frail Individuals
The goal of this clinical trial is to see how small blood vessels respond to the stress of high intensity exercise, and if a safe and simple intervention called ischemic conditioning can protect blood vessels from the stress of…
- Conditions
- Aging, Fragility, Endothelial Dysfunction
- Trial name
- NCT05808686
- Testing
- Ischemic Conditioning
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Covid19, Ischemia
Can RIC Prevent Deterioration to Critical Care in Covid19
The coronavirus disease (COVID-19) emerged in late 2019 and has since been diagnosed in over a million persons worldwide. As this virus progresses, it causes an extreme and uncontrolled response from the patient's immune system…
- Trial name
- NCT04699227
- Testing
- Cuff application with inflation
- Where
- 4 sites in Brazil, South Africa and 1 more
- Volunteers
- 40 people
- Sponsor
- Derek Yellon
Chronic Kidney Diseases, Hypertension
Remote Ischaemic Conditioning on Blood Pressure Control in Chronic Kidney Disease Patients
Chronic kidney disease (CKD) is one of the leading causes of death and disability in Singapore and worldwide. Hypertension is commonly inadequately controlled in patients with CKD and this is associated with CKD progression and…
- Conditions
- Chronic Kidney Diseases, Hypertension, Cardiovascular Diseases
- Trial name
- ERIC-BP-CKD (NCT03236350)
- Testing
- Active autoRIC® (CRIC Treatment)
- Where
- Singapore
- Volunteers
- 85 people
- Sponsor
- Singapore General Hospital
Parkinson Disease (PD), Insomnia
Remote Ischemic Conditioning for Sleep Disturbances and Other Non-motor Symptoms in Parkinson's Disease
This single-center, randomized, single-blind, sham-controlled clinical trial aims to evaluate whether remote ischemic conditioning (RIC) can improve sleep disturbances and other non-motor symptoms in patients with Parkinson's…
- Trial name
- NCT07299240
- Testing
- Remote ischemic conditioning device
- Where
- China
- Volunteers
- 48 people
- Sponsor
- Jiangsu Province Nanjing Brain Hospital
Healthy, Young Adults
Effect of Number of Remote Limb Ischemic Conditioning Cycles on Learning Enhancement
The purpose of this research study is to determine the effect of number of remote limb ischemic conditioning (RLIC) cycles on enhancing learning in neurologically intact young adults.
- Trial name
- RLICC (NCT03512041)
- Testing
- RLIC - 5 cycles, RLIC - 4 Cycles, RLIC - 3 Cycles
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Children With Cerebral Palsy
Remote Ischemic Conditioning and Spinal Reflex Modulation in Children With Cerebral Palsy
Remote ischemic conditioning (RIC) is a clinically feasible intervention involving brief, sublethal periods of ischemia followed by reperfusion that has been shown to enhance motor performance, strength, and balance when combined…
- Trial name
- NCT07390760
- Testing
- Remote Ischemic Condtioning (RIC), Balance training
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- East Carolina University
Acute Stroke
Ischemic Conditioning During Air tRansport Save penUmbral Tissue
The purpose of this study is to demonstrate the feasibility of performing remote limb ischemic conditioning (RLIC) using the Doctormate device, a special blood pressure device used to perform RLIC, on patients with acute ischemic…
- Trial name
- ICARUS (NCT03481205)
- Testing
- Ischemic conditioning device
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Enrique Leira
Acute Ischemic Stroke
The Efficacy of Remote Ischemic Conditioning on Stroke-induced Immunodeficiency
to detect the effects of RIC on stroke-induced immunodeficiency and inflammation response in acute ischemic stroke patients
- Trial name
- RIC-SIID (NCT04069546)
- Testing
- remote ischemic conditioning
- Where
- China
- Volunteers
- 46 people
- Sponsor
- Capital Medical University
Acute Myocardial Infarction
Phase II Clinical Trial to Evaluate the Benefits of Postconditioning in ST-Elevation Myocardial Infarction (STEMI)
This study will evaluate change in heart muscle function from baseline to three months and twelve months in participants who present with a heart attack and a completely occluded coronary artery.
- Trial name
- NCT01324453
- Testing
- Post Conditioning + Primary PCI, Standard Primary PCI
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- Minneapolis Heart Institute Foundation
Septic Shock, Sepsis
The Effect of Remote Ischemic Conditioning on the Microcirculation in Sepsis
This study is an evaluation of the effect of Remote ischemic conditioning on sublingual microcirculation in patients with sepsis.
