Clinical trials: Islet Transplantation
Type 1 Diabetes Mellitus
Strategies to Improve Islet Survival
Type 1 diabetes is an autoimmune disease in which the insulin-producing pancreatic beta cells are destroyed, resulting in poor blood sugar control.
- Trial name
- NCT00464555
- Testing
- Islet transplant, Antithymocyte globulin, Basiliximab
- Where
- 2 sites in United States
- Volunteers
- 5 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Pancreatitis, Diabetes
Sitagliptin Therapy to Improve Outcomes After Islet Autotransplant
The purpose of the study is to test the effects of sitagliptin on the need for insulin (the hormone that lowers blood sugars) by patients who receive a pancreatectomy and islet autotransplant for chronic pancreatitis.
- Trial name
- NCT01186562
- Testing
- Sitagliptin
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- University of Minnesota
Brittle Type 1 Diabetes Mellitus
Allogeneic Regenerative Islet Transplantation for the Treatment of Brittle Type 1 Diabetes Mellitus
This is a single-center, single-arm Phase Investigational Intervention Trial (IIT) clinical trial aimed at evaluating the safety and efficacy of allogeneic regenerative islet transplantation for the treatment of brittle type 1…
- Trial name
- NCT06196996
- Testing
- The method of islet transplantation is through percutaneous transhepatic portal vein puncture.
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Shanghai Changzheng Hospital
Diabetic Retinopathy, Diabetic Macular Edema
A Comparison of Islet Cell Transplantation With Medical Therapy for the Treatment of Diabetic Eye Disease
Diabetic eye disease remains a major cause of visual loss for individuals with type 1 diabetes, despite currently available treatments.
- Trial name
- NCT00853424
- Testing
- islet cell transplant, Medical therapy
- Sponsor
- University of British Columbia
Type 1 Diabetes Mellitus, End-stage Renal Disease
Simultaneous Islet-Kidney Transplantation in Patients of Type 1 Diabetes With End-stage Renal Disease
The aim of this study was to evaluate the efficiency and safety of simultaneous islet-kidney transplantation in patients of type 1 diabetes with end-stage renal disease using a glucocorticoid-free immunosuppressive regimen with…
- Trial name
- NCT00692562
- Testing
- simultaneous islet-kidney transplantation
- Where
- China
- Volunteers
- 7 people
- Sponsor
- Fuzhou General Hospital
Islet Transplantation
Islet Transplantation With Recipient T-Reg Cells or Deceased Donor Vertebral Bone Marrow Therapy
The goal of this clinical trial is to learn if patients who have brittle type 1 diabetes receiving an islet transplantation will have better control of their sugars if they also receive one of 2 types of immune cells along with…
- Trial name
- NCT05973734
- Testing
- Infusion of recipient T regulatory cell, Infusion of concomitant Donor Derived Vertebral Bone Marrow
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Stanford University
Type 1 Diabetes Mellitus
Islet Transplantation Using PKX-001
Islet Transplantation is a procedure used in people with difficult to control Type 1 Diabetes. Insulin producing cells (islets) are isolated from a deceased donor pancreas.
- Trial name
- NCT03073577
- Testing
- Antiaging Glycopeptide
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- University of Alberta
Type 1 Diabetes
Pancreatic Islet Cell Transplantation
The purpose of this study is to assess a novel approach to immunosuppression in allogenic pancreatic islet cell transplant recipients.
- Trial name
- NCT00214786
- Testing
- Islet cell transplantation
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Baylor Research Institute
Type 1 Diabetes Mellitus
Safety and Efficacy Study of Encapsulated Human Islets Allotransplantation to Treat Type 1 Diabetes
In view to avoid immunosuppression, the investigators are submitting a Phase 1 clinical trial protocol testing the safety and the efficacy of encapsulated human islets in a "Monolayer Cellular Device" for allogeneic islets…
- Trial name
- NCT00790257
- Testing
- Encapsulated human islets in a "Monolayer Cellular Device"
- Where
- Belgium
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Diabetes Mellitus
Clinical Study on the Safety and Efficacy of Immunophenotyped Pancreatic Endocrine Organoid Bank in Treating Patients With T3c Diabetes
Islet cells are isolated from resected pancreatic tissue obtained from patients undergoing surgery, followed by ex vivo expansion and culture.
- Trial name
- NCT06991829
- Testing
- HLA-matched pancreatic endocrine organoids transplantation
- Where
- China
- Volunteers
- 29 people
- Sponsor
- Shanghai Zhongshan Hospital
Cystic Fibrosis, Diabetes Related Cystic Fibrosis
Metabolic Efficiency of Combined Pancreatic Islet and Lung Transplant for the Treatment of End-Stage Cystic Fibrosis
Patients with end-stage cystic fibrosis (CF) and severe CF-related diabetes (CFRD) may benefit from combined lung-pancreatic islet transplantation.
