Clinical trials: Ischemic Lesions
Coronary Artery Disease
BIOTRONIKS - Safety and Performance in de NOvo Lesion of NatiVE Coronary Arteries With Magmaris- Registry: BIOSOLVE-IV
The registry will investigate the clinical performance and long-term safety of Magmaris in a real world setting
- Trial name
- BIOSOLVE-IV (NCT02817802)
- Testing
- Magmaris
- Where
- 2 sites in Belgium, Hong Kong
- Volunteers
- 2,066 people
- Sponsor
- Biotronik AG
Coronary Artery Disease
Advanced NanoTherapies Dual-API DCB to Treat De-Novo Lesions in Patients With Symptomatic Coronary Artery Disease
This prospective, single-arm, multi-center, safety and feasibility first-in-human study will evaluate the safety and feasibility of the SirPlux Duo™ Dual-API Coated PTCA Balloon Catheter to treat de-novo lesions between ≥2.0 and…
- Trial name
- ADVANCE-DCB (NCT05521542)
- Testing
- SirPlux Duo™ Dual-API Coated PTCA Balloon Catheter
- Where
- 5 sites in Australia, Dominican Republic and 1 more
- Volunteers
- 28 people
- Sponsor
- Advanced NanoTherapies
Coronary Artery Disease
Nordic-Baltic Coronary Revascularization Study in Patients With Proximal Left Descending Coronary Artery (LAD) Lesion.
The Nordic-Baltic Heart Team Initiative for improved long-term coronary artery revascularization outcome compares quality of life and survival after coronary bypass grafting (CABG) vs.
- Trial name
- NOBLE-LAD (NCT03538886)
- Testing
- Coronary artery bypass grafting (CABG), Percutaneous coronary intervention (PCI)
- Where
- Denmark
- Volunteers
- 4 people
- Sponsor
- Aalborg University Hospital
Coronary Disease
Lipid Rich Necrotic Core Lesion Detected by Cardiac Magnetic Resonance Imaging (CMR)
The purpose of this study is to evaluate whether some features of plaques in coronary arteries predispose the heart muscle to injuries during angioplasty in patients with a narrowing in at least one of the arteries that may need…
- Trial name
- Hawaii (NCT01284270)
- Testing
- Cardiac MRI
- Sponsor
- Piedmont Healthcare
Coronary Artery Disease
The Treatment of Coronary Artery Lesions Using the PRO-Kinetic Energy Cobalt-Chromium, Bare-Metal Stent
The purpose of this study is to the assess the clinical performance of the BIOTRONIK PRO-Kinetic Energy stent in subjects with atherosclerotic disease of native coronary arteries.
- Trial name
- BIOHELIX-II (NCT01811927)
- Testing
- PRO-Kinetic Energy Stent
- Where
- 3 sites in Netherlands, Switzerland
- Volunteers
- 43 people
- Sponsor
- Biotronik AG
Coronary Arterial Disease (CAD)
Comparative of Plasma Proteomics & Metabolomics in Coronary Artery Disease: Obstructive,Non-Obstructive, & No Lesions
The presence and clinical evolution of coronary atherosclerosis depend on various classic risk factors and biomarkers. However, the search for more specific markers is necessary, especially for individuals with non-obstructive…
- Trial name
- PROTEODAC (NCT06900270)
- Where
- Brazil
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Critical Limb Ischemia
MOTIV BTK Randomized Controlled Trial
Pre-market clinical evaluation of the MOTIV Sirolimus-Eluting Bioresorbable Scaffold for the planned treatment of infrapopliteal lesions.
- Trial name
- NCT05406622
- Testing
- MOTIV Sirolimus-Eluting Bioresorbable Scaffold, Percutaneous Transluminal Angioplasty (PTA) Device
- Where
- 26 sites in United States, Germany
- Volunteers
- 292 people
- Sponsor
- REVA Medical, Inc.
