Clinical trials: Islet Transplantation
Brittle Type 1 Diabetes Mellitus
Safety, Tolerability, and Efficacy of Immunomodulation With AT-1501 in Combination With Transplanted Islet Cells in Adults With Brittle T1D
This study will evaluate the safety, tolerability and efficacy of AT-1501 in an immunomodulation regimen in adult patients with T1D undergoing an islet cell transplant.
- Trial name
- NCT05480657
- Testing
- AT-1501 IV Infusion, Isolated cadaveric islet cells
- Where
- United States
- Sponsor
- Eledon Pharmaceuticals
Diabete Type 1, Chronic Kidney Disease
Breakthrough - T1DM and Chronic Kidney Disease
Single arm- subject treated with Tegoprubart and everolimus. The purpose of this research is to gather information on the safety and effectiveness of investigational regimen containing 2 experimental components: An…
- Trial name
- NCT07592000
- Testing
- Tegoprubart, Islet Cell Transplant
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- University of Chicago
Immunosuppression, Hyperlipidemias
Cholesterol and Fatty Acid Synthesis in Islet and Liver Transplant Patients and Effect of Dietary Intervention
The purpose is to investigate possible mechanisms of increased blood lipid levels following transplantation, and also to see if a comprehensive dietary intervention is effective in reducing blood lipid levels in post-transplant…
- Conditions
- Immunosuppression, Hyperlipidemias, Diabetes Mellitus, Type 1
- Trial name
- NCT00947635
- Testing
- Dietary intervention - supplements
- Where
- Canada
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Type 1 Diabetes Mellitus
Islet Transplantation in Type 1 Diabetic Patients Using the University of Illinois at Chicago (UIC) Protocol
In an earlier Phase 1/2 clinical trial using the Edmonton Protocol of steroid free immunosuppression, investigators at University of Illinois at Chicago (UIC) demonstrated the safety of islet preparation, iset transplantation…
- Trial name
- NCT00679042
- Testing
- Islets of Langerhans transplantation
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- CellTrans Inc.
Diabetes Mellitus, Type 1
Trial Comparing Metabolic Efficiency of Islet Graft to Intensive Insulin Therapy for Type 1 Diabetes's Treatment
Efficacy of pancreatic islet transplantation at 6 months compared to an intensive insulin therapy for 2 categories of patients: patients with unstable diabetes and patients who underwent kidney transplantation.
- Trial name
- TRIMECO (NCT01148680)
- Testing
- Islet Graft
- Where
- 9 sites in France, Switzerland
- Volunteers
- 50 people
- Sponsor
- University Hospital, Grenoble
Diabetes Mellitus, Type 2
Autologous Islet Transplantation for Diabetes
This study aims to conduct an exploratory clinical trial recruiting insulin-dependent diabetic patients who meet the criteria for islet transplantation.
- Trial name
- APPITD (NCT07118475)
- Testing
- Autologous islet transplantation
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Shanghai Zhongshan Hospital
Postpancreatectomy Hyperglycemia
Islet Autotransplantation in Patients at Very High-risk Pancreatic Anastomosis
The goal of the proposal is to demonstrate that, in patients with disease of the pancreatic head with very high-risk of complications of pancreatojejunal reconstruction (soft pancreas and pancreatic duct diameter <3 mm), total…
- Trial name
- PAN-IT (NCT01346098)
- Testing
- Pancreaticoduodenectomy with pancreatic anastomosis, Total pancreatectomy with islet autotransplantation
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Ospedale San Raffaele
Diabetes Mellitus, Type I
Islet Cell Transplantation Alone in Patients With Type 1 Diabetes Mellitus: Steroid-Free Immunosuppression
SPECIFIC AIMS: 1. To reverse hyperglycemia and insulin dependency in patients with Type 1 Diabetes Mellitus by islet cell transplantation; 2.
- Trial name
- NCT00306098
- Testing
- islets
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Rodolfo Alejandro
Diabetes Mellitus, Type 1
Study to Evaluate Safety and Efficacy of IBsolvMIR in Islet Transplantation
This is a Phase II open, randomized, active comparator-controlled multi center study in patients with severe type-1 diabetes. This is a two-armed study where patients are randomized in a 2:1 ratio between IBsolvMIR and heparin.
- Trial name
- NCT03867851
- Testing
- IBsolvMIR, Heparin
- Where
- 5 sites in Netherlands, Norway and 1 more
- Volunteers
- 7 people
- Sponsor
- TikoMed AB
Brittle Type 1 Diabetes
Allogeneic Transplantation of Expanded Pancreatic Islet Cells
This study will evaluate the efficacy and safety of allogeneic pancreatic islet cells transplantation in patients with "brittle" type 1 diabetes.
