Clinical trials: Ischemic Disease
Diabetes Mellitus Type II, Acute Coronary Syndrome
VERifynow in DIabetes Non-responsiveness: a Study on Switching From Clopidogrel to Prasugrel
The purpose of this study is to determine if, in type 2 diabetic patients undergoing treatment with PCI and a stent, who fail to respond to normal doses of clopidogrel, a loading dose of 60 mg of prasugrel followed by 10 mg once…
- Trial name
- VERDI (NCT01684813)
- Testing
- Prasugrel., Clopidogrel
- Where
- Spain
- Volunteers
- 65 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Ischemic Stroke
Ticagrelor Versus Clopidogrel in Ischemic Stroke
Along with the current clinical trial, the efficacy and safety of 180 mg loading dose of ticagrelor administered within the first 24 hours of first-ever ischemic stroke compared to 300 mg clopidogrel were assessed through NIHSS…
- Trial name
- NCT05553613
- Testing
- Ticagrelor 90 MG Oral Tablet, Clopidogrel tablet
- Where
- Egypt
- Volunteers
- 900 people
- Sponsor
- Kafrelsheikh University
Hypertension, Coronary Artery Disease
Cardiovascular Epidemiology in Russian Federation
The study addresses epidemiology of cardiovascular risk factors and major cardiovascular diseases in Russian Federation (urban and rural population). 12 regions of 1600 participants in each will be included.
- Conditions
- Hypertension, Coronary Artery Disease, Diabetes, Heart Failure
- Trial name
- ESSE-RF (NCT02449460)
- Where
- 2 sites in Russia
- Volunteers
- 18,000 people, healthy volunteers welcome
- Sponsor
- Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health
Acute Ischemic Stroke
GD-11 for Injection in the Treatment of Acute Ischemic Stroke
Phase III Clinical Trial of GD-11 for Injection in the Treatment of Acute Ischemic Stroke - A Multi-Center, Randomized, Double-Blind, Parallel, Placebo-Controlled Phase III Clinical Study with the primary objective of evaluation…
- Trial name
- NCT06299579
- Testing
- GD-11 for injection test group
- Where
- 2 sites in China
- Volunteers
- 980 people
- Sponsor
- Beijing Tiantan Hospital
Coronary Artery Disease
Prospective Observational Study of Trimetazidine Influence on Mitochondrial Metabolism in Human Heart Ventricle
Trimetazidine (1-[2,3,4-trimethoxybenzyl] piperazine dihydrochloride) is a clinically effective antianginal agent. Despite these clinical successes, the understanding of trimetazidine's mechanism of action remains incomplete…
- Trial name
- NCT02152527
- Where
- Croatia
- Volunteers
- 55 people
- Sponsor
- University of Split, School of Medicine
Ischemia Reperfusion Injury
Feasibility and Safety of Allogeneic Adipose Mesenchymal Stem Cells (aMSCs) Delivery Into Kidney Allografts Procured From Deceased Donors With High Kidney Donor Profile Index (KDPI)
The purpose of this research is to test an investigational drug called Adipose Mesenchymal Stem Cells (aMSCs) for the treatment of ischemia re-perfusion injury (IRI) in patients that have had a kidney transplant.
- Trial name
- NCT04388761
- Testing
- Allogeneic adipose derived mesenchymal stem cells
- Sponsor
- Tambi Jarmi
Myocardial Infarction
Beta Blocker Interruption After Uncomplicated Myocardial Infarction
ABYSS is a national, multicenter, randomised, open label trial using the PROBE study design, that will evaluate the non-inferiority of the interruption of ΒB therapy after an uncomplicated MI after six months or more of follow-up…
- Trial name
- AβYSS (NCT03498066)
- Testing
- Beta-blockers withdrawal, Continuation of the Betablockers (βB) treatment
- Where
- France
- Volunteers
- 3,700 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Myocardial Infarction, Glycation End Products, Advanced
Role of Glycation and Inflammation in Acute Ischemic Heart Disease
This study requires the consecutive enrollment of 60 patients following the first event of acute myocardial infarction, evaluating B-Cell Activating Factor (BAFF) and methylglyoxal (MGO) levels in the acute setting…
- Conditions
- Myocardial Infarction, Glycation End Products, Advanced, Inflammation, Heart Injuries
- Trial name
- AGLIANICO (NCT05112731)
- Testing
- BAFF and MGO
- Where
- Italy
- Volunteers
- 16 people
- Sponsor
- GEK Srl
Cardiorenal Metabolic Syndrome, Atherosclerotic Cardiovascular Disease
Effect of Secukinumab on Cardiorenal Outcomes in Patients With Cardiorenal Metabolic Syndrome and Atherosclerotic Cardiovascular Disease
This is a prospective, randomized, open-label, parallel-controlled clinical trial to evaluate the efficacy and safety of targeted IL-17A inhibition with secukinumab on cardiovascular and renal endpoints in 100 patients with…
- Conditions
- Cardiorenal Metabolic Syndrome, Atherosclerotic Cardiovascular Disease, Chronic Kidney Disease, Coronary Artery Disease
- Trial name
- NCT07704190
- Testing
- Secukinumab (75 mg), Standard Medical Therapy
- Volunteers
- 100 people
- Sponsor
- Peking University Third Hospital
Stroke, Cerebral Infarction
Transcranial Stimulation and Motor Training in Stroke Rehabilitation
This study aims to test whether repeated sessions of tDCS result in long-lasting improvements in motor function in patients with chronic stroke.
- Conditions
- Stroke, Cerebral Infarction, Cerebrovascular Disorders, Brain Diseases
- Trial name
- tDCS (NCT01414582)
- Testing
- Anodal tDCS, Motor Training
- Where
- United Kingdom
- Volunteers
- 80 people
- Sponsor
- University of Oxford
Iliotibial Band Syndrome
Neuromuscular Inhibition Technique on Iliotibial Band Friction Syndrome
The goal of this clinical trial is to find the effect of integrated neuromuscular inhibition technique for iliotibial band in iliotibial band friction syndrome on pain intensity level, pressure pain threshold, knee range of…
- Trial name
- NCT06980324
- Testing
- integrated neuromuscular inhibition technique, conventional physical therapy treatment
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Ischemic Heart Disease
Safety and Clinical Performance of the Yukon Choice PC, Yukon Chrome PC & Yukon Choice Flex Stents in Routine Practice
The goal of this observational study is to collect safety and performance information in the setting of a large-scale clinical registry.
- Trial name
- e-Yukon (NCT05703646)
- Where
- United Arab Emirates
- Volunteers
- 5,000 people
- Sponsor
- Translumina GmbH
Myocardial Ischemia
Impact of Perivascular Tissue on Endothelial Function in Coronary Artery Bypass Grafting
The success of coronary artery bypass grafting is reliant on the quality of the grafts used. A new technique for harvesting veins used as grafts has been introduced.
- Trial name
- IMPROVE-CABG (NCT01834846)
- Testing
- no-touch, conventional
- Where
- Norway
- Volunteers
- 100 people
- Sponsor
- Norwegian University of Science and Technology
Ischemic Stroke, Acute, Rehabilitation Outcome
Cerebrolysin in Early Stroke Rehabilitation - Tertiary Study
The study evaluates the effect and safety of Cerebrolysin administered during early rehabilitation in patients with moderate neurological impairment after acute ischemic stroke, conducted at the Department of Vascular Neurology…
- Conditions
- Ischemic Stroke, Acute, Rehabilitation Outcome, Cerebrolysin
- Trial name
- NCT07043686
- Testing
- Cerebrolysin treatment, Standard treatment (including neurorehabilitation) of acute ischemic stroke
- Where
- Slovenia
- Volunteers
- 30 people
- Sponsor
- University Medical Centre Ljubljana
Liver Failure, End Stage Liver Disease
Dual Hypothermic Oxygenated Perfusion of DCD Liver Grafts in Preventing Biliary Complications After Transplantation
Rationale: Recent publications report good results of controlled donation after circulatory death (DCD) Maastricht category III liver transplantation when strict donor-recipient matching is applied and ischemia times are kept to…
- Conditions
- Liver Failure, End Stage Liver Disease, Biliary Tract Diseases
- Trial name
- DHOPE-DCD (NCT02584283)
- Testing
- Dual hypothermic oxygenated perfusion, Liver Assist®, Perfusion fluid
- Where
- 6 sites in Belgium, Netherlands and 1 more
- Volunteers
- 157 people
- Sponsor
- Robert J. Porte
Coronary Artery Disease
Tailoring P2Y12 Inhibiting Therapy in Patients Requiring Oral Anticoagulation After PCI
Clopidogrel is the P2Y12 inhibitor of choice in PCI patients requiring OAC. However, concerns have been raised based on the notion that a considerable number of patients may have inadequate response to clopidogrel.
- Trial name
- SWAP-AC-2 (NCT04483583)
- Testing
- Ticagrelor 60mg, Clopidogrel
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- University of Florida
Carotid Artery Stenosis, Carotid Artery Disease
Neuropsychometric Outcome After Carotid Endarterectomy
The purpose of this study is to determine how well patients undergoing carotid endarterectomy will perform on a battery of tests to assess brain function before and after surgery as compared to a control group of patients…
- Conditions
- Carotid Artery Stenosis, Carotid Artery Disease, Transient Ischemic Attack, Stroke
- Trial name
- CEA (NCT00597883)
- Testing
- Carotid endarterectomy, Neurological and neuropsychological evaluations
- Where
- United States
- Volunteers
- 817 people
- Sponsor
- Columbia University
Cardiogenic Shock
Clinical Study of Extra-Corporal Life Support in Cardiogenic Shock Complicating Acute Myocardial Infarction
This study compares standard treatment plus Extra-Corporal Life Support (ECLS) versus standard treatment alone in patients with cardiogenic shock due to myocardial infarction.
- Trial name
- ECLS-SHOCK (NCT02544594)
- Testing
- Extra-Corporal Life Support (ECLS)
- Where
- Germany
- Volunteers
- 42 people
- Sponsor
- LMU Klinikum
Refractory Angina
A Study to Evaluate the Safety, Tolerability, and Efficacy of IMB-1018972 in Patients With Refractory Angina
The objectives of the study are to assess the safety, tolerability, and potential efficacy of IMB-1018972 on patients with refractory angina.
- Trial name
- NCT04306237
- Testing
- IMB-1018972
- Where
- United States
- Sponsor
- Imbria Pharmaceuticals, Inc.
Acute Ischemic Cerebrovascular Disease, Post Stroke Aphasia
EFFECT OF ANODAL TRANSCRANIAL DIRECT CURRENT STIMULATION ON NAMING IN APHASIC PATIENTS WITH ACUTE ISCHEMIC STROKE
The use of transcranial direct current stimulation (tDCS) for the management of deficits developed in stroke is a relatively new type of management option.
- Conditions
- Acute Ischemic Cerebrovascular Disease, Post Stroke Aphasia, Aphasia Following Cerebral Infarction, Aphasia, Acquired
- Trial name
- NCT07496645
- Testing
- Transcranial Direct Current Stimulation
- Where
- India
- Volunteers
- 28 people
- Sponsor
- Dr. Ram Manohar Lohia Hospital
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.