Clinical trials: Islet Transplantation
Type 1 Diabetes
Energy Balance Following Islet Transplantation
Islet transplantation may be appropriate in up to 10% of adults with Type 1 diabetes who suffer repeated episodes of hypoglycaemia with severely impaired awareness of hypoglycaemia (IAH) (1).
- Trial name
- EBFIT (NCT03063229)
- Testing
- Accelerometer, Anthropomentry, Blood tests
- Where
- United Kingdom
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Islet Cell Transplantation, Type 1 Diabetes
Pancreatic Islet Cell Transplantation After Kidney Transplantation - A Novel Approach to Immunosupression
The purpose of this study is to further test islet cell transplant in patients who have had a kidney transplant. This study will also evaluate the safety and effectiveness of the anti-rejection medications used to prevent…
- Trial name
- NCT03047200
- Testing
- Islet cell transplantation
- Where
- United States
- Sponsor
- Baylor Research Institute
Type One Diabetes Mellitus
Islet Function and Clinical Analyses of Transplant Recipients
To follow the patterns and natural history of Islet Transplant recipients (the ones that were involved in the Modified Edmonton Protocol) using oral glucose to check sugar levels as well as insulin and C-peptide over the course…
- Trial name
- Islet OGTT (NCT00870831)
- Testing
- OGTT (Oral Glucose Tolerance Test)
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Immunodeficiency Secondary to Organ Transplantation
Evolution of Interleukin 7, Fat Mass and Metabolic Profile Before and After Transplantation
Three different white adipose tissue-related disorders, whether due to its excess (obesity), absence (lipoatrophies) or aberrant distribution (lipodystrophies), are paradoxically able to induce metabolic insulin resistance…
- Trial name
- IL-7tran (NCT01414660)
- Testing
- transplantation
- Where
- 5 sites in France
- Volunteers
- 49 people
- Sponsor
- University Hospital, Lille
Solid Organ Transplantation, Pregnancy
Long-term Follow-up of the Offspring Born to Mothers With a Solid Organ Transplant, Transplantlines Next Generation
Background Pregnancy after all types of solid organ transplantation (SOT) is possible, although these have higher risk of pregnancy complications for mother and child, such as preeclampsia and preterm birth.
- Conditions
- Solid Organ Transplantation, Pregnancy, Long-term Follow-up, Kidney Transplant
- Trial name
- NCT07291258
- Where
- Netherlands
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Diabetes Mellitus, Type 1, Hypoglycemia
A Study to Investigate Safety and Effectiveness of Porcine Pancreatic Cells (OPF-310) in Patients With Type 1 Diabetes Mellitus
This study is First In Human study for Encapsulated Porcine Islet Cells for Xenotransplantation (OPF-310). The purpose of this study to assess the safety, tolerability, and efficacy of OPF-310 transplantation and to define the…
- Conditions
- Diabetes Mellitus, Type 1, Hypoglycemia, Islet Cell Transplantation, Type 1 Diabetes
- Trial name
- NCT06575426
- Testing
- OPF-310
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Otsuka Pharmaceutical Factory, Inc.
Type 1 Diabetes Mellitus
Islet Transplantation in Type I Diabetic Patients Using the University of Illinois at Chicago (UIC) Protocol
A Phase 3 clinical trial has been completed and demonstrated the safety and efficacy of allogeneic islet transplantation in improving glycemic control in Type 1 diabetic patients using the UIC protocol.The objective in offering…
- Trial name
- NCT03791567
- Testing
- Donislecel (allogeneic islets of Langerhans for transplant)
- Where
- United States
- Sponsor
- CellTrans Inc.
Type 1 Diabetes Mellitus, Hypoglycemia
Islet Transplant for Type 1 or Surgical Diabetes
The purpose of this study is to evaluate the safety and efficacy of islet transplants from human cadaver donors into type 1 or surgical diabetes mellitus patients who experience frequent acute or advanced chronic complications…
- Conditions
- Type 1 Diabetes Mellitus, Hypoglycemia, Labile Diabetes, End-stage Renal Disease
- Trial name
- EXAX (NCT01606475)
- Testing
- Allogeneic islets of Langerhans
- Where
- United States
- Sponsor
- University of Minnesota
Cancer
Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain
This is a phase III, randomized, double-blind, placebo-controlled, multicenter study of the clinical response to fentanyl sublingual spray as a treatment for breakthrough cancer pain.
- Trial name
- NCT00538850
- Testing
- Fentanyl sublingual spray
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- INSYS Therapeutics Inc
Diabetes Mellitus
Modification of the "Edmonton Protocol" to Allow for Successful Islet Transplantation From a Single Pancreas and Extension of the "Edmonton Protocol" to Kidney Transplant Recipients
The experience of the Edmonton Group with islet transplantation and use of the "Edmonton Protocol" provides much promise for T1DM patients.
