Clinical trials: Islet Transplantation
Diabetes Mellitus, Insulin-Dependent, Diabetes Mellitus, Experimental
hOKT3gamma1 (Ala-Ala) for the Prevention of Human Islet Allograft Failure
The broad, long-term goal of this proposal is to improve the results and applicability of islet allotransplantation early in the course of type 1 diabetes through the administration of selective and short-term immunotherapy.
- Conditions
- Diabetes Mellitus, Insulin-Dependent, Diabetes Mellitus, Experimental, Transplantation, Homologous, Islets of Langerhans Transplantation
- Trial name
- NCT00008801
- Testing
- hOKT3gamma1 (Ala-ala)
- Where
- United States
- Sponsor
- National Center for Research Resources (NCRR)
Diabetes Mellitus, Type 1
Islet Cell Transplants for Diabetes
The purpose of this study is to test the safety and efficacy of islet cell transplants for the treatment of type 1 diabetes mellitus.
- Trial name
- NCT00303134
- Testing
- Islet Cell Transplantation
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Weill Medical College of Cornell University
Diabetes Mellitus, Type 1
Islet Transplantation in Type 1 Diabetics Using the Edmonton Protocol of Steroid Free Immunosuppression
This trial will study the ability of islet transplantation to restore glycemic control and achieve insulin independence in type 1 diabetic subjects with life-threatening hypoglycemia and unawareness, or recurrent hyperglycemia…
- Trial name
- NCT00133809
- Testing
- Transplantation of Human Islets
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Emory University
Type 1 Diabetes, Hypoglycemia
Islet Allotransplantation With Steroid Free Immunosuppression
The restoration of endogenous insulin secretion carries significant hopes for shifting the paradigm of life long exogenous insulin therapy in selected groups of patients with type 1 diabetes(T1D).
- Conditions
- Type 1 Diabetes, Hypoglycemia, Metabolic Diseases
- Trial name
- NCT00446264
- Testing
- islet transplantation, daclizumab - sirolimus - tacrolimus
- Where
- France
- Volunteers
- 14 people
- Sponsor
- University Hospital, Lille
Type 1 Diabetes Mellitus
Safety, Tolerability and Efficacy of Immunomodulation With AT-1501 in Islet Cell Transplantation
This study will evaluate the safety, tolerability and efficacy of AT-1501 in an immunomodulation regimen in adult patients with T1D undergoing an islet cell transplant.
- Trial name
- NCT04711226
- Testing
- AT-1501
- Where
- Canada
- Sponsor
- Anelixis Therapeutics, LLC
Type 1 Diabetes
Omental Islet Transplant
Islet transplantation is a relatively new procedure used in people with difficult to control Type 1 diabetes. Insulin producing cells (islets) are isolated from a pancreas of a deceased organ donor.
- Trial name
- NCT02821026
- Testing
- Omental Islet transplant, Anti-Thymocyte Globulin, Mycophenolate mofetil
- Where
- Canada
- Volunteers
- 4 people
- Sponsor
- University of Alberta
Type 1 Diabetes
ENCRT-103-hPI: Evaluation of an Immune-protected ENCRT-103-hPI Containing Primary Human Islets in Adults With Type 1 Diabetes, With and Without Standard-of-care Portal Vein Islet Infusion.
This study will evaluate the safety and performance of ENCRT-103-hPI, which is a cargo of primary islets inside Encellin's ENC-103-CED.
- Trial name
- NCT07680673
- Testing
- ENCRT-103-hPI encompasses the ENC-103 device, which will be implanted once loaded with primary islet cargo.
- Where
- 2 sites in Canada
- Volunteers
- 10 people
- Sponsor
- Encellin
Type 1 Diabetes
Incretin Effect and Use After Clinical Islet Transplantation
We aim to study if the administration of medications to increase the secretion of hormones from the intestines can improve glycemic control, reduce insulin use and promote β-cell regeneration/expansion in subjects with type 1…
- Trial name
- NCT00768651
- Testing
- Pantoprazole, Sitagliptin
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- University of Alberta
Type 1 Diabetes Mellitus
MRI Imaging of Labeled Human Islets Transplanted Into the Liver
The purpose of the study is to determine whether human islets labeled by iron contrast agents could be imaged using magnetic resonance after transplantation into the liver of Type 1 diabetic recipients.
- Trial name
- NCT01050166
- Testing
- Transplantation of labeled islets
- Where
- Czechia
- Volunteers
- 8 people
- Sponsor
- Frantisek Saudek
Diabetes Mellitus
Patterns and Natural History of Insulin Secretion in Islet Cell Transplant Recipients and Controls
This grant is to study patients that have received a kidney transplant AND an Islet Cell transplant and to discover how the transplant is functioning.
