Clinical trials: Islet Transplantation
Diabetes Mellitus, Type 1
Islet Cell Transplantation Alone in Patients With Type I Diabetes Mellitus: Steroid-free Immunosuppression
The goal of islet cell transplantation in patients with Type 1 Diabetes Mellitus is to provide constant normal blood glucose levels.
- Trial name
- NCT00021788
- Testing
- islet cell transplantation
- Where
- United States
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Pancreatitis, Chronic; Diabetes; Transplant
Anti-inflammatory Therapy to Improve Outcomes After TPIAT
Patients with severe chronic pancreatitis may be candidates to have their pancreas removed and their islets transplanted into the liver to reduce the risk of diabetes mellitus, a procedure called total pancreatectomy with islet…
- Trial name
- NCT02713997
- Testing
- etanercept, Alpha 1-Antitrypsin
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- University of Minnesota
Diabetes
Nitrite Infusion in Islet Cell Transplantation
This study seeks to investigate the effects of administering nitrite to pancreatic islet cells that have been removed from a patient for autotransplantation.
- Trial name
- NCT03544242
- Testing
- Control, Pre-Isolation Infusion, Post-Isolation Infusion
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Alabama at Birmingham
Chronic Pancreatitis
Carbon Monoxide-Saturated Medium for Islet Isolation
The goal of this study is to determine whether harvesting islets using carbon monoxide (CO)-saturated mediums can protect islet cell from death after autologous islet transplantation in patients with chronic pancreatitis.
- Trial name
- NCT02567240
- Testing
- Carbon monoxide-bubbled mediums
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Medical University of South Carolina
Islet Transplantation, Type1 Diabetes Mellitus
CGM Use in Islet Transplant Recipients
A study assessing glucose variability in subjects with Type 1 Diabetes who have had islet transplant.
- Trial name
- NCT03427931
- Testing
- Continuous Glucose Monitor (CGM)
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Virginia
Diabetes Mellitus, Type 1
Islet Cell Transplantation in Patients With Type I Diabetes With Previous Kidney Transplantation
The purpose of this study is to reverse hyperglycemia and insulin dependency, by islet cell transplantation, in patients with type 1 diabetes mellitus who have a stable kidney allograft.
- Trial name
- NCT00315588
- Testing
- Islet Transplantation
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Rodolfo Alejandro
Type 1 Diabetes
Islet Transplantation in Type 1 Diabetic Patients
Our hypothesis is that a successful clinical islet transplant program can be established at the University of Wisconsin using a steroid -free, sirolimus- and low dose tacrolimus - based immunosuppressive drug regimen (Edmonton…
- Trial name
- NCT00214253
- Testing
- Thiazolidinedione
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Wisconsin, Madison
Type 1 Diabetes Mellitus
Islet Cell Transplantation Alone and CD34+ Enriched Bone Marrow Cell Infusion in Patients With Diabetes Mellitus: Steroid-Free Regimen
The goal of islet cell transplantation in Type 1 diabetics is to provide those affected with constant normal blood glucose levels, thereby reducing or eliminating altogether the need for injected insulin.
- Trial name
- NCT00021801
- Testing
- Islet Cell Transplantation
- Where
- United States
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Diabetes Mellitus, Cancer
Finding the Cause for Post-Transplant Diabetes Mellitus After Allogeneic Hematopoietic Cell Transplant
This clinical research studies the physiology and immunology of new-onset post-transplant diabetes mellitus in patients undergoing allogeneic stem cell transplantation.
- Trial name
- NCT03415139
- Testing
- Oral Glucose Tolerance Test (OGTT), 2 OGTTs with and without GLP-1 analogue, Hyperglycemic clamp procedure
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Diabetes Mellitus, Type I
Study of Islet Transplantation in Type 1 Diabetic Kidney Transplant Recipients
The purpose of the study is to learn if islet transplantation is an effective treatment for Type 1 diabetes in people who have had a kidney transplant.
- Trial name
- NCT00888628
- Testing
- Purified Pancreatic Islets, Etanercept
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Massachusetts General Hospital
Type 1 Diabetes, Severe Hypoglycemic Unawareness
A Phase 3 Single Center Study of Islet Transplantation in Non-uremic Diabetic Patients
Type 1 diabetes is an autoimmune disease in which the insulin-producing pancreatic beta cells are destroyed, resulting in poor blood sugar control.
- Trial name
- NCT01897688
- Testing
- Islet Cell Transplant
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Northwestern University
Diabetes Mellitus, Type 1
Immunosuppressive Medications for Participants in ITN005CT (NCT00014911)
The purpose of this protocol is to provide continued acess to immunosuppressive medications to subjects from the completed/closed trial ITN005CT (NIS01,NCT00014911).
- Trial name
- NCT01309022
- Testing
- Sirolimus, Tacrolimus, Mycophenolate mofetil
- Where
- 3 sites in United States
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Type 1 Diabetes, Organ Transplantation
Islet Cell Transplantation in Patients With Type I Diabetes With Previous Kidney Transplantation
This single center phase 2 clinical trial, is designed for confirming the efficacy and safety of sequential islet allotransplantation with steroid free immunosuppression in patients with previous kidney transplantation.
- Conditions
- Type 1 Diabetes, Organ Transplantation, Immunosuppression
- Trial name
- NCT01123187
- Testing
- islet transplantation
- Where
- France
- Volunteers
- 14 people
- Sponsor
- University Hospital, Lille
Type 1 Diabetes (T1D), Islets of Langerhans Transplantation
Efficacy of Islet Re-transplantation After Failure of Beta-cell Replacement
Islet transplantation and pancreas transplantation are established therapeutic options for selected individuals with type 1 diabetes experiencing severe glycemic instability and recurrent hypoglycemia.
- Trial name
- MULT-ILOT (NCT07666789)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Montpellier
Diabetes
Extending Indication for Islet Autotransplantation in Pancreatic Surgery
Islet autotransplantation (IAT) is a therapeutic approach used to prevent pancreatogenic diabetes or to reduce the severity of diabetes after a major pancreatectomy.
- Trial name
- AutoTx (NCT01702051)
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Ospedale San Raffaele
Islets of Langerhans Transplantation, Diabetes Mellitus, Type 1
Calcineurin Inhibitor-free, Steroid-free Immunosuppressive Regimen in Simultaneous Islet-Kidney Transplantation for Uremic Type 1 Diabetic Patients
The investigators hypothesize that a calcineurin inhibitor-free, steroid-free, co-stimulatory blockade-based immunosuppressive regimen, in combination with a GLP-1 agonist, will reduce the islet mass required to achieve and…
- Conditions
- Islets of Langerhans Transplantation, Diabetes Mellitus, Type 1, Kidney Transplantation
- Trial name
- NCT01033500
- Testing
- Belatacept
- Where
- United States
- Sponsor
- University of Wisconsin, Madison
Disorder of Endocrine Pancreas
Evaluation of the Efficacy of Intramuscular Islet Autograft After Extensive Pancreatectomy
The liver may not be an optimal site for islet transplantation due to obstacles by an instant blood-mediated inflammatory response, and low revascularization of transplanted islets.
- Trial name
- AUTOGRAFTIM (NCT02872571)
- Testing
- Intramuscular Islet Autograft
- Where
- 4 sites in France
- Volunteers
- 35 people
- Sponsor
- University Hospital, Lille
Type 1 Diabetes Mellitus
A Safety, Tolerability and Efficacy Study of Sernova's Cell Pouch™ for Clinical Islet Transplantation
The Cell Pouch™ is a novel implantable device, that is transplanted with therapeutic cells such as insulin producing islets. This combination product is designed for the treatment of Type 1 Diabetes Mellitus (T1D) with…
- Trial name
- NCT03513939
- Testing
- Sernova Cell Pouch
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Sernova Biotherapeutics Inc.
Diabetes
Pancreatic Islet Transplantation Into the Anterior Chamber of the Eye
The intervention in this trial is intraocular islet transplantation. A single dose of 1000 - 3000 Islet Equivalents (IEQ)/kg recipient body weight (BW) will be infused into the anterior chamber of the eye through a self-sealing…
- Trial name
- NCT02846571
- Testing
- Human Pancreatic Islet Transplantation
- Where
- 2 sites in United States
- Volunteers
- 2 people
- Sponsor
- Midhat H. Abdulreda
Kidney Transplant, Pancreatic Transplat
SARS-CoV2 (COVID-19) Seroepidemiological Transplanted Subjects (Kidney, Kidney-pancreas, Pancreas, Langerhans Islets)
Evaluate SARS-CoV2 infection and the degree of immunity possibly developed in transplanted population using the Luciferase Immuno Precipitation System (LIPS) test.
- Conditions
- Kidney Transplant, Pancreatic Transplat, Pancreatic Islets Langerhans
- Trial name
- NCT04487197
- Testing
- blood sample for seroepidemiological investigation
- Where
- Italy
- Volunteers
- 282 people
- Sponsor
- Antonio Secchi