Clinical trials: Isotretinoin
HIV Infections, Anus Neoplasms
Chemoprevention of Anal Neoplasia Arising Secondary to Anogenital Human Papillomavirus Infection in Persons With HIV Infection.
PRIMARY: In Phase I, to define a broadly tolerable dose of isotretinoin that can be used in combination with interferon alfa-2a (IFN alfa-2a).
- Trial name
- NCT00000764
- Testing
- Isotretinoin, Interferon alfa-2a
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Neuroblastoma
ZD6474 Alone and in Combination With Retinoic Acid in Pediatric Neuroblastoma
The goal of this clinical research study is to find the highest safe dose of the drug ZactimaTM (ZD6474) in patients with neuroblastoma or medulloblastoma that has gotten worse, has come back, or has not responded to the…
- Trial name
- NCT00533169
- Testing
- ZD6474, Retinoic Acid
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- M.D. Anderson Cancer Center
Acne Vulgaris
Facial Skin Microbiome in Patients With Moderate-to-Severe Acne Vulgaris Treated With Isotretinoin
Acne vulgaris is associated with changes in the facial skin microbiome, but longitudinal microbiome changes during isotretinoin therapy remain incompletely understood.
- Trial name
- FACEMICRO (NCT07834138)
- Testing
- ISOtretinoin 10 MG
- Where
- Vietnam
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Can Tho University of Medicine and Pharmacy
COVID
Combination of Recombinant Bacterial ACE2 Receptors -Like Enzyme of B38-CAP and Isotretinoin Could be Promising Treatment for COVID-19 Infection- and Its Inflammatory Complications
Combination of Recombinant Bacterial ACE2 receptors -like enzyme of B38-CAP and Isotretinoin could be promising treatment for COVID-19 infection- and Its inflammatory complications Mahmoud ELkazzaz1 1Department of chemistry and…
- Trial name
- NCT04382950
- Testing
- Recombinant Bacterial ACE2 receptors -like enzyme of B38-CAP (rbACE2) plus Aerosolized 13 cis retinoic acid
- Volunteers
- 24 people
- Sponsor
- Kafrelsheikh University
Papular-pustular Rosacea
Isotretinoin in Papular-Pustular Rosacea
A national, multicentre, prospective, randomised, double-blind, phase III study in 2 parallel groups of isotretinoin versus placebo in patients presenting papular-pustular rosacea resistant to standard therapy.
- Trial name
- ISOROS (NCT00882531)
- Testing
- isotretinoin
- Volunteers
- 156 people
- Sponsor
- Laboratoires Bailleul-Biorga
Recurrent Neuroblastoma, Refractory Neuroblastoma
Lenalidomide and Dinutuximab With or Without Isotretinoin in Treating Younger Patients With Refractory or Recurrent Neuroblastoma
This phase I trial studies the side effects and best dose of lenalidomide when given together with dinutuximab with or without isotretinoin in treating younger patients with neuroblastoma that does not respond to treatment or…
- Trial name
- NCT01711554
- Testing
- Dinutuximab, Isotretinoin, Laboratory Biomarker Analysis
- Where
- 15 sites in United States, Canada
- Volunteers
- 27 people
- Sponsor
- National Cancer Institute (NCI)
Acne
Efficacy and Safety of Painless 5-aminolevulinic Acid Photodynamic Therapy for Moderate and Severe Acne Vulgaris
This study is being done to compare a new, continuous illumination and short Incubation time regimen of 5-aminolevulinic acid photodynamic therapy (painless ALA- PDT) to low-dose and conventional dose of oral isotretinoin for…
- Trial name
- NCT04167982
- Testing
- Aminolevulinic acid photodynamic therapy, Oral conventional-dose isotretinoin, Oral low-dose isotretinoin
- Where
- China
- Volunteers
- 234 people
- Sponsor
- Shanghai Dermatology Hospital
Acneiform Eruptions, Cancer, Treatment-Related
Doxycycline vs Isotretinoin for Acneiform Eruptions of TKI
Tyrosine Kinase inhibitors (TKIs) have become standard of care in patients with EGFR mutations in non-small cell lung cancer and other EGFR-mutated cancers.
- Trial name
- NCT04864717
- Testing
- Doxycycline 100mg po once daily x 6 months, Isotretinoin 40 mg po once daily x 6 months
- Where
- Canada
- Volunteers
- 98 people
- Sponsor
- Lady Davis Institute
Hepatic Insufficiency
Pharmacokinetics of 9-cis-retinoic Acid (Alitretinoin, Toctino®) in Patients With Hepatic Disease
This study aims to investigate whether liver patients may tolerate alitretinoin by comparing metabolism in 8 such patients with the metabolism in 8 healthy controls
- Trial name
- NCT01261923
- Testing
- Alitretinoin
- Where
- Denmark
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Glioblastoma, Gliomas
Temozolomide & RT Followed by Dose Dense vs Temozolomide & Retinoic Acid in Pts w/Glioblastoma
Patients have a newly diagnosed brain tumor called a malignant glioma and participate in the study to see if it is possible to increase the benefit of temozolomide when given after radiation.
- Trial name
- NCT00200161
- Testing
- Temozolomide
- Where
- 3 sites in United States
- Volunteers
- 127 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Ganglioneuroblastoma, Nodular, Neuroblastoma
Treatment With Dinutuximab, Sargramostim (GM-CSF), and Isotretinoin in Combination With Irinotecan and Temozolomide After Intensive Therapy for People With High-Risk Neuroblastoma (NBL)
This phase II trial studies if dinutuximab, GM-CSF, isotretinoin in combination with irinotecan, and temozolomide (chemo-immunotherapy) can be given safely to patients with high-risk neuroblastoma after Consolidation therapy…
- Trial name
- NCT04385277
- Testing
- Biospecimen Collection, Bone Marrow Aspiration, Bone Marrow Biopsy
- Where
- 77 sites in United States, Australia and 2 more
- Volunteers
- 41 people
- Sponsor
- Children's Oncology Group
Neuroblastoma
Isotretinoin in Treating Young Patients With High-Risk Neuroblastoma
RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors plan better treatment for patients receiving isotretinoin.
- Trial name
- NCT00939965
- Testing
- isotretinoin, DNA analysis, polymerase chain reaction
- Where
- 3 sites in United Kingdom
- Volunteers
- 75 people
- Sponsor
- Children's Cancer and Leukaemia Group
Primary Refractory Neuroblastoma
A Study of MAb-3F8 Plus Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) Versus 13-cis-Retinoic Acid (RA) Plus GM-CSF in Primary Refractory Neuroblastoma Patients
This is a multicenter, randomized, controlled, open-label study. Patients meeting inclusion/exclusion criteria will be randomized (1:1) to receive two cycles of MAb-3F8 plus GM-CSF or RA plus GM-CSF.
- Trial name
- NCT00969722
- Testing
- MAb-3F8, Subcutaneous Granulocyte Macrophage Colony Stimulating Factor (GM-CSF), 13-cis-Retinoic Acid
- Where
- 15 sites in United States
- Volunteers
- 1 people
- Sponsor
- United Therapeutics
Contraception
The Effect of Isotretinoin on the Etonogestrel Contraceptive Implant
This exploratory study will fill a knowledge gap regarding the pharmacokinetic effects of isotretinoin on the etonogestrel (ENG) contraceptive implant.
- Trial name
- NCT02967055
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Hepatic Insufficiency
Single Dose of 9-cis-retinoic Acid in Hepatic Patients
To test whether patients with hepatic insufficiency can tolerate one oral dose of 9-cis-retinoic acid and to test whether the metabolism of retinoic acid is altered.
- Trial name
- NCT01891526
- Testing
- 9-cis-retinoic acid
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Seborrhea, Seborrheic Dermatitis
Efficacy and Safety of Low-dose Oral Isotretinoin for Seborrhea
Oral isotretinoin is the gold standard drug to treat moderate to severe acne. Other indications like seborrhea, seborrheic dermatitis have been suggested.
- Conditions
- Seborrhea, Seborrheic Dermatitis, Quality of Life
- Trial name
- NCT01139749
- Testing
- oral isotretinoin, salicylic acid and ciclopirox olamine
- Where
- Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Neuroblastoma
Combination Chemotherapy Followed by Stem Cell Transplant and Isotretinoin in Treating Young Patients With High-Risk Neuroblastoma
RATIONALE: Giving chemotherapy before an autologous stem cell transplant stops the growth of tumor cells by stopping them from dividing or by killing them. It also prepares the patient's bone marrow for the stem cell transplant.
- Trial name
- NCT00526318
- Testing
- filgrastim, carboplatin, cisplatin
- Where
- 68 sites in Germany, Switzerland
- Volunteers
- 360 people
- Sponsor
- German Society for Pediatric Oncology and Hematology GPOH gGmbH
Recurrent Neuroblastoma
Biological Therapy, Sargramostim, and Isotretinoin in Treating Patients With Relapsed or Refractory Neuroblastoma
This phase II trial is studying how well hu14.18-interleukin-2 (IL2) fusion protein works when given together with sargramostim and isotretinoin in treating patients with relapsed or refractory neuroblastoma.
- Trial name
- NCT01334515
- Testing
- hu14.18-IL2 fusion protein, isotretinoin, sargramostim
- Where
- 76 sites in United States, Canada
- Volunteers
- 52 people
- Sponsor
- Children's Oncology Group
Acne
Proof of Concept Study to Investigate the Recurrence of Acne Post Isotretinoin
The use of topical retinoids is a mainstay and basis of early acne treatment to prevent the progression to inflammatory lesions. Post oral isotretinoin, it is not uncommon for non-inflammatory papules and comedones to recur.
- Trial name
- NCT00939133
- Testing
- tretinoin microsphere 0.04% gel, vehicle gel
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Dermatrials Research
Medulloblastoma, Pineoblastoma
Vorinostat Combined With Isotretinoin and Chemotherapy in Treating Younger Patients With Embryonal Tumors of the Central Nervous System
This pilot clinical trial studies the side effects and the best way to give vorinostat with isotretinoin and combination chemotherapy and to see how well they work in treating younger patients with embryonal tumors of the central…
- Conditions
- Medulloblastoma, Pineoblastoma, Supratentorial Embryonal Tumor, Not Otherwise Specified
- Trial name
- NCT00867178
- Testing
- 3-Dimensional Conformal Radiation Therapy, Carboplatin, Cisplatin
- Where
- 15 sites in United States
- Volunteers
- 33 people
- Sponsor
- National Cancer Institute (NCI)