- Trial name
- NCT00018122
- Where
- United States
- Sponsor
- National Center for Research Resources (NCRR)
Pancreatic Islet Transplantation in Type 1 Diabetes Mellitus
Reparixin in Pancreatic Islet Transplantation
Inhibition of CXCL8 activity might represent a relevant therapeutic target to prevent injury occurring after pancreatic islet transplantation. Reparixin is a novel and specific inhibitor of CXCL8.
- Trial name
- NCT01220856
- Testing
- Reparixin
- Where
- 2 sites in Germany, Italy
- Volunteers
- 9 people
- Sponsor
- Dompé Farmaceutici S.p.A
Diabetes Mellitus, Type 1
Minimal Islet Transplant at Diabetes Onset
This is a prospective phase 2, single-arm, mono-center pilot study. It has been designed to investigate whether giving the combination therapy consisting of minimal islet transplantation (1500 EIQ/Kg body weight), Thymoglobulin®…
- Trial name
- MITO (NCT02505893)
- Testing
- Human pancreatic islet, ATG, Pegylated G-CSF
- Where
- Italy
- Volunteers
- 6 people
- Sponsor
- Ospedale San Raffaele
Type 1 Diabetes Mellitus, Hypoglycemia
MGA031, Sirolimus and Tacrolimus in Islet Transplantation
This clinical trial is designed to extend the observations made in our pilot clinical trial (IND 8971, Study #1) on the safety and efficacy of immunotherapy with the anti-CD3 monoclonal antibody hOKT3γ1 (Ala-Ala), (currently…
- Trial name
- NCT00265473
- Testing
- Allogeneic Islets of Langerhans
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Minnesota
Type 1 Diabetes Mellitus
Islet Transplantation in Type 1 Diabetes
Type 1 diabetes is an autoimmune disease in which the insulin-producing pancreatic beta cells are destroyed, resulting in poor blood sugar control.
- Trial name
- NCT00434811
- Testing
- Allogeneic Pancreatic Islet Cells, Antithymocyte Globulin, Sirolimus
- Where
- 8 sites in United States, Canada
- Volunteers
- 48 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Type 1 Diabetes, Hypoglycemia Unawareness
Measurement of Glucose Metabolism in Humans Using Magnetic Resonance at 4 Tesla. Substudy: Hypoglycemia Unawareness
The purpose of this study is to determine whether islet transplantation alters brain glucose concentrations in patients with type 1 diabetes, recurrent hypoglycemia, and hypoglycemia unawareness when compared to that measured…
- Trial name
- NCT00793741
- Testing
- somatostatin
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Type 1 Diabetes Mellitus
Islet Transplantation Through an Indwelling Catheter in the Umbilical Vein
Islet transplantation is one of the effective and promising options for type 1 diabetes mellitus treatment1-4. The liver is the primary target location for infusion and portal vein catheterization is generally used.
- Trial name
- NCT02367534
- Testing
- umbilical vein catheterization
- Volunteers
- 12 people
- Sponsor
- Fuzhou General Hospital
Diabetes Mellitus, Type 1
Treatment of Type I Diabetes by Islet Transplantation Into the Gastric Submucosa Study Protocol
The goal of this trial is to gain initial clinical experience regarding the safety and efficacy of treating type I diabetes in people who have received a kidney transplant by transplanting islets into a new transplant site in the…
- Trial name
- NCT02402439
- Testing
- Islet cells, Islet transplantation into the gastrointestinal submucosa
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Chuck Rickert, MD, PhD
Type 1 Diabetes Mellitus
Islet Transplantation Using Abatacept
Islet transplantation in type 1 diabetics with hypoglycemic unawareness using abatacept as a part of a novel calcineurin-inhibitor-sparing immunosuppressive regimen.
- Trial name
- NCT00276250
- Testing
- Efalizumab, Abatacept, Belatacept
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Emory University
Type 1 Diabetes Mellitus, Hypoglycemia
Anti-Thymocyte Globulin, Cyclosporine, and RAD in Islet Transplantation
This study was designed to test the safety and efficacy of up to 3 pancreatic alloislet transplants in type 1 diabetic patients with hypoglycemia unawareness.
- Trial name
- NITA (NCT00286624)
- Testing
- Allogeneic Islets of Langerhans, Everolimus, anti-thymocyte globulin
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Minnesota
Diabetes Mellitus, Type 1
Safety of ENC-201-CED ENCRT
The purpose of the study is to evaluate the safety and tolerability of ENC-201-CED in a subcutaneous space in patients with Type I diabetes.
- Trial name
- NCT06408311
- Testing
- ENC-201-CED hPI
- Where
- 2 sites in Canada
- Volunteers
- 10 people
- Sponsor
- Encellin