Clinical trials: Islet Transplantation
Type 1 Diabetes
Islet Allotransplantation in Type 1 Diabetes
Islet transplantation can provide physiologic insulin replacement to patients with type 1 diabetes without the complications associated with whole pancreas transplantation.
- Trial name
- NCT01705899
- Testing
- Human Pancreatic Islets
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Ohio State University
Islets of Langerhans Transplantation
Novel Method of Pancreatic Islet Transplantation Into the Omentum
The investigators propose to conduct a pilot clinical study in 10 type 1 diabetic subjects suffering from hypoglycemia unawareness syndrome and episodes of severe hypoglycemia, in which therapy with transplantation of allogeneic…
- Trial name
- NCT04884633
- Testing
- Pancreatic islet transplantation
- Where
- Czechia
- Volunteers
- 6 people
- Sponsor
- Frantisek Saudek
Diabetes Mellitus
Complement Inhibitor Eculizumab in Clinical Islet Transplantation
This is a dual centre, single arm, exploratory study of the possibility to use eculizumab (Soliris) to prevent/reduce destruction of islets of Langerhans after portal infusion of the islets in patients with diabetics accepted for…
- Trial name
- ICC (NCT02727608)
- Testing
- Eculizumab
- Where
- Sweden
- Volunteers
- 3 people
- Sponsor
- Uppsala University
Type 1 Diabetes
Clinical Islet Transplantation Using the Edmonton Protocol
The purpose of this study is to perform a series of islet transplants using the Edmonton protocol. Patients with Type I Diabetes and glycemic lability, severe hypoglycemia or hypoglycemic unawareness will undergo transplantation…
- Trial name
- NCT00309231
- Testing
- Islet Allotransplantation
- Where
- Canada
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Diabetes, Kidney Transplantation
Islet Transplantation in Type 1 Diabetic Recipients of Kidney Transplants
Study hypothesis is that we can reproduce results of islet transplantation in type one diabetics in patients with a kidney transplant.
- Trial name
- NCT00288977
- Testing
- Islet Infusion
- Volunteers
- 8 people
- Sponsor
- Beth Israel Deaconess Medical Center
Pancreatitis, Chronic, Pancreatectomy; Hyperglycemia
A Prospective Observational Study of TPIAT
Multi-center, prospective, observational cohort study of patients undergoing total pancreatectomy with islet autotransplantation (TPIAT)
- Conditions
- Pancreatitis, Chronic, Pancreatectomy; Hyperglycemia, Pancreatitis
- Trial name
- POST (NCT03260387)
- Testing
- TPIAT
- Where
- 12 sites in United States
- Volunteers
- 433 people
- Sponsor
- University of Minnesota
Kidney Transplant, Pancreas Tranplant
Observational Study Concerning COVID-19 Infection in Transplanted Kidney, Pancreas or Pancreatic Islet Patients
Collect informations on the health status of transplanted patients (kidney, kidney / pancreas, pancreas or pancreatic islet) during the COVID-19 pandemic. All informations will be collected by short questionnaire via phone.
- Conditions
- Kidney Transplant, Pancreas Tranplant, Pancreatic Islet Transplantation
- Trial name
- NCT04377776
- Testing
- Practice details
- Where
- Italy
- Volunteers
- 644 people
- Sponsor
- IRCCS San Raffaele
Type1diabetes, Hypoglycemia
Adrenergic System in Islet Transplantation
To determine the effect of sympathetic neural and hormonal (epinephrine) input on islet cell hormonal responses to insulin-induced hypoglycemia in type 1 diabetic recipients of intrahepatic islet transplantation.
- Conditions
- Type1diabetes, Hypoglycemia, Hypoglycemia Unawareness, Islet Cell Transplantation
- Trial name
- NCT03079921
- Testing
- Phentolamine, Propranolol
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Pennsylvania
Diabetes Mellitus, Kidney Failure
Screening for Patients Needing Kidney, Kidney-Pancreas, or Islet-Cell Transplant
Kidney transplantation is the preferred treatment for most end-stage kidney disease. This procedure is limited, however, by two major factors: 1) a shortage of donor organs and 2) organ rejection by the recipient.
- Trial name
- NCT00001859
- Where
- United States
- Volunteers
- 621 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type 1 Diabetes Mellitus, Hypoglycemia
Allogeneic Islet Cells Transplanted Onto the Omentum
Current islet transplantation into the portal vein of the liver has shown the unique ability of islets to stabilize blood glucose levels and prevent severe hypoglycemia in a selected group of subjects with Type 1 diabetes.
