Clinical trials: Ischemic White Matter Disease
Ischemic White Matter Disease, Transient Ischemic Attack
Cognitive Changes and Rehabilitation in People With Transient Ischemic Attack, Stroke, or Stroke Risk Factors
Stroke is a leading cause of disability; most strokes (80%) are subcortical, with ischemic damage due to occlusion in penetrating arteries.
- Conditions
- Ischemic White Matter Disease, Transient Ischemic Attack, Mild Stroke, Stroke Risk
- Trial name
- NCT01951612
- Testing
- Executive Function Training Program, Psychoeducational Training Program
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Baycrest
Cerebral Small Vessel Diseases, Cerebral Small Vessel Ischemic Disease
Cambridge 7 Tesla Cerebral Small Vessel Disease Study
CamSVD is jointly sponsored by the University of Cambridge and Cambridge University Hospitals NHS Foundation Trust. We aim to explore and understand the underlying arterial pathology in Cerebral Small Vessel Disease (SVD) using…
- Conditions
- Cerebral Small Vessel Diseases, Cerebral Small Vessel Ischemic Disease, Lacunar Stroke
- Trial name
- CamSVD (NCT04330222)
- Testing
- 7 Tesla Magnetic Resonance Imaging, Brief Memory and Executive Test
- Where
- United Kingdom
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- University of Cambridge
Heart Arrest, Out-Of-Hospital, Computed Tomography
Head Computed Tomography for Predicting Neurological Outcome After Cardiac Arrest
The European Resuscitation Council (ERC) and the European Society of Intensive Care Medicine (ESICM) joint guidelines for post-resuscitation care recommend a multimodal approach to prognostication of neurological outcome.
- Conditions
- Heart Arrest, Out-Of-Hospital, Computed Tomography, Unconsciousness, Neurologic Deficits
- Trial name
- NCT03913065
- Testing
- CT
- Where
- Sweden
- Volunteers
- 400 people
- Sponsor
- Lund University
Migraine, Small Vessel Ischemic Disease
A Study to Evaluate White Matter Hyperintensities in Migraine
The purpose of this research is to better understand brain white matter hyperintensities (WMH) in women with migraines
- Conditions
- Migraine, Small Vessel Ischemic Disease, Multiple Sclerosis
- Trial name
- NCT05112289
- Testing
- Brain Neuroimaging
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Mayo Clinic
Chronic Stable Angina, Vascular Dementia
The Effect of Danzhu Fuyuan Granule as Adjunctive Therapy for Chronic Stable Angina, Vascular Dementia and Idiopathic Membranous Nephropathy: A Bayesian Basket Trial
This study is designed as a bayesian basket trial , which aims to evaluate the efficacy of Danzhu Fuyuan Granule in patients with Chronic Stable Angina, Vascular Dementia and Idiopathic Membranous Nephropathy
- Conditions
- Chronic Stable Angina, Vascular Dementia, Idiopathic Membranous Nephropathy
- Trial name
- NCT04498962
- Testing
- Danzhu Fuyuan Granule
- Where
- 7 sites in China
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Jingqing Hu
Leukodystrophy, White Matter Disease
LeukoSEQ: Whole Genome Sequencing as a First-Line Diagnostic Tool for Leukodystrophies
Leukodystrophies, and other heritable disorders of the white matter of the brain, were previously resistant to genetic characterization, largely due to the extreme genetic heterogeneity of molecular causes.
- Conditions
- Leukodystrophy, White Matter Disease, 4H Syndrome, Adrenoleukodystrophy
- Trial name
- NCT02699190
- Where
- United States
- Volunteers
- 236 people
- Sponsor
- Children's Hospital of Philadelphia
CADASIL
Imaging Study of Neurovascular Coupling in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (CADASIL)
The aim of this study is to investigate using fMRI methods, EEG and dedicated mathematical models, the potential alterations of neurovascular coupling in CADASIL.
- Trial name
- MACOUPLING-CAD (NCT02071784)
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Cerebrovascular Disorders, Dementia
Study of Factors Influencing Post-stroke Dementia
If the risk of dementia occurrence after stroke is well known, few data exist about the factors influencing positively or negatively the developement of cognitive disorders or dementia.
- Trial name
- strokdem (NCT01330160)
- Where
- 4 sites in France
- Volunteers
- 229 people
- Sponsor
- University Hospital, Lille
Ischaemic Stroke, Alzheimer's Disease
Cognition And Neocortical Volume After Stroke
Stroke and dementia are two of the most common and disabling conditions worldwide, responsible for an enormous and growing burden of disease.
- Conditions
- Ischaemic Stroke, Alzheimer's Disease, Vascular Dementia
- Trial name
- CANVAS (NCT02205424)
- Where
- 3 sites in Australia
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- The Florey Institute of Neuroscience and Mental Health
Frontotemporal Dementia, Dementia
Care of Persons With Dementia in Their Environments (COPE) in Programs of All-Inclusive Care of the Elderly (PACE)
The protocol is organized into three Phases - In Phase I an online training program will be developed in "Care of Persons with Dementia in their Environments" (COPE) -an evidence-based bio-behavioral dementia program -using…
- Conditions
- Frontotemporal Dementia, Dementia, Multi-Infarct Dementia, Vascular Dementia
- Trial name
- NCT04165213
- Testing
- Care of Older Persons in their Environment (COPE) online module training
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Dementia, Dementia, Vascular
Virtual Individual Cognitive Stimulation Therapy: a Proof of Concept Study
Due to COVID-19, the routine treatment for dementia, Cognitive Stimulation Therapy (CST), is currently suspended in multiple countries. Access to treatment is, therefore, paramount.
