Clinical trials: Ischemic Leg
Peripheral Arterial Disease (PAD)
Post-marketing Study in Femoral Popliteal Artery of Drug Coated Balloon Used for Treatment of Lower Limb Ischemia
The objective of this prospective, multi-center, single arm study is to obtain further data on the safety and performance of the Drug-coated Balloon catheters in the treatment of the Superficial Femoral Artery (SFA) and Popliteal…
- Trial name
- UltraFuture I (NCT05498740)
- Testing
- Drug eluting Balloon
- Where
- 24 sites in China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Zhejiang Zylox Medical Device Co., Ltd.
Myocardial Infarction, Stroke
Women's Health Initiative Strong and Healthy Study
The WHISH trial applies state-of-the science behavioral principles and currently available technologies to deliver a physical activity intervention without face-to-face contact to ~25,000 older U.S. women expected to consent.
- Conditions
- Myocardial Infarction, Stroke, Cardiovascular Mortality, Hip Fractures
- Trial name
- WHISH (NCT02425345)
- Testing
- Physical Activity
- Volunteers
- 49,331 people, healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center
Diabetes, Foot Ulcers
Outcomes of Non-infected Diabetic Foot Ulcers With/Without Antibiotics
The overall objective is to investigate whether antibiotics in the treatment of clinically clean neuropathic and ischaemic ulcers in diabetic foot patients could reduce the incidence of infection and therefore lead to improved…
- Conditions
- Diabetes, Foot Ulcers, Infection
- Trial name
- KADFUT (NCT01418456)
- Testing
- antibiotics
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- King's College Hospital NHS Trust
Peripheral Arterial Occlusive Disease Fontaine Stage IIa
Acute Local Metabolomic Alterations in Blood and Muscle Tissue in Intermittent Claudication
The most common clinical presentation of lower extremity arterial disease is intermittent claudication. Current understanding of the pathophysiology of intermittent claudication, as well as its treatment options are limited.
- Trial name
- NCT05111379
- Where
- Estonia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Tartu
Coronary Heart Disease, Stroke
Examining the Long-Term Risks of Oophorectomy
At the time of hysterectomy for benign disease, the overall health benefits of preserving ovarian function in a large population of women have not been established.
- Conditions
- Coronary Heart Disease, Stroke, Breast Cancer, Ovarian Cancer
- Trial name
- NCT00655447
- Where
- United States
- Volunteers
- 32,175 people, healthy volunteers welcome
- Sponsor
- Parker, William H., M.D.
Microcirculation, Orthostatic Intolerance
Influence of RIC on the Orthostatic Competence of the Microcirculation
The goal of this clinical trial (pilot study) is to learn about the microcirculatory regulation of the lower extremity under orthostatic stress with and without RIC - Remote Ischemic Preconditioning in healthy participants.
- Conditions
- Microcirculation, Orthostatic Intolerance, Remote Ischemic Preconditioning, Hemodynamics
- Trial name
- NCT05990907
- Testing
- Remote ischemic preconditioning
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- ISAR Klinikum
Diabetes Mellitus, Type 1, Ischemia
Non-enhanced Magnetic Resonance Angiography of Diabetic Ischemic Lower Limbs
Diabetic foot ulcers often progresses after many years of diabetes where the patients system is so damaged that normal heeling of ulcers cannot happen.
- Conditions
- Diabetes Mellitus, Type 1, Ischemia, Foot Ulcer
- Trial name
- NCT01614379
- Where
- 2 sites in Denmark
- Volunteers
- healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Myocardial Injury After Non-cardiac Surgery, Hypotension During Surgery
The Effects of General Versus Spinal Anesthesia on Postoperative Myocardial Injury
In this prospective, randomized, single-blind study, we aim to compare the effects of general anesthesia and spinal anesthesia on postoperative myocardial injury in elderly patients undergoing hip surgery.
- Conditions
- Myocardial Injury After Non-cardiac Surgery, Hypotension During Surgery, Anesthesia, General, Anesthesia, Spinal
- Trial name
- NCT06343259
- Testing
- General Anesthesia, Spinal Anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Diabetic Foot, Peripheral Arterial Disease
Microwave Radiometry Thermometry for the Diagnosis of Critical Limb Ischemia in Diabetic Patients
Diagnosis of vascular involvement in diabetic foot disease remains challenging. Differential diagnosis between pure neuropathic or neuro-ischemic diabetic foot requires a combination of clinical examination, medical history and…
- Conditions
- Diabetic Foot, Peripheral Arterial Disease, Ischaemic Neuropathy
- Trial name
- NCT03002116
- Testing
- Tissue thermometry using non-invasive microwave radiometry device
- Where
- 3 sites in Greece, United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Attikon Hospital
STEMI - ST Elevation Myocardial Infarction
Noninvasive Artificial Venous Stasis for Reperfusion in STEMI
This prospective, randomized study was designed to evaluate whether the noninvasive artificial venous stasis / RE-START procedure, administered prior to primary percutaneous coronary intervention, increases the frequency of…
- Trial name
- RE-START (NCT07689591)
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Firat University
Diabetic Foot, Lower Limb Ischemia
Stem Cell Therapy for Patients With Vascular Occlusive Diseases Such as Diabetic Foot
Mesenchymal stem cells with multidirectional differentiation potential,autologous stem cell transplantation into ischemic foot, make its differentiation to form new blood capillary, improve and restore the local blood flow.