- Conditions
- Type 1 Diabetes Mellitus, Hypoglycemia, Hypoglycemia Unawareness
- Trial name
- NCT02213003
- Testing
- Islet transplantation
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Rodolfo Alejandro
Diabetes, Diabetes Mellitus, Type 1
PolyTreg Immunotherapy in Islet Transplantation
Islet transplantation is a relatively new procedure used in people with difficult to control Type 1 diabetes. Patients who receive an islet transplant take medication that suppresses their immune system and prevent rejection of…
- Trial name
- NCT03444064
- Testing
- PolyTregs
- Where
- Canada
- Volunteers
- 11 people
- Sponsor
- University of Alberta
Chronic Pancreatitis
Analysis of Graft Function Following Autologous Islet Transplantation
Analyze inflammatory markers and islet graft function through blood samples collected from subjects with chronic pancreatitis who undergo total pancreatectomy with auto islet transplantation.
- Trial name
- NCT03097185
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Baylor Research Institute
Diabetes Mellitus, Type 1
Islet Transplantation in Type 1 Diabetic Patients Using the Edmonton Protocol of Steroid Free Immunosuppression
The primary purpose of this study is to demonstrate the safety of allogeneic islet transplantation in type 1 diabetic patients performed at the University of Illinois at Chicago (UIC).
- Trial name
- NCT00566813
- Testing
- Islet Cell Transplant, Islet Cell Transplant plus
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Illinois Chicago
Type 1 Diabetes Mellitus
Cotransplantation of Islet and Mesenchymal Stem Cell in Type 1 Diabetic Patients
The study evaluates the safety and efficacy of Cotransplantation of Islet and Mesenchymal Stem Cell in Type 1 Diabetic Patients.
- Trial name
- NCT00646724
- Testing
- cotransplantation of islet and mesenchymal stem cell
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Fuzhou General Hospital
Islet Transplantation, Diabetes Type 1
Imaging of Islet Transplantation With PET and MRT
Islets of Langerhans intended for clinical transplantation are labelled with a radioactive tracer. The tracer is retained in viable cells of the transplant.
- Trial name
- NCT00417131
- Where
- 2 sites in Sweden
- Volunteers
- 8 people
- Sponsor
- Uppsala University Hospital
Type 1 Diabetes Mellitus
Pancreatic Islet Transplantation in the Anterior Chamber of the Human Eye - a Pilot Study
The overall objective is to establish that transplantation of allogeneic pancreatic islet cells into the anterior chamber of a severely visual impaired diabetic human eye is safe and does not cause ophthalmic or systemic…
- Trial name
- NCT02916680
- Testing
- Pancreatic islet transplantation in the anterior chamber
- Where
- Switzerland
- Volunteers
- 4 people
- Sponsor
- University Hospital, Basel, Switzerland
Islets of Langerhans Transplantation, Diabetes Mellitus, Type 1
Islet Transplant Alone in OMENtum
The study is a phase 2, monocentric, open-label study. The investigators will recruit 12 patients with T1D to be randomly (1:1) assigned to receive islet either into the liver through the portal venous circulation (standard…
- Trial name
- ITA-OMEN (NCT02803905)
- Testing
- Biological: Islet transplantation
- Where
- Italy
- Volunteers
- 12 people
- Sponsor
- Lorenzo Piemonti
type1diabetes, Renal Failure
Kidney Alone Versus Islet-After-Kidney in Type 1 Diabetic Kidney Transplant Recipient.
Islet transplantation is associated with a benefit on glycaemic control compared to optimized insulin therapy in recent clinical trials.
- Conditions
- type1diabetes, Renal Failure, End Stage Renal Disease
- Trial name
- KA-IAK (NCT05662267)
- Testing
- Pancreatic islet transplantation after kidney transplantation
- Where
- France
- Volunteers
- 327 people
- Sponsor
- University Hospital, Lille
Diabetes Mellitus
Islet After Kidney Transplantation (IAK) in Patients With Type 1 Diabetes
The purpose of this study is to determine the safety of islet transplantation in patients with type 1 diabetes who have had a successful kidney transplant and have been maintained for at least three months on anti-rejection…
- Trial name
- NCT00708604
- Testing
- Islet Transplantation, Islet cell transplantation
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- City of Hope Medical Center
Diabetes Mellitus, Type 1
Improving Islet Transplantation Outcomes With Gastrin for Type I Diabetes
This clinical study will evaluate the safety and effectiveness of Gastrin treatment with islet transplantation to help patients with difficult to control type 1 diabetes make insulin again and improve blood sugar control.
- Trial name
- NCT03746769
- Testing
- Allogenic Human Islet Cells, Gastrin 17
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- City of Hope Medical Center