In-Stent Restenosis, Cardiovascular Diseases
MagicTouch for Treatment of In-Stent Restenosis in Coronary Artery Lesions
A Prospective, Multicenter, Randomized, Two-Arm, Single-blind Superiority Trial to Evaluate the Safety and Efficacy of the MagicTouch™ Sirolimus- Coated Balloon in the Treatment of Coronary Drug-Eluting Stent In-Stent Restenosis.
- Conditions
- In-Stent Restenosis, Cardiovascular Diseases, Coronary Artery Disease
- Trial name
- MAGICAL ISR (NCT05908331)
- Testing
- Sirolimus Drug Coated Balloon, Plan balloon Angioplasty (POBA)
- Where
- 28 sites in United States
- Volunteers
- 492 people
- Sponsor
- Concept Medical Inc.
Coronary Artery Disease
Prevail Global Study
The purpose of the study is to evaluate the clinical safety and efficacy of the Prevail DCB.
- Trial name
- NCT06535854
- Testing
- Prevail DCB, Agent DCB
- Where
- 79 sites in United States, Canada and 7 more
- Volunteers
- 1,205 people
- Sponsor
- Medtronic Vascular
Coronary Artery Disease
Aspirin and a PoTent P2Y12 Inhibitor Versus Aspirin and Clopidogrel in Patients Undergoing PCI for Complex Lesion
This study is a prospective, open label, two-arm, randomized multicenter trial to evaluate the efficacy and safety of aspirin plus prasugrel as compared with aspirin plus clopidogrel in patients undergoing elective percutaneous…
- Trial name
- ATTEMPT (NCT04014803)
- Testing
- Dual antiplatelet therapy with a P2Y12 inhibitor plus aspirin
- Where
- 2 sites in South Korea
- Volunteers
- 3,500 people
- Sponsor
- Samsung Medical Center
Coronary Artery Disease (CAD), Coronary Bifurcation Lesion
Stenting Versus Drug Eluting Balloons Only in Treatment of Coronary Bifurcation Lesion (ROBUST Study)
The goal of this clinical trial is to learn immediate and follow up results of percutaneous treatment of coronary bifurcation lesion using drug eluting balloons (DEB) only in patients with chronic coronary syndrome (CCS).
- Conditions
- Coronary Artery Disease (CAD), Coronary Bifurcation Lesion, Coronary Stenting, Drug Eluting Balloon
- Trial name
- ROBUST (NCT07552194)
- Testing
- Balloon Angioplasty with or without drug administration
- Volunteers
- 272 people
- Sponsor
- Avtandil M. Babunashvili
Ischemic White Matter Lesions (WMIL), Cerebral Small Vessel Disease
Atorvastatin Mitigates WMH-Related Cognitive Impairment by Reducing VCAM-1
This prospective study will enroll patients younger than 60 years with ischemic white matter lesions (WMIL) and age-matched healthy controls.
- Conditions
- Ischemic White Matter Lesions (WMIL), Cerebral Small Vessel Disease, Vascular Cell Adhesion Molecule-1, VCAM-1
- Trial name
- NCT07128212
- Testing
- Atorvastatin 10 mg daily
- Where
- China
- Volunteers
- 401 people, healthy volunteers welcome
- Sponsor
- Suzhou Municipal Hospital of Anhui Province
Coronary Artery Disease, Drug-coated Balloon
Long-term Efficacy of Drug-coated Balloon Versus Drug-eluting Stent in Large de Novo Coronary Lesions
To evaluate the efficacy of drug-coated balloon versus drug-eluting stent for the treatment of large de novo coronary lesions(RVD=2.75~4.0mm).
- Trial name
- NCT05101005
- Testing
- Drug-Coated Balloon, Sirolimus-Eluting Stent
- Volunteers
- 400 people
- Sponsor
- Lepu Medical Technology (Beijing) Co., Ltd.
Cardiovascular Diseases, Coronary Artery Disease
The ASSURE ROT Registry: Bioresorbable Vascular Scaffold Following Rotablation for Complex Coronary Lesions
The registry aims to evaluate the safety, performance and efficacy of the Everolimus-eluting bioresorbable vascular scaffold (BVS) system following rotational atherectomy in patients with complex de novo native coronary artery…
- Conditions
- Cardiovascular Diseases, Coronary Artery Disease, Myocardial Ischemia, Coronary Disease
- Trial name
- ASSURE ROT (NCT01915420)
- Where
- Germany
- Volunteers
- 42 people
- Sponsor
- Medical Care Center Prof. Mathey, Prof. Schofer, Ltd.