- Conditions
- Cystic Fibrosis, Diabetes Related Cystic Fibrosis, Insulin-dependent Diabetes
- Trial name
- PIM (NCT01548729)
- Testing
- Combined pancreatic islet and lung transplantation
- Where
- 28 sites in France
- Volunteers
- 14 people
- Sponsor
- University Hospital, Strasbourg, France
Type 1 Diabetes Mellitus
Islet of Langerhans Graft Monitoring by Magnetic Resonance Imaging
The primary objective of this pilot study is to assess the feasibility and safety of ex vivo islet labelling prior to intraportal transplantation in patients with type 1 diabetes with the purpose of islet graft imaging.
- Trial name
- NCT00453817
- Testing
- ferucarbotran (iron-based MRI contrast agent), Islet transplantation, Magnetic resonance imaging
- Where
- Switzerland
- Volunteers
- 5 people
- Sponsor
- University Hospital, Geneva
Chronic Pancreatitis, Diabetes
Mesenchymal Stem Cell and Islet Co-transplantation
The purpose of this study is to show safety and tolerability to our mesenchymal stromal cells (MSCs) product which will be autologous in nature, expanded using a non-xenogeneic, human component expansion media (pooled human…
- Trial name
- NCT02384018
- Testing
- autologous mesenchymal stromal cell
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Medical University of South Carolina
Type 1 Diabetes
Device-Less Technique in Islet Transplantation
Islet transplantation is an effective modality for treating type 1 diabetes. Despite marked progress in clinical islet transplantation with the achievement and maintenance of insulin independence in over half of recipients up to…
- Trial name
- NCT05073302
- Testing
- Implantation of Nylon catheter (Device-less sentinel unit)
- Where
- Canada
- Volunteers
- 5 people
- Sponsor
- University of Alberta
Diabetes Mellitus, Type 1
Allogenic Islet Cell Transplantation
The purpose of this study is to determine the safety of transplanting human islet cells for controlling hyperglycemia in brittle and/or complex patients with type 1 diabetes.
- Trial name
- NCT00160732
- Testing
- Allogenic islet cells (human, U. Chicago), Intraportal infusion of islet cells
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Chicago
Partial Islet Function, TPIAT
SGLT2i Therapy in Islet Transplantation (SIT)
This pilot clinical trial is designed to gather preliminary data on the efficacy and safety of empagliflozin, a diabetes drug in the sodium-glucose cotransporter 2 inhibitor (SGLT2i) class, in islet autotransplant recipients who…
- Conditions
- Partial Islet Function, TPIAT, Diabetes
- Trial name
- NCT07228195
- Testing
- Empagliflozin 25 MG Oral Tablet, Empagliflozin 10 MG Oral Tablet [Jardiance]
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Minnesota
Islets of Langerhans Transplantation, Diabetes Mellitus
Arginine-stimulated Indication of Early Outcome After Islet Transplantation
Through islet transplantation, functional β-cell mass can be restored. Allogeneic islet transplantation is a treatment modality for a select group of patients with complicated type 1 diabetes mellitus.
- Conditions
- Islets of Langerhans Transplantation, Diabetes Mellitus, Chronic Pancreatitis
- Trial name
- ALADDIN (NCT05540197)
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Leiden University Medical Center
Type 1 Diabetes Mellitus
Islet Cell Transplant for Type 1 Diabetes
City of Hope National Medical Center, located in Duarte, CA, is hosting a clinical study on islet cell transplantation, an experimental procedure being evaluated as a treatment for patients with type 1 diabetes.
- Trial name
- TCD (NCT01909245)
- Testing
- Allogenic Human Islet Cells, Immunosuppressive Agents, Gastrin 17
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- City of Hope Medical Center
Islets of Langerhans Transplantation, Diabetes Mellitus, Type 1
Cadaveric Islet Transplantation in Patients With Insulin-Dependent Diabetes Mellitus
We hypothesize that the following improvements to islet transplantation will increase the islet mass successfully isolated and allow for engraftment from a single pancreas.
- Trial name
- NCT00579371
- Testing
- Islets of Langerhans
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Nebraska
Islet Transplantation, Type 1 Diabetes
Comparison of Sirolimus Alone With Sirolimus Plus Tacrolimus in Type 1 Diabetic Recipients of Cultured Islet Cell Grafts
Proof of concept study in islet transplantation, two treatment arms (ATG SIR-TAC versus ATG SIR) each consisting of ten type 1 diabetic patients
- Trial name
- NCT00409461
- Testing
- ATG-Sirolimus-Tacrolimus
- Where
- 2 sites in Belgium
- Sponsor
- Universitair Ziekenhuis Brussel