- Trial name
- NCT04644926
- Testing
- Remote ischemic conditioning
- Where
- Lithuania
- Volunteers
- 26 people
- Sponsor
- Lithuanian University of Health Sciences
Burns
Remote Ischemic Conditioning to Reduce Burn Wound Progression
Burned skin areas, which were initially vital, can be irreversibly damaged by wound progression. The aim of the present study is to evaluate the feasibility of ischemic conditioning to reduce secondary wound progression.
- Trial name
- RIC in burns (NCT03027596)
- Testing
- Remote ischemic conditioning
- Where
- Germany
- Volunteers
- 140 people
- Sponsor
- BG Trauma Center Tuebingen
Parkinson Disease
The Effects of Ischemic Conditioning in Individuals With Parkinson's Disease
Ischemic conditioning (IC) is a promising therapy that can mimic the physiological effects of physical exercise. IC consists of using a cuff to measure blood pressure and calibrate 200 mmHg on the upper or lower limb.
- Trial name
- NCT06293118
- Testing
- Ischemic conditioning group
- Volunteers
- 50 people
- Sponsor
- Hospital Israelita Albert Einstein
Coronary Artery Disease
Ischaemic Pre-Conditioning in Elective Percutaneous Coronary Intervention (PCI) Patients
This study aims to assess the potential for ischaemic peri-conditioning (IP) in elective percutaneous coronary intervention (PCI) patients to attenuate ischaemia in an animal model of myocardial infarct.
- Trial name
- NCT00765908
- Testing
- Angioplasty balloon
- Volunteers
- 20 people
- Sponsor
- University Health Network, Toronto
Myocardial Infarction, Acute
Combined Application of Remote and Intra-Coronary Ischemic Conditioning in Acute Myocardial Infarction
Infarct size is a major determinant of prognosis after AMI. Evidence indicates that the combination of intracoronary ischemic conditioning (ICIC) and remote ischemic conditioning (RIC) can significantly reduce infarct size in…
- Trial name
- CARIOCA (NCT03155022)
- Testing
- Remote ischemic conditioning and intracoronary ischemic conditioning, Patients with no remote ischemic conditioning and no intracoronary ischemic conditioning
- Where
- 4 sites in Belgium, France
- Volunteers
- 750 people
- Sponsor
- Hospices Civils de Lyon
Acute Myocardial Infarction
The Acute and Chronic Effects of Remote Ischemic Conditioning on Cardiovascular Function
The investigators are going to examine 270 patients within 48h of STEMI with primary percutaneuous intervention. The investigators utilise either a double -with a 15- min intervening interval-, or a single ischemic stimulus by…
- Trial name
- NCT03984123
- Testing
- Brachial cuff, in order to achieve ischemic stimuli
- Where
- Greece
- Volunteers
- 270 people
- Sponsor
- University of Athens
Acute Myocardial Infarction
Minimizing Reperfusion Injury in Patients With Acute Myocardial Infarction
The size of a heart attack will be decreased by the use of timed balloon inflations to open the blocked blood vessel.
- Trial name
- PCinAMI (NCT00846378)
- Testing
- Post conditioning, Usual Care for STEMI
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Cincinnati
Heart Defects, Congenital, Myocardial Reperfusion Injury
Morphine Versus Fentanyl for Myocardial Protection in Acyanotic Children Undergoing Congenital Open-Heart Surgery
This study compared two opioid pain medications - morphine and fentanyl - used during open-heart surgery in young children born with heart defects (congenital heart disease).
- Trial name
- MorphPed (NCT07839273)
- Testing
- Fentanyl (IV), morphine
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Baskent University
Intracranial Atherosclerosis
Remote Ischemic Conditioning for Avoiding Recurrence of Symptomatic Intracranial Atherosclerotic Stenosis (sICAS)
The primary objective of the study will be to determine whether remote limb ischemic conditioning (RLIC) compared with sham RLIC (placebo) treatment reduces the 12-month risk of recurrent IS in patients with a recent TIA or IS…
- Trial name
- NCT02534545
- Testing
- Doctormate® (200mmHg), Doctormate® (60mmHg)
- Where
- 50 sites in China
- Volunteers
- 3,000 people
- Sponsor
- Ji Xunming,MD,PhD