- Trial name
- NCT00021580
- Testing
- human cadaveric islet cell transplantation
- Where
- United States
- Sponsor
- National Center for Research Resources (NCRR)
Pancreatectomy for Chronic Pancreatitis
Efficacy and Safety of Reparixin in Pancreatic Islet Auto-transplantation
The study is a phase 2/3, multicenter, double-blind, parallel assignment study. It involves 100 adult recipients of an intra-hepatic pancreatic Islet Auto-Transplantation (IAT).
- Trial name
- NCT01967888
- Testing
- Reparixin
- Where
- 9 sites in United States, Canada
- Volunteers
- 104 people
- Sponsor
- Dompé Farmaceutici S.p.A
Type 1 Diabetes Mellitus, Hypoglycemia
Raptiva and Sirolimus in Islet Transplantation for Type 1 Diabetes
The primary objective of this protocol is to test the safety and efficacy of a treatment regimen consisting of maintenance therapy with efalizumab and sirolimus for 1 year followed by withdrawal of efalizumab and maintenance…
- Trial name
- RAPTIVA (NCT00672204)
- Testing
- Allogeneic islets of Langerhans transplant, Raptiva, Sirolimus
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Minnesota
Type 1 Diabetes
11C-5-HTP PET in Clinical Islet Transplantation
In people with type I diabetes, the insulin producing cells in the pancreas have been destroyed. Presently one can only evaluate the function of the graft through laboratory tests, blood sugars and the insulin requirements.
- Trial name
- NCT02689479
- Testing
- Positron-Emission Tomography, 11C-5-HTP, Magnetic Resonance Imaging
- Where
- 2 sites in Sweden
- Volunteers
- 8 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Type 1 Diabetes
Health Economic Analysis of Islet Cell Transplantation for the Stabilization of the Severe Forms of Type 1 Diabetes
The main goal is to perform a cost-utility analysis to compare islet cell transplantation versus best medical treatment (defined as Sensor augmented pump therapy) for patients with brittle type1 diabetes.
- Trial name
- STABILOT (NCT02854696)
- Testing
- Islet graft, best medical care
- Where
- 11 sites in France, Switzerland
- Volunteers
- 42 people
- Sponsor
- University Hospital, Grenoble
Islets of Langerhans Transplantation, Pancreatitis, Chronic
Clinical Outcome After Total Pancreatectomy With Islet Autotransplantation
A total pancreatectomy with islet autotransplantation (TPIAT) can be performed for a number of benign indications, such as chronic pancreatitis.
- Conditions
- Islets of Langerhans Transplantation, Pancreatitis, Chronic, Diabetes Mellitus
- Trial name
- TOPPER (NCT05287737)
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Leiden University Medical Center
Type 1 Diabetes Mellitus
Human Islet Transplantation in Brittle Type 1 Diabetes Mellitus. The GRAGIL 2 Study.
This research project is supported by a multicentric network of collaborators whose goal is to assess the efficacy of transplanting allogenic pancreas islets to restore insulin secretion in patients with brittle type 1…
- Trial name
- NCT00321256
- Testing
- human pancreatic islet transplantation
- Where
- 6 sites in France, Switzerland
- Volunteers
- 22 people
- Sponsor
- University Hospital, Grenoble
Diabetes Mellitus, Type 1, Islet Transplantation
A Comparison of Strict Glucose Control With Usual Care at the Time of Islet Cell Transplantation
Islet transplants for those with type 1 diabetes have enabled many to initially eliminate insulin, however, only a fraction of the transplanted cells typically survive and the functioning of these decrease over time.
- Trial name
- NCT01123122
- Testing
- Strict glucose control
- Where
- Canada
- Sponsor
- Vancouver Coastal Health
Type 1 Diabetes (T1D)
Cohort Study to Refine the Positioning of Closed-loop Therapy Versus Islet Transplantation in the Management of Patients With Unstable Type 1 Diabetes
Prospective, multicenter, descriptive cohort (RIPH3 study under the Jardé Act), STABILOOP study aims to describe whether BF may be an appropriate therapeutic option for the cohort of patients who are theoretically candidates for…
- Trial name
- STABILOOP (NCT07006272)
- Where
- 7 sites in France
- Volunteers
- 35 people
- Sponsor
- University Hospital, Grenoble
Diabetes Mellitus, Type I
Safety and Effectiveness of Low Molecular Weight Sulfated Dextran in Islet Transplantation After Kidney Transplant
Type 1 diabetes mellitus (T1D) is an autoimmune disease in which the insulin-producing pancreatic beta cells are destroyed, resulting in poor blood sugar control.
- Trial name
- NCT00790439
- Testing
- Low Molecular Weight Sulfated Dextran, Heparin, Mycophenolate Mofetil
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Type 1 Diabetes
Islet Transplantation Using Campath-1H and Infliximab Induction
Islet transplantation has been investigated as a treatment for Type 1 diabetes mellitus in selected patients with inadequate glucose control despite insulin therapy.
- Trial name
- NCT00175266
- Testing
- alemtuzumab, islet transplant, infliximab
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- University of Alberta