Clinical trials: Ischemic Disease
Hypertrophic Cardiomyopathy, Coronary Artery Disease
Hypertrophic Cardiomyopathy Pilot Study
This study evaluates mechanisms of arrhythmogenicity in hypertrophic cardiomyopathy, in comparison to patients with well-understood arrhythmogenic substrate (ischemic cardiomyopathy), as well as to individuals free from…
- Trial name
- NCT02806479
- Testing
- Observational: Arrhythmogenic Substrate
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Oregon Health and Science University
Contraception, Female Contraception
A Postmarketing Study of the Risk of Venous Thromboembolism (Blood Clots), Myocardial Infarction (Heart Attacks), and Stroke Among Women Using ORTHO EVRA (Norelgestromin and Ethinyl Estradiol Contraceptive Patch) Compared With Women Who Take Oral Contraceptives for Birth Control
The purpose of the study is to use data from a health care information database to assess the risk of venous thromboembolism (blood clots), myocardial infarction (heart attacks), and stroke among women using a transdermal…
- Trial name
- NCT00377988
- Testing
- Transdermal Contraceptive System, Norgestimate-containing oral contraceptives with EE
- Volunteers
- 423 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Patent Foramen Ovale
Paradigm I Clinical Trial: Study of the PFX Closure System in Subjects With Cryptogenic Stroke, Transient Ischemia Attack or Paradoxical Embolism
The primary objective of this study is to demonstrate the safety of the PFX Closure System when utilized for patients with patent foramen ovale (PFO) suffering from cryptogenic stroke, transient ischemic attacks or paradoxical…
- Trial name
- NCT00196027
- Testing
- PFX Closure System
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cierra
Cerebrovascular Accident
A Study to Evaluate the Effects of ONO-2506 Intravenous Infusion in Patients With Acute Ischemic Stroke
The primary objective of this study is to compare the efficacy of ONO-2506 versus placebo in neurological stroke outcome in patients with acute ischemic stroke.
- Trial name
- NCT00046761
- Testing
- ONO-2506
- Where
- 148 sites in United States, Canada
- Volunteers
- 1,320 people
- Sponsor
- Ono Pharma USA Inc
Coronary Arteriosclerosis, Ischemic Heart Disease
Copenhagen Arterial Revascularization Randomized Patency and Outcome Trial
There is a remarkable lack of randomized trials concerning the potential benefit of using arterial conduits for coronary bypass surgery. This is the purpose of the present trial.
- Conditions
- Coronary Arteriosclerosis, Ischemic Heart Disease, Angina Pectoris
- Trial name
- CARRPO (NCT00159991)
- Testing
- Total arterial revascularization, Conventional revascularization
- Where
- Denmark
- Volunteers
- 331 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Ischemic Heart Disease
DSE vs. FFR in SCAD and BYSTANDER Lesions
Enrollment: Patients with stable coronary artery disease (SCAD) and moderate coronary artery stenoses (30-70 %) Patients with acute myocardial infarction and moderate stenosis of non-culprit arteries (NCL; BYSTANDER LESION) Aims…
- Trial name
- DSE-vs-FFR (NCT03383718)
- Testing
- Revascularisation, Optimal Medical Treatment/OMT
- Volunteers
- 200 people
- Sponsor
- Bajcsy-Zsilinszky Hospital
Coronary Artery Disease
Safety and Efficacy Between the Distal and Proximal Radial Vascular Access Technique
The investigators are conducting a randomized clinical trial, having as a primary objective, to compare vascular access time between distal and proximal radial approach.
- Trial name
- NCT05066074
- Testing
- Distal Radial Vascular Access
- Where
- Mexico
- Volunteers
- 64 people
- Sponsor
- Instituto Mexicano del Seguro Social
Coronary Artery Disease
FUNctional eFficacy of Hybrid coronAry REvascularization
The purpose of the study is to compare iFR-guided hybrid coronary revascularization (HCR) and traditional coronary artery bypass grafting (CABG) in terms of a functional efficacy of revascularization assessed by weighted average…
- Trial name
- FUNFARE (NCT04698460)
- Testing
- Hybrid coronary revascularization, Coronary artery bypass grafting
- Where
- Russia
- Volunteers
- 13 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Acute Anterior ST-Segment Elevation Myocardial Infarction
A Research Study to Evaluate the Efficacy and Safety of SGC001 in Patients With Anterior Wall ST-Segment Elevation Myocardial Infarction
This is a multicenter, randomized, double-blind, placebo-controlled, single-dose, Phase II clinical study to evaluate the efficacy, safety, and pharmacokinetic (PK) characteristics of SGC001 injection administered in addition to…
- Trial name
- NCT07306182
- Testing
- SGC001 injection
- Where
- China
- Volunteers
- 210 people
- Sponsor
- Beijing Sungen Biomedical Technology Co., Ltd
Coronary Heart Disease, Stable Angina Pectoris
BuMA OCT Study(A Comparative Evaluation of the Extent of Neointima Formation at 3 Months After Implantation Using OCT)
The objective of this study is a comparative evaluation of BuMA stent and of EXCEL stent in terms of the extent of neointima formation at 3 months after implantation using OCT.
- Conditions
- Coronary Heart Disease, Stable Angina Pectoris, Unstable Angina Pectoris, Silent Myocardial Ischemia
- Trial name
- NCT01752582
- Testing
- BuMA stent, EXCEL stent
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Sino Medical Sciences Technology Inc.
Coronary Artery Disease, Endotoxin-mediated Complications From Cardiopulmonary Bypass Surgery
Efficacy and Safety Study on bIAP
The study drug bIAP, or matching placebo, will be administered as a bolus of 1000 Units bIAP or matching placebo prior to anaesthesia (T = -15 minutes), directly followed by intravenous continuous infusion of about 5.6 units per…
- Trial name
- APPIRED (NCT01010724)
- Testing
- bIAP
- Where
- Netherlands
- Sponsor
- Catharina Ziekenhuis Eindhoven
Stroke, Acute Ischemic, Albumin
Intra-arterial Albumin Infusion After Endovascular Therapy for Stroke Patients
The purpose of this study is to investigate the safety and feasibility of intra-arterial albumin infusion for patients with acute ischemic stroke after successful thrombectomy and to further explore the optimal dose of albumin…
- Conditions
- Stroke, Acute Ischemic, Albumin, Endovascular Procedures, Large Vessel Occlusion
- Trial name
- NCT05953623
- Testing
- Albumin
- Where
- China
- Volunteers
- 57 people
- Sponsor
- Tianjin Huanhu Hospital
Takotsubo Cardiomyopathy, Acute Coronary Syndrome
Effectiveness of a Resilience-Based Rehabilitation Program for Patients With Coronary Heart Disease
To handle daily life challenges, one needs to be psychologically resilient. It plays a crucial role in disease development, prognosis, as well as social, occupational, and community participation.
- Conditions
- Takotsubo Cardiomyopathy, Acute Coronary Syndrome, Psychological Resilience
- Trial name
- NCT06332859
- Testing
- Resilience training
- Where
- Austria
- Volunteers
- 130 people
- Sponsor
- Pensionsversicherungsanstalt
Ischemic Stroke
Myocardial Damage In Patients With Cerebral Infarction
Introduction For several years "ischemic" electrocardiographic (ECG) changes in the acute phase of ischemic stroke have been reported. Whether these ECG changes reflect true myocardial ischemia remains controversial.
- Trial name
- NCT00306579
- Volunteers
- 250 people
- Sponsor
- Danish Heart Foundation
Acute Coronary Syndrome With ST Elevation on Electrocardiogram, Acute Coronary Syndrome Without ST Elevation on Electrocardiogram
Tryptase and Coronary Heart Disease
The main aim of this study will evaluate differences in serum levels of tryptase in study population. Will be selected a number of 350 patients hospitalized for coronary heart disease.
- Conditions
- Acute Coronary Syndrome With ST Elevation on Electrocardiogram, Acute Coronary Syndrome Without ST Elevation on Electrocardiogram, Noncritical Coronary Artery Disease Coronary Stenosis Less Than 50 Per Cent, Aortic Aneurysms
- Trial name
- NCT01618279
- Where
- Italy
- Volunteers
- 350 people
- Sponsor
- Niguarda Hospital
Transient Ischemic Attack, Minor Ischemic Stroke
Dabigatran Treatment Following Transient Ischemic Attack and Minor Stroke
Objective: Demonstrate the safety of early use of dabigatran following TIA/minor stroke. Background: Although aggressive antithrombotic therapy has been shown to reduce the number of new ischemic events following stroke/TIA, this…
- Trial name
- DATAS (NCT01769703)
- Testing
- Dabigatran 110/150 mg BID
- Where
- Canada
- Volunteers
- 53 people
- Sponsor
- University of Alberta
Stroke, Acute, Stroke, Ischemic
Personalized Patient and Caregiver Education After Stroke
This is a randomized pilot trial to evaluate the impact of a customizable stroke education app (vs standard of care discharge education) on patient satisfaction and education retention.
- Conditions
- Stroke, Acute, Stroke, Ischemic, Stroke
- Trial name
- MyStroke (NCT05118503)
- Testing
- Customized education, Standard of care discharge education
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Pennsylvania
Acute Ischemic Stroke
A Study to Assess the Efficacy, Safety, and Pharmacokinetics of TB006 in Participants With Acute Ischemic Stroke
This multi-center, randomized, parallel-group, double-blind, placebo-controlled study will evaluate the efficacy and safety of TB006 in participants with an Acute Ischemic Stroke (AIS) event with 57 days of treatment.
- Trial name
- NCT05156827
- Testing
- TB006
- Sponsor
- TrueBinding, Inc.
Ischemia Reperfusion Injury, Endothelial Function
The Metformin-FMD Trial
In acute myocardial infarction early restoration of coronary blood flow is the most effective strategy to limit infarct-size. Paradoxically, reperfusion itself also aggravates myocardial injury and contributes to final infarct…
- Trial name
- MetFMD (NCT01610401)
- Testing
- Metformin, Pretreatment with metformin in combination of infusion of caffeine., No pretreatment with metformin in combination with infusion of caffeine
- Where
- Netherlands
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Coronary Artery Disease
Randomized MicroPort's Firehawk DES Versus Xience V: TARGET I Trial
The purpose of this study is to evaluate new generation drug eluting stent (DES) of MicroPort of its safety, efficacy and delivery system in treating CAD.
- Trial name
- NCT01196819
- Testing
- Firehawk, Xience V
- Where
- China
- Volunteers
- 458 people
- Sponsor
- Shanghai MicroPort Medical (Group) Co., Ltd.
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