Coronary Artery Disease, Native Coronary Artery Stenosis
MagicTouch™Sirolimus-Coated Balloon for Treatment of Coronary Artery Lesions in Small Vessels
This is a multicenter, randomized, single-blind pivotal study to evaluate the safety and efficacy of the MagicTouchTM Drug coated balloon in treatment of small vessels in patients with coronary artery disease.
- Conditions
- Coronary Artery Disease, Native Coronary Artery Stenosis, Cardiovascular Diseases
- Trial name
- MAGICAL SV (NCT06271590)
- Testing
- Sirolimus Drug Coated Balloon, Drug eluting stents (DES)
- Where
- 24 sites in United States
- Volunteers
- 1,605 people
- Sponsor
- Concept Medical Inc.
Coronary Artery Disease
Optical Coherence Tomography in Long Lesions
Increasing lesion complexity in percutaneous coronary interventions (PCI) has warranted the use of overlapping drug-eluting stents.
- Trial name
- LONG OCT (NCT01133925)
- Testing
- Resolute Sprint, Sirolimus Eluting Stent, Paclitaxel Eluting Stent
- Where
- Italy
- Volunteers
- 22 people
- Sponsor
- A.O. Ospedale Papa Giovanni XXIII
Coronary Artery Disease
DEBSCAN-IVL. Drug Eluting Balloon or Drug Eluting Stent to Treat CAlcified Nodules After IntraVascular Lithotripsy.
International, investigator-driven, multicenter, open-label, prospective randomized controlled trial where patients with de novo lesions due to calcified nodules (CN) were randomized to drug eluting balloon (DEB) or drug eluting…
- Trial name
- DEBSCAN-IVL (NCT06657833)
- Testing
- Percutaneous coronary intervention of a calcified nodule with intravascular lithotripsy followed by drug eluting balloon, Percutaneous coronary intervention of a calcified nodule with intravascular lithotripsy followed by drug eluting stent
- Where
- 15 sites in Netherlands, Spain
- Volunteers
- 128 people
- Sponsor
- Fundación EPIC
Coronary Artery Disease
A Study of the TAXUS Liberté Stent for the Treatment of de Novo Coronary Artery Lesions in Small Vessels
TAXUS ATLAS Small Vessel is a global, multi-center, single-arm, trial of patients with coronary arteries less than 2.5 mm in diameter who are treated with the TAXUS Liberté stent versus an historical TAXUS Express control derived…
- Trial name
- NCT00371748
- Testing
- TAXUS Liberté-SR, TAXUS™ Express2, Express2
- Where
- 25 sites in United States, New Zealand and 1 more
- Volunteers
- 261 people
- Sponsor
- Boston Scientific Corporation
Acute Stroke, Hyperglycemia
SELESTIAL: Trial of Insulin to Control Blood Sugar After Acute Stroke Using Magnetic Resonance Imaging (MRI) End-Points
High blood sugar (hyperglycaemia) affects 40% of acute stroke patients and has a major adverse effect on survival and recovery. Increased production of lactic acid in brain tissue that has a poor blood supply is postulated to be…
- Trial name
- NCT00124826
- Testing
- Insulin
- Where
- United Kingdom
- Volunteers
- 45 people
- Sponsor
- University of Glasgow
Peripheral Arterial Diseases
Auryon Atherectomy System With Standard Balloon Angioplasty Versus Standard Balloon Angioplasty Alone
The goal of this clinical trial is to learn if the Auryon Atherectomy System with balloon angioplasty safe and effective in treating lower limb blockages.
- Trial name
- AMBITION BTK (NCT06777901)
- Testing
- Auryon Atherectomy System, Balloon Angioplasty
- Where
- 9 sites in United States
- Volunteers
- 224 people
- Sponsor
- Angiodynamics, Inc.