Clinical trials: Ischemic Symptoms
Chronic Coronary Syndrome, Coronary Artery Disease
Feasibility of a Deep Learning-based Algorithm for Non-invasive Assessment of Vulnerable Coronary Plaque
The primary objective of this study is to assess the accuracy in terms of sensitivity, specificity, negative and positive predicted values of the DL-based algorithm with respect to correct identification of the plaque and…
- Conditions
- Chronic Coronary Syndrome, Coronary Artery Disease, Stable Angina, Acute Coronary Syndrome
- Trial name
- FOCUS DL (NCT06186336)
- Testing
- Deep Learning-based Vulnerable Plaque Detection and Assessment Tool
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- GE Healthcare
Diabetes Mellitus, Type 2, Myocardial Infarction
GLP-1RAs) and SGLT2is Combination Therapy and MACEs in Patients with Type 2 Diabetes.
Management of type 2 diabetes mellitus (T2DM) has evolved from a glucocentric to a cardiometabolic approach. Both glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium-glucose cotransporter-2 inhibitors (SGLT2is) reduce…
- Trial name
- NCT06017544
- Testing
- PCI
- Where
- Italy
- Volunteers
- 257 people
- Sponsor
- University of Campania Luigi Vanvitelli
Coronary Disease, Myocardial Infarction
Stem Cell Therapy to Improve Myocardial Function in Patients Undergoing Coronary Artery Bypass Grafting (CABG)
The purpose of this study is to determine whether intracoronary transfer of autologous bone marrow cells can induce angiogenesis, subsequently improving regional myocardial perfusion, and finally resulting in improved systolic…
- Trial name
- NCT00395811
- Testing
- Bone Marrow Stem Cell Therapy combined CABG
- Where
- China
- Volunteers
- 50 people
- Sponsor
- China National Center for Cardiovascular Diseases
Infarction, Middle Cerebral Artery, Middle Cerebral Artery Stroke
Multicenter Efficacy Study of Recombinant Human Erythropoietin in Acute Ischemic Stroke
The purpose of this randomized, double-blind, placebo-controlled multicenter study is to determine in a cohort of 506 patients with acute ischemic stroke in the middle cerebral artery territory, the effect of a three-day…
- Conditions
- Infarction, Middle Cerebral Artery, Middle Cerebral Artery Stroke, Stroke, Acute
- Trial name
- ESS (NCT00604630)
- Testing
- recombinant human erythropoietin alfa, 0.9% NaCl
- Where
- 9 sites in Germany
- Volunteers
- 522 people
- Sponsor
- Max-Planck-Institute of Experimental Medicine
Cardiovascular Diseases, Coronary Disease
Intravenous Streptokinase in Acute Myocardial Infarction
To determine whether the administration of intravenous streptokinase (SK) early in the course of acute, transmural myocardial infarction would limit myocardial damage.
- Conditions
- Cardiovascular Diseases, Coronary Disease, Heart Diseases, Myocardial Infarction
- Trial name
- NCT00000507
- Testing
- streptokinase
- Sponsor
- University of Washington
Myocardial Infarction
The Impact of Compound Danshen Dropping Pills (CDDP) on the Post-myocardial Infarction Ventricular Remodeling
This study is designed to evaluate the efficacy and safety of compound Danshen dropping pills (CDDP) in improving ventricular remodeling and cardiac function after acute anterior wall ST-Elevation myocardial infarction(STEMI).
- Trial name
- NCT05000411
- Testing
- Compound Danshen Dropping Pills (CDDP)
- Where
- China
- Volunteers
- 268 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Arterial Line, Ischemia
Subcutaneous Nitroglycerin to Prevent Radial Artery Occlusion in Children
The primary objective of the study is to evaluate the vasodilative effect of subcutaneous nitroglycerin to prevent radial arterial occlusion(RAO) after removal of the radial arterial catheter in pediatric patients.
- Trial name
- NCT05443061
- Testing
- Nitroglycerin, Normal saline
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Seoul National University Hospital
Coronary Artery Disease, Internal Mammary-Coronary Artery Anastomosis
Clinical Efficacy of Permanent Internal Mammary Artery Occlusion in Stable Coronary Artery Disease
Cardiovascular diseases remain the number one cause of death globally, primarily consequence of myocardial infarction. Although widely used in stable coronary artery disease (CAD), percutaneous coronary intervention (PCI) has not…
- Conditions
- Coronary Artery Disease, Internal Mammary-Coronary Artery Anastomosis, Ischemia, Circulation, Collateral
- Trial name
- NCT03710070
- Testing
- Amplatzer vascular plug 4
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Congenital Heart Disease, Atherosclerosis
Cardiovascular Disease Screening
This study will evaluate volunteers 18 years of age and older to see if they qualify for one of NHLBI s research studies. Tests include the following: General medical evaluation, which may include blood tests, chest x-ray…
- Conditions
- Congenital Heart Disease, Atherosclerosis, Myocardial Ischemia, Myocardial Infarction
- Trial name
- NCT00483951
- Testing
- Toshiba Aquilion ONE CT, SWiemens MRI scanner
- Where
- 2 sites in United States
- Volunteers
- 1,325 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Vision Loss Partial, Vision; Loss, Both Eyes
Effect of Visual Retraining After Stroke
This project is intended to collect data using standard clinical tests and psychophysics to quantify the effect of visual cortical damage on the structure of the residual visual system, visual perception, spatial awareness, and…
- Conditions
- Vision Loss Partial, Vision; Loss, Both Eyes, Hemianopia Homonymous, Hemianopia
- Trial name
- urochester (NCT06121219)
- Testing
- Training in the Blind Field
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Acute Ischemic Stroke, Atrial Fibrillation
Early Versus Late Initiation of Anticoagulation in Mild-to-moderate AIS Patients With NVAF
The goal of this clinical trial is to compare the effectiveness between early and late initiation of anticoagulation therapy in acute ischemic stroke (AIS) patients with non-valvular atrial fibrillation (NVAF).
- Trial name
- ASAP (NCT06057467)
- Testing
- Anticoagulation Agents
- Where
- 2 sites in China
- Volunteers
- 2,351 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Cardiovascular Diseases, Heart Diseases
National Growth and Health Study (NGHS)
To determine if the Black-white differences in the development of obesity in pubescent females were due to differences in psychosocial, socioeconomic and other environmental factors.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Obesity, Coronary Disease
- Trial name
- NCT00005132
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Depression, Acute Coronary Syndrome
The Effect of MElatonin on Depression, Anxiety, CIrcadian and Sleep Disturbances in Patients After Acute Myocardial Syndrome
The objective of the study is to investigate whether prophylactic treatment with melatonin has an effect on depressive symptoms. Secondarily melatonin's effect on anxiety, sleep and circadian disturbances will be investigated.
- Trial name
- MEDACIS (NCT02451293)
- Testing
- Melatonin (N-acetyl-5-methoxytryptamine)
- Where
- 6 sites in Denmark
- Volunteers
- 252 people
- Sponsor
- Zealand University Hospital
Statins, Myocardial Infarction
Statin Eligibility Prior to Myocardial InfarCtion
The study (Statin Eligibility Prior to myocardial infarction (MI) in Jordanians, StatinEPIC) is 1. Cross sectional 2. Non interventional 3. One encounter per patient. No follow up.
- Trial name
- StatinEPIC (NCT03485742)
- Testing
- No intervention
- Where
- 5 sites in Jordan
- Volunteers
- 740 people
- Sponsor
- Jordan Collaborating Cardiology Group
Hemodilution, Coronary Artery Disease
Retrograde Autologous Priming and Mannitol for Reducing Hemodilution in Cardiac Surgery
Hemodilution reduces concentrations of blood constituents: concentration of hemoglobin, red blood cells (hematocrit), physiological ions and coagulation factors that can contribute to impaired hemostasis and increasing the risk…
- Conditions
- Hemodilution, Coronary Artery Disease, Fluid Overload
- Trial name
- RAPPER-MAN (NCT04870073)
- Testing
- Retrograde autologous priming, Mannitol, Conventional Priming
- Where
- Canada
- Sponsor
- Hamilton Health Sciences Corporation
Cardiogenic Shock
ECMOsorb Trial - Impact of a VA-ECMO in Combination With CytoSorb in Critically Ill Patients With Cardiogenic Shock
In the ECMOsorb study the impact of a veno-arterial -ECMO in combination with an extracorporeal cytokine hemadsorption system in critically ill patients with cardiogenic shock is to be examined
- Trial name
- ECMOsorb (NCT05027529)
- Testing
- CytoSorb, VA-ECMO only
- Where
- Germany
- Volunteers
- 42 people
- Sponsor
- Christian Schulze
Ischemic Stroke, Acute Disease
Adjunctive Intra-arterial Tenecteplase Following Mechanical Thrombectomy (ALLY) II Trial
The study objective is to evaluate the safety and efficacy of Intra arterial (IA) Tenecteplase (TNK) as an adjunctive therapy in acute ischemic stroke (AIS) patients with large vessel occlusions (LVO) in the anterior circulation…
- Trial name
- ALLY II TNK (NCT06949228)
- Testing
- tenecteplase
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- ProMedica Health System
Stable Coronary Artery Disease
Prognostic Models for People With Stable Coronary Artery Disease
There is currently no published algorithm for secondary prevention prognosis of CHD that is representative of the England GP-registered population and that includes both symptomatic and asymptomatic patients (as identified…
- Trial name
- NCT01609465
- Where
- United Kingdom
- Volunteers
- 300,000 people
- Sponsor
- University College, London
Stroke, Acute Stroke
Effectiveness of Best Care Practices in Acute Stroke in Conventional Hospitalization (BEST CARE ICTUS_HC)
The goal of this clinical trial is to evaluate whether a multicomponent nurse-led intervention (BEST CARE ICTUS_HC) can reduce stroke-related complications and improve recovery in adults (18 years and older) hospitalized with an…
- Conditions
- Stroke, Acute Stroke, Ischemic Stroke, Hemorrhagic Stroke
- Trial name
- BESTCAREICTUS (NCT07627399)
- Testing
- BEST CARE ICTUS_HC BUNDLE
- Where
- 4 sites in Spain
- Volunteers
- 700 people
- Sponsor
- University of Malaga
Socioeconomic Status, Secondary Prevention
Socioeconomic Status, Secondary Prevention Activities and Recurrence After a Myocardial Infarction
This is a nationwide cohort study on real-world patients (n≈30,000) surviving a first myocardial infarction (MI) 2006-2013 and alive to attend a routine 1-year follow-up.
- Conditions
- Socioeconomic Status, Secondary Prevention, Myocardial Infarction, Cardiovascular Disease
- Trial name
- NCT04199663
- Volunteers
- 30,191 people
- Sponsor
- Karolinska Institutet
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