Clinical trials: Islets of Langerhans Transplantation
Type 1 Diabetes Mellitus
Islet Transplantation for Type 1 Diabetes Mellitus
The complex program of insulin replacement for type 1 diabetes that is current clinical standard of care is difficult to implement for long periods of time, associated with an increased risk of severe hypoglycemia and implemented…
- Trial name
- NCT00437398
- Testing
- Islet Transplant
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Mayo Clinic
Type 1 Diabetes Mellitus
Safety and Efficacy Study of Encapsulated Human Islets Allotransplantation to Treat Type 1 Diabetes
In view to avoid immunosuppression, the investigators are submitting a Phase 1 clinical trial protocol testing the safety and the efficacy of encapsulated human islets in a "Monolayer Cellular Device" for allogeneic islets…
- Trial name
- NCT00790257
- Testing
- Encapsulated human islets in a "Monolayer Cellular Device"
- Where
- Belgium
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Islets of Langerhans Transplantation, Diabetes Mellitus, Type 1
Calcineurin Inhibitor-free, Steroid-free Immunosuppressive Regimen in Simultaneous Islet-Kidney Transplantation for Uremic Type 1 Diabetic Patients
The investigators hypothesize that a calcineurin inhibitor-free, steroid-free, co-stimulatory blockade-based immunosuppressive regimen, in combination with a GLP-1 agonist, will reduce the islet mass required to achieve and…
- Conditions
- Islets of Langerhans Transplantation, Diabetes Mellitus, Type 1, Kidney Transplantation
- Trial name
- NCT01033500
- Testing
- Belatacept
- Where
- United States
- Sponsor
- University of Wisconsin, Madison
Type 1 Diabetes Mellitus
Islet Transplantation in Type 1 Diabetic Patients Using the University of Illinois at Chicago (UIC) Protocol
In an earlier Phase 1/2 clinical trial using the Edmonton Protocol of steroid free immunosuppression, investigators at University of Illinois at Chicago (UIC) demonstrated the safety of islet preparation, iset transplantation…
- Trial name
- NCT00679042
- Testing
- Islets of Langerhans transplantation
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- CellTrans Inc.
Diabete Type 1, Chronic Kidney Disease
Breakthrough - T1DM and Chronic Kidney Disease
Single arm- subject treated with Tegoprubart and everolimus. The purpose of this research is to gather information on the safety and effectiveness of investigational regimen containing 2 experimental components: An…
- Trial name
- NCT07592000
- Testing
- Tegoprubart, Islet Cell Transplant
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- University of Chicago
Diabetes Mellitus, Insulin-Dependent
Islet Transplantation for Type 1 Diabetes
The purpose of this study is to test whether the islet cell transplantation procedures and results from a previous study in Edmonton, Canada, can be repeated.
- Trial name
- NCT00014911
- Testing
- Islet Transplantation, Sirolimus, Tacrolimus
- Where
- 9 sites in United States, Canada and 3 more
- Volunteers
- 36 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Type 1 Diabetes Mellitus
Islet Transplantation in Type I Diabetic Patients Using the University of Illinois at Chicago (UIC) Protocol
A Phase 3 clinical trial has been completed and demonstrated the safety and efficacy of allogeneic islet transplantation in improving glycemic control in Type 1 diabetic patients using the UIC protocol.The objective in offering…
- Trial name
- NCT03791567
- Testing
- Donislecel (allogeneic islets of Langerhans for transplant)
- Where
- United States
- Sponsor
- CellTrans Inc.
Type 1 Diabetes
Pancreatic Islet Cell Transplantation
The purpose of this study is to assess a novel approach to immunosuppression in allogenic pancreatic islet cell transplant recipients.
- Trial name
- NCT00214786
- Testing
- Islet cell transplantation
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Baylor Research Institute
Type 1 Diabetes Mellitus
Strategies to Improve Islet Survival
Type 1 diabetes is an autoimmune disease in which the insulin-producing pancreatic beta cells are destroyed, resulting in poor blood sugar control.
- Trial name
- NCT00464555
- Testing
- Islet transplant, Antithymocyte globulin, Basiliximab
- Where
- 2 sites in United States
- Volunteers
- 5 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Type 1 Diabetes Mellitus
Aralast NP in Islet Transplant
Islet transplantation is a relatively new procedure used in people with difficult to control Type 1 diabetes. Insulin producing cells (islets) are isolated from a pancreas donated by the next of kin of a person who is brain dead.
- Trial name
- NCT02520076
- Testing
- Alpha-1 Antitrypsin
- Where
- Canada
- Volunteers
- 5 people
- Sponsor
- University of Alberta
Type 1 Diabetes Mellitus
Screening of Subjects With Type I Diabetes to Determine Eligibility for Islet Transplantation
Protocol to screen potential subjects for islet transplantation
- Trial name
- NCT02004964
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Rodolfo Alejandro
Diabetes Mellitus, Type 1
Minimal Islet Transplant at Diabetes Onset
This is a prospective phase 2, single-arm, mono-center pilot study. It has been designed to investigate whether giving the combination therapy consisting of minimal islet transplantation (1500 EIQ/Kg body weight), Thymoglobulin®…
- Trial name
- MITO (NCT02505893)
- Testing
- Human pancreatic islet, ATG, Pegylated G-CSF
- Where
- Italy
- Volunteers
- 6 people
- Sponsor
- Ospedale San Raffaele
Islets of Langerhans Transplantation, Diabetes Mellitus, Type 1
Cadaveric Islet Transplantation in Patients With Insulin-Dependent Diabetes Mellitus
We hypothesize that the following improvements to islet transplantation will increase the islet mass successfully isolated and allow for engraftment from a single pancreas.
- Trial name
- NCT00579371
- Testing
- Islets of Langerhans
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Nebraska
Diabetes Mellitus, Type 1
Islet Transplantation in Patients With "Brittle" Type I Diabetes
The purpose of this study is to learn about the safety of islet transplantation for Type 1 diabetes mellitus, which may provide more normal control of blood sugar without the need for insulin shots.
- Trial name
- NCT01630850
- Testing
- Allogenic islet cells (human, U. Chicago), Intraportal infusion of islet cells
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Chicago
Type 1 Diabetes
Bone Marrow vs Liver as Site for Islet Transplantation
The goal of this study is to evaluate safety and efficacy of bone marrow (BM) as site for pancreatic islet transplantationin humans.
- Trial name
- IsletBOM2 (NCT01722682)
- Testing
- Human pancreatic islet transplantation
- Where
- Italy
- Volunteers
- 9 people
- Sponsor
- Ospedale San Raffaele
Type 1 Diabetes
Prevention of Autoimmune Destruction and Rejection of Human Pancreatic Islets Following Transplantation for Insulin Dependent Diabetes Mellitus
Pancreatic islets are the part of the pancreas that produce insulin and help control the blood sugar. This study aims to improve islet transplantation as a treatment for Type 1 Diabetes by using a new combination of…
- Trial name
- NCT00501709
- Testing
- Belatacept and Raptiva
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of California, San Francisco
Type 1 Diabetes Mellitus
B-Lymphocyte Immunotherapy in Islet Transplantation
Type 1 diabetes is an autoimmune disease in which the insulin-producing pancreatic beta cells are destroyed, resulting in poor blood sugar control.
- Trial name
- NCT00468442
- Testing
- Allogeneic Pancreatic Islet Cells, Antithymocyte globulin, Daclizumab
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Islet Cell Transplantation, Type 1 Diabetes
Pancreatic Islet Cell Transplantation - A Novel Approach to Improve Islet Quality and Engraftment
The purpose of this study is to assess a novel approach to immunosuppression in allogenic pancreatic islet cell transplant recipients.
- Trial name
- NCT00530686
- Testing
- Islet cell transplantation
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Baylor Research Institute
Diabetes Mellitus, Type 1
Islet Cell Transplantation Alone in Patients With Type I Diabetes Mellitus: Steroid-free Immunosuppression
The goal of islet cell transplantation in patients with Type 1 Diabetes Mellitus is to provide constant normal blood glucose levels.
- Trial name
- NCT00021788
- Testing
- islet cell transplantation
- Where
- United States
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Diabetes Mellitus, Type I
Islet Cell Transplantation Alone in Patients With Type 1 Diabetes Mellitus: Steroid-Free Immunosuppression
SPECIFIC AIMS: 1. To reverse hyperglycemia and insulin dependency in patients with Type 1 Diabetes Mellitus by islet cell transplantation; 2.
- Trial name
- NCT00306098
- Testing
- islets
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Rodolfo Alejandro