- Conditions
- Dementia, Dementia, Vascular, Dementia, Mixed, Dementia With Lewy Bodies
- Trial name
- V-iCST (NCT04828434)
- Testing
- Virtual Individual Cognitive Simulation Therapy
- Where
- United Kingdom
- Volunteers
- 34 people
- Sponsor
- University College, London
Cerebral Small Vessel Diseases, Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy
Retina is a Marker for Cerebrovascular Heath
Cerebral small vessel disease (SVD), present in 80-94% of adults over age 65 years, increases the risk of stroke by 2-fold, and dementia by 2.3-fold. There is currently no treatment to slow SVD progression.
- Conditions
- Cerebral Small Vessel Diseases, Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy, Cerebral Microbleeding, Sporadic White Matter Disease
- Trial name
- NCT04753970
- Testing
- Cilostazol
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Preterm Birth, Periventricular Leukomalacia
Neuroprotection by Magnesium Sulfate Given to Women at Risk of Very Preterm Birth
Magnesium is neuroprotective in neonatal animal models of acquired hypoxic-ischemic and/or inflammatory cerebral lesions. It is associated with a significant reduction of perinatal death and cerebral palsy in some observational…
- Conditions
- Preterm Birth, Periventricular Leukomalacia, Brain Ischemia, Intracranial Hemorrhages
- Trial name
- NCT00120588
- Testing
- magnesium
- Where
- France
- Volunteers
- 700 people
- Sponsor
- University Hospital, Rouen
Vascular Dementia, Cerebral Small Vessel Diseases
Trial of Remote Ischemic Pre-conditioning in Vascular Cognitive Impairment
Cerebral small vessel disease is a common cause of cognitive impairment. Remote ischemic pre-conditioning (RIC) is a technique to induce brief periods of limb ischemia-reperfusion that is hypothesized to increase tolerance of the…
- Conditions
- Vascular Dementia, Cerebral Small Vessel Diseases, Cerebral Small Vessel Ischaemic Disease, Vascular Cognitive Impairment
- Trial name
- TRIC-VCI (NCT04109963)
- Testing
- Remote ischemic conditioning
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- University of Calgary
CADASIL
Research Study on Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (CADASIL)
The purpose of this study is to delineate early neurological features and their progression in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) in order to…
- Trial name
- NCT01114815
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- NYU Langone Health
CADASIL, Cavernous Angioma
Biological Collection of the Rare Diseases of the Brain and Eye Vessels Cohort - 2
CERVCO is the French National Reference Centre for Rare Cerebrovascular and Retinal Diseases, accredited by the Ministry of Health since 2005.
- Conditions
- CADASIL, Cavernous Angioma, Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy, Small Vessel Disease
- Trial name
- B-MRVC2 (NCT07650110)
- Testing
- Biocollection, Neurological evaluation and Biocollection
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Perinatal Stroke, Hypoxic-ischemic Encephalopathy
Protein Supplementation in Infants With Brain Injury
To date, few studies have been done regarding nutrition supplementation in infants with brain injury. Therefore, the investigators are proposing to study the effects of protein supplementation in this group of babies.
- Conditions
- Perinatal Stroke, Hypoxic-ischemic Encephalopathy, White Matter Injury
- Trial name
- NCT01936246
- Testing
- Increased protein
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Cerebrovascular Disease, Ischemic Stroke
Florida Cerebrovascular Disease Biorepository and Genomics Center
The purpose of this study is to create a state-wide biorepository and resource center for cerebrovascular diseases in Florida, which will include collecting medical history information and blood from subjects affected by…
- Conditions
- Cerebrovascular Disease, Ischemic Stroke, Transient Ischemic Attack, Intracerebral Hemorrhage
- Trial name
- NCT05491980
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Mayo Clinic
Cognitive Decline, Dementia, Vascular
Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) Diet in Stroke Patients Patients
To test the effects of a 2- to 3-year intervention of the MIND diet versus usual post-stroke care on cognitive decline, the characteristic feature of dementia, and on brain biomarkers of Alzheimer's Disease (AD) and vascular…
- Conditions
- Cognitive Decline, Dementia, Vascular, Alzheimer Disease, Dementia
- Trial name
- NCT04337255
- Testing
- Behavioral Dietary intervention ( MIND Diet), Behavioral Usual Care Diet Intervention
- Where
- United States
- Volunteers
- 266 people
- Sponsor
- Rush University Medical Center
CADASIL, Cerebral Autosomal Dominant Arteriopatie With Subcortical Infarcts and Leukoencephalopathy
Long-term Prospective Study of Korean CADASIL Patients
K-CADASIL is a 10-year prospective study of 500 Korean patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), a genetic brain disease that causes stroke and dementia.
- Trial name
- K-CADASIL (NCT07497867)
- Where
- South Korea
- Volunteers
- 500 people
- Sponsor
- Jeju National University Hospital