Clinical trials: Isolation
Aortic Valve Disease, Mitral Valve Disease
The Study on the Use of "UniLine" Bioprosthesis in the Treatment of Isolated Aortic and Mitral Valve Diseases
The goal of this open, prospective, multicenter study is analyze long-term outcomes of aortic/mitral valve replacement using the "UniLine" bioprosthesis in patients with acquired aortic or mitral valve diseases.
- Trial name
- Uniline (NCT06025149)
- Where
- Russia
- Volunteers
- 300 people
- Sponsor
- Closed Joint-Stock Company NeoCor
Multiple Sclerosis, NMO Spectrum Disorder
Clinical Impact Through AI-assisted MS Care - A Retrospective Multi-center Observational Study.
The RECLAIM study aims to gather a centralized and harmonized dataset, enabling the secondary use of data for building AI-based models that will support diagnosis and prognosis of individual Multiple Sclerosis patient's disease…
- Conditions
- Multiple Sclerosis, NMO Spectrum Disorder, Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease, Radiologically Isolated Syndrome
- Trial name
- RECLAIM (NCT06280755)
- Where
- 3 sites in Czechia, Germany
- Volunteers
- 7,000 people, healthy volunteers welcome
- Sponsor
- icometrix
AF - Atrial Fibrillation, HTN-Hypertension
Pulmonary Vein Isolation (PVI) Combined With Renal Denervation (RDN) in Atrial Fibrillation (AF) and Hypertension (HTN)
The close relationship between the increase of sympathetic tension, AF, and HTN cannot be ignored. In addition, the significant failure rate of PVI (20-50%) in the treatment of AF makes it very necessary to explore the effect of…
- Trial name
- NCT05841615
- Testing
- Renal Denervation operation, Pulmonary vein isolation
- Where
- China
- Volunteers
- 120 people
- Sponsor
- The First Affiliated Hospital of Xiamen University
Aortic Valve Disease, Aortic Stenosis
EDWARDS INTUITY Elite Valve System
The purpose of this active, observational, open-label, non-randomized, post-market surveillance study is to confirm that EDWARDS INTUITY Elite reduces cross clamp time (XCT) in MIS setting when compared to published data with a…
- Trial name
- MISSION (NCT02907463)
- Where
- 23 sites in Austria, Denmark and 7 more
- Volunteers
- 280 people
- Sponsor
- Edwards Lifesciences
Chronic Atrial Fibrillation
CFAE/Spatiotemporal Dispersion Guided Ablation Versus PVI Guided Ablation in Persistent AF
Objective: The purpose of this study is to compare the efficacy and safety of ablation of Atrial Fibrillation (AF) drivers marked by spatiotemporal dispersions and Complex Fractionated Atrial Electrocardiograms (CFAEs) to…
- Trial name
- CIPA (NCT02696265)
- Testing
- CFAE guided ablation, PVI guided ablation
- Where
- 4 sites in France, Japan and 1 more
- Volunteers
- 180 people
- Sponsor
- Diagram B.V.
Covid-19 in Pregnancy
COVID-19 Among Pregnant Women in Assiut
COVID-19 is a new disease , little is known about COVID-19 during pregnancy and to the best of our knowledge no published studies in Assiut . Aims of the Research : 1.
- Trial name
- NCT04822402
- Volunteers
- 50 people
- Sponsor
- Assiut University
Older Adults, Muscle Protein Synthetic Response to Protein
Influence of Reduced Daily Step Count and Anabolic Interventions on Muscle Protein Metabolism in Older Persons
As the loss of muscle mass with aging is associated with a dysregulation of muscle protein synthesis (MPS) that is generally characterized by an 'anabolic resistance' to nutrients, the primary outcome of the trial is to…
- Conditions
- Older Adults, Muscle Protein Synthetic Response to Protein, Reduced Physical Activity
- Trial name
- NCT02347137
- Testing
- step-reduction, step-reduction plus resistance exercise
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- McMaster University
Atrial Fibrillation Chronic
Comparing Pulmonary Vein Isolation to Pulmonary Vein Isolation + OPTIMA Ablation in Patients Undergoing Ablation for Atrial Fibrillation
Catheter ablation is an established cornerstone of therapy for patients with symptomatic atrial fibrillation (AF) who wish to avoid anti-arrhythmic drug therapy or for whom anti-arrhythmics have proven ineffective.
- Trial name
- OPTIMA (NCT04101539)
- Testing
- OPTIMA-guided catheter ablation, Standard PVI
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- Johns Hopkins University
Atrial Fibrillation (AF)
Assessment of Pulmonary Vein Isolation Using a Balloon Catheter With Pulsed Field Energy in Atrial Fibrillation
The goal of this clinical trial is to evaluate whether pulsed field ablation (PFA) using the novel VOLT catheter is as safe and effective as conventional thermal ablation (radiofrequency or cryotherapy) for the treatment of…
- Trial name
- ILLUMINATE-AF (NCT07156877)
- Testing
- Pulsed Field Ablation (PFA) with VOLT Catheter, Thermal Ablation (Radiofrequency or Cryoablation)
- Where
- 2 sites in Belgium
- Volunteers
- 136 people
- Sponsor
- Sebastien Knecht
Healthy
Promoting Community Mobility for Wellness in Older Adults in Urban Environments
This study evaluates the program outcomes of the Let's Go program. The standardized community mobility program employs multi-modal group and individual sessions to facilitate wellness in older adults.