- Trial name
- NCT02304588
- Testing
- Mesenchymal stem cells
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Physical Performance, Neuromuscular Function
Tissue Flossing and Lower Limb Neuromuscular Function
There is no study investigating different volumes, that is various sets of the configuration of tissue flossing on neuromuscular function.
- Conditions
- Physical Performance, Neuromuscular Function, Tissue Flossing, Ischemic Preconditioning
- Trial name
- MF2-TMG-CMJ (NCT05219344)
- Testing
- Tissue flossing
- Where
- Slovenia
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Ljubljana
Aging, Walking, Difficulty
Chronic Wounds and Blood Circulation Detection
Lower limb circulatory insufficiency and the associated chronic wounds are common health problems among the elderly. These issues not only affect the individual's mobility and quality of life but also potentially increase medical…
- Conditions
- Aging, Walking, Difficulty, Chronic Limb-Threatening Ischemia, Chronic Disease
- Trial name
- NCT07330635
- Testing
- Intervention 1: Mixed exercise program, Intervention 2: High-intensity rowing exercise, Intervention 3: Vibration exercise
- Where
- Taiwan
- Volunteers
- 425 people, healthy volunteers welcome
- Sponsor
- National Health Research Institutes, Taiwan
Wound Healing
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Study of Single and Repeated Doses of Topical GSK1278863
This is a randomized, placebo-controlled, single-blind (subjects and investigators will be blinded, GSK internal personnel will not be blinded), parallel-group, two part (Part A, Part B) trial in healthy volunteers and subjects…
- Trial name
- NCT01831804
- Testing
- GSK1278863
- Where
- 7 sites in United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Chronic Limb-threatening Ischemia, Microtia
the Gut Microbiome and Metabolomics in Chronic Lower extreMities Threatening Ischemia
Intestinal floras and their metabolites are involved in progressing metabolic and cardiovascular diseases. However, currently, articles related to the relationship between intestinal floras and atherosclerosis mainly focus on…
- Trial name
- MMM (NCT06220994)
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Myocardial Ischemia, Diabetes Complication
Evaluation of Perioperative Myocardial Injury in Patients Undergoing Below-Knee Lower Extremity Surgery
The aim of this observational study was to detect myocardial damage by monitoring high-sensitive troponin I levels in patients undergoing below-knee extremity surgery with peripheral nerve block.
- Trial name
- NCT07241572
- Testing
- high sensitive Troponin I
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Diabetic Foot Ulcer
Low Level Laser Therapy and Expression of VEGF, NO, VEGFR-2, HIF-1α in Diabetic Foot Ulcers
The purpose of this study is to examine the changes of factors including Vascular Endothelial Growth Factor(VEGF), VEGFReceptor-2, Nitric Oxide and hypoxia-inducible factor-1α (HIF-1α), measurements of oxygen saturation in…
- Trial name
- NCT02452086
- Testing
- Low Level Laser(Ga-As)
- Where
- Iran
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Tarbiat Modarres University
Percutaneous Transluminal Angioplasty, Atherosclerosis of Arteries of the Extremities, Unspecified
Skin Microcirculation in Patients With Lower Limb Atherosclerosis
The aim of this study is to explore the ability of the non-invasive device ODI-Tech® to monitor changes in microvascular blood flow in patients with lower limb ischemia undergoing the procedure percutaneous transluminal…
- Trial name
- SMILLA (NCT07312383)
- Testing
- Examination with the ODI-Tech medical device
- Where
- Norway
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- ODI Medical AS
Diabetic Retinopathy, Macular Degeneration
Advancing Understanding of Transportation Options
This Stage II randomized, controlled, longitudinal trial seeks to assess the acceptability, feasibility, and effects of a driving decision aid use among geriatric patients and providers.
- Conditions
- Diabetic Retinopathy, Macular Degeneration, Glaucoma, Retinitis Pigmentosa
- Trial name
- AUTO (NCT04141891)
- Testing
- Driving Decision Aid, Older Drivers Website
- Where
- 3 sites in United States
- Volunteers
- 529 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Critical Limb Ischaemia, Claudication
Peripheral Vascular Disease and Nerve Stimulation
A study to see what effect the geko™ device has on blood flow in patients with lower limb vascular disease.
- Conditions
- Critical Limb Ischaemia, Claudication, Ulcers, Varicose Veins
- Trial name
- CCLINS (NCT01942941)
- Testing
- geko™ electrical stimulation
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Hull University Teaching Hospitals NHS Trust