- Trial name
- NCT05990530
- Testing
- YD02-2022
- Where
- China
- Volunteers
- 6 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Type 1 Diabetes
Alemtuzumab Induction in Islet Transplantation
Our experience suggests that further research with alemtuzumab is attractive in islet transplantation. Therefore, in this study we propose to combine alemtuzumab induction pre-transplant, with tacrolimus and mycophenolate mofetil…
- Trial name
- NCT00175253
- Testing
- alemtuzumab, islet transplant
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- University of Alberta
Type I Diabetes
A Phase I/II Study of the Safety and Efficacy of Sernova's Cell PouchTM for Therapeutic Islet Transplantation
This is an open-label, single arm, non-randomized safety and efficacy study, where participants with Type-1 diabetes will receive the Sernova Cell Pouch™ implanted in the subcutaneous site, two to approximately twelve weeks prior…
- Trial name
- NCT01652911
- Testing
- Sernova Cell Pouch
- Where
- Canada
- Volunteers
- 3 people
- Sponsor
- University of Alberta
Type 1 Diabetes Mellitus
Efficacy of Islet After Kidney Transplantation
Type 1 diabetes is an autoimmune disease in which the insulin-producing pancreatic beta cells are destroyed, resulting in poor blood sugar control.
- Trial name
- NCT00468117
- Testing
- Islet transplantation, Antithymocyte Globulin, Daclizumab or Basiliximab
- Where
- 10 sites in United States, Canada
- Volunteers
- 24 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Diabetes Mellitus, Type 1
Islet Transplantation for Patients With Type 1 Diabetes
This protocol will test whether Type 1 diabetes (T1DM) can be reversed in patients with stable renal allografts by islet transplantation.
- Trial name
- NCT00073281
- Testing
- Islet transplantation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Transplant
Immune Response to Influenza Vaccine in Islet Cell Transplant Recipients
Influenza virus is an important cause of morbidity in the transplant population and can lead to viral and bacterial pneumonia. Although the annual influenza vaccine is recommended for organ transplant patients, studies have shown…
- Trial name
- NCT01149382
- Where
- Canada
- Volunteers
- 61 people
- Sponsor
- University of Alberta
Chronic Pancreatitis, Diabetes Mellitus
Closed Loop Insulin Pump Therapy After Islet Auto-Transplantation
The purpose of this study is to determine the effectiveness of closed loop insulin pump therapy to control blood sugar following total pancreatectomy and islet auto-transplantation (TPIAT).
- Trial name
- NCT01945138
- Testing
- Closed Loop Insulin
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Minnesota
Type 1 Diabetes Mellitus
Mechanisms of Glucose Counterregulation in Pancreatic Islet Transplantation
Pancreatic islet transplantation improves glucose counterregulation and stabilizes glycemic control in patients with type 1 diabetes mellitus prone to severe hypoglycemia even if insulin independence is not achieved.
- Trial name
- NCT01668485
- Testing
- Hypoglycemic and euglycemic glucose clamp
- Where
- Germany
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Giessen
Kidney Transplant, Type 1 Diabetes
Multicenter Trial of the Effect of AAT on Islet Transplant Engraftment and Durability After Renal Transplant
Patients meeting the study entry criteria will receive 1-3 infusion(s) of in vitro cultured islets. Patients will receive three times a week AAT infusions in the peri-transplant period for three weeks.
- Trial name
- NCT02464878
- Testing
- Alpha 1-Antitrypsin, Islet Transplantation, Thymoglobulin
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Massachusetts General Hospital
Type 1 Diabetes Mellitus
Visualizing Beta Cells After Islet Transplantation
In patients with type 1 diabetes (T1D) that have undergone islet of Langerhans transplantation or are on the waiting list for transplantation, Ga-68-exendin PET imaging is performed to study the visualization of transplanted…
- Trial name
- GLP1-transpl (NCT03785236)
- Testing
- 68Ga-NODAGA-exendin PET/CT
- Where
- 2 sites in Netherlands, Sweden
- Volunteers
- 13 people
- Sponsor
- Radboud University Medical Center
Type 1 Diabetes
Islet Isolation Using MnTE-2-PyP (BMX-010) - Pilot Study
In this study, the investigators hypothesize that the addition of antioxidant BMX-010 to perfusion solution, digestion solution and culture medium during islet isolation process, can lead to greater preservation of islet mass and…
- Trial name
- NCT02457858
- Testing
- Islet isolation using BMX-010
- Where
- Canada
- Volunteers
- 5 people
- Sponsor
- University of Alberta