- Trial name
- NCT02916758
- Testing
- Let's Go Community Mobility Program
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Kean University
Chronic Myeloproliferative Disorders, Graft Versus Host Disease
Bone Marrow and Peripheral Stem Cell Transplantation in Treating Patients With Hematologic Cancer
RATIONALE: Bone marrow and peripheral stem cell transplantation may be able to replace immune cells that were destroyed by chemotherapy or radiation therapy used to kill tumor cells.
- Conditions
- Chronic Myeloproliferative Disorders, Graft Versus Host Disease, Leukemia, Lymphoma
- Trial name
- NCT00004232
- Testing
- filgrastim, cyclosporine, methylprednisolone
- Where
- United States
- Sponsor
- Northwestern University
Left Ventricular Noncompaction, Isolated Noncompaction of the Ventricular Myocardium
Cardiac Computed Tomography: Characteristics of Isolated Left Ventricular Non-compaction
The diagnostic criteria for isolated left ventricular non-compaction cardiomyopathy (IVNC) have been well established for echocardiography and cardiac magnetic resonance, such validation is lacking for computed tomography (CT).
- Trial name
- NCT01470014
- Where
- Switzerland
- Volunteers
- 39 people
- Sponsor
- University of Zurich
Gingival Recession
Effect of Hyaluronic Acid on Gingival Recession Treatment
Gingival marginal tissue recession is the displacement of the soft tissue margin apical to the cementoenamel junction (CEJ) with exposure of the root surface.
- Trial name
- NCT04692558
- Testing
- HYALURONIC ACID, coronally advanved flap with connective tissue harvesting
- Where
- India
- Volunteers
- 20 people
- Sponsor
- Krishnadevaraya College of Dental Sciences & Hospital
Varicose Veins of Lower Limb, Saphenous Vein
Isolated Great Saphenous Vein Stripping for Treatment of Varicose Veins in Lower Limbs
The goal of this clinical trial is to compare two surgical approaches for treating varicose veins in the lower limbs in adults: performing varicose vein removal at the same time as great saphenous vein stripping (concomitant)…
- Conditions
- Varicose Veins of Lower Limb, Saphenous Vein, Venous Insufficiency
- Trial name
- NCT07616115
- Testing
- Great saphenous vein stripping, Varicose veins removal
- Where
- Brazil
- Volunteers
- 34 people
- Sponsor
- Hospital Israelita Albert Einstein
Isolated Intrauterine Growth Restriction (IUGR)
Assessment of Invasive Genetic Testing in Fetuses With Isolated Intrauterine Growth Restriction Diagnosed After 28 Weeks of Gestation at Strasbourg University Hospitals (2016-2023)
This study evaluates the diagnostic yield of invasive genetic testing in fetuses with isolated intrauterine growth restriction diagnosed after 28 weeks of gestation, in order to better define indications for invasive procedures…
- Trial name
- RCIU (NCT07864272)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Strasbourg, France
Multiple Sclerosis, Clinically Isolated Syndrome
A Study Evaluating B Cell Levels In Infants Potentially Exposed To Ocrelizumab During Pregnancy
This study will evaluate the potential placental transfer of ocrelizumab in pregnant women with clinically isolated syndrome (CIS) or multiple sclerosis (MS) [in line with the locally approved indications] whose last dose of…
- Trial name
- MINORE (NCT04998812)
- Testing
- Ocrelizumab
- Where
- 11 sites in United States, France and 3 more
- Volunteers
- 70 people
- Sponsor
- Hoffmann-La Roche
Multiple Sclerosis, Clinically Isolated Syndrome
Evaluation of an Automatic Segmentation Software (Pixyl.Neuro) to Track Lesions in Multiple Sclerosis Patients Via Cerebral MRI
Using an automatic software tool, Pixyl.Neuro, to conduct a retrospective analysis (detection of lesions + segmentation of images + tracking over time) of cerebral MRI images acquired during a prospective study of patients…
- Trial name
- PIXCIS (NCT03438357)
- Testing
- Analysis of cerebral MRI with automatic segmentation software
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Atrial Fibrillation, Arrhythmia
Comparison of Rotational Angiography/Electroanatomical Mapping Fusion Versus CT/Electroanatomical Mapping Fusion to Guide AF Ablation
The purpose of this study is to compare rotational angiography (3DATG technology)intra-procedure (during the ablation procedure) with CT (x-ray) pre-procedure (before the ablation procedure) fusion to create an anatomical picture…
- Trial name
- 3DATGvsCT (NCT01537237)
- Where
- 2 sites in United States
- Volunteers
- 37 people
- Sponsor
- Steward St. Elizabeth's Medical Center of Boston, Inc.
Multiple Sclerosis, Magnetic Resonance Imaging
Risk Factors in Early Multiple Sclerosis
The central hypothesis of this protocol is that it is possible, using First Degree Relatives (FDRs) of patients with Multiple Sclerosis (MS) and assessing a variety of both known and unknown risk factors for MS, to define a risk…
- Conditions
- Multiple Sclerosis, Magnetic Resonance Imaging, Biomarkers, Clinically Isolated Syndrome
- Trial name
- RISEMS (NCT03586986)
- Testing
- Brain MRI
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Colorado, Denver
Cancer
Caspofungin Acetate in Treating Aspergillosis in Patients With Hematologic Cancer or in Patients Who Have Undergone a Stem Cell Transplant
RATIONALE: Antifungals, such as caspofungin acetate, may be effective in treating fungal infections caused by chemotherapy or stem cell transplant.
- Trial name
- NCT00110045
- Testing
- caspofungin acetate
- Where
- 13 sites in Belgium, France and 5 more
- Volunteers
- 171 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
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