Clinical trials: Isoflurane
Liver Disease
Isoflurane Preconditioning for Liver Resections
The objective is to examine the efficacy of isoflurane (inhaled anesthetic gas) to induce clinically effective preconditioning in patients undergoing elective hepatic surgery.
- Trial name
- NCT01031550
- Testing
- isoflurane, propofol
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Rutgers, The State University of New Jersey
Toxicity, Hydrocephalus
Isoflurane-induced Neuroinflammation in Children With Hydrocephalus
The investigators will quantify inflammatory biomarkers in cerebrospinal fluid (CSF) and serum of children with hydrocephalus who are undergoing ventriculoperitoneal shunt placement under isoflurane anesthesia.
- Trial name
- NCT02512809
- Testing
- Isoflurane, Dexmedetomidine
- Volunteers
- 25 people
- Sponsor
- Nationwide Children's Hospital
Postoperative Pain
Pain After Laparoscopic Cholecystectomy
To the investigators' knowledge, no study has looked at differences in postoperative pain when comparing maintenance of anesthesia with isoflurane, desflurane, sevoflurane, and propofol in laparoscopic cholecystectomy.
- Trial name
- NCT00983918
- Testing
- Desflurane, Sevoflurane, Isoflurane
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Baylor College of Medicine
Delirium on Emergence
Post Anesthesia Emergence and Behavioral Changes in Children Undergoing MRI
Children who receive general anesthesia may become agitated (emergence delirium) in the recovery period. This occurs more often after inhalational anesthetics, particularly sevoflurane and desflurane than after propofol.
- Trial name
- NCT02111447
- Testing
- Propofol, Sevoflurane, Isoflurane
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- State University of New York at Buffalo
Duration of Hospitalization
Volatile Anesthetic Choice and Duration of Hospitalization: A Quality Improvement and Cost-control Project
Preliminary retrospective data suggest that the relatively soluble but inexpensive volatile anesthesia isoflurane prolongs the duration of hospitalization compared to the less soluble but more expensive anesthetic sevoflurane.
- Trial name
- NCT01379664
- Testing
- Isoflurane, Sevoflurane
- Where
- United States
- Volunteers
- 1,584 people
- Sponsor
- The Cleveland Clinic
Delayed Emergence From Anesthesia
General Anesthesia Emergence Induced by Methylphenidate
The purpose of this study is to assess whether methylphenidate affects time of emergence from isoflurane general anesthesia. Time to emergence was defined as the time from termination of isoflurane to extubation.
- Trial name
- MPOrtho (NCT02327195)
- Testing
- Methylphenidate HCl
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Nicoleta Stoicea
One-Lung Ventilation
Estimating Blood Concentrations of Anaesthetics During One-Lung Ventilation (OLV)
The aims of the study is to determine if end-tidal concentrations of the anaesthetic gases isoflurane and sevoflurane as measured by a standard gas monitor are related to the blood levels during one-lung ventilation.
- Trial name
- NCT02821455
- Testing
- Lung Surgery with One-Lung Ventilation
- Where
- United Kingdom
- Volunteers
- 19 people
- Sponsor
- University of Edinburgh
Postoperative Delirium
Comparison of Postoperative Delirium in Patients Anaesthetised With Isoflurane and Desflurane During Spinal Surgery
Postoperative delirium (POD) is a known complication of inhalational agents used to anaesthetise patients for surgery with potential long term implications.The incidence of postoperative delirium in spine surgery is 3.3% to…
- Trial name
- NCT02925611
- Testing
- Isoflurane, Desflurane
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Sedation
Effect & Safety of Inhaled Isoflurane vs IV Midazolam for Sedation in Mechanically Ventilated Children 3-17 Years Old
This is a study to compare safety and efficacy of inhaled isoflurane delivered by the AnaConDa-S (Anaesthetic Conserving Device (ACD)) versus intravenous midazolam for sedation in mechanically ventilated children admitted to an…
- Trial name
- IsoCOMFORT (NCT04684238)
- Testing
- Midazolam, Isoflurane
- Where
- 24 sites in France, Germany and 3 more
- Volunteers
- 94 people
- Sponsor
- Sedana Medical
Sedation
Efficacy and Safety of Inhaled Isoflurane Delivered Via the Sedaconda ACD-S Compared to Intravenous Propofol for Sedation of Mechanically Ventilated Intensive Care Unit Adult Patients (INSPiRE-ICU2)
This is a study to compare safety and efficacy of inhaled isoflurane administered via the Sedaconda ACD-S device system versus intravenous propofol for sedation of mechanically ventilated patients in the Intensive Care Unit (ICU)…
- Trial name
- INSPiRE-ICU2 (NCT05327296)
- Testing
- Isoflurane, Propofol
- Where
- 16 sites in United States
- Volunteers
- 282 people
- Sponsor
- Sedana Medical
Sedation
Efficacy and Safety of Inhaled Isoflurane Delivered Via the Sedaconda ACD-S Compared to Intravenous Propofol for Sedation of Mechanically Ventilated Intensive Care Unit Adult Patients (INSPiRE-ICU1)
This is a study to compare safety and efficacy of inhaled isoflurane administered via the Sedaconda ACD-S device system versus intravenous propofol for sedation of mechanically ventilated patients in the Intensive Care Unit (ICU)…
- Trial name
- INSPiRE-ICU1 (NCT05312385)
- Testing
- Isoflurane, Propofol, Isoflurane (run-ins)
- Where
- 14 sites in United States
- Volunteers
- 277 people
- Sponsor
- Sedana Medical
Postoperative Pain
Anesthesia and Postoperative Pain
The purpose of this study is to compare post-operative pain after anesthesia with either isoflurane or propofol. Each group will be further randomized to receive intranasal nicotine or placebo in order to detect potential…
- Trial name
- NCT00232817
- Testing
- Nicotine (drug)
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Columbia University
Open Heart Surgery
Closed Loop Isoflurane Administration With Bispectral Index in Open Heart Surgery
With the advancement in microprocessor technology and better understanding of pharmacodynamics and pharmacokinetics of anaesthetic agents, computer facilitated closed loop control of anaesthesia using propofol has been shown to…
- Trial name
- NCT01069562
- Testing
- Conventional control, Closed loop control
- Where
- India
- Volunteers
- 40 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Alzheimers Disease, Postoperative Delirium
Markers of Alzheimers Disease and Cognitive Outcomes After Perioperative Care
This study will examine the hypothesis that changes in the cognition (i.e. thinking and memory) after anesthesia and surgery are correlated with changes in markers of Alzheimers Disease in the fluid around the brain and spinal…
- Conditions
- Alzheimers Disease, Postoperative Delirium, Post Operative Cognitive Dysfunction
- Trial name
- MADCO-PC (NCT01993836)
- Testing
- Total intravenous anesthesia with propofol, General anesthesia with isoflurane
- Where
- United States
- Volunteers
- 191 people
- Sponsor
- Duke University