Clinical trials: Ischemic Disease
Stroke, Stroke, Ischemic
Bio-Repository of DNA in Stroke: an Epidemiological and Genetic Study
The Bio-Repository of DNA in Stroke (BRAINS) recruits all subtypes of stroke as well as controls from two different continents, Europe and Asia.
- Conditions
- Stroke, Stroke, Ischemic, Stroke Hemorrhagic
- Trial name
- BRAINS (NCT05491824)
- Where
- United Kingdom
- Volunteers
- 7,500 people
- Sponsor
- Royal Holloway University
Coronary Artery Disease
VIBE-assisted DEB Registry
VIBER aims at assessing angiographic outcome of drug-eluting balloon angioplasty assisted by the Vascular Imaging Balloon Catheter (VIBE, Volcano, San Diego, CA) device, which integrates a predilation catheter with electronic…
- Trial name
- VIBER (NCT01411462)
- Testing
- VIBE + drug-eluting balloon
- Where
- Italy
- Sponsor
- Ospedale Santa Maria Goretti
Coronary Artery Disease (CAD) Mortality
Coronary Artery Disease Mortality in Turkiye
This study aims to analyze the geographical variations and identify key environmental and behavioral predictors of coronary artery disease (CAD) mortality in Turkiye.
- Trial name
- NCT06506383
- Testing
- No Intervention as this is an ecological study
- Where
- Turkey (Türkiye)
- Volunteers
- 81 people
- Sponsor
- Medipol University
Optic Neuropathy, NAION - Non-Arteritic Ischemic Optic Neuropathy
Clinical Study of FB1001 in Patients
This study is designed for single-center, open-label, dose escalation phase I trial to evaluate the safety and tolerability of a single/multiple intravitreal injection of FB1001 in patients with APACG(Acute Primary Angle-Closure…
- Conditions
- Optic Neuropathy, NAION - Non-Arteritic Ischemic Optic Neuropathy, APAC - Acute Primary Angle Closure, Glaucoma, Angle-Closure
- Trial name
- NCT06506305
- Testing
- FB1001
- Where
- China
- Volunteers
- 59 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Coronary Artery Disease
Simulator Training to Improve Interventional Cardiologist Skills (STARTERS) Trial
The goal of this clinical trial is to learn if simulator-based training will improve interventional cardiology fellows' skills and will improve patient outcomes.
- Trial name
- STARTERS (NCT06358105)
- Testing
- Simulator-based training, Standard training
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Ischemic Stroke, Acute Stroke
Mechanical Thrombectomy for Acute Large Vessel Occlusion Stroke With Mild Symptoms
Mechanical thrombectomy(MT) has been recommended in patients with acute large vessel occlusion stroke(LVO) , especially for those with National Institutes of Health Stroke Scale (NIHSS) score ≥6.
- Trial name
- NCT04526756
- Testing
- Mechanical Thrombectomy
- Where
- China
- Volunteers
- 105 people
- Sponsor
- Shanghai East Hospital
Non-ischemic Dilated Cardiomyopathy, Heart Failure With Reduced Ejection Fraction
High Fat Diet for Cardiac Metabolic Reprogramming
Heart failure (HF) continues to be a leading cause of morbidity and mortality worldwide, despite advances in treatment. HF is often characterized by an altered metabolism in the heart, where glucose is favored over fatty acids as…
- Trial name
- HF4HF (NCT06747429)
- Testing
- High fat diet, Standard diet
- Where
- 5 sites in France, Italy and 2 more
- Volunteers
- 80 people
- Sponsor
- Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III
CHD, AMI
Lifestyle Intervention in a General Population for Prevention of Ischaemic Heart Disease
In spite of declining trend coronary heart disease (CHD) is still a leading cause of morbidity and mortality. Many years of epidemiological research have identified several risk factors for CHD.
- Conditions
- CHD, AMI, CVD, Type 2 Diabetes
- Trial name
- NCT00289237
- Testing
- Lifestyle intervention
- Where
- Denmark
- Volunteers
- 61,301 people, healthy volunteers welcome
- Sponsor
- Glostrup University Hospital, Copenhagen
Coronary Artery Disease
Coronary CT Angiography as the Primary Initial Method of Evaluating Patients With Subacute Chest Pain (CT PRIME)
This study is designed to evaluate a new approach to the diagnosis of chronic or sub-acute chest pain patients in the out-patient setting.
- Trial name
- CTPRIME (NCT00584337)
- Where
- United States
- Sponsor
- Corewell Health East
Cardiac Rehabilitation, Acute Coronary Syndrome
Mobile Tele-Monitoring Guided Cardiac Rehabilitation in Post-Acute Coronary Syndrome Patients
Cardiac rehabilitation (CR) programmes are effective measures to reduce recurrent ischemic events in post-acute coronary syndrome (ACS) patients.
- Trial name
- REHAB+ (NCT05207072)
- Where
- 4 sites in Netherlands, Spain
- Volunteers
- 900 people
- Sponsor
- Maastricht University
Hypoxic Ischemic Encephalopathy
Clinical Utility of Serum Biomarkers for the Management of Neonatal Hypoxic Ischemic Encephalopathy (Control Levels)
Hypoxic-ischemic encephalopathy (HIE) is a serious birth complication due to systemic asphyxia which occurs in about 20 of 1,000 full-term infants and nearly 60% of premature newborns.
- Trial name
- NCT02349672
- Testing
- blood sample
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Florida
Stroke
Ex Vivo Cultured Adult Allogenic MSCs in Ischemic Cerebral Stroke
This study will evaluate the safety and efficacy of intravenous ex vivo cultured adult allogenic mesenchymal stem cells in patients with ischemic cerebral stroke.
- Trial name
- NCT01091701
- Testing
- Ex vivo cultured adult allogenic MSCs, Plasmalyte-A
- Where
- 6 sites in Malaysia
- Sponsor
- Stempeutics Research Pvt Ltd
Ischemic Heart Disease
The Danish On-pump, Off-pump Randomization Study (DOORS)
Background: Coronary artery bypass grafting (CABG) can be performed either with or without the use of cardiopulmonary bypass (CPB) to obtain myocardial re-vascularisation.
- Trial name
- NCT00123981
- Testing
- Off-Pump Coronary Artery Bypass Grafting
- Where
- Denmark
- Volunteers
- 900 people
- Sponsor
- Kim Houlind
Acute Ischemic Stroke
Identification of Stroke Patients ≤ 3 and ≤ 4.5 Hours of Symptom Onset by Fluid Attenuated Inversion Recovery (FLAIR) Imaging and Diffusion Weighted Imaging (DWI)
The aim of the study is to evaluate the use of combined fluid attenuated inversion recovery (FLAIR) imaging and diffusion weighted imaging (DWI) as surrogate marker of lesion age within the first 6 hours of ischemic stroke in…
- Trial name
- PRE-FLAIR (NCT01021319)
- Where
- 2 sites in Germany
- Volunteers
- 643 people
- Sponsor
- Götz Thomalla, MD
Heart Defects, Congenital, Myocardial Reperfusion Injury
Morphine Versus Fentanyl for Myocardial Protection in Acyanotic Children Undergoing Congenital Open-Heart Surgery
This study compared two opioid pain medications - morphine and fentanyl - used during open-heart surgery in young children born with heart defects (congenital heart disease).
- Trial name
- MorphPed (NCT07839273)
- Testing
- Fentanyl (IV), morphine
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Baskent University
Coronary Artery Disease
Advanced Cardiac Magnetic Resonance Imaging for Assessment of Obstructive Coronary Artery Disease: ADVOCATE-CMR
Stress perfusion cardiovascular magnetic resonance (CMR) imaging is an established non-invasive imaging test for detection of obstructive coronary artery disease (CAD).
- Trial name
- ADVOCATE-CMR (NCT06419894)
- Volunteers
- 182 people
- Sponsor
- Amsterdam UMC, location VUmc
Ischemic Heart Disease, Atherosclerosis
Graft Patency as a Predictor of Health-related Quality of Life.
The health-related quality of life questionnaire "EQ-5D" has been collected in connection with several interventional and observational studies where the no-touch vein harvesting technique in CABG has been used.
- Trial name
- NCT02547194
- Where
- Sweden
- Volunteers
- 254 people, healthy volunteers welcome
- Sponsor
- Örebro County Council
Coronary Artery Disease
Influence of Different Forms of Exercise Training in Patients With Coronary Artery Disease
The aim of the study is to compare the effect of water-based and land-based exercise training, and usual care (no exercise training) in patient with coronary artery disease, on exercise capacity, vascular function, arrhythmogenic…
- Trial name
- NCT02831829
- Testing
- water-based exercise training, land-based exercise training
- Where
- 2 sites in Slovenia
- Volunteers
- 90 people
- Sponsor
- University Medical Centre Ljubljana
Coronary Atherosclerosis, Cardiovascular Disease
Regular Physical Exercise and Salt Diet on Coronary Artery Disease in Patients With Prehypertension(RESTRAIN Pre-HT)
The epidemic data shows that prehypertension is associated with cardiovascular disease, and heavy dietary salt intake could improve the developing of hypertension.
- Trial name
- NCT02076802
- Testing
- physical exercises
- Where
- China
- Volunteers
- 120 people
- Sponsor
- General Hospital of Shenyang Military Region
ST Elevation Myocardial Infarction, NSTEMI - Non-ST Segment Elevation MI
Ticagrelor Administered as Standard Tablet or Orodispersible Formulation
Randomized clinical study evaluating superiority in platelet inhibition after administration of Ticagrelor 180 mg loading dose as an orodispersible formulation versus traditional coated tablets in patients admitted for ST…
- Trial name
- TASTER (NCT03822377)
- Testing
- Ticagrelor orodispersible tablets, Ticagrelor standard tablets
- Where
- Italy
- Volunteers
- 130 people
- Sponsor
- Azienda Ospedaliero Universitaria di Sassari
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