Clinical trials: Ivf
Infertility (IVF Patients)
CircularRNA-microRNA-mRNA Regulatory Axis in IVF
1. Investigate the expression levels of circ-0033392, miR-375, miR-1305, JAK2, and PTEN in follicular fluids of females candidate for IVF. 2.
- Trial name
- IVF (NCT06792266)
- Where
- Egypt
- Volunteers
- 56 people
- Sponsor
- Assiut University
STERILITY
Assessment of the Effectiveness and Tolerability of Ovarian Hyperstimulation
The aim of the study is to assess the effectiveness of 5 mixed protocols of ovarian hyperstimulation with urinary gonadotrophins to achieve clinical pregnancy in females undergoing assisted reproductive techniques (IVF/ICSI)…
- Trial name
- DESCARTES (NCT01331720)
- Testing
- hMG-HP
- Where
- 14 sites in Spain
- Volunteers
- 279 people
- Sponsor
- Ferring Pharmaceuticals
Infertility, Implantation Failure
ISM1 Versus EmbrioGen Media for Embryo Culture With Previous Failure Implantation in ART Treatments
Recently, it has been suggested that culture of embryos in EmbryoGen medium can increase the live birth rate in IVF patients with a previous history of pregnancy loss.
- Trial name
- NCT01689454
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Biogenesi
Assisted Hatching, Advanced Age
The Impact of Assisted Hatching on Pregnancy Outcomes After Vitrified-Warmed Embryo Transfer in Advanced-age Patients
The goal of this clinical trial is to evaluate the effect of laser assisted hatching (LAH) on pregnancy outcomes, with live birth rate as the primary outcome, in advanced age infertile women aged ≥35 years who are undergoing…
- Trial name
- NCT07490561
- Testing
- Laser assisted hatching
- Volunteers
- 916 people
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Failure After Assisted Reproductive Technology
Observation on the Curative Effect of Assisted Reproduction by TCM Multi-channel Interventional Therapy
Objective: To evaluate the curative effect of TCM multi-channel interventional therapy on women with ART Failure; to compare the curative effect of the dual therapy and triple therapy on women with ART Failure; to choose the best…
- Trial name
- NCT03078205
- Testing
- The dual therapy, The triple therapy
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Chengdu University of Traditional Chinese Medicine
IVF
Progesterone Levels and Frozen Embryo Transfer Outcomes
Frozen embryo transfers (FET) now represent the majority of all embryo transfer cycles, and upwards of 60% live births in United States are now attributable to frozen embryo transfers (1).
- Trial name
- PLATO (NCT07252622)
- Testing
- Blood draw
- Volunteers
- 659 people
- Sponsor
- Shady Grove Fertility Reproductive Science Center
Infertility
NATural Ovarian Stimulation
To overcome unsuitable effects of controlled ovarian hyperstimulation (COH )while maintaining large oocyte availability, investigators elaborated an innovative protocol (NATural Ovarian Stimulation) that dissociates E2 production…
- Trial name
- NATOS (NCT02892942)
- Testing
- Gonal-F®, Cetrotide®
- Where
- France
- Volunteers
- 129 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Infertility, IVF
Outcomes of 36 vs 38 Hour Intervals From Ovulation Trigger To Oocyte Pick-Up:A Multi-Center Randomized Controlled Trial
Women who undergo assisted reproduction technology (ART) treatment will be eligible for this study. The goal of this randomized clinical trial is to compare the outcomes of ART treatment between women who have 36 and 38 hours…
- Trial name
- NCT05803655
- Testing
- 36-hour duration between ovulation triggering and oocyte pick-up procedure, 38-hour duration between ovulation triggering and oocyte pick-up procedure
- Where
- 7 sites in Turkey (Türkiye)
- Volunteers
- 850 people
- Sponsor
- Koç University
Diminished Ovarian Reserve
The Effeciency of NMN in Improving IVF/ICSI-ET Pregnancy Outcomes in Patients With DOR
The purpose of the study is to understand the effect of nicotinamide mononucleotide (NMN) on patients with diminished ovarian reserve and the outcomes of IVF/ICSI-ET.
- Trial name
- NCT06426355
- Testing
- NMN
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking University Third Hospital
Reproductive Medicine
Evaluate the Interest of the Pre-conceptional Endometrial Immune Profiling to Increase Birth Rates
A prospective, randomized, controlled, open two-arm study to evaluate the interest of the pre-conceptional endometrial immune profiling to increase birth rates.
- Trial name
- PRECONCEPTIO (NCT02262117)
- Testing
- standard care, specific treatment
- Where
- France
- Volunteers
- 493 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Embryo Aneuploidies, Implantation Rates
Preimplantation Genetic Screening (PGS) in Advanced Female Age and Male Severe Factor
Preimplantation Genetic Screening (PGS) is used for the selection of chromosomally normal embryos before the transfer in IVF treatments in many cases.
- Conditions
- Embryo Aneuploidies, Implantation Rates, Infertility
- Trial name
- NCT01571076
- Testing
- PGS, Prolonged culture
- Where
- Spain
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Igenomix
Polycystic Ovary Syndrome, Obesity
The Effect of a Liraglutide on IVF in Obese PCOS
The aim of this study was to evaluate the impact of low dose liraglutide in combination with metformin compared to metformin alone on IVF pregnancy rate (PR) and cumulatively PR (IVF and spontaneous) in infertile obese women with…
- Conditions
- Polycystic Ovary Syndrome, Obesity, Infertility, Female
- Trial name
- NCT03353948
- Testing
- MET, COMBI
- Volunteers
- 30 people
- Sponsor
- University Medical Centre Ljubljana
Female Infertility Due to Diminished Ovarian Reserve
Human Growth Hormone Pre-treatment for 6 Weeks Prior to Ovulation Induction for IVF
Synthetic human growth hormone (HGH) has been available for more than a decade for specific indication in children and adults. Past Randomized Control Trials (RCT)s of HGH (under off-label use) for improving ovarian function have…
- Trial name
- NCT02179255
- Testing
- Human Growth Hormone, Follicle Stimulating Hormone
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Center for Human Reproduction
Ovarian Reserve, Poor Responders
Controlled Ovarian Stimulation Versus Modified Natural Cycles in Poor Responders
This is a prospective, randomized, single center, phase 4 controlled trial. The study will compare the efficacy of two different strategies for the management of predicted poor response patients under stimulation for IVF/ICSI: up…
- Conditions
- Ovarian Reserve, Poor Responders, IVF
- Trial name
- MONACO (NCT04487925)
- Testing
- A single Gonadotropin-Releasing Hormone (GnRH) antagonist corifollitropin alfa (CFA) stimulation, Up to three modified natural cycles with Follitropin beta.
- Where
- Belgium
- Volunteers
- 208 people
- Sponsor
- University Hospital, Ghent
IVF
Luteal Phase Estradiol Support for In Vitro Fertilization/Intracytoplasmic Sperm Injection Cycles
Optimizing in vitro fertilization (IVF) success is more important than ever, in light of new public funding of IVF in Ontario, Canada.
- Trial name
- NCT02677259
- Testing
- 17-beta estradiol, Micronized progesterone
- Volunteers
- 506 people, healthy volunteers welcome
- Sponsor
- One Fertility
Euploid Embryos
Embryo Aneuploidies and Morphokinetics in Ovarian Stimulated and Non Stimulated IVF Cycles
The purpose of this study is to compare the number of euploid embryos obtained per metaphase II oocyte in unstimulated (modified natural cycles) and stimulated IVF cycles.
- Trial name
- AMOS (NCT03128580)
- Where
- 3 sites in Spain
- Volunteers
- 40 people
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
ART, IVF
Health in Childhood Following Assisted Reproductive Technology
The purpose of this trial is to investigate the metabolic and cardiovascular health in children aged 6-8 years born after in-vitro fertilization with frozen embryo transfer
- Conditions
- ART, IVF, Cardiovascular Risk Factor, Hypertension
- Trial name
- HiCART (NCT03719703)
- Where
- Denmark
- Volunteers
- 606 people, healthy volunteers welcome
- Sponsor
- Anja Bisgaard Pinborg
Pain, Postoperative, IVF
OPU-LUX: Virtual Reality for Pain and Anxiety Management During Oocyte Pick-up
In vitro fertilization (IVF) cycles are increasingly performed worldwide. Transvaginal oocyte pick-up (OPU) is a painful part of IVF. OPU in polyfollicular IVF is usually performed under sedation and pain relief.
- Trial name
- OPU-LUX (NCT05830513)
- Testing
- Virtual Reality
- Where
- Switzerland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Luzerner Kantonsspital
Infertility
Diafert for Embryo Selection and Fertility Improvement (DESTINy)
Prospective, single-center, single-blind, randomized, controlled, two-arm, interventional study.
- Trial name
- DESTINy (NCT02593513)
- Testing
- Daifert, Control Group
- Where
- Hungary
- Volunteers
- 108 people
- Sponsor
- Forest Laboratories
Infertility
Evaluation Study Between Density Gradient and Swimming Down for Semen Processing
This study evaluates the quality of sperm produced after semen processing using Density Gradient (DG) and swimming down (SD).
- Trial name
- NCT02329704
- Testing
- Diff-Quik staining for morphology evaluation, Motility Evaluation for grade A and B, Concentration (mil/ml)
- Where
- 2 sites in Bahrain, Egypt
- Volunteers
- 100 people
- Sponsor
- Ahmad Mustafa Mohamed Metwalley
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