Clinical trials: Isolated REM Sleep Behavior Disorder
Polyneuropathy, Alpha-Synucleinopathy
Prodromal Model of Parkinson's Disease Confined to The Peripheral Nervous System
Description of a method to detect Parkinson's disease or Parkinson's-like disease at an early stage (Prodromal Parkinson's Disease) where damage is still confined to the peripheral nervous system damage.
- Conditions
- Polyneuropathy, Alpha-Synucleinopathy, Lewy Body Disease, Parkinson Disease (PD)
- Trial name
- Prompark (NCT06745011)
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- University of Aarhus
REM Sleep Behavior Disorder
Effect of PXS-4728A on Microglia Activation in Participants With Isolated Rapid Eye Movement Sleep Behaviour Disorder
This study is to investigate the safety and efficacy of PXS-4728A as an intervention therapy in participants with iRBD. This study will be conducted in participants aged 50 to 80 years of age and will investigate a single dose…
- Trial name
- NCT05904717
- Testing
- PXS-4728 (A)
- Where
- 3 sites in Australia, United Kingdom
- Volunteers
- 40 people
- Sponsor
- Syntara
REM Sleep Behavior Disorder
DREAMER - IsolateD REM Sleep Without Atonia as a Risk Factor for REM Sleep Behavior disordER
This study aims at the constitution of a large cohort of adult subjects without Rapid eye movement (REM) sleep behavior disorder (RBD), among whom subjects with isolated REM sleep without atonia (RSWA) will be identified; their…
- Trial name
- DREAMER (NCT06140511)
- Testing
- Polysomnography
- Volunteers
- 600 people
- Sponsor
- Oasi Research Institute-IRCCS
REM Sleep Behavior Disorder, Neurodegenerative Diseases
Striatal Dopamine Transmission in Individuals With Isolated Rapid Eye Movement Sleep With Atonia: a Search for Precursor Biomarker for Neurodegeneration
Background: Previous studies have confirmed that most patients with idiopathic REM sleep behaviour disorder (iRBD) eventually develop neurodegenerative diseases.
- Trial name
- NCT03353207
- Where
- Hong Kong
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Parkinson Disease, REM Sleep Behavior Disorder (iRBD)
Study of Sleep Disorders in Prodromal and Definite Parkinsons Disease
Multicenter controlled study of sleep disorders in isolated REM Behavior Disorder and Parkinson\'s disease (SOMPARK)
- Trial name
- SOMPARK (NCT06582121)
- Testing
- Polysomnography
- Where
- 6 sites in France
- Volunteers
- 457 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Parkinson Disease, REM Sleep Behavior Disorder (iRBD)
Role of Slow Waves in the Progression of Neurodegeneration in Isolated REM Sleep Behavior Disorder
This study tests whether enhancing deep sleep with gentle sounds at night can slow progression in people with iRBD or early Parkinson's disease. Participants wear a sensor headband and headphones for 18 months.
- Trial name
- SloW-iRBD (NCT07355842)
- Testing
- Tosoo Axora
- Where
- Switzerland
- Volunteers
- 80 people
- Sponsor
- University of Zurich
REM Sleep Behavior Disorder, Isolated REM Sleep Behavior Disorder
Unmet Needs Among Patients With Isolated REM Sleep Behavior Disorder (iRBD) and Their Significant Others
The goal of this observational study is to explore the unmet needs and the psychosocial impact of isolated REM Sleep Behavior Disorder (iRBD) on patients and their significant others.
- Trial name
- NCT07498452
- Where
- 8 sites in Italy
- Volunteers
- 150 people
- Sponsor
